The Journal of Immunology: 206 (5)

March 1, 2021; Volume 206,Issue 5

BRIEF REVIEWS

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Coronavirus Receptors as Immune Modulators
Charan Kumar V. Devarakonda, Emily Meredith, Mallika Ghosh and Linda H. Shapiro

J Immunol March 1, 2021, 206 (5) 923-929; DOI: https://doi.org/10.4049/jimmunol.2001062

CUTTING EDGE

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Cutting Edge: Mouse SARS-CoV-2 Epitope Reveals Infection and Vaccine-Elicited CD8 T Cell Responses
Vineet Joag, Sathi Wijeyesinghe, J. Michael Stolley, Clare F. Quarnstrom, Thamotharampillai Dileepan, Andrew G. Soerens, Jules A. Sangala, Stephen D. O’Flanagan, Noah V. Gavil, Sung-Wook Hong, Siddheshvar Bhela, Sailaja Gangadhara, Eyob Weyu, William E. Matchett, Joshua Thiede, Venkatramana Krishna, Maxim C.-J. Cheeran, Tyler D. Bold, Rama Amara, Peter Southern, Geoffrey T. Hart, Luca Schifanella, Vaiva Vezys, Marc K. Jenkins, Ryan A. Langlois and David Masopust

J Immunol March 1, 2021, 206 (5) 931-935; DOI: https://doi.org/10.4049/jimmunol.2001400
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Cutting Edge: Hypoxia-Induced Ubc9 Promoter Hypermethylation Regulates IL-17 Expression in Ulcerative Colitis
Ritesh Kumar, Amir Kumar Singh, Petro Starokadomskyy, Weibo Luo, Arianne L. Theiss, Ezra Burstein and K. Venuprasad

J Immunol March 1, 2021, 206 (5) 936-940; DOI: https://doi.org/10.4049/jimmunol.2000015

AUTOIMMUNITY

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Gut Commensal Segmented Filamentous Bacteria Fine-Tune T Follicular Regulatory Cells to Modify the Severity of Systemic Autoimmune Arthritis
Nicholas A. Bates, Anna Li, Tingting Fan, Madeline P. Cutcliffe, Caitlyn B. Dagenet, Kiah C. Sleiman, Heqing Ma, Shekha Tahsin, Candace S. Garrett, Jesse Altemus and Hsin-Jung Joyce Wu

J Immunol March 1, 2021, 206 (5) 941-952; DOI: https://doi.org/10.4049/jimmunol.2000663
Open Access
SZB120 Exhibits Immunomodulatory Effects by Targeting eIF2α to Suppress Th17 Cell Differentiation
Author Choice Article

Linjiao Chen, Jing Bai, Danhong Peng, Yuanyuan Gao, Xiaojie Cai, Junxun Zhang, Sibei Tang, Liman Niu, Yang Sun, Fangzhou Lou, Hong Zhou, Qianqian Yin, Zhikai Wang, Libo Sun, Xuemei Du, Zhenyao Xu, Hong Wang, Qun Li and Honglin Wang

J Immunol March 1, 2021, 206 (5) 953-962; DOI: https://doi.org/10.4049/jimmunol.2000036

IMMUNE REGULATION

Open Access
The Anti-Inflammatory Immune Response in Early Trichinella spiralis Intestinal Infection Depends on Serine Protease Inhibitor–Mediated Alternative Activation of Macrophages
Author Choice Article

Ning Xu, Xue Bai, Yan Liu, Yaming Yang, Bin Tang, Hai Ning Shi, Isabelle Vallee, Pascal Boireau, Xiaolei Liu and Mingyuan Liu

J Immunol March 1, 2021, 206 (5) 963-977; DOI: https://doi.org/10.4049/jimmunol.2000290

IMMUNOTHERAPY AND VACCINES

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Interruption of Thymic Activity in Adult Mice Improves Responses to Tumor Immunotherapy
José Almeida-Santos, Marie-Louise Bergman, Inês Amendoeira Cabral and Jocelyne Demengeot

J Immunol March 1, 2021, 206 (5) 978-986; DOI: https://doi.org/10.4049/jimmunol.2000626
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Manganese-Doped Silica-Based Nanoparticles Promote the Efficacy of Antigen-Specific Immunotherapy
Janin Chandra, Siok Min Teoh, Paula Kuo, Lynn Tolley, Abate Assefa Bashaw, Zewen Kelvin Tuong, Yang Liu, Zibin Chen, James W. Wells, Chengzhong Yu, Ian H. Frazer and Meihua Yu

J Immunol March 1, 2021, 206 (5) 987-998; DOI: https://doi.org/10.4049/jimmunol.2000355
Open Access
Polyfunctional Tier 2–Neutralizing Antibodies Cloned following HIV-1 Env Macaque Immunization Mirror Native Antibodies in a Human Donor
Author Choice Article

David A. Spencer, Delphine C. Malherbe, Néstor Vázquez Bernat, Monika Ádori, Benjamin Goldberg, Nicholas Dambrauskas, Heidi Henderson, Shilpi Pandey, Tracy Cheever, Philip Barnette, William F. Sutton, Margaret E. Ackerman, James J. Kobie, D. Noah Sather, Gunilla B. Karlsson Hedestam, Nancy L. Haigwood and Ann J. Hessell

J Immunol March 1, 2021, 206 (5) 999-1012; DOI: https://doi.org/10.4049/jimmunol.2001082

INFECTIOUS DISEASE AND HOST RESPONSE

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The Phosphoenolpyruvate Carboxykinase Is a Key Metabolic Enzyme and Critical Virulence Factor of Leishmania major
Aida Feiz Barazandeh, Zhirong Mou, Nnamdi Ikeogu, Edgard M. Mejia, Chidalu A. Edechi, Wen-Wei Zhang, Javad Alizadeh, Grant M. Hatch, Saeid Ghavami, Greg Matlashewski, Aaron J. Marshall and Jude E. Uzonna

J Immunol March 1, 2021, 206 (5) 1013-1026; DOI: https://doi.org/10.4049/jimmunol.2000517
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Mobilization of γδ T Cells and IL-10 Production at the Acute Phase of Hepatitis E Virus Infection in Cytomegalovirus Carriers
Hugo Barragué, Jessica Fontaine, Florence Abravanel, Emilie Mauré, Jean-Marie Péron, Laurent Alric, Martine Dubois, Jacques Izopet and Eric Champagne

J Immunol March 1, 2021, 206 (5) 1027-1038; DOI: https://doi.org/10.4049/jimmunol.2000187

INNATE IMMUNITY AND INFLAMMATION

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Activated Neutrophils Propagate Fetal Membrane Inflammation and Weakening through ERK and Neutrophil Extracellular Trap–Induced TLR-9 Signaling
Mancy Tong, Abigail H. Smith and Vikki M. Abrahams

J Immunol March 1, 2021, 206 (5) 1039-1045; DOI: https://doi.org/10.4049/jimmunol.2001268
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Identification and Characterization of Zebrafish Tlr4 Coreceptor Md-2
Andrea N. Loes, Melissa N. Hinman, Dylan R. Farnsworth, Adam C. Miller, Karen Guillemin and Michael J. Harms

J Immunol March 1, 2021, 206 (5) 1046-1057; DOI: https://doi.org/10.4049/jimmunol.1901288
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IL-38 Ablation Reduces Local Inflammation and Disease Severity in Experimental Autoimmune Encephalomyelitis
Arnaud Huard, Hoai Nam Do, Ann-Christin Frank, Evelyn Sirait-Fischer, Dominik Fuhrmann, Martine Catharina Josephine Hofmann, Rebecca Raue, Gaby Palmer, Bernhard Brüne, Natasja de Bruin and Andreas Weigert

J Immunol March 1, 2021, 206 (5) 1058-1066; DOI: https://doi.org/10.4049/jimmunol.2000923

MOLECULAR AND STRUCTURAL IMMUNOLOGY

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Structure and Functional Characterization of a Humanized Anti-CCL20 Antibody following Exposure to Serum Reveals the Formation of Immune Complex That Leads to Toxicity
Andrew S. Thomson, Shing H. Mai, Gerben Bouma, Michael Herdman, Michael Byrne, Charles S. Hottenstein, Joseph Minetti, Stephen Trulli, J. David Taylor, John R. White and Shugui Chen

J Immunol March 1, 2021, 206 (5) 1067-1076; DOI: https://doi.org/10.4049/jimmunol.2000336
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Loss of the Transfer RNA Wobble Uridine–Modifying Enzyme Elp3 Delays T Cell Cycle Entry and Impairs T Follicular Helper Cell Responses through Deregulation of Atf4
Pierre Lemaitre, Qiang Bai, Céline Legrand, Alain Chariot, Pierre Close, Fabrice Bureau and Christophe J. Desmet

J Immunol March 1, 2021, 206 (5) 1077-1087; DOI: https://doi.org/10.4049/jimmunol.2000521

MUCOSAL IMMUNOLOGY

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Prevailing Role of Mucosal Igs and B Cells in Teleost Skin Immune Responses to Bacterial Infection
Xiao-Ting Zhang, Yong-Yao Yu, Hao-Yue Xu, Zhen-Yu Huang, Xia Liu, Jia-Feng Cao, Kai-Feng Meng, Zheng-Ben Wu, Guang-Kun Han, Meng-Ting Zhan, Li-Guo Ding, Wei-Guang Kong, Nan Li, Fumio Takizawa, J. Oriol Sunyer and Zhen Xu

J Immunol March 1, 2021, 206 (5) 1088-1101; DOI: https://doi.org/10.4049/jimmunol.2001097

NOVEL IMMUNOLOGICAL METHODS

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CTLA4-Ig–Based Bifunctional Costimulation Inhibitor Blocks CD28 and ICOS Signaling to Prevent T Cell Priming and Effector Function
Radhika Goenka, Zhenghai Xu, Josue Samayoa, David Banach, Christine Beam, Sahana Bose, Gerri Dooner, Charles M. Forsyth, Xiaoqing Lu, Limary Medina, Ramkrishna Sadhukhan, Bernhard Sielaff, Silvino Sousa, Qingfeng Tao, Debra Touw, Fei Wu, Gillian A. Kingsbury and Yoshiko Akamatsu

J Immunol March 1, 2021, 206 (5) 1102-1113; DOI: https://doi.org/10.4049/jimmunol.2001100

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TOP READS

BRIEF REVIEWS

CUTTING EDGE

AUTOIMMUNITY

IMMUNE REGULATION

IMMUNOTHERAPY AND VACCINES

INFECTIOUS DISEASE AND HOST RESPONSE

INNATE IMMUNITY AND INFLAMMATION

MOLECULAR AND STRUCTURAL IMMUNOLOGY

MUCOSAL IMMUNOLOGY

NOVEL IMMUNOLOGICAL METHODS

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