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H and O Agglutination in Typhoid Fever, Other Febrile Diseases, and in Vaccination

Anna Dean Dulaney and Walter T. Wikle
J Immunol March 1, 1933, 24 (3) 235-246;
Anna Dean Dulaney
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Walter T. Wikle
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Abstract

The qualitative receptor analysis of Weil and Felix (1), and Felix (2) for the serodiagnosis of typhoid fever has received little attention in this country. Since the incidence of typhoid fever in this especial locality offers unusual opportunities for such a study, the qualitative receptor analysis has been applied to a series of patients in the Memphis General Hospital who were suffering from typhoid fever and other febrile diseases, and to healthy vaccinated individuals. In all, 243 serums were studied and the results of these tests are presented in the tables which follow.

Felix (2) claims to be able to differentiate the agglutination reaction produced by infection from the one which follows the administration of typhoid vaccine on the basis of the type of macroscopic clumping obtained. The motile bacilli of the typhoid-paratyphoid group possess the double receptor apparatus originally described for the proteus bacilli, which indicates two important antigenic components, the H and O.

  • Received July 21, 1932.
  • Copyright, 1933, by The Williams & Wilkins Company
  • Copyright © 1933 by The American Association of Immunologists, Inc.

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The Journal of Immunology
Vol. 24, Issue 3
1 Mar 1933
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H and O Agglutination in Typhoid Fever, Other Febrile Diseases, and in Vaccination
Anna Dean Dulaney, Walter T. Wikle
The Journal of Immunology March 1, 1933, 24 (3) 235-246;

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H and O Agglutination in Typhoid Fever, Other Febrile Diseases, and in Vaccination
Anna Dean Dulaney, Walter T. Wikle
The Journal of Immunology March 1, 1933, 24 (3) 235-246;
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Print ISSN 0022-1767        Online ISSN 1550-6606