The Journal of Immunology: 203 (5)

September 1, 2019; Volume 203,Issue 5

IN THIS ISSUE

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In This Issue
Surfactant Protein Regulates Eosinophil Resolution in Asthma See article p. 1122
When CD4Cre Strays off Target See article p. 1208
Templated Mutagenesis in Murine and Human B Cells See article p. 1252
Cytotoxic CD4⁺ T Cells in Acute Viral Responses See article p. 1276
Shifting the Balance in Sepsis Treatment See article p. 1298

J Immunol September 1, 2019, 203 (5) 1091-1092; DOI: https://doi.org/10.4049/jimmunol.1990014

PILLARS OF IMMUNOLOGY

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Assembling the Inflammasome, Piece by Piece
Fiachra Humphries and Katherine A. Fitzgerald

J Immunol September 1, 2019, 203 (5) 1093-1094; DOI: https://doi.org/10.4049/jimmunol.1900764

BRIEF REVIEWS

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Functional Diversity of Myeloid-Derived Suppressor Cells: The Multitasking Hydra of Cancer
Asha Jayakumar and Alfred L. M. Bothwell

J Immunol September 1, 2019, 203 (5) 1095-1103; DOI: https://doi.org/10.4049/jimmunol.1900500

CUTTING EDGE

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Cutting Edge: Targeting Thrombocytes to Rewire Anticancer Immunity in the Tumor Microenvironment and Potentiate Efficacy of PD-1 Blockade
Brian P. Riesenberg, Ephraim A. Ansa-Addo, Jennifer Gutierrez, Cynthia D. Timmers, Bei Liu and Zihai Li

J Immunol September 1, 2019, 203 (5) 1105-1110; DOI: https://doi.org/10.4049/jimmunol.1900594

ALLERGY AND OTHER HYPERSENSITIVITIES

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The Il9 CNS-25 Regulatory Element Controls Mast Cell and Basophil IL-9 Production
Amina Abdul Qayum, Byunghee Koh, Rebecca K. Martin, Blake T. Kenworthy, Rakshin Kharwadkar, Yongyao Fu, Wenting Wu, Daniel H. Conrad and Mark H. Kaplan

J Immunol September 1, 2019, 203 (5) 1111-1121; DOI: https://doi.org/10.4049/jimmunol.1900272
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Genetic Variation in Surfactant Protein-A2 Delays Resolution of Eosinophilia in Asthma
Alane Blythe C. Dy, Muhammad Z. Arif, Kenneth J. Addison, Loretta G. Que, Scott Boitano, Monica Kraft and Julie G. Ledford

J Immunol September 1, 2019, 203 (5) 1122-1130; DOI: https://doi.org/10.4049/jimmunol.1900546

ANTIGEN RECOGNITION AND RESPONSES

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MD-2 Homologue Recognizes the White Spot Syndrome Virus Lipid Component and Induces Antiviral Molecule Expression in Shrimp
Jie Gao, Jin-Xing Wang and Xian-Wei Wang

J Immunol September 1, 2019, 203 (5) 1131-1141; DOI: https://doi.org/10.4049/jimmunol.1900268

AUTOIMMUNITY

Open Access
IL-11 Induces Encephalitogenic Th17 Cells in Multiple Sclerosis and Experimental Autoimmune Encephalomyelitis
Author Choice Article

Xin Zhang, Nazanin Kiapour, Sahil Kapoor, Tabish Khan, Madhan Thamilarasan, Yazhong Tao, Stephanie Cohen, Ryan Miller, Raymond A. Sobel and Silva Markovic-Plese

J Immunol September 1, 2019, 203 (5) 1142-1150; DOI: https://doi.org/10.4049/jimmunol.1900311

CLINICAL AND HUMAN IMMUNOLOGY

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Bidirectional Cross-Talk between Biliary Epithelium and Th17 Cells Promotes Local Th17 Expansion and Bile Duct Proliferation in Biliary Liver Diseases
Hannah C. Jeffery, Stuart Hunter, Elizabeth H. Humphreys, Ricky Bhogal, Rebecca E. Wawman, Jane Birtwistle, Muhammad Atif, Christopher J. Bagnal, Giovanny Rodriguez Blanco, Naomi Richardson, Suz Warner, Warwick B. Dunn, Simon C. Afford, David H. Adams and Ye Htun Oo

J Immunol September 1, 2019, 203 (5) 1151-1159; DOI: https://doi.org/10.4049/jimmunol.1800455
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Early T Cell Differentiation with Well-Maintained Function across the Adult Life Course in Sub-Saharan Africa
David J. C. Miles, Florence Shumba, Annette Pachnio, Jusnara Begum, Elizabeth L. Corbett, Robert S. Heyderman and Paul Moss

J Immunol September 1, 2019, 203 (5) 1160-1171; DOI: https://doi.org/10.4049/jimmunol.1800866

IMMUNE REGULATION

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Ancestral T Cells in Fish Require mTORC1-Coupled Immune Signals and Metabolic Programming for Proper Activation and Function
Xiumei Wei, Kete Ai, Huiying Li, Yu Zhang, Kang Li and Jialong Yang

J Immunol September 1, 2019, 203 (5) 1172-1188; DOI: https://doi.org/10.4049/jimmunol.1900008
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Control of Tissue-Resident Invariant NKT Cells by Vitamin A Metabolites and P2X7-Mediated Cell Death
Qingyang Liu and Chang H. Kim

J Immunol September 1, 2019, 203 (5) 1189-1197; DOI: https://doi.org/10.4049/jimmunol.1900398
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Lipopolysaccharide Downregulates 11β-Hydroxysteroid Dehydrogenase 2 Expression through Inhibiting Peroxisome Proliferator–Activated Receptor-γ in Placental Trophoblasts
Lin Fu, Yuan-Hua Chen, Qing-Li Bo, Ya-Ping Song, Li Ma, Bo Wang, Shen Xu, Cheng Zhang, Hua Wang and De-Xiang Xu

J Immunol September 1, 2019, 203 (5) 1198-1207; DOI: https://doi.org/10.4049/jimmunol.1900132
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Efficient CD4Cre-Mediated Conditional KRas Expression in Alveolar Macrophages and Alveolar Epithelial Cells Causes Fatal Hyperproliferative Pneumonitis
Pengcheng Chen, Shang Wang, Kyathanahalli S. Janardhan, Rachel L. Zemans, Wenhai Deng, Peer Karmaus, Shudan Shen, Mary Sunday, Loretta G. Que, Michael B. Fessler and Xiao-Ping Zhong

J Immunol September 1, 2019, 203 (5) 1208-1217; DOI: https://doi.org/10.4049/jimmunol.1900566
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Mycobacterium tuberculosis PPE2 Protein Interacts with p67^phox and Inhibits Reactive Oxygen Species Production
Shruti Srivastava, Madhu Babu Battu, Mehak Zahoor Khan, Vinay Kumar Nandicoori and Sangita Mukhopadhyay

J Immunol September 1, 2019, 203 (5) 1218-1229; DOI: https://doi.org/10.4049/jimmunol.1801143
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The Transcription Factor PLZF Is Necessary for the Development and Function of Mouse Basophils
Sai Zhang, Joshua A. Vieth, Agata Krzyzanowska, Everett K. Henry, Lisa K. Denzin, Mark C. Siracusa and Derek B. Sant’Angelo

J Immunol September 1, 2019, 203 (5) 1230-1241; DOI: https://doi.org/10.4049/jimmunol.1900068

IMMUNE SYSTEM DEVELOPMENT

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Complex and Multilayered Role of IL-21 Signaling during Thymic Development
Magali M. Moretto, SuJin Hwang, Keer Chen and Imtiaz A. Khan

J Immunol September 1, 2019, 203 (5) 1242-1251; DOI: https://doi.org/10.4049/jimmunol.1800743

IMMUNOGENETICS

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Clustered Mutations at the Murine and Human IgH Locus Exhibit Significant Linkage Consistent with Templated Mutagenesis
Gordon A. Dale, Daniel J. Wilkins, Caitlin D. Bohannon, Dario Dilernia, Eric Hunter, Trevor Bedford, Rustom Antia, Ignacio Sanz and Joshy Jacob

J Immunol September 1, 2019, 203 (5) 1252-1264; DOI: https://doi.org/10.4049/jimmunol.1801615
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Ancient Use of Ig Variable Domains Contributes Significantly to the TCRδ Repertoire
Thaddeus C. Deiss, Breanna Breaux, Jeannine A. Ott, Rebecca A. Daniel, Patricia L. Chen, Caitlin D. Castro, Yuko Ohta, Martin F. Flajnik and Michael F. Criscitiello

J Immunol September 1, 2019, 203 (5) 1265-1275; DOI: https://doi.org/10.4049/jimmunol.1900369

INFECTIOUS DISEASE AND HOST RESPONSE

Open Access
Primary EBV Infection Induces an Acute Wave of Activated Antigen-Specific Cytotoxic CD4⁺ T Cells
Author Choice Article

Benjamin J. Meckiff, Kristin Ladell, James E. McLaren, Gordon B. Ryan, Alison M. Leese, Eddie A. James, David A. Price and Heather M. Long

J Immunol September 1, 2019, 203 (5) 1276-1287; DOI: https://doi.org/10.4049/jimmunol.1900377
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GNAQ Negatively Regulates Antiviral Innate Immune Responses in a Calcineurin-Dependent Manner
Ning Wang, Hongjun Huang, Qingqing Xiong, Naiyang Chen, Nanxi Xi, Peilun Wu, Mingyao Liu, Min Qian, Qin Wang and Bing Du

J Immunol September 1, 2019, 203 (5) 1288-1297; DOI: https://doi.org/10.4049/jimmunol.1900427
Open Access
Immune Response Resetting in Ongoing Sepsis
Author Choice Article

Alexandre E. Nowill, Márcia C. Fornazin, Maria C. Spago, Vicente Dorgan Neto, Vitória R. P. Pinheiro, Simônia S. S. Alexandre, Edgar O. Moraes, Gustavo H. M. F. Souza, Marcos N. Eberlin, Lygia A. Marques, Eduardo C. Meurer, Gilberto C. Franchi Jr. and Pedro O. de Campos-Lima

J Immunol September 1, 2019, 203 (5) 1298-1312; DOI: https://doi.org/10.4049/jimmunol.1900104
Open Access
Prostaglandin E₂–Induced Immune Exhaustion and Enhancement of Antiviral Effects by Anti–PD-L1 Antibody Combined with COX-2 Inhibitor in Bovine Leukemia Virus Infection
Author Choice Article

Yamato Sajiki, Satoru Konnai, Tomohiro Okagawa, Asami Nishimori, Naoya Maekawa, Shinya Goto, Kei Watari, Erina Minato, Atsushi Kobayashi, Junko Kohara, Shinji Yamada, Mika K. Kaneko, Yukinari Kato, Hirofumi Takahashi, Nobuhiro Terasaki, Akira Takeda, Keiichi Yamamoto, Mikihiro Toda, Yasuhiko Suzuki, Shiro Murata and Kazuhiko Ohashi

J Immunol September 1, 2019, 203 (5) 1313-1324; DOI: https://doi.org/10.4049/jimmunol.1900342

INNATE IMMUNITY AND INFLAMMATION

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Myeloid-Derived Suppressor Cells Confer Infectious Tolerance to Dampen Virus-Induced Tissue Immunoinflammation
Roman Sarkar, Amal Mathew and Sharvan Sehrawat

J Immunol September 1, 2019, 203 (5) 1325-1337; DOI: https://doi.org/10.4049/jimmunol.1900142
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Phosphatase PPM1L Prevents Excessive Inflammatory Responses and Cardiac Dysfunction after Myocardial Infarction by Inhibiting IKKβ Activation
Bo Wang, Qingqing Zhou, Yong Bi, Wenhui Zhou, Qiyan Zeng, Zhongmin Liu, Xingguang Liu and Zhenzhen Zhan

J Immunol September 1, 2019, 203 (5) 1338-1347; DOI: https://doi.org/10.4049/jimmunol.1900148
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ZBP1/DAI Drives RIPK3-Mediated Cell Death Induced by IFNs in the Absence of RIPK1
Justin P. Ingram, Roshan J. Thapa, Amanda Fisher, Bart Tummers, Ting Zhang, Chaoran Yin, Diego A. Rodriguez, Hongyan Guo, Rebecca Lane, Riley Williams, Michael J. Slifker, Suresh H. Basagoudanavar, Glenn F. Rall, Christopher P. Dillon, Douglas R. Green, William J. Kaiser and Siddharth Balachandran

J Immunol September 1, 2019, 203 (5) 1348-1355; DOI: https://doi.org/10.4049/jimmunol.1900216
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Singleton-Merten Syndrome–like Skeletal Abnormalities in Mice with Constitutively Activated MDA5
Nobumasa Soda, Nobuhiro Sakai, Hiroki Kato, Masamichi Takami and Takashi Fujita

J Immunol September 1, 2019, 203 (5) 1356-1368; DOI: https://doi.org/10.4049/jimmunol.1900354
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Teleost Gasdermin E Is Cleaved by Caspase 1, 3, and 7 and Induces Pyroptosis
Shuai Jiang, Hanjie Gu, Yan Zhao and Li Sun

J Immunol September 1, 2019, 203 (5) 1369-1382; DOI: https://doi.org/10.4049/jimmunol.1900383

MOLECULAR AND STRUCTURAL IMMUNOLOGY

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Integrin Binding to the Trimeric Interface of CD40L Plays a Critical Role in CD40/CD40L Signaling
Yoko K. Takada, Jessica Yu, Michiko Shimoda and Yoshikazu Takada

J Immunol September 1, 2019, 203 (5) 1383-1391; DOI: https://doi.org/10.4049/jimmunol.1801630

TRANSPLANTATION

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Postoperative Portal Hypertension Enhances Alloimmune Responses after Living-Donor Liver Transplantation in Patients and in a Mouse Model
Shinji Hashimoto, Takashi Onoe, Masataka Banshodani, Kazuhiro Taguchi, Yuka Tanaka and Hideki Ohdan

J Immunol September 1, 2019, 203 (5) 1392-1403; DOI: https://doi.org/10.4049/jimmunol.1701147

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Table of Contents

IN THIS ISSUE

PILLARS OF IMMUNOLOGY

BRIEF REVIEWS

CUTTING EDGE

ALLERGY AND OTHER HYPERSENSITIVITIES

ANTIGEN RECOGNITION AND RESPONSES

AUTOIMMUNITY

CLINICAL AND HUMAN IMMUNOLOGY

IMMUNE REGULATION

IMMUNE SYSTEM DEVELOPMENT

IMMUNOGENETICS

INFECTIOUS DISEASE AND HOST RESPONSE

INNATE IMMUNITY AND INFLAMMATION

MOLECULAR AND STRUCTURAL IMMUNOLOGY

TRANSPLANTATION

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