On the cover: Inhibition of autophagy flux in an optineurin knockout cell after HSV-2 infection. Cells expressing LC3-GFP-mCherry were observed using confocal microscopy. Lack of optineurin inhibits degradation of HSV-2 in lysosomes (red) and causes an increase in the number of enlarged autophagasomes (yellow). Nucleus in blue stained with Hoechst stain. Patil, C. D., R. Suryawanshi, J. Ames, R. Koganti, A. Agelidis, D. Kapoor, T. Yadavalli, L. Koujah, H. C. Tseng, and D. Shukla. 2022. Intrinsic antiviral activity of optineurin prevents hyperproliferation of a primary herpes simplex virus type 2 infection. J. Immunol. 208: 63–73.