The Journal of Immunology: 208 (1)

January 1, 2022; Volume 208,Issue 1

ANTIGEN RECOGNITION AND RESPONSES

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Protective HLA Alleles Recruit Biased and Largely Similar Antigen-Specific T Cell Repertoires across Different Outcomes in HIV Infection
Dan Koning, Esther D. Quakkelaar, Ingrid M. M. Schellens, Eric Spierings and Debbie van Baarle

J Immunol January 1, 2022, 208 (1) 3-15; DOI: https://doi.org/10.4049/jimmunol.2001145

AUTOIMMUNITY

Open Access
CD8⁺ T Cells Expressing an HLA-DR1 Chimeric Antigen Receptor Target Autoimmune CD4⁺ T Cells in an Antigen-Specific Manner and Inhibit the Development of Autoimmune Arthritis
Author Choice Article

Karen B. Whittington, Amanda Prislovsky, Jacob Beaty, Lorraine Albritton, Marko Radic and Edward F. Rosloniec

J Immunol January 1, 2022, 208 (1) 16-26; DOI: https://doi.org/10.4049/jimmunol.2100643

CLINICAL AND HUMAN IMMUNOLOGY

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Stereotypic Expansion of T Regulatory and Th17 Cells during Infancy Is Disrupted by HIV Exposure and Gut Epithelial Damage
Sonwabile Dzanibe, Katie Lennard, Agano Kiravu, Melanie S. S. Seabrook, Berenice Alinde, Susan P. Holmes, Catherine A. Blish, Heather B. Jaspan and Clive M. Gray

J Immunol January 1, 2022, 208 (1) 27-37; DOI: https://doi.org/10.4049/jimmunol.2100503
Open Access
HuR-Targeted Inhibition Impairs Th2 Proinflammatory Responses in Asthmatic CD4⁺ T Cells
Author Choice Article

Fatemeh Fattahi, Jason S. Ellis, Michael Sylvester, Kristin Bahleda, Samuel Hietanen, Luis Correa, Njira L. Lugogo and Ulus Atasoy

J Immunol January 1, 2022, 208 (1) 38-48; DOI: https://doi.org/10.4049/jimmunol.2100635

IMMUNE REGULATION

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HLA-H*02:07 Is a Membrane-Bound Ligand of Denisovan Origin That Protects against Lysis by Activated Immune Effectors
Lucas Hubert, Julien Paganini, Christophe Picard, Jacques Chiaroni, Laurent Abi-Rached, Pierre Pontarotti and Julie Di Cristofaro

J Immunol January 1, 2022, 208 (1) 49-53; DOI: https://doi.org/10.4049/jimmunol.2100358

IMMUNOTHERAPY AND VACCINES

Open Access
Combination Immune Checkpoint Blockade Enhances IL-2 and CD107a Production from HIV-Specific T Cells Ex Vivo in People Living with HIV on Antiretroviral Therapy
Author Choice Article

Chris Y. Chiu, Judy J. Chang, Ashanti I. Dantanarayana, Ajantha Solomon, Vanessa A. Evans, Rachel Pascoe, Céline Gubser, Lydie Trautman, Rémi Fromentin, Nicolas Chomont, James H. McMahon, Paul U. Cameron, Thomas A. Rasmussen and Sharon R. Lewin

J Immunol January 1, 2022, 208 (1) 54-62; DOI: https://doi.org/10.4049/jimmunol.2100367

INFECTIOUS DISEASE AND HOST RESPONSE

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Intrinsic Antiviral Activity of Optineurin Prevents Hyperproliferation of a Primary Herpes Simplex Virus Type 2 Infection
Chandrashekhar D. Patil, Rahul Suryawanshi, Joshua Ames, Raghuram Koganti, Alex Agelidis, Divya Kapoor, Tejabhiram Yadavalli, Lulia Koujah, Henry C. Tseng and Deepak Shukla

J Immunol January 1, 2022, 208 (1) 63-73; DOI: https://doi.org/10.4049/jimmunol.2100472
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ORAI1 Limits SARS-CoV-2 Infection by Regulating Tonic Type I IFN Signaling
Beibei Wu, Arunachalam Ramaiah, Gustavo Garcia Jr., Spyridon Hasiakos, Vaithilingaraja Arumugaswami and Sonal Srikanth

J Immunol January 1, 2022, 208 (1) 74-84; DOI: https://doi.org/10.4049/jimmunol.2100742

INNATE IMMUNITY AND INFLAMMATION

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A Soluble PrP^C Derivative and Membrane-Anchored PrP^C in Extracellular Vesicles Attenuate Innate Immunity by Engaging the NMDA-R/LRP1 Receptor Complex
Elisabetta Mantuano, Pardis Azmoon, Michael A. Banki, Christina J. Sigurdson, Wendy M. Campana and Steven L. Gonias

J Immunol January 1, 2022, 208 (1) 85-96; DOI: https://doi.org/10.4049/jimmunol.2100412
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Divergent Genetic Regulation of Nitric Oxide Production between C57BL/6J and Wild-Derived PWD/PhJ Mice Controls Postactivation Mitochondrial Metabolism, Cell Survival, and Bacterial Resistance in Dendritic Cells
Julia P. Snyder, Soyeon K. Gullickson, Roxana del Rio-Guerra, Andrea Sweezy, Bay Vagher, Tyler C. Hogan, Karolyn G. Lahue, Julie A. Reisz, Angelo D’Alessandro, Dimitry N. Krementsov and Eyal Amiel

J Immunol January 1, 2022, 208 (1) 97-109; DOI: https://doi.org/10.4049/jimmunol.2100375
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Nanoparticle-Induced Airway Eosinophilia Is Independent of ILC2 Signaling but Associated With Sex Differences in Macrophage Phenotype Development
Jessica L. Ray, Pam K. Shaw, Britten Postma, Celine A. Beamer and Andrij Holian

J Immunol January 1, 2022, 208 (1) 110-120; DOI: https://doi.org/10.4049/jimmunol.2100769
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Serglycin Is Involved in Adipose Tissue Inflammation in Obesity
Atanaska I. Doncheva, Frode A. Norheim, Marit Hjorth, Mirjana Grujic, Aida Paivandy, Simon N. Dankel, Jens Kristoffer Hertel, Tone G. Valderhaug, Yvonne Böttcher, Johan Fernø, Gunnar Mellgren, Knut T. Dalen, Gunnar Pejler and Svein O. Kolset

J Immunol January 1, 2022, 208 (1) 121-132; DOI: https://doi.org/10.4049/jimmunol.2100231
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Unexpected Off-Target Activities for Recombinant C5a in Human Macrophages
Xaria X. Li, Declan M. Gorman, John D. Lee, Richard J. Clark and Trent M. Woodruff

J Immunol January 1, 2022, 208 (1) 133-142; DOI: https://doi.org/10.4049/jimmunol.2100444

MOLECULAR AND STRUCTURAL IMMUNOLOGY

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Ig Enhancers Increase RNA Polymerase II Stalling at Somatic Hypermutation Target Sequences
Alina Tarsalainen, Yaakov Maman, Fei-Long Meng, Minna K. Kyläniemi, Anni Soikkeli, Paulina Budzyńska, Jessica J. McDonald, Filip Šenigl, Frederic W. Alt, David G. Schatz and Jukka Alinikula

J Immunol January 1, 2022, 208 (1) 143-154; DOI: https://doi.org/10.4049/jimmunol.2100923
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Prosurvival IL-7–Stimulated Weak Strength of mTORC1-S6K Controls T Cell Memory via Transcriptional FOXO1–TCF1–Id3 and Metabolic AMPKα1–ULK1–ATG7 Pathways
Aizhang Xu, Scot C. Leary, Md. Fahmid Islam, Zhaojia Wu, Kalpana Kalyanasundaram Bhanumathy, Anjuman Ara, Rajni Chibbar, Andrew Fleywald, Khawaja Ashfaque Ahmed and Jim Xiang

J Immunol January 1, 2022, 208 (1) 155-168; DOI: https://doi.org/10.4049/jimmunol.2100452

TUMOR IMMUNOLOGY

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Engineering Cancer Antigen-Specific T Cells to Overcome the Immunosuppressive Effects of TGF-β
Jonathan D. Silk, Rachel J. M. Abbott, Katherine J. Adams, Alan D. Bennett, Sara Brett, Terri V. Cornforth, Katherine L. Crossland, David J. Figueroa, Junping Jing, Caitriona O’Connor, Annette Pachnio, Lea Patasic, Carlos E. Peredo, Adriano Quattrini, Laura L. Quinn, Alistair G. Rust, Manoj Saini, Joseph P. Sanderson, Dylan Steiner, Barbara Tavano, Preetha Viswanathan, Guy E. Wiedermann, Ryan Wong, Bent K. Jakobsen, Cedrik M. Britten, Andrew B. Gerry and Joanna E. Brewer

J Immunol January 1, 2022, 208 (1) 169-180; DOI: https://doi.org/10.4049/jimmunol.2001357

NOVEL IMMUNOLOGICAL METHODS

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Cas9-Based Local Enrichment and Genomics Sequence Revision of Megabase-Sized Shark IgNAR Loci
Hongming Dong, Yaolei Zhang, Jiahao Wang, Haitao Xiang, Tianhang Lv, Likun Wei, Shaosen Yang, Xiaopan Liu, Bingzhao Ren, Xiuqing Zhang, Lirong Liu, Jun Cao, Meiniang Wang, Jiahai Shi and Naibo Yang

J Immunol January 1, 2022, 208 (1) 181-189; DOI: https://doi.org/10.4049/jimmunol.2100844

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ANTIGEN RECOGNITION AND RESPONSES

AUTOIMMUNITY

CLINICAL AND HUMAN IMMUNOLOGY

IMMUNE REGULATION

IMMUNOTHERAPY AND VACCINES

INFECTIOUS DISEASE AND HOST RESPONSE

INNATE IMMUNITY AND INFLAMMATION

MOLECULAR AND STRUCTURAL IMMUNOLOGY

TUMOR IMMUNOLOGY

NOVEL IMMUNOLOGICAL METHODS

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