Summary
Rhesus monkeys have been artificially sensitized to poison ivy. Such sensitized animals have been shown also to be specifically sensitive to poison oak. This not only demonstrates the common antigenic principle in the two substances but confirms the specific nature of the cutaneous reactions obtained. Sensitivity lasts at least 8 months.
For experiments in contact-dermatitis the Rhesus monkey presents advantages over other laboratory animals because he is more closely related to man, and because, as judged by these experiments, his reactions very closely simulate those previously observed in human infants. Further investigations, which are impracticable in humans, are made possible by the use of the Rhesus monkey.
Footnotes
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↵1 This study was aided by a grant from the Carl Leff Research Fund.
- Received December 7, 1936.
- Copyright © 1937 by The American Association of Immunologists, Inc.
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