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Unraveling the Effect of a Potentiating Anti–Factor H Antibody on Atypical Hemolytic Uremic Syndrome–Associated Factor H Variants

Gillian Dekkers, Mieke C. Brouwer, Jorn Jeremiasse, Angela Kamp, Robyn M. Biggs, Gerard van Mierlo, Scott Lauder, Suresh Katti, Taco W. Kuijpers, Theo Rispens and Ilse Jongerius
J Immunol October 1, 2020, 205 (7) 1778-1786; DOI: https://doi.org/10.4049/jimmunol.2000368
Gillian Dekkers
*Department of Immunopathology, Sanquin Research, Landsteiner Laboratory, Amsterdam UMC, University of Amsterdam, 1066 CX Amsterdam, the Netherlands;
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Mieke C. Brouwer
*Department of Immunopathology, Sanquin Research, Landsteiner Laboratory, Amsterdam UMC, University of Amsterdam, 1066 CX Amsterdam, the Netherlands;
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Jorn Jeremiasse
*Department of Immunopathology, Sanquin Research, Landsteiner Laboratory, Amsterdam UMC, University of Amsterdam, 1066 CX Amsterdam, the Netherlands;
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Angela Kamp
*Department of Immunopathology, Sanquin Research, Landsteiner Laboratory, Amsterdam UMC, University of Amsterdam, 1066 CX Amsterdam, the Netherlands;
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Robyn M. Biggs
†Gemini Therapeutics Inc., Cambridge, MA 02139;
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Gerard van Mierlo
*Department of Immunopathology, Sanquin Research, Landsteiner Laboratory, Amsterdam UMC, University of Amsterdam, 1066 CX Amsterdam, the Netherlands;
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Scott Lauder
†Gemini Therapeutics Inc., Cambridge, MA 02139;
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Suresh Katti
†Gemini Therapeutics Inc., Cambridge, MA 02139;
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Taco W. Kuijpers
‡Department of Pediatric Immunology, Rheumatology and Infectious Diseases, Emma Children’s Hospital, Amsterdam UMC, 1105 AZ Amsterdam, the Netherlands; and
§Department of Blood Cell Research, Sanquin Research, Landsteiner Laboratory, Amsterdam UMC, University of Amsterdam, 1066 CX Amsterdam, the Netherlands
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Theo Rispens
*Department of Immunopathology, Sanquin Research, Landsteiner Laboratory, Amsterdam UMC, University of Amsterdam, 1066 CX Amsterdam, the Netherlands;
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Ilse Jongerius
*Department of Immunopathology, Sanquin Research, Landsteiner Laboratory, Amsterdam UMC, University of Amsterdam, 1066 CX Amsterdam, the Netherlands;
‡Department of Pediatric Immunology, Rheumatology and Infectious Diseases, Emma Children’s Hospital, Amsterdam UMC, 1105 AZ Amsterdam, the Netherlands; and
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The Journal of Immunology: 205 (7)
The Journal of Immunology
Vol. 205, Issue 7
1 Oct 2020
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Unraveling the Effect of a Potentiating Anti–Factor H Antibody on Atypical Hemolytic Uremic Syndrome–Associated Factor H Variants
Gillian Dekkers, Mieke C. Brouwer, Jorn Jeremiasse, Angela Kamp, Robyn M. Biggs, Gerard van Mierlo, Scott Lauder, Suresh Katti, Taco W. Kuijpers, Theo Rispens, Ilse Jongerius
The Journal of Immunology October 1, 2020, 205 (7) 1778-1786; DOI: 10.4049/jimmunol.2000368

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Unraveling the Effect of a Potentiating Anti–Factor H Antibody on Atypical Hemolytic Uremic Syndrome–Associated Factor H Variants
Gillian Dekkers, Mieke C. Brouwer, Jorn Jeremiasse, Angela Kamp, Robyn M. Biggs, Gerard van Mierlo, Scott Lauder, Suresh Katti, Taco W. Kuijpers, Theo Rispens, Ilse Jongerius
The Journal of Immunology October 1, 2020, 205 (7) 1778-1786; DOI: 10.4049/jimmunol.2000368
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