Skip to main content

Main menu

  • Home
  • Articles
    • Current Issue
    • Next in The JI
    • Archive
    • Brief Reviews
    • Pillars of Immunology
    • Translating Immunology
    • Most Read
    • Top Downloads
    • Annual Meeting Abstracts
  • COVID-19/SARS/MERS Articles
  • Info
    • About the Journal
    • For Authors
    • Journal Policies
    • Influence Statement
    • For Advertisers
  • Editors
  • Submit
    • Submit a Manuscript
    • Instructions for Authors
    • Journal Policies
  • Subscribe
    • Journal Subscriptions
    • Email Alerts
    • RSS Feeds
    • ImmunoCasts
  • More
    • Most Read
    • Most Cited
    • ImmunoCasts
    • AAI Disclaimer
    • Feedback
    • Help
    • Accessibility Statement
  • Other Publications
    • American Association of Immunologists
    • ImmunoHorizons

User menu

  • Subscribe
  • Log in

Search

  • Advanced search
The Journal of Immunology
  • Other Publications
    • American Association of Immunologists
    • ImmunoHorizons
  • Subscribe
  • Log in
The Journal of Immunology

Advanced Search

  • Home
  • Articles
    • Current Issue
    • Next in The JI
    • Archive
    • Brief Reviews
    • Pillars of Immunology
    • Translating Immunology
    • Most Read
    • Top Downloads
    • Annual Meeting Abstracts
  • COVID-19/SARS/MERS Articles
  • Info
    • About the Journal
    • For Authors
    • Journal Policies
    • Influence Statement
    • For Advertisers
  • Editors
  • Submit
    • Submit a Manuscript
    • Instructions for Authors
    • Journal Policies
  • Subscribe
    • Journal Subscriptions
    • Email Alerts
    • RSS Feeds
    • ImmunoCasts
  • More
    • Most Read
    • Most Cited
    • ImmunoCasts
    • AAI Disclaimer
    • Feedback
    • Help
    • Accessibility Statement
  • Follow The Journal of Immunology on Twitter
  • Follow The Journal of Immunology on RSS

Tissue-Resident Memory T Cells in Mice and Humans: Towards a Quantitative Ecology

Sinead E. Morris, Donna L. Farber and Andrew J. Yates
J Immunol November 15, 2019, 203 (10) 2561-2569; DOI: https://doi.org/10.4049/jimmunol.1900767
Sinead E. Morris
*Department of Pathology and Cell Biology, Columbia University Medical Center, New York, NY 10032;
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Sinead E. Morris
Donna L. Farber
†Columbia Center for Translational Immunology, Columbia University Medical Center, New York, NY 10032;
‡Department of Microbiology and Immunology, Columbia University Medical Center, New York, NY 10032; and
§Department of Surgery, Columbia University Medical Center, New York, NY 10032
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Donna L. Farber
Andrew J. Yates
*Department of Pathology and Cell Biology, Columbia University Medical Center, New York, NY 10032;
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Andrew J. Yates
  • Article
  • Figures & Data
  • Info & Metrics
  • PDF
Loading

Article Figures & Data

Figures

  • Tables
  • FIGURE 1.
    • Download figure
    • Open in new tab
    • Download powerpoint
    FIGURE 1.

    Schematic of TRM homeostasis model. Cells are recruited at a constant rate r, self-renew through division at rate p, and are lost at rate d, leading to exponentially distributed residence times within the tissue. Extensions of this model include different residence time distributions or decomposing the decay rate into distinct terms for cell death and tissue egress (107).

  • FIGURE 2.
    • Download figure
    • Open in new tab
    • Download powerpoint
    FIGURE 2.

    Impact of heterogeneity on population dynamics. (A) Assuming precursor input is negligible, homogeneity in the net loss rate across the population leads to a single exponential decay function (Eq. 2). (B) Conversely, if there is heterogeneity in net loss among cell subsets (e.g., because of different death rates), then the observed decay (dashed line) reflects the sum of the decay kinetics of each subset (red and blue lines).

  • FIGURE 3.
    • Download figure
    • Open in new tab
    • Download powerpoint
    FIGURE 3.

    Mathematical analysis of published TRM data. Eq. 2 fitted to data from (66) (A) and (67) (B). Solid lines are the model predictions, points are the data, and gray shaded regions are prediction envelopes obtained by sampling parameters from their 95% confidence intervals. Least-squares optimization was performed on the log-scale and residuals were normally distributed (using the Shapiro–Wilk test), except those for the nasal tissues (NT). The NT fits are thus included for approximate comparison only. Note that we use the above approach to illustrate how a simple model can be applied to experimental data. In a more thorough analysis, these predictions would then be compared with those from alternative models to identify the most parsimonious description of the data. Code for the above analysis can be found at https://github.com/SineadMorris/TRMecology.

Tables

  • Figures
    • View popup
    Table I. Experimental estimates of CD8+ TRM population parameters in different murine tissues and infection settings
    TissueSystemTime Detectable (d)Population t1/2aSelf-RenewalReferences
    LungsInfluenza<2105–7 dNo BrdU uptake detected(7, 67, 77)
    LiverMalaria>10028–36 d(11, 68)
    LCMV>120(17)
    FRTHSV>80(5, 35)
    LCMV>120(17)
    IntestineYersinia pseudotuberculosis>120(16)
    LCMV>120(17)
    BrainVACV>120<1% BrdU+ in 1 wk(74)
    LCMV>2409% Ki67+(12)
    SkinVACV>160(6)
    LCMV>200(67)
    HSV>540<5% BrdU+ in 1 wk(3, 4, 56, 81)
    • Time detectable represents the maximum observed duration of TRM persistence; tissues are approximately arranged in order of increasing estimates.

    • ↵a t1/2 estimates do not account for any ongoing recruitment from circulating subsets.

    • LCMV, lymphocytic choriomeningitis; VACV, vaccinia virus.

PreviousNext
Back to top

In this issue

The Journal of Immunology: 203 (10)
The Journal of Immunology
Vol. 203, Issue 10
15 Nov 2019
  • Table of Contents
  • Table of Contents (PDF)
  • About the Cover
  • Advertising (PDF)
  • Back Matter (PDF)
  • Editorial Board (PDF)
  • Front Matter (PDF)
Print
Download PDF
Article Alerts
Sign In to Email Alerts with your Email Address
Email Article

Thank you for your interest in spreading the word about The Journal of Immunology.

NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.

Enter multiple addresses on separate lines or separate them with commas.
Tissue-Resident Memory T Cells in Mice and Humans: Towards a Quantitative Ecology
(Your Name) has forwarded a page to you from The Journal of Immunology
(Your Name) thought you would like to see this page from the The Journal of Immunology web site.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Citation Tools
Tissue-Resident Memory T Cells in Mice and Humans: Towards a Quantitative Ecology
Sinead E. Morris, Donna L. Farber, Andrew J. Yates
The Journal of Immunology November 15, 2019, 203 (10) 2561-2569; DOI: 10.4049/jimmunol.1900767

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
Share
Tissue-Resident Memory T Cells in Mice and Humans: Towards a Quantitative Ecology
Sinead E. Morris, Donna L. Farber, Andrew J. Yates
The Journal of Immunology November 15, 2019, 203 (10) 2561-2569; DOI: 10.4049/jimmunol.1900767
del.icio.us logo Digg logo Reddit logo Twitter logo CiteULike logo Facebook logo Google logo Mendeley logo
  • Tweet Widget
  • Facebook Like

Jump to section

  • Article
    • Abstract
    • Introduction
    • Conclusions
    • Disclosures
    • Footnotes
    • References
  • Figures & Data
  • Info & Metrics
  • PDF

Related Articles

Cited By...

More in this TOC Section

  • The Ugly Duckling Turned to Swan: A Change in Perception of Bystander-Activated Memory CD8 T Cells
  • Stromal Cell–Mediated Coordination of Immune Cell Recruitment, Retention, and Function in Brain-Adjacent Regions
  • Afferent Lymphatic Transport and Peripheral Tissue Immunity
Show more BRIEF REVIEWS

Similar Articles

Navigate

  • Home
  • Current Issue
  • Next in The JI
  • Archive
  • Brief Reviews
  • Pillars of Immunology
  • Translating Immunology

For Authors

  • Submit a Manuscript
  • Instructions for Authors
  • About the Journal
  • Journal Policies
  • Editors

General Information

  • Advertisers
  • Subscribers
  • Rights and Permissions
  • Accessibility Statement
  • Public Access
  • Privacy Policy
  • Disclaimer

Journal Services

  • Email Alerts
  • RSS Feeds
  • ImmunoCasts
  • Twitter

Copyright © 2021 by The American Association of Immunologists, Inc.

Print ISSN 0022-1767        Online ISSN 1550-6606