Skip to main content

Main menu

  • Home
  • Articles
    • Current Issue
    • Next in The JI
    • Archive
    • Brief Reviews
    • Pillars of Immunology
    • Translating Immunology
    • Most Read
    • Top Downloads
    • Annual Meeting Abstracts
  • COVID-19/SARS/MERS Articles
  • Info
    • About the Journal
    • For Authors
    • Journal Policies
    • Influence Statement
    • For Advertisers
  • Editors
  • Submit
    • Submit a Manuscript
    • Instructions for Authors
    • Journal Policies
  • Subscribe
    • Journal Subscriptions
    • Email Alerts
    • RSS Feeds
    • ImmunoCasts
  • More
    • Most Read
    • Most Cited
    • ImmunoCasts
    • AAI Disclaimer
    • Feedback
    • Help
    • Accessibility Statement
  • Other Publications
    • American Association of Immunologists
    • ImmunoHorizons

User menu

  • Subscribe
  • Log in

Search

  • Advanced search
The Journal of Immunology
  • Other Publications
    • American Association of Immunologists
    • ImmunoHorizons
  • Subscribe
  • Log in
The Journal of Immunology

Advanced Search

  • Home
  • Articles
    • Current Issue
    • Next in The JI
    • Archive
    • Brief Reviews
    • Pillars of Immunology
    • Translating Immunology
    • Most Read
    • Top Downloads
    • Annual Meeting Abstracts
  • COVID-19/SARS/MERS Articles
  • Info
    • About the Journal
    • For Authors
    • Journal Policies
    • Influence Statement
    • For Advertisers
  • Editors
  • Submit
    • Submit a Manuscript
    • Instructions for Authors
    • Journal Policies
  • Subscribe
    • Journal Subscriptions
    • Email Alerts
    • RSS Feeds
    • ImmunoCasts
  • More
    • Most Read
    • Most Cited
    • ImmunoCasts
    • AAI Disclaimer
    • Feedback
    • Help
    • Accessibility Statement
  • Follow The Journal of Immunology on Twitter
  • Follow The Journal of Immunology on RSS

Natural and Induced Tolerogenic Dendritic Cells

Courtney A. Iberg and Daniel Hawiger
J Immunol February 15, 2020, 204 (4) 733-744; DOI: https://doi.org/10.4049/jimmunol.1901121
Courtney A. Iberg
Department of Molecular Microbiology and Immunology, Saint Louis University School of Medicine, St. Louis, MO 63104
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Daniel Hawiger
Department of Molecular Microbiology and Immunology, Saint Louis University School of Medicine, St. Louis, MO 63104
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • Article
  • Figures & Data
  • Info & Metrics
  • PDF
Loading

Abstract

Dendritic cells (DCs) are highly susceptible to extrinsic signals that modify the functions of these crucial APCs. Maturation of DCs induced by diverse proinflammatory conditions promotes immune responses, but certain signals also induce tolerogenic functions in DCs. These “induced tolerogenic DCs” help to moderate immune responses such as those to commensals present at specific anatomical locations. However, also under steady-state conditions, some DCs are characterized by inherent tolerogenic properties. The immunomodulatory mechanisms constitutively present in such “natural tolerogenic DCs” help to promote tolerance to peripheral Ags. By extending tolerance initially established in the thymus, these functions of DCs help to regulate autoimmune and other immune responses. In this review we will discuss the mechanisms and functions of natural and induced tolerogenic DCs and offer further insight into how their possible manipulations may ultimately lead to more precise treatments for various immune-mediated conditions and diseases.

Footnotes

  • This work was supported in part by National Institute of Allergy and Infectious Diseases/National Institutes of Health Grant R01AI113903 (to D.H.).

  • Abbreviations used in this article:

    AHR
    aryl hydrocarbon receptor
    BMDC
    bone marrow–derived DC
    BTLA
    B and T lymphocyte associated
    cDC
    conventional DC
    DC
    dendritic cell
    DC-SIGN
    DC-specific ICAM-3–grabbing nonintegrin
    EAE
    experimental autoimmune encephalomyelitis
    HVEM
    herpesvirus entry mediator
    itDC
    induced tolerogenic DC
    LN
    lymph node
    MHCII
    MHC class II
    moDC
    monocyte-derived DC
    MS
    multiple sclerosis
    mTOR
    mammalian target of rapamycin
    ntDC
    natural tolerogenic DC
    PD-1
    programmed death-1
    pDC
    plasmacytoid DC
    PD-L1
    programmed death ligand-1
    PRR
    pattern recognition receptor
    pTreg
    peripherally formed Treg
    RA
    retinoic acid
    Treg
    regulatory T
    tTreg
    thymically derived regulatory T
    VDR
    vitamin D receptor.

  • Received September 16, 2019.
  • Accepted October 4, 2019.
  • Copyright © 2020 by The American Association of Immunologists, Inc.
View Full Text

Pay Per Article - You may access this article (from the computer you are currently using) for 1 day for US$37.50

Regain Access - You can regain access to a recent Pay per Article purchase if your access period has not yet expired.

Log in using your username and password

Forgot your user name or password?
PreviousNext
Back to top

In this issue

The Journal of Immunology: 204 (4)
The Journal of Immunology
Vol. 204, Issue 4
15 Feb 2020
  • Table of Contents
  • Table of Contents (PDF)
  • About the Cover
  • Advertising (PDF)
  • Back Matter (PDF)
  • Editorial Board (PDF)
  • Front Matter (PDF)
Print
Download PDF
Article Alerts
Sign In to Email Alerts with your Email Address
Email Article

Thank you for your interest in spreading the word about The Journal of Immunology.

NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.

Enter multiple addresses on separate lines or separate them with commas.
Natural and Induced Tolerogenic Dendritic Cells
(Your Name) has forwarded a page to you from The Journal of Immunology
(Your Name) thought you would like to see this page from the The Journal of Immunology web site.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Citation Tools
Natural and Induced Tolerogenic Dendritic Cells
Courtney A. Iberg, Daniel Hawiger
The Journal of Immunology February 15, 2020, 204 (4) 733-744; DOI: 10.4049/jimmunol.1901121

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
Share
Natural and Induced Tolerogenic Dendritic Cells
Courtney A. Iberg, Daniel Hawiger
The Journal of Immunology February 15, 2020, 204 (4) 733-744; DOI: 10.4049/jimmunol.1901121
del.icio.us logo Digg logo Reddit logo Twitter logo CiteULike logo Facebook logo Google logo Mendeley logo
  • Tweet Widget
  • Facebook Like

Jump to section

  • Article
    • Abstract
    • Introduction
    • Conclusions
    • Disclosures
    • Footnotes
    • References
  • Figures & Data
  • Info & Metrics
  • PDF

Related Articles

Cited By...

More in this TOC Section

  • Stromal Cell–Mediated Coordination of Immune Cell Recruitment, Retention, and Function in Brain-Adjacent Regions
  • Afferent Lymphatic Transport and Peripheral Tissue Immunity
  • Immune Cell–Stromal Circuitry in Lupus Photosensitivity
Show more BRIEF REVIEWS

Similar Articles

Navigate

  • Home
  • Current Issue
  • Next in The JI
  • Archive
  • Brief Reviews
  • Pillars of Immunology
  • Translating Immunology

For Authors

  • Submit a Manuscript
  • Instructions for Authors
  • About the Journal
  • Journal Policies
  • Editors

General Information

  • Advertisers
  • Subscribers
  • Rights and Permissions
  • Accessibility Statement
  • Public Access
  • Privacy Policy
  • Disclaimer

Journal Services

  • Email Alerts
  • RSS Feeds
  • ImmunoCasts
  • Twitter

Copyright © 2021 by The American Association of Immunologists, Inc.

Print ISSN 0022-1767        Online ISSN 1550-6606