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About the Cover

August 1, 2020; Volume 205,Issue 3

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On the cover: H&E stained image of Trypanosoma cruzi–infected skeletal muscle following doxycycline-induced MHC class I overexpression. Initially, overexpression specifically in skeletal muscle increases CD8+ T cell surveillance and in vivo effector function and significantly reduces infection intensity. However, prolonged overexpression (>30 d) compromises systemic parasite control in a PD-L1–dependent manner. Pack, A. D., and R. L. Tarleton. 2020. Cutting edge: augmenting muscle MHC expression enhances systemic pathogen control at the expense of T cell exhaustion. J. Immunol. 205: 573–578.

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This Issue

The Journal of Immunology: 205 (3)
The Journal of Immunology
Vol. 205, Issue 3
1 Aug 2020
  • Table of Contents
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  • TOP READS
  • BRIEF REVIEWS
  • CUTTING EDGE
  • AUTOIMMUNITY
  • CLINICAL AND HUMAN IMMUNOLOGY
  • IMMUNE REGULATION
  • IMMUNE SYSTEM DEVELOPMENT
  • IMMUNOGENETICS
  • IMMUNOTHERAPY AND VACCINES
  • INFECTIOUS DISEASE AND HOST RESPONSE
  • INNATE IMMUNITY AND INFLAMMATION
  • MOLECULAR AND STRUCTURAL IMMUNOLOGY
  • MUCOSAL IMMUNOLOGY
  • SYSTEMS IMMUNOLOGY
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Immunodominant AH1 Antigen-Deficient Necroptotic, but Not Apoptotic, Murine Cancer Cells Induce Antitumor Protection
Osteoclasts Derive Predominantly from Bone Marrow–Resident CX3CR1+ Precursor Cells in Homeostasis, whereas Circulating CX3CR1+ Cells Contribute to Osteoclast Development during Fracture Repair
Intracellular IL-1 Receptor Antagonist Isoform 1 Released from Keratinocytes upon Cell Death Acts as an Inhibitor for the Alarmin IL-1α
Polysaccharide Capsules Equip the Human Symbiont Bacteroides thetaiotaomicron to Modulate Immune Responses to a Dominant Antigen in the Intestine
Natural and Induced Tolerogenic Dendritic Cells
Cutting Edge: IL-6–Driven Immune Dysregulation Is Strictly Dependent on IL-6R α-Chain Expression

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Print ISSN 0022-1767        Online ISSN 1550-6606