Abstract
Since, on the one hand, the injection of old tuberculin into a tuberculous animal is followed by inflammation in organs containing tuberculous tissue, and, on the other hand, inflammation is associated with an increased sinking velocity of red blood cells in the sedimentation test tube, the injection of old tuberculin might be expected to cause an increase in the sedimentation rate of red blood cells of tuberculous animals. If so, it may be possible to demonstrate hypersensitiveness by measuring the rate of sedimentation of erythrocytes before and after the injection of old tuberculin. To test this possibility we have chosen the rabbit as our experimental animal. This test may prove useful in detecting tuberculous infection in rabbits, since in this animal neither the skin nor the temperature reaction is a dependable indication of hypersensitiveness to tuberculin.
The settling of red blood cells was observed in tubes 40 mm. long with an inner bore 5 mm. in diameter.
- Received July 25, 1932.
- Copyright, 1933, by The Williams & Wilkins Company
- Copyright © 1933 by The American Association of Immunologists, Inc.
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