The Journal of Immunology: 209 (1)

July 1, 2022; Volume 209,Issue 1

PILLARS OF IMMUNOLOGY

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Long Live the Plasma Cell: The Basis of Sustained Humoral Immunity
Marios Koutsakos and Ali H. Ellebedy

J Immunol July 1, 2022, 209 (1) 3-4; DOI: https://doi.org/10.4049/jimmunol.2200121

ANTIGEN RECOGNITION AND RESPONSES

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The Pre-Existing Human Antibody Repertoire to Computationally Optimized Influenza H1 Hemagglutinin Vaccines
Kaito Nagashima, John V. Dzimianski, Julianna Han, Nada Abbadi, Aaron D. Gingerich, Fredejah Royer, Sara O’Rourke, Giuseppe A. Sautto, Ted M. Ross, Andrew B. Ward, Rebecca M. DuBois and Jarrod J. Mousa

J Immunol July 1, 2022, 209 (1) 5-15; DOI: https://doi.org/10.4049/jimmunol.2101171
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At Critically Low Antigen Densities, IgM Hexamers Outcompete Both IgM Pentamers and IgG1 for Human Complement Deposition and Complement-Dependent Cytotoxicity
Nienke Oskam, Pleuni Ooijevaar-de Heer, Ninotska I. L. Derksen, Simone Kruithof, Steven W. de Taeye, Gestur Vidarsson, Sanne Reijm, Theresa Kissel, René E. M. Toes and Theo Rispens

J Immunol July 1, 2022, 209 (1) 16-25; DOI: https://doi.org/10.4049/jimmunol.2101196
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Mouse Liver B Cells Phagocytose Streptococcus pneumoniae and Initiate Immune Responses against Their Antigens
Masahiro Nakashima, Manabu Kinoshita, Hiroyuki Nakashima, Azusa Kato, Kazuma Mori, Kazuki Koiwai, Nariyoshi Shinomiya and Shuhji Seki

J Immunol July 1, 2022, 209 (1) 26-37; DOI: https://doi.org/10.4049/jimmunol.2100520

AUTOIMMUNITY

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Profibrotic Role of Inducible Heat Shock Protein 90α Isoform in Systemic Sclerosis
Jorge RuizdelRio, Pedro Muñoz, Patricia Carreira, David Maestro, Jose L. Pablos, Ana Palanca, Jesus Merino, Anna Serrano-Mollar, Ramon Merino, Esther Tamayo, Marcos Lopez-Hoyos, Federico Diaz-Gonzalez, Victor Martinez-Taboada and Ana V. Villar

J Immunol July 1, 2022, 209 (1) 38-48; DOI: https://doi.org/10.4049/jimmunol.2100430

CLINICAL AND HUMAN IMMUNOLOGY

Open Access
Therapeutic Effect of Anti-CD52 Monoclonal Antibody in Multiple Sclerosis and Its Animal Models Is Mediated via T Regulatory Cells
Author Choice Article

Nazanin Kiapour, Bing Wu, Yan Wang, Maryamsadat Seyedsadr, Sahil Kapoor, Xin Zhang, Manal Elzoheiry, Ezgi Kasimoglu, Yisong Wan and Silva Markovic-Plese

J Immunol July 1, 2022, 209 (1) 49-56; DOI: https://doi.org/10.4049/jimmunol.2100176

IMMUNE REGULATION

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STAP-2 Is a Novel Positive Regulator of TCR-Proximal Signals
Kodai Saitoh, Jun-ichi Kashiwakura, Kota Kagohashi, Yuto Sasaki, Shoya Kawahara, Yuichi Sekine, Yuichi Kitai, Ryuta Muromoto, Michiko Ichii, Hiroko Nakatsukasa, Akihiko Yoshimura, Kenji Oritani and Tadashi Matsuda

J Immunol July 1, 2022, 209 (1) 57-68; DOI: https://doi.org/10.4049/jimmunol.2101014
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High-Fat Diet–Induced Obesity Alters Dendritic Cell Homeostasis by Enhancing Mitochondrial Fatty Acid Oxidation
I-Chun Chen, Deepika Awasthi, Chia-Lang Hsu, Minkyung Song, Chang-Suk Chae, Andrew J. Dannenberg and Juan R. Cubillos-Ruiz

J Immunol July 1, 2022, 209 (1) 69-76; DOI: https://doi.org/10.4049/jimmunol.2100567

IMMUNE SYSTEM DEVELOPMENT

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Realization of the T Lineage Program Involves GATA-3 Induction of Bcl11b and Repression of Cdkn2b Expression
Patrycja K. Thompson, Edward L. Y. Chen, Renée F. de Pooter, Catherine Frelin, Walter K. Vogel, Christina R. Lee, Thomas Venables, Divya K. Shah, Norman N. Iscove, Mark Leid, Michele K. Anderson and Juan Carlos Zúñiga-Pflücker

J Immunol July 1, 2022, 209 (1) 77-92; DOI: https://doi.org/10.4049/jimmunol.2100366
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Monogenic TCRβ Assembly and Expression Are Paramount for Uniform Antigen Receptor Specificity of Individual αβ T Lymphocytes
Erica J. Culberson and Craig H. Bassing

J Immunol July 1, 2022, 209 (1) 93-98; DOI: https://doi.org/10.4049/jimmunol.2200176

IMMUNOTHERAPY AND VACCINES

Open Access
Viral Delivery of IL-7 Is a Potent Immunotherapy Stimulating Innate and Adaptive Immunity and Confers Survival in Sepsis Models
Author Choice Article

Karine Lélu, Clarisse Dubois, Alexei Evlachev, Morgane Crausaz, Marie Baldazza, Nadine Kehrer, Renée Brandely, Yasmin Schlesinger, Nathalie Silvestre, Jean-Baptiste Marchand, Bérangère Bastien, Stéphane Leung-Theung-Long, Jacqueline Unsinger, Perrine Martin and Geneviève Inchauspé

J Immunol July 1, 2022, 209 (1) 99-117; DOI: https://doi.org/10.4049/jimmunol.2101145
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Improved Durability to SARS-CoV-2 Vaccine Immunity following Coimmunization with Molecular Adjuvant Adenosine Deaminase-1
Gina M. Cusimano, Ebony N. Gary, Matthew R. Bell, Bryce M. Warner, Jennifer Connors, Nicholas J. Tursi, Ali R. Ali, Shiyu Zhang, Gabriela Canziani, Bhavani Taramangalam, Emma A. Gordon, Irwin M. Chaiken, Sarah K. Wootton, Trevor Smith, Stephanie Ramos, Darwyn Kobasa, David B. Weiner, Michele A. Kutzler and Elias K. Haddad

J Immunol July 1, 2022, 209 (1) 118-127; DOI: https://doi.org/10.4049/jimmunol.2200056

INFECTIOUS DISEASE AND HOST RESPONSE

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Type I IFN Signaling Is Essential for Preventing IFN-γ Hyperproduction and Subsequent Deterioration of Antibacterial Immunity during Postinfluenza Pneumococcal Infection
Sunil Palani, Shruti Bansal, Atul K. Verma, Christopher Bauer, Shengjun Shao, Md Bashir Uddin and Keer Sun

J Immunol July 1, 2022, 209 (1) 128-135; DOI: https://doi.org/10.4049/jimmunol.2101135

INNATE IMMUNITY AND INFLAMMATION

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Extracellular pH Controls Chemotaxis of Neutrophil Granulocytes by Regulating Leukotriene B₄ Production and Cdc42 Signaling
Leonie Oster, Julia Schröder, Micol Rugi, Sandra Schimmelpfennig, Sarah Sargin, Albrecht Schwab and Karolina Najder

J Immunol July 1, 2022, 209 (1) 136-144; DOI: https://doi.org/10.4049/jimmunol.2100475

MOLECULAR AND STRUCTURAL IMMUNOLOGY

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Efficient Identification of Tembusu Virus CTL Epitopes in Inbred HBW/B4 Ducks Using a Novel MHC Class I–Restricted Epitope Screening Scheme
Lin Zhang, Zhuolin Li, Ziche Tang, Lingxia Han, Xiaohui Wei, Xiaoli Xie, Shuaimeng Ren, Kai Meng, Yueyue Liu, Minli Xu, Lihong Qi, Hongyan Chen, Jiaqiang Wu and Nianzhi Zhang

J Immunol July 1, 2022, 209 (1) 145-156; DOI: https://doi.org/10.4049/jimmunol.2100382

SYSTEMS IMMUNOLOGY

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Spinal Cord Injury Impairs Lung Immunity in Mice
Katherine A. Mifflin, Faith H. Brennan, Zhen Guan, Kristina A. Kigerl, Angela R. Filous, Xiaokui Mo, Jan M. Schwab and Phillip G. Popovich

J Immunol July 1, 2022, 209 (1) 157-170; DOI: https://doi.org/10.4049/jimmunol.2200192

TUMOR IMMUNOLOGY

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Identification of RPL15 60S Ribosomal Protein as a Novel Topotecan Target Protein That Correlates with DAMP Secretion and Antitumor Immune Activation
Shunsuke Yamada, Yuichi Kitai, Takashi Tadokoro, Runa Takahashi, Haruka Shoji, Taiga Maemoto, Marie Ishiura, Ryuta Muromoto, Jun-ichi Kashiwakura, Ken J. Ishii, Katsumi Maenaka, Taro Kawai and Tadashi Matsuda

J Immunol July 1, 2022, 209 (1) 171-179; DOI: https://doi.org/10.4049/jimmunol.2100963
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Apo-Form Selective Inhibition of IDO for Tumor Immunotherapy
Wen Liu, Yi Zou, Kaiming Li, Haiqing Zhong, Longbo Yu, Shushan Ge, Yisheng Lai, Xianchi Dong, Qiang Xu and Wenjie Guo

J Immunol July 1, 2022, 209 (1) 180-191; DOI: https://doi.org/10.4049/jimmunol.2100938

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PILLARS OF IMMUNOLOGY

ANTIGEN RECOGNITION AND RESPONSES

AUTOIMMUNITY

CLINICAL AND HUMAN IMMUNOLOGY

IMMUNE REGULATION

IMMUNE SYSTEM DEVELOPMENT

IMMUNOTHERAPY AND VACCINES

INFECTIOUS DISEASE AND HOST RESPONSE

INNATE IMMUNITY AND INFLAMMATION

MOLECULAR AND STRUCTURAL IMMUNOLOGY

SYSTEMS IMMUNOLOGY

TUMOR IMMUNOLOGY

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