On the cover: Soluble recombinant Ts-serpin mimics the spatial conformation of naturally occurring protein secreted by Trichinella spiralis and specifically recognizes infected serum of T. spiralis to form immune complexes. Xu, N., X. Bai, Y. Liu, Y. Yang, B. Tang, H. N. Shi, I. Vallee, P. Boireau, X. Liu, and M. Liu. 2021. The anti-inflammatory immune response in early Trichinella spiralis intestinal infection depends on serine protease inhibitor–mediated alternative activation of macrophages. J. Immunol. 206: 963–977.