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Table of Contents

September 1, 2019; Volume 203,Issue 5

IN THIS ISSUE

  • You have accessRestricted access
    In This Issue

    Surfactant Protein Regulates Eosinophil Resolution in Asthma See article p. 1122

    When CD4Cre Strays off Target See article p. 1208

    Templated Mutagenesis in Murine and Human B Cells See article p. 1252

    Cytotoxic CD4+ T Cells in Acute Viral Responses See article p. 1276

    Shifting the Balance in Sepsis Treatment See article p. 1298

    J Immunol September 1, 2019, 203 (5) 1091-1092; DOI: https://doi.org/10.4049/jimmunol.1990014

PILLARS OF IMMUNOLOGY

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    Assembling the Inflammasome, Piece by Piece
    Fiachra Humphries and Katherine A. Fitzgerald
    J Immunol September 1, 2019, 203 (5) 1093-1094; DOI: https://doi.org/10.4049/jimmunol.1900764

BRIEF REVIEWS

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    Functional Diversity of Myeloid-Derived Suppressor Cells: The Multitasking Hydra of Cancer
    Asha Jayakumar and Alfred L. M. Bothwell
    J Immunol September 1, 2019, 203 (5) 1095-1103; DOI: https://doi.org/10.4049/jimmunol.1900500

CUTTING EDGE

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    Cutting Edge: Targeting Thrombocytes to Rewire Anticancer Immunity in the Tumor Microenvironment and Potentiate Efficacy of PD-1 Blockade
    Brian P. Riesenberg, Ephraim A. Ansa-Addo, Jennifer Gutierrez, Cynthia D. Timmers, Bei Liu and Zihai Li
    J Immunol September 1, 2019, 203 (5) 1105-1110; DOI: https://doi.org/10.4049/jimmunol.1900594

ALLERGY AND OTHER HYPERSENSITIVITIES

  • The <em>Il9</em> CNS-25 Regulatory Element Controls Mast Cell and Basophil IL-9 Production
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    The Il9 CNS-25 Regulatory Element Controls Mast Cell and Basophil IL-9 Production
    Amina Abdul Qayum, Byunghee Koh, Rebecca K. Martin, Blake T. Kenworthy, Rakshin Kharwadkar, Yongyao Fu, Wenting Wu, Daniel H. Conrad and Mark H. Kaplan
    J Immunol September 1, 2019, 203 (5) 1111-1121; DOI: https://doi.org/10.4049/jimmunol.1900272
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    Genetic Variation in Surfactant Protein-A2 Delays Resolution of Eosinophilia in Asthma
    Alane Blythe C. Dy, Muhammad Z. Arif, Kenneth J. Addison, Loretta G. Que, Scott Boitano, Monica Kraft and Julie G. Ledford
    J Immunol September 1, 2019, 203 (5) 1122-1130; DOI: https://doi.org/10.4049/jimmunol.1900546

ANTIGEN RECOGNITION AND RESPONSES

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    MD-2 Homologue Recognizes the White Spot Syndrome Virus Lipid Component and Induces Antiviral Molecule Expression in Shrimp
    Jie Gao, Jin-Xing Wang and Xian-Wei Wang
    J Immunol September 1, 2019, 203 (5) 1131-1141; DOI: https://doi.org/10.4049/jimmunol.1900268

AUTOIMMUNITY

  • Open Access
    IL-11 Induces Encephalitogenic Th17 Cells in Multiple Sclerosis and Experimental Autoimmune Encephalomyelitis

    Author Choice Article

    Xin Zhang, Nazanin Kiapour, Sahil Kapoor, Tabish Khan, Madhan Thamilarasan, Yazhong Tao, Stephanie Cohen, Ryan Miller, Raymond A. Sobel and Silva Markovic-Plese
    J Immunol September 1, 2019, 203 (5) 1142-1150; DOI: https://doi.org/10.4049/jimmunol.1900311

CLINICAL AND HUMAN IMMUNOLOGY

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    Bidirectional Cross-Talk between Biliary Epithelium and Th17 Cells Promotes Local Th17 Expansion and Bile Duct Proliferation in Biliary Liver Diseases
    Hannah C. Jeffery, Stuart Hunter, Elizabeth H. Humphreys, Ricky Bhogal, Rebecca E. Wawman, Jane Birtwistle, Muhammad Atif, Christopher J. Bagnal, Giovanny Rodriguez Blanco, Naomi Richardson, Suz Warner, Warwick B. Dunn, Simon C. Afford, David H. Adams and Ye Htun Oo
    J Immunol September 1, 2019, 203 (5) 1151-1159; DOI: https://doi.org/10.4049/jimmunol.1800455
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    Early T Cell Differentiation with Well-Maintained Function across the Adult Life Course in Sub-Saharan Africa
    David J. C. Miles, Florence Shumba, Annette Pachnio, Jusnara Begum, Elizabeth L. Corbett, Robert S. Heyderman and Paul Moss
    J Immunol September 1, 2019, 203 (5) 1160-1171; DOI: https://doi.org/10.4049/jimmunol.1800866

IMMUNE REGULATION

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    Ancestral T Cells in Fish Require mTORC1-Coupled Immune Signals and Metabolic Programming for Proper Activation and Function
    Xiumei Wei, Kete Ai, Huiying Li, Yu Zhang, Kang Li and Jialong Yang
    J Immunol September 1, 2019, 203 (5) 1172-1188; DOI: https://doi.org/10.4049/jimmunol.1900008
  • Control of Tissue-Resident Invariant NKT Cells by Vitamin A Metabolites and P2X7-Mediated Cell Death
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    Control of Tissue-Resident Invariant NKT Cells by Vitamin A Metabolites and P2X7-Mediated Cell Death
    Qingyang Liu and Chang H. Kim
    J Immunol September 1, 2019, 203 (5) 1189-1197; DOI: https://doi.org/10.4049/jimmunol.1900398
  • Lipopolysaccharide Downregulates 11β-Hydroxysteroid Dehydrogenase 2 Expression through Inhibiting Peroxisome Proliferator–Activated Receptor-γ in Placental Trophoblasts
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    Lipopolysaccharide Downregulates 11β-Hydroxysteroid Dehydrogenase 2 Expression through Inhibiting Peroxisome Proliferator–Activated Receptor-γ in Placental Trophoblasts
    Lin Fu, Yuan-Hua Chen, Qing-Li Bo, Ya-Ping Song, Li Ma, Bo Wang, Shen Xu, Cheng Zhang, Hua Wang and De-Xiang Xu
    J Immunol September 1, 2019, 203 (5) 1198-1207; DOI: https://doi.org/10.4049/jimmunol.1900132
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    Efficient CD4Cre-Mediated Conditional KRas Expression in Alveolar Macrophages and Alveolar Epithelial Cells Causes Fatal Hyperproliferative Pneumonitis
    Pengcheng Chen, Shang Wang, Kyathanahalli S. Janardhan, Rachel L. Zemans, Wenhai Deng, Peer Karmaus, Shudan Shen, Mary Sunday, Loretta G. Que, Michael B. Fessler and Xiao-Ping Zhong
    J Immunol September 1, 2019, 203 (5) 1208-1217; DOI: https://doi.org/10.4049/jimmunol.1900566
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    Mycobacterium tuberculosis PPE2 Protein Interacts with p67phox and Inhibits Reactive Oxygen Species Production
    Shruti Srivastava, Madhu Babu Battu, Mehak Zahoor Khan, Vinay Kumar Nandicoori and Sangita Mukhopadhyay
    J Immunol September 1, 2019, 203 (5) 1218-1229; DOI: https://doi.org/10.4049/jimmunol.1801143
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    The Transcription Factor PLZF Is Necessary for the Development and Function of Mouse Basophils
    Sai Zhang, Joshua A. Vieth, Agata Krzyzanowska, Everett K. Henry, Lisa K. Denzin, Mark C. Siracusa and Derek B. Sant’Angelo
    J Immunol September 1, 2019, 203 (5) 1230-1241; DOI: https://doi.org/10.4049/jimmunol.1900068

IMMUNE SYSTEM DEVELOPMENT

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    Complex and Multilayered Role of IL-21 Signaling during Thymic Development
    Magali M. Moretto, SuJin Hwang, Keer Chen and Imtiaz A. Khan
    J Immunol September 1, 2019, 203 (5) 1242-1251; DOI: https://doi.org/10.4049/jimmunol.1800743

IMMUNOGENETICS

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    Clustered Mutations at the Murine and Human IgH Locus Exhibit Significant Linkage Consistent with Templated Mutagenesis
    Gordon A. Dale, Daniel J. Wilkins, Caitlin D. Bohannon, Dario Dilernia, Eric Hunter, Trevor Bedford, Rustom Antia, Ignacio Sanz and Joshy Jacob
    J Immunol September 1, 2019, 203 (5) 1252-1264; DOI: https://doi.org/10.4049/jimmunol.1801615
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    Ancient Use of Ig Variable Domains Contributes Significantly to the TCRδ Repertoire
    Thaddeus C. Deiss, Breanna Breaux, Jeannine A. Ott, Rebecca A. Daniel, Patricia L. Chen, Caitlin D. Castro, Yuko Ohta, Martin F. Flajnik and Michael F. Criscitiello
    J Immunol September 1, 2019, 203 (5) 1265-1275; DOI: https://doi.org/10.4049/jimmunol.1900369

INFECTIOUS DISEASE AND HOST RESPONSE

  • Open Access
    Primary EBV Infection Induces an Acute Wave of Activated Antigen-Specific Cytotoxic CD4+ T Cells

    Author Choice Article

    Benjamin J. Meckiff, Kristin Ladell, James E. McLaren, Gordon B. Ryan, Alison M. Leese, Eddie A. James, David A. Price and Heather M. Long
    J Immunol September 1, 2019, 203 (5) 1276-1287; DOI: https://doi.org/10.4049/jimmunol.1900377
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    GNAQ Negatively Regulates Antiviral Innate Immune Responses in a Calcineurin-Dependent Manner
    Ning Wang, Hongjun Huang, Qingqing Xiong, Naiyang Chen, Nanxi Xi, Peilun Wu, Mingyao Liu, Min Qian, Qin Wang and Bing Du
    J Immunol September 1, 2019, 203 (5) 1288-1297; DOI: https://doi.org/10.4049/jimmunol.1900427
  • Immune Response Resetting in Ongoing Sepsis
    Open Access
    Immune Response Resetting in Ongoing Sepsis

    Author Choice Article

    Alexandre E. Nowill, Márcia C. Fornazin, Maria C. Spago, Vicente Dorgan Neto, Vitória R. P. Pinheiro, Simônia S. S. Alexandre, Edgar O. Moraes, Gustavo H. M. F. Souza, Marcos N. Eberlin, Lygia A. Marques, Eduardo C. Meurer, Gilberto C. Franchi Jr. and Pedro O. de Campos-Lima
    J Immunol September 1, 2019, 203 (5) 1298-1312; DOI: https://doi.org/10.4049/jimmunol.1900104
  • Open Access
    Prostaglandin E2–Induced Immune Exhaustion and Enhancement of Antiviral Effects by Anti–PD-L1 Antibody Combined with COX-2 Inhibitor in Bovine Leukemia Virus Infection

    Author Choice Article

    Yamato Sajiki, Satoru Konnai, Tomohiro Okagawa, Asami Nishimori, Naoya Maekawa, Shinya Goto, Kei Watari, Erina Minato, Atsushi Kobayashi, Junko Kohara, Shinji Yamada, Mika K. Kaneko, Yukinari Kato, Hirofumi Takahashi, Nobuhiro Terasaki, Akira Takeda, Keiichi Yamamoto, Mikihiro Toda, Yasuhiko Suzuki, Shiro Murata and Kazuhiko Ohashi
    J Immunol September 1, 2019, 203 (5) 1313-1324; DOI: https://doi.org/10.4049/jimmunol.1900342

INNATE IMMUNITY AND INFLAMMATION

  • Myeloid-Derived Suppressor Cells Confer Infectious Tolerance to Dampen Virus-Induced Tissue Immunoinflammation
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    Myeloid-Derived Suppressor Cells Confer Infectious Tolerance to Dampen Virus-Induced Tissue Immunoinflammation
    Roman Sarkar, Amal Mathew and Sharvan Sehrawat
    J Immunol September 1, 2019, 203 (5) 1325-1337; DOI: https://doi.org/10.4049/jimmunol.1900142
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    Phosphatase PPM1L Prevents Excessive Inflammatory Responses and Cardiac Dysfunction after Myocardial Infarction by Inhibiting IKKβ Activation
    Bo Wang, Qingqing Zhou, Yong Bi, Wenhui Zhou, Qiyan Zeng, Zhongmin Liu, Xingguang Liu and Zhenzhen Zhan
    J Immunol September 1, 2019, 203 (5) 1338-1347; DOI: https://doi.org/10.4049/jimmunol.1900148
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    ZBP1/DAI Drives RIPK3-Mediated Cell Death Induced by IFNs in the Absence of RIPK1
    Justin P. Ingram, Roshan J. Thapa, Amanda Fisher, Bart Tummers, Ting Zhang, Chaoran Yin, Diego A. Rodriguez, Hongyan Guo, Rebecca Lane, Riley Williams, Michael J. Slifker, Suresh H. Basagoudanavar, Glenn F. Rall, Christopher P. Dillon, Douglas R. Green, William J. Kaiser and Siddharth Balachandran
    J Immunol September 1, 2019, 203 (5) 1348-1355; DOI: https://doi.org/10.4049/jimmunol.1900216
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    Singleton-Merten Syndrome–like Skeletal Abnormalities in Mice with Constitutively Activated MDA5
    Nobumasa Soda, Nobuhiro Sakai, Hiroki Kato, Masamichi Takami and Takashi Fujita
    J Immunol September 1, 2019, 203 (5) 1356-1368; DOI: https://doi.org/10.4049/jimmunol.1900354
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    Teleost Gasdermin E Is Cleaved by Caspase 1, 3, and 7 and Induces Pyroptosis
    Shuai Jiang, Hanjie Gu, Yan Zhao and Li Sun
    J Immunol September 1, 2019, 203 (5) 1369-1382; DOI: https://doi.org/10.4049/jimmunol.1900383

MOLECULAR AND STRUCTURAL IMMUNOLOGY

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    Integrin Binding to the Trimeric Interface of CD40L Plays a Critical Role in CD40/CD40L Signaling
    Yoko K. Takada, Jessica Yu, Michiko Shimoda and Yoshikazu Takada
    J Immunol September 1, 2019, 203 (5) 1383-1391; DOI: https://doi.org/10.4049/jimmunol.1801630

TRANSPLANTATION

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    Postoperative Portal Hypertension Enhances Alloimmune Responses after Living-Donor Liver Transplantation in Patients and in a Mouse Model
    Shinji Hashimoto, Takashi Onoe, Masataka Banshodani, Kazuhiro Taguchi, Yuka Tanaka and Hideki Ohdan
    J Immunol September 1, 2019, 203 (5) 1392-1403; DOI: https://doi.org/10.4049/jimmunol.1701147
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This Issue

The Journal of Immunology: 203 (5)
The Journal of Immunology
Vol. 203, Issue 5
1 Sep 2019
  • Table of Contents
  • Table of Contents (PDF)
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  • Advertising (PDF)
  • Back Matter (PDF)
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  • Front Matter (PDF)

Issue highlights

  • Functional Diversity of Myeloid-Derived Suppressor Cells: The Multitasking Hydra of Cancer
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  • IN THIS ISSUE
  • PILLARS OF IMMUNOLOGY
  • BRIEF REVIEWS
  • CUTTING EDGE
  • ALLERGY AND OTHER HYPERSENSITIVITIES
  • ANTIGEN RECOGNITION AND RESPONSES
  • AUTOIMMUNITY
  • CLINICAL AND HUMAN IMMUNOLOGY
  • IMMUNE REGULATION
  • IMMUNE SYSTEM DEVELOPMENT
  • IMMUNOGENETICS
  • INFECTIOUS DISEASE AND HOST RESPONSE
  • INNATE IMMUNITY AND INFLAMMATION
  • MOLECULAR AND STRUCTURAL IMMUNOLOGY
  • TRANSPLANTATION
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Immunodominant AH1 Antigen-Deficient Necroptotic, but Not Apoptotic, Murine Cancer Cells Induce Antitumor Protection
Osteoclasts Derive Predominantly from Bone Marrow–Resident CX3CR1+ Precursor Cells in Homeostasis, whereas Circulating CX3CR1+ Cells Contribute to Osteoclast Development during Fracture Repair
Intracellular IL-1 Receptor Antagonist Isoform 1 Released from Keratinocytes upon Cell Death Acts as an Inhibitor for the Alarmin IL-1α
Polysaccharide Capsules Equip the Human Symbiont Bacteroides thetaiotaomicron to Modulate Immune Responses to a Dominant Antigen in the Intestine
Natural and Induced Tolerogenic Dendritic Cells
Cutting Edge: IL-6–Driven Immune Dysregulation Is Strictly Dependent on IL-6R α-Chain Expression

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