Genome-Wide Mapping of Plasma IgG N-Glycan Quantitative Trait Loci Identifies a Potentially Causal Association between IgG N-Glycans and Rheumatoid Arthritis

Di Liu; Jing Dong; Jie Zhang; Xizhu Xu; Qiuyue Tian; Xiaoni Meng; Lijuan Wu; Deqiang Zheng; Xi Chu; Wei Wang; Qun Meng; Youxin Wang

doi:10.4049/jimmunol.2100080

Genome-Wide Mapping of Plasma IgG N-Glycan Quantitative Trait Loci Identifies a Potentially Causal Association between IgG N-Glycans and Rheumatoid Arthritis

Di Liu, Jing Dong, Jie Zhang, Xizhu Xu, Qiuyue Tian, Xiaoni Meng, Lijuan Wu, Deqiang Zheng, Xi Chu, Wei Wang, Qun Meng and Youxin Wang

J Immunol June 1, 2022, 208 (11) 2508-2514; DOI: https://doi.org/10.4049/jimmunol.2100080

Di Liu

*Department of Epidemiology and Health Statistics, School of Public Health, Beijing Municipal Key Laboratory of Clinical Epidemiology, Capital Medical University, Beijing, China;

†Center for Biomedical Information Technology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, Guangdong, China;

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Jing Dong

‡Health Management Center, Xuanwu Hospital, Capital Medical University, Beijing, China;

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Jie Zhang

*Department of Epidemiology and Health Statistics, School of Public Health, Beijing Municipal Key Laboratory of Clinical Epidemiology, Capital Medical University, Beijing, China;

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Xizhu Xu

§School of Public Health, Shandong First Medical University and Shandong Academy of Medical Sciences, Tai’an, China; and

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Qiuyue Tian

*Department of Epidemiology and Health Statistics, School of Public Health, Beijing Municipal Key Laboratory of Clinical Epidemiology, Capital Medical University, Beijing, China;

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Xiaoni Meng

*Department of Epidemiology and Health Statistics, School of Public Health, Beijing Municipal Key Laboratory of Clinical Epidemiology, Capital Medical University, Beijing, China;

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Lijuan Wu

*Department of Epidemiology and Health Statistics, School of Public Health, Beijing Municipal Key Laboratory of Clinical Epidemiology, Capital Medical University, Beijing, China;

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Deqiang Zheng

*Department of Epidemiology and Health Statistics, School of Public Health, Beijing Municipal Key Laboratory of Clinical Epidemiology, Capital Medical University, Beijing, China;

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Xi Chu

‡Health Management Center, Xuanwu Hospital, Capital Medical University, Beijing, China;

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Wei Wang

*Department of Epidemiology and Health Statistics, School of Public Health, Beijing Municipal Key Laboratory of Clinical Epidemiology, Capital Medical University, Beijing, China;

§School of Public Health, Shandong First Medical University and Shandong Academy of Medical Sciences, Tai’an, China; and

¶Centre for Precision Health, ECU Strategic Research Centre, Edith Cowan University, Perth, Western Australia, Australia

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ORCID record for Wei Wang

Qun Meng

*Department of Epidemiology and Health Statistics, School of Public Health, Beijing Municipal Key Laboratory of Clinical Epidemiology, Capital Medical University, Beijing, China;

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Youxin Wang

*Department of Epidemiology and Health Statistics, School of Public Health, Beijing Municipal Key Laboratory of Clinical Epidemiology, Capital Medical University, Beijing, China;

¶Centre for Precision Health, ECU Strategic Research Centre, Edith Cowan University, Perth, Western Australia, Australia

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ORCID record for Youxin Wang

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The Journal of Immunology

Vol. 208, Issue 11

1 Jun 2022

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Genome-Wide Mapping of Plasma IgG N-Glycan Quantitative Trait Loci Identifies a Potentially Causal Association between IgG N-Glycans and Rheumatoid Arthritis

Di Liu, Jing Dong, Jie Zhang, Xizhu Xu, Qiuyue Tian, Xiaoni Meng, Lijuan Wu, Deqiang Zheng, Xi Chu, Wei Wang, Qun Meng, Youxin Wang

The Journal of Immunology June 1, 2022, 208 (11) 2508-2514; DOI: 10.4049/jimmunol.2100080

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Genome-Wide Mapping of Plasma IgG N-Glycan Quantitative Trait Loci Identifies a Potentially Causal Association between IgG N-Glycans and Rheumatoid Arthritis