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The Journal of Immunology

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Table of Contents

April 15, 2021; Volume 206,Issue 8

TOP READS

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    Top Reads

    Treg Expansion Strategy See article p. 1740

    Taking the Sting out of Swine Fever See article p. 1844

    Inhibition of Neutrophil Priming See article p. 1858

    Mitochondrial DNA Mischief See article p. 1890

    J Immunol April 15, 2021, 206 (8) 1679; DOI: https://doi.org/10.4049/jimmunol.2190004

BRIEF REVIEWS

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    Revisiting Current Concepts on the Tolerogenicity of Steady-State Dendritic Cell Subsets and Their Maturation Stages
    Manfred B. Lutz, Ronald A. Backer and Björn E. Clausen
    J Immunol April 15, 2021, 206 (8) 1681-1689; DOI: https://doi.org/10.4049/jimmunol.2001315

CUTTING EDGE

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    Cutting Edge: Reduced Adenosine-to-Inosine Editing of Endogenous Alu RNAs in Severe COVID-19 Disease
    Philip S. Crooke III, John T. Tossberg, Krislyn P. Porter and Thomas M. Aune
    J Immunol April 15, 2021, 206 (8) 1691-1696; DOI: https://doi.org/10.4049/jimmunol.2001428

ANTIGEN RECOGNITION AND RESPONSES

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    Immunoproteasome Upregulation Is Not Required to Control Protein Homeostasis during Viral Infection
    Michael Basler, Marleen Christ, Heike Goebel and Marcus Groettrup
    J Immunol April 15, 2021, 206 (8) 1697-1708; DOI: https://doi.org/10.4049/jimmunol.2000822
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    Novel Potent IFN-γ–Inducing CD8+ T Cell Epitopes Conserved among Diverse Bovine Viral Diarrhea Virus Strains
    Neha Sangewar, Suryakant D. Waghela, Jianxiu Yao, Huldah Sang, Jocelyn Bray and Waithaka Mwangi
    J Immunol April 15, 2021, 206 (8) 1709-1718; DOI: https://doi.org/10.4049/jimmunol.2001424

AUTOIMMUNITY

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    The Regulatory Subunit PPP2R2A of PP2A Enhances Th1 and Th17 Differentiation through Activation of the GEF-H1/RhoA/ROCK Signaling Pathway
    Wenliang Pan, Kamalpreet Nagpal, Abel Suárez-Fueyo, Andrew Ferretti, Nobuya Yoshida, Maria G. Tsokos and George C. Tsokos
    J Immunol April 15, 2021, 206 (8) 1719-1728; DOI: https://doi.org/10.4049/jimmunol.2001266
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    Mood Disorder in Systemic Lupus Erythematosus Induced by Antiribosomal P Protein Antibodies Associated with Decreased Serum and Brain Tryptophan
    Takamasa Cho, Hiroe Sato, Ayako Wakamatsu, Riuko Ohashi, Yoichi Ajioka, Toshio Uchiumi, Shin Goto, Ichiei Narita and Yoshikatsu Kaneko
    J Immunol April 15, 2021, 206 (8) 1729-1739; DOI: https://doi.org/10.4049/jimmunol.2000260

IMMUNE REGULATION

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    Characterization of a TNFR2-Selective Agonistic TNF-α Mutant and Its Derivatives as an Optimal Regulatory T Cell Expander
    Masaki Inoue, Kanako Yamashita, Yuta Tsuji, Midori Miki, Shota Amano, Taichi Okumura, Koki Kuge, Takao Tone, Shota Enomoto, Chinatsu Yoshimine, Yuki Morita, Daisuke Ando, Haruhiko Kamada, Norihisa Mikami, Yasuo Tsutsumi and Shin-ichi Tsunoda
    J Immunol April 15, 2021, 206 (8) 1740-1751; DOI: https://doi.org/10.4049/jimmunol.2000871
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    Erythropoietin Protects against Diffuse Alveolar Hemorrhage in Mice by Regulating Macrophage Polarization through the EPOR/JAK2/STAT3 Axis
    Zhongnan Yang, Lei Yan, Huixia Cao, Yue Gu, Pan Zhou, Mingyue Shi, Guodong Li, Xiaojing Jiao, Na Li, Xiangnan Li, Kai Sun and Fengmin Shao
    J Immunol April 15, 2021, 206 (8) 1752-1764; DOI: https://doi.org/10.4049/jimmunol.1901312
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    The Ancient Cytokine BAFF- and APRIL-like Molecule Regulates the Functionality of Teleost IgM+ B Cells Similarly to BAFF and APRIL
    Rocío Simón, Patricia Díaz-Rosales and Carolina Tafalla
    J Immunol April 15, 2021, 206 (8) 1765-1775; DOI: https://doi.org/10.4049/jimmunol.2000762
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    PDK1 Is Required for Maintenance of CD4+ Foxp3+ Regulatory T Cell Function
    Hyunju Oh, Jingyao Zhao, Yenkel Grinberg-Bleyer, Thomas S. Postler, Pingzhang Wang, Sung-Gyoo Park, Raul Rabadan, Matthew S. Hayden and Sankar Ghosh
    J Immunol April 15, 2021, 206 (8) 1776-1783; DOI: https://doi.org/10.4049/jimmunol.2000051
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    Cross-Talk between the Complement Pathway and the Contact Activation System of Coagulation: Activated Factor XI Neutralizes Complement Factor H
    Cristina Puy, Jiaqing Pang, Stéphanie E. Reitsma, Christina U. Lorentz, Erik I. Tucker, David Gailani, András Gruber, Florea Lupu and Owen J. T. McCarty
    J Immunol April 15, 2021, 206 (8) 1784-1792; DOI: https://doi.org/10.4049/jimmunol.2000398
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    CD154 Resistant to Cleavage from Intracellular Milieu and Cell Surface Induces More Potent CD40-Mediated Responses
    Suzanne Salti, Loubna Al-Zoobi, Youssef Darif, Ghada S. Hassan and Walid Mourad
    J Immunol April 15, 2021, 206 (8) 1793-1805; DOI: https://doi.org/10.4049/jimmunol.2001340

IMMUNOTHERAPY AND VACCINES

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    Glycolipid-Containing Nanoparticle Vaccine Engages Invariant NKT Cells to Enhance Humoral Protection against Systemic Bacterial Infection but Abrogates T-Independent Vaccine Responses
    Travis Shute, Eyal Amiel, Noran Alam, Jennifer L. Yates, Katya Mohrs, Elizabeth Dudley, Briana Salas, Chloe Mesa, Adriana Serrata, Daniel Angel, Brandy K. Vincent, Amanda Weyers, Paula A. Lanthier, Emilie Vomhof-Dekrey, Rachel Fromme, Mitchell Laughlin, Olivia Durham, Jianjun Miao, Devon Shipp, Robert J. Linhardt, Kelly Nash and Elizabeth A. Leadbetter
    J Immunol April 15, 2021, 206 (8) 1806-1816; DOI: https://doi.org/10.4049/jimmunol.2001283
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    Inclusion of an Optimized Plasmodium falciparum Merozoite Surface Protein 2–Based Antigen in a Trivalent, Multistage Malaria Vaccine
    Jacqueline S. Eacret, Elizabeth M. Parzych, Donna M. Gonzales and James M. Burns Jr.
    J Immunol April 15, 2021, 206 (8) 1817-1831; DOI: https://doi.org/10.4049/jimmunol.2000927

INFECTIOUS DISEASE AND HOST RESPONSE

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    OTUD1 Regulates Antifungal Innate Immunity through Deubiquitination of CARD9
    Xiaorong Chen, Honghai Zhang, Xueer Wang, Zhugui Shao, Yanqi Li, Guimin Zhao, Feng Liu, Bingyu Liu, Yi Zheng, Tian Chen, Hui Zheng, Lei Zhang and Chengjiang Gao
    J Immunol April 15, 2021, 206 (8) 1832-1843; DOI: https://doi.org/10.4049/jimmunol.2001253
  • African Swine Fever Virus MGF-505-7R Negatively Regulates cGAS–STING-Mediated Signaling Pathway
    Open Access
    African Swine Fever Virus MGF-505-7R Negatively Regulates cGAS–STING-Mediated Signaling Pathway

    Author Choice Article

    Dan Li, Wenping Yang, Lulu Li, Pan Li, Zhao Ma, Jing Zhang, Xiaolan Qi, Jingjing Ren, Yi Ru, Qingli Niu, Zhijie Liu, Xiangtao Liu and Haixue Zheng
    J Immunol April 15, 2021, 206 (8) 1844-1857; DOI: https://doi.org/10.4049/jimmunol.2001110
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    Pinaverium Bromide Attenuates Lipopolysaccharide-Induced Excessive Systemic Inflammation via Inhibiting Neutrophil Priming
    Xiaohuan Chen, Yun Liu, Hallie Dolin, Jinghua Liu, Yong Jiang and Zhixing K. Pan
    J Immunol April 15, 2021, 206 (8) 1858-1865; DOI: https://doi.org/10.4049/jimmunol.1900975

INNATE IMMUNITY AND INFLAMMATION

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    IFN-λ Regulates Neutrophil Biology to Suppress Inflammation in Herpes Simplex Virus-1–Induced Corneal Immunopathology
    Ferrin Antony, Chetan Pundkar, Maninder Sandey, Anil K. Jaiswal, Amarjit Mishra, Ashok Kumar, Rudragouda Channappanavar and Amol Suryawanshi
    J Immunol April 15, 2021, 206 (8) 1866-1877; DOI: https://doi.org/10.4049/jimmunol.2000979
  • Noncanonical Roles of Caspase-4 and Caspase-5 in Heme-Driven IL-1β Release and Cell Death
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    Noncanonical Roles of Caspase-4 and Caspase-5 in Heme-Driven IL-1β Release and Cell Death
    Beatriz E. Bolívar, Alexandra N. Brown-Suedel, Brittany A. Rohrman, Chloé I. Charendoff, Vanda Yazdani, John D. Belcher, Gregory M. Vercellotti, Jonathan M. Flanagan and Lisa Bouchier-Hayes
    J Immunol April 15, 2021, 206 (8) 1878-1889; DOI: https://doi.org/10.4049/jimmunol.2000226
  • Loss of Mitochondrial Protease CLPP Activates Type I IFN Responses through the Mitochondrial DNA–cGAS–STING Signaling Axis
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    Loss of Mitochondrial Protease CLPP Activates Type I IFN Responses through the Mitochondrial DNA–cGAS–STING Signaling Axis
    Sylvia Torres-Odio, Yuanjiu Lei, Suzana Gispert, Antonia Maletzko, Jana Key, Saeed S. Menissy, Ilka Wittig, Georg Auburger and A. Phillip West
    J Immunol April 15, 2021, 206 (8) 1890-1900; DOI: https://doi.org/10.4049/jimmunol.2001016
  • <em>Mycobacterium smegmatis</em> Resists the Bactericidal Activity of Hypochlorous Acid Produced in Neutrophil Phagosomes
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    Mycobacterium smegmatis Resists the Bactericidal Activity of Hypochlorous Acid Produced in Neutrophil Phagosomes
    Heather A. Parker, Nina Dickerhof, Lorna Forrester, Heath Ryburn, Leon Smyth, Joris Messens, Htin L. Aung, Gregory M. Cook, Anthony J. Kettle and Mark B. Hampton
    J Immunol April 15, 2021, 206 (8) 1901-1912; DOI: https://doi.org/10.4049/jimmunol.2001084
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    Pyroptosis Mediates Neutrophil Extracellular Trap Formation during Bacterial Infection in Zebrafish
    Weijie Chen, Jingjing Zhao, Di Mu, Zhuang Wang, Qin Liu, Yuanxing Zhang and Dahai Yang
    J Immunol April 15, 2021, 206 (8) 1913-1922; DOI: https://doi.org/10.4049/jimmunol.2001335
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    Neutrophils and IL-1α Regulate Surfactant Homeostasis during Cigarette Smoking
    Nadia Milad, Marie Pineault, Ariane Lechasseur, Joanie Routhier, Marie-Josée Beaulieu, Sophie Aubin and Mathieu C. Morissette
    J Immunol April 15, 2021, 206 (8) 1923-1931; DOI: https://doi.org/10.4049/jimmunol.2001182
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    Long Noncoding RNA EGOT Responds to Stress Signals to Regulate Cell Inflammation and Growth
    Marina Barriocanal, Celia Prior, Beatriz Suarez, Juan Pablo Unfried, Nerea Razquin, Sandra Hervás-Stubbs, Bruno Sangro, Victor Segura and Puri Fortes
    J Immunol April 15, 2021, 206 (8) 1932-1942; DOI: https://doi.org/10.4049/jimmunol.1900776
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    Human Inflammatory Neutrophils Express Genes Encoding Peptidase Inhibitors: Production of Elafin Mediated by NF-κB and CCAAT/Enhancer-Binding Protein β
    Isabelle Allaeys, Flavia Ribeiro de Vargas, Sylvain G. Bourgoin and Patrice E. Poubelle
    J Immunol April 15, 2021, 206 (8) 1943-1956; DOI: https://doi.org/10.4049/jimmunol.2000852

MOLECULAR AND STRUCTURAL IMMUNOLOGY

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    Two Human Monoclonal HLA-Reactive Antibodies Cross-React with Mamu-B*008, a Rhesus Macaque MHC Allotype Associated with Control of Simian Immunodeficiency Virus Replication
    Natasja G. de Groot, Corrine M. C. Heijmans, Suzanne Bezstarosti, Jesse Bruijnesteijn, Geert W. Haasnoot, Arend Mulder, Frans H. J. Claas, Sebastiaan Heidt and Ronald E. Bontrop
    J Immunol April 15, 2021, 206 (8) 1957-1965; DOI: https://doi.org/10.4049/jimmunol.2001405

TUMOR IMMUNOLOGY

  • Open Access
    IL-1α Mediates Innate and Acquired Resistance to Immunotherapy in Melanoma

    Author Choice Article

    Shubhra Singh, Zhilan Xiao, Karishma Bavisi, Jason Roszik, Brenda D. Melendez, Zhiqiang Wang, Mark J. Cantwell, Richard E. Davis, Greg Lizee, Patrick Hwu, Sattva S. Neelapu, Willem W. Overwijk and Manisha Singh
    J Immunol April 15, 2021, 206 (8) 1966-1975; DOI: https://doi.org/10.4049/jimmunol.2000523
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The Journal of Immunology: 206 (8)
The Journal of Immunology
Vol. 206, Issue 8
15 Apr 2021
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  • Revisiting Current Concepts on the Tolerogenicity of Steady-State Dendritic Cell Subsets and Their Maturation Stages
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  • TOP READS
  • BRIEF REVIEWS
  • CUTTING EDGE
  • ANTIGEN RECOGNITION AND RESPONSES
  • AUTOIMMUNITY
  • IMMUNE REGULATION
  • IMMUNOTHERAPY AND VACCINES
  • INFECTIOUS DISEASE AND HOST RESPONSE
  • INNATE IMMUNITY AND INFLAMMATION
  • MOLECULAR AND STRUCTURAL IMMUNOLOGY
  • TUMOR IMMUNOLOGY
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Immunodominant AH1 Antigen-Deficient Necroptotic, but Not Apoptotic, Murine Cancer Cells Induce Antitumor Protection
Osteoclasts Derive Predominantly from Bone Marrow–Resident CX3CR1+ Precursor Cells in Homeostasis, whereas Circulating CX3CR1+ Cells Contribute to Osteoclast Development during Fracture Repair
Intracellular IL-1 Receptor Antagonist Isoform 1 Released from Keratinocytes upon Cell Death Acts as an Inhibitor for the Alarmin IL-1α
Polysaccharide Capsules Equip the Human Symbiont Bacteroides thetaiotaomicron to Modulate Immune Responses to a Dominant Antigen in the Intestine
Natural and Induced Tolerogenic Dendritic Cells
Cutting Edge: IL-6–Driven Immune Dysregulation Is Strictly Dependent on IL-6R α-Chain Expression

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Print ISSN 0022-1767        Online ISSN 1550-6606