Summary
The growth and migration of cells in explants from the spleen and bone marrow of tuberculous guinea pigs are inhibited by the addition of tuberculin; those explanted from non-tuberculous guinea pigs sensitized by a single injection of horse serum are not inhibited by horse serum.
Migration and growth in similar explants from tuberculous guinea pigs sensitized to horse serum are not inhibited by the addition of horse serum; it was found that they are, on the other hand, inhibited by tuberculin.
When the Arthus phenomenon was elicited by injections of horse serum into normal and tuberculous guinea pigs the tissue cultures were unaffected by the addition of the serum.
These tissue-culture experiments suggest that the mechanism underlying the tuberculin reaction is different from the mechanisms of anaphylaxis and the Arthus phenomenon.
- Received November 5, 1932.
- Copyright © 1933 by The American Association of Immunologists, Inc.
Pay Per Article - You may access this article (from the computer you are currently using) for 1 day for US$37.50
Regain Access - You can regain access to a recent Pay per Article purchase if your access period has not yet expired.
Log in using your username and password
In this issue
