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Afferent Lymphatic Transport and Peripheral Tissue Immunity

Maria M. Steele and Amanda W. Lund
J Immunol January 15, 2021, 206 (2) 264-272; DOI: https://doi.org/10.4049/jimmunol.2001060
Maria M. Steele
*Ronald O. Perelman Department of Dermatology, New York University Grossman School of Medicine, New York, NY 10016;
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Amanda W. Lund
*Ronald O. Perelman Department of Dermatology, New York University Grossman School of Medicine, New York, NY 10016;
†Department of Pathology, New York University Grossman School of Medicine, New York, NY 10016; and
‡Laura and Isaac Perlmutter Cancer Center, New York University Grossman School of Medicine, New York, NY 10016
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Abstract

Lymphatic vessels provide an anatomical framework for immune surveillance and adaptive immune responses. Although appreciated as the route for Ag and dendritic cell transport, peripheral lymphatic vessels are often not considered active players in immune surveillance. Lymphatic vessels, however, integrate contextual cues that directly regulate transport, including changes in intrinsic pumping and capillary remodeling, and express a dynamic repertoire of inflammatory chemokines and adhesion molecules that facilitates leukocyte egress out of inflamed tissue. These mechanisms together contribute to the course of peripheral tissue immunity. In this review, we focus on context-dependent mechanisms that regulate fluid and cellular transport out of peripheral nonlymphoid tissues to provide a framework for understanding the effects of afferent lymphatic transport on immune surveillance, peripheral tissue inflammation, and adaptive immunity.

Footnotes

  • A.W.L. was supported by the National Institutes of Health (NIH), National Cancer Institute (NCI) (R01CA238163 and P50CA225450), the American Cancer Society (RSG-18-169-01-LIB), the Cancer Research Institute (Lloyd J. Old STAR Award), and The Mark Foundation for Cancer Research (Emerging Leader Award). M.M.S. received support from NIH/NCI Basis of Skin/Mucosa Pathobiology Training Grant 5T32CA106195-15.

  • Abbreviations used in this article:

    ACKR
    atypical chemokine receptor
    cDC
    conventional DC
    DC
    dendritic cell
    H1
    type 1 histamine
    LEC
    lymphatic endothelial cell
    LMC
    lymphatic muscle cell
    LN
    lymph node
    PD-L1
    programmed death-ligand 1
    TREG
    regulatory T cell
    S1P
    sphingosine-1-phosphate
    VEGF
    vascular endothelial growth factor.

  • Received September 15, 2020.
  • Accepted November 11, 2020.
  • Copyright © 2021 by The American Association of Immunologists, Inc.
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The Journal of Immunology: 206 (2)
The Journal of Immunology
Vol. 206, Issue 2
15 Jan 2021
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Afferent Lymphatic Transport and Peripheral Tissue Immunity
Maria M. Steele, Amanda W. Lund
The Journal of Immunology January 15, 2021, 206 (2) 264-272; DOI: 10.4049/jimmunol.2001060

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Afferent Lymphatic Transport and Peripheral Tissue Immunity
Maria M. Steele, Amanda W. Lund
The Journal of Immunology January 15, 2021, 206 (2) 264-272; DOI: 10.4049/jimmunol.2001060
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Print ISSN 0022-1767        Online ISSN 1550-6606