The Journal of Immunology: 203 (1)

July 1, 2019; Volume 203,Issue 1

IN THIS ISSUE

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In This Issue
Inhibiting Drug Allergy with Engineered Small Molecules See article p. 21
Antagonist against Lupus See article p. 58
Thymus-Derived, Bone Marrow to Thrive See article p. 167
Boosting Protection See article p. 188

J Immunol July 1, 2019, 203 (1) 1; DOI: https://doi.org/10.4049/jimmunol.1990010

PILLARS OF IMMUNOLOGY

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Complement in Motion: The Evolution of CD46 from a Complement Regulator to an Orchestrator of Normal Cell Physiology
M. Kathryn Liszewski and Claudia Kemper

J Immunol July 1, 2019, 203 (1) 3-5; DOI: https://doi.org/10.4049/jimmunol.1900527
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Pillars Article: Identification of an Additional Class of C3-Binding Membrane Proteins of Human Peripheral Blood Leukocytes and Cell Lines. Proc. Natl. Acad. Sci. UAS. 1985. 82: 859–863
Joe L. Cole, George A. Housley Jr., Thomas R. Dykman, Richard P. Macdermott and John P. Atkinson

J Immunol July 1, 2019, 203 (1) 6-10;

BRIEF REVIEWS

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The Role of Memory CD8⁺ T Cells in Vitiligo
Rebecca L. Riding and John E. Harris

J Immunol July 1, 2019, 203 (1) 11-19; DOI: https://doi.org/10.4049/jimmunol.1900027

ALLERGY AND OTHER HYPERSENSITIVITIES

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Covalent Heterobivalent Inhibitor Design for Inhibition of IgE-Dependent Penicillin Allergy in a Murine Model
Peter E. Deak, Baksun Kim, Byunghee Koh, Amina Abdul Qayum, Tanyel Kiziltepe, Mark H. Kaplan and Basar Bilgicer

J Immunol July 1, 2019, 203 (1) 21-30; DOI: https://doi.org/10.4049/jimmunol.1900225
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Alternaria B Cell Mimotope Immunotherapy Alleviates Allergic Responses in a Mouse Model
Jie Li, Lin Yang, Jingru Wang, Yongshi Yang, Yuying Wu, Qing Jiang, Yaqi Yang, Dongxia Ma, Rui Zhang, Nan Huang, Wenjing Li, Guanghui Liu and Rongfei Zhu

J Immunol July 1, 2019, 203 (1) 31-38; DOI: https://doi.org/10.4049/jimmunol.1801182
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HB-EGF Synthesized by CD4 T Cells Modulates Allergic Airway Eosinophilia by Regulating IL-5 Synthesis
Soroor Farahnak, Leora Simon, Toby K. McGovern, Michael Chen, Niusha Khazaei and James G. Martin

J Immunol July 1, 2019, 203 (1) 39-47; DOI: https://doi.org/10.4049/jimmunol.1801686

AUTOIMMUNITY

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Nanoparticles Containing an Insulin–ChgA Hybrid Peptide Protect from Transfer of Autoimmune Diabetes by Shifting the Balance between Effector T Cells and Regulatory T Cells
Braxton L. Jamison, Tobias Neef, Andrew Goodspeed, Brenda Bradley, Rocky L. Baker, Stephen D. Miller and Kathryn Haskins

J Immunol July 1, 2019, 203 (1) 48-57; DOI: https://doi.org/10.4049/jimmunol.1900127
Open Access
Treatment with a CD40 Antagonist Antibody Reverses Severe Proteinuria and Loss of Saliva Production and Restores Glomerular Morphology in Murine Systemic Lupus Erythematosus
Author Choice Article

Stuart J. Perper, Susan V. Westmoreland, Jozsef Karman, Rachel Twomey, Jane Seagal, Rui Wang, Bradford L. McRae and Stephen H. Clarke

J Immunol July 1, 2019, 203 (1) 58-75; DOI: https://doi.org/10.4049/jimmunol.1900043
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A Deficit of CEACAM-1–Expressing T Lymphocytes Supports Inflammation in Primary Progressive Multiple Sclerosis
Federica Piancone, Marina Saresella, Ivana Marventano, Francesca La Rosa, Domenico Caputo, Laura Mendozzi, Marco Rovaris and Mario Clerici

J Immunol July 1, 2019, 203 (1) 76-83; DOI: https://doi.org/10.4049/jimmunol.1801625

CLINICAL AND HUMAN IMMUNOLOGY

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Widespread Tau-Specific CD4 T Cell Reactivity in the General Population
Cecilia S. Lindestam Arlehamn, John Pham, Roy N. Alcalay, April Frazier, Evan Shorr, Chelsea Carpenter, John Sidney, Rekha Dhanwani, Julian Agin-Liebes, Francesca Garretti, Amy W. Amara, David G. Standaert, Elizabeth J. Phillips, Simon A. Mallal, Bjoern Peters, David Sulzer and Alessandro Sette

J Immunol July 1, 2019, 203 (1) 84-92; DOI: https://doi.org/10.4049/jimmunol.1801506
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CD25 and Protein Phosphatase 2A Cooperate to Enhance IL-2R Signaling in Human Regulatory T Cells
Ying Ding, Aixin Yu, George C. Tsokos and Thomas R. Malek

J Immunol July 1, 2019, 203 (1) 93-104; DOI: https://doi.org/10.4049/jimmunol.1801570

IMMUNE REGULATION

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Protease-Activated Receptor 1 Deletion Causes Enhanced Osteoclastogenesis in Response to Inflammatory Signals through a Notch2-Dependent Mechanism
Sandra Jastrzebski, Judith Kalinowski, Sehwan Mun, Bongjin Shin, Naga Suresh Adapala, Christian E. Jacome-Galarza, Faryal Mirza, H. Leonardo Aguila, Hicham Drissi, Archana Sanjay, Ernesto Canalis, Sun-Kyeong Lee and Joseph A. Lorenzo

J Immunol July 1, 2019, 203 (1) 105-116; DOI: https://doi.org/10.4049/jimmunol.1801032
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The Lysophosphatidylcholine Transporter MFSD2A Is Essential for CD8⁺ Memory T Cell Maintenance and Secondary Response to Infection
Ann R. Piccirillo, Eric J. Hyzny, Lisa Y. Beppu, Ashley V. Menk, Callen T. Wallace, William F. Hawse, Heather M. Buechel, Bernice H. Wong, Juat Chin Foo, Amaury Cazenave-Gassiot, Markus R. Wenk, Greg M. Delgoffe, Simon C. Watkins, David L. Silver and Louise M. D’Cruz

J Immunol July 1, 2019, 203 (1) 117-126; DOI: https://doi.org/10.4049/jimmunol.1801585
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Metformin Augments Anti-Inflammatory and Chondroprotective Properties of Mesenchymal Stem Cells in Experimental Osteoarthritis
Min-Jung Park, Su-Jin Moon, Jin-Ah Baek, Eun-Jung Lee, Kyung-Ah Jung, Eun-Kyung Kim, Da-Som Kim, Jung-Ho Lee, Seung-Ki Kwok, Jun-Ki Min, Seok Jung Kim, Sung-Hwan Park and Mi-La Cho

J Immunol July 1, 2019, 203 (1) 127-136; DOI: https://doi.org/10.4049/jimmunol.1800006
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Effects of PI3K Inhibition on Afucosylated Antibody–Driven FcγRIIIa Events and Phospho-S6 Activity in NK Cells
Valentina Romeo, Sarah Gierke, Kyle A. Edgar and Scot D. Liu

J Immunol July 1, 2019, 203 (1) 137-147; DOI: https://doi.org/10.4049/jimmunol.1801418
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The Cross-Talk between miR-511-3p and C-Type Lectin Receptors on Dendritic Cells Affects Dendritic Cell Function
Dennis Awuah, Meshal Alobaid, Arsalan Latif, Fabián Salazar, Richard D. Emes and Amir M. Ghaemmaghami

J Immunol July 1, 2019, 203 (1) 148-157; DOI: https://doi.org/10.4049/jimmunol.1801108
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Regulation of Diabetogenic Immunity by IL-15–Activated Regulatory CD8 T Cells in Type 1 Diabetes
Blair T. Stocks, Christopher S. Wilson, Andrew F. Marshall, Emilee M. Hoopes and Daniel J. Moore

J Immunol July 1, 2019, 203 (1) 158-166; DOI: https://doi.org/10.4049/jimmunol.1800976

IMMUNE SYSTEM DEVELOPMENT

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Thymic Development of a Unique Bone Marrow–Resident Innate-like T Cell Subset with a Potent Innate Immune Function
Ryusuke Yamamoto, Yan Xu, Satoshi Ikeda, Kentaro Sumida, Hiroki Tanaka, Katsuto Hozumi, Akifumi Takaori-Kondo and Nagahiro Minato

J Immunol July 1, 2019, 203 (1) 167-177; DOI: https://doi.org/10.4049/jimmunol.1900111
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Phosphorylation at S2053 in Murine (S2056 in Human) DNA-PKcs Is Dispensable for Lymphocyte Development and Class Switch Recombination
Wenxia Jiang, Verna M. Estes, Xiaobin S. Wang, Zhengping Shao, Brian J. Lee, Xiaohui Lin, Jennifer L. Crowe and Shan Zha

J Immunol July 1, 2019, 203 (1) 178-187; DOI: https://doi.org/10.4049/jimmunol.1801657

IMMUNOTHERAPY AND VACCINES

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SOCS1 Antagonist–Expressing Recombinant Bacillus Calmette–Guérin Enhances Antituberculosis Protection in a Mouse Model
Satoru Mizuno, Shogo Soma, Hiroyasu Inada, Tomohiro Kanuma, Kazuhiro Matsuo and Yasuhiro Yasutomi

J Immunol July 1, 2019, 203 (1) 188-197; DOI: https://doi.org/10.4049/jimmunol.1800694
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Armored Inducible Expression of IL-12 Enhances Antitumor Activity of Glypican-3–Targeted Chimeric Antigen Receptor–Engineered T Cells in Hepatocellular Carcinoma
Ying Liu, Shengmeng Di, Bizhi Shi, Honghong Zhang, Yi Wang, Xiuqi Wu, Hong Luo, Huamao Wang, Zonghai Li and Hua Jiang

J Immunol July 1, 2019, 203 (1) 198-207; DOI: https://doi.org/10.4049/jimmunol.1800033

INFECTIOUS DISEASE AND HOST RESPONSE

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T Cell–Dependent Maturation of Pathogen-Specific Igs in the Antrum of Chronically Helicobacter pylori–Infected Patients
Laura Neumann, Verena Moos, Claudia Giesecke-Thiel, Thomas Dörner, Ralf Ignatius, Kristina Allers, Toni Aebischer and Thomas Schneider

J Immunol July 1, 2019, 203 (1) 208-215; DOI: https://doi.org/10.4049/jimmunol.1900074

INNATE IMMUNITY AND INFLAMMATION

Open Access
Evidence of Trained Immunity in a Fish: Conserved Features in Carp Macrophages
Author Choice Article

Jules Petit, Carmen W. E. Embregts, Maria Forlenza and Geert F. Wiegertjes

J Immunol July 1, 2019, 203 (1) 216-224; DOI: https://doi.org/10.4049/jimmunol.1900137
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C-Reactive Protein Promotes Inflammation through FcγR-Induced Glycolytic Reprogramming of Human Macrophages
Melissa Newling, Lathees Sritharan, Alwin J. van der Ham, Willianne Hoepel, Renée H. Fiechter, Leonie de Boer, Sebastian A. J. Zaat, Radjesh J. Bisoendial, Dominique L. P. Baeten, Bart Everts and Jeroen den Dunnen

J Immunol July 1, 2019, 203 (1) 225-235; DOI: https://doi.org/10.4049/jimmunol.1900172
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Inflammasome-Independent and Atypical Processing of IL-1β Contributes to Acid Aspiration–Induced Acute Lung Injury
Yoshiko Mizushina, Tadayoshi Karasawa, Kenichi Aizawa, Hiroaki Kimura, Sachiko Watanabe, Ryo Kamata, Takanori Komada, Naoko Mato, Tadashi Kasahara, Shinichiro Koyama, Masashi Bando, Koichi Hagiwara and Masafumi Takahashi

J Immunol July 1, 2019, 203 (1) 236-246; DOI: https://doi.org/10.4049/jimmunol.1900168
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Macrophages Guard Endothelial Lineage by Hindering Endothelial-to-Mesenchymal Transition: Implications for the Pathogenesis of Systemic Sclerosis
Pier Andrea Nicolosi, Enrico Tombetti, Anna Giovenzana, Eleonora Donè, Eleonora Pulcinelli, Raffaella Meneveri, Mario Tirone, Norma Maugeri, Patrizia Rovere-Querini, Angelo A. Manfredi and Silvia Brunelli

J Immunol July 1, 2019, 203 (1) 247-258; DOI: https://doi.org/10.4049/jimmunol.1800883
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USP19 Inhibits TNF-α– and IL-1β–Triggered NF-κB Activation by Deubiquitinating TAK1
Cao-Qi Lei, Xin Wu, Xuan Zhong, Lu Jiang, Bo Zhong and Hong-Bing Shu

J Immunol July 1, 2019, 203 (1) 259-268; DOI: https://doi.org/10.4049/jimmunol.1900083

MOLECULAR AND STRUCTURAL IMMUNOLOGY

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CUL7 E3 Ubiquitin Ligase Mediates the Degradation of Activation-Induced Cytidine Deaminase and Regulates the Ig Class Switch Recombination in B Lymphocytes
Yuewen Luo, Yang Liu, Liyang Wu, Xiancai Ma, Qin Liu, Feng Huang, Xu Zhang, Yiwen Zhang, Junsong Zhang, Haihua Luo, Yanyan Yang, Gen Lu, Xiaoping Tang, Linghua Li, Yixin Zeng, Ting Pan and Hui Zhang

J Immunol July 1, 2019, 203 (1) 269-281; DOI: https://doi.org/10.4049/jimmunol.1900125

MUCOSAL IMMUNOLOGY

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Microbiota Metabolite Short-Chain Fatty Acids Facilitate Mucosal Adjuvant Activity of Cholera Toxin through GPR43
Wenjing Yang, Yi Xiao, Xiangsheng Huang, Feidi Chen, Mingming Sun, Anthony J. Bilotta, Leiqi Xu, Yao Lu, Suxia Yao, Qihong Zhao, Zhanju Liu and Yingzi Cong

J Immunol July 1, 2019, 203 (1) 282-292; DOI: https://doi.org/10.4049/jimmunol.1801068

CORRECTIONS

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Correction: CRACR2A-Mediated TCR Signaling Promotes Local Effector Th1 and Th17 Responses
Jin Seok Woo, Sonal Srikanth, Kyun-Do Kim, Heidi Elsaesser, Jing Lu, Matteo Pellegrini, David G. Brooks, Zuoming Sun and Yousang Gwack

J Immunol July 1, 2019, 203 (1) 293; DOI: https://doi.org/10.4049/jimmunol.1900492

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Table of Contents

IN THIS ISSUE

PILLARS OF IMMUNOLOGY

BRIEF REVIEWS

ALLERGY AND OTHER HYPERSENSITIVITIES

AUTOIMMUNITY

CLINICAL AND HUMAN IMMUNOLOGY

IMMUNE REGULATION

IMMUNE SYSTEM DEVELOPMENT

IMMUNOTHERAPY AND VACCINES

INFECTIOUS DISEASE AND HOST RESPONSE

INNATE IMMUNITY AND INFLAMMATION

MOLECULAR AND STRUCTURAL IMMUNOLOGY

MUCOSAL IMMUNOLOGY

CORRECTIONS

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