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Integration of the Transcriptome and Genome-Wide Landscape of BRD2 and BRD4 Binding Motifs Identifies Key Superenhancer Genes and Reveals the Mechanism of Bet Inhibitor Action in Rheumatoid Arthritis Synovial Fibroblasts

Vinod Krishna, Xuefeng Yin, Qingxuan Song, Alice Walsh, David Pocalyko, Kurtis Bachman, Ian Anderson, Loui Madakamutil and Sunil Nagpal
J Immunol January 15, 2021, 206 (2) 422-431; DOI: https://doi.org/10.4049/jimmunol.2000286
Vinod Krishna
*Discovery Sciences, Janssen Research and Development, Spring House, PA 19477; and
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Xuefeng Yin
†Discovery Immunology, Janssen Research and Development, Spring House, PA 19477
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Qingxuan Song
†Discovery Immunology, Janssen Research and Development, Spring House, PA 19477
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Alice Walsh
†Discovery Immunology, Janssen Research and Development, Spring House, PA 19477
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David Pocalyko
*Discovery Sciences, Janssen Research and Development, Spring House, PA 19477; and
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Kurtis Bachman
*Discovery Sciences, Janssen Research and Development, Spring House, PA 19477; and
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Ian Anderson
†Discovery Immunology, Janssen Research and Development, Spring House, PA 19477
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Loui Madakamutil
†Discovery Immunology, Janssen Research and Development, Spring House, PA 19477
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Sunil Nagpal
†Discovery Immunology, Janssen Research and Development, Spring House, PA 19477
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The Journal of Immunology: 206 (2)
The Journal of Immunology
Vol. 206, Issue 2
15 Jan 2021
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Integration of the Transcriptome and Genome-Wide Landscape of BRD2 and BRD4 Binding Motifs Identifies Key Superenhancer Genes and Reveals the Mechanism of Bet Inhibitor Action in Rheumatoid Arthritis Synovial Fibroblasts
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Integration of the Transcriptome and Genome-Wide Landscape of BRD2 and BRD4 Binding Motifs Identifies Key Superenhancer Genes and Reveals the Mechanism of Bet Inhibitor Action in Rheumatoid Arthritis Synovial Fibroblasts
Vinod Krishna, Xuefeng Yin, Qingxuan Song, Alice Walsh, David Pocalyko, Kurtis Bachman, Ian Anderson, Loui Madakamutil, Sunil Nagpal
The Journal of Immunology January 15, 2021, 206 (2) 422-431; DOI: 10.4049/jimmunol.2000286

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Integration of the Transcriptome and Genome-Wide Landscape of BRD2 and BRD4 Binding Motifs Identifies Key Superenhancer Genes and Reveals the Mechanism of Bet Inhibitor Action in Rheumatoid Arthritis Synovial Fibroblasts
Vinod Krishna, Xuefeng Yin, Qingxuan Song, Alice Walsh, David Pocalyko, Kurtis Bachman, Ian Anderson, Loui Madakamutil, Sunil Nagpal
The Journal of Immunology January 15, 2021, 206 (2) 422-431; DOI: 10.4049/jimmunol.2000286
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Print ISSN 0022-1767        Online ISSN 1550-6606