The Journal of Immunology: 202 (9)

May 1, 2019; Volume 202,Issue 9

IN THIS ISSUE

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In This Issue
Affinity in Action See article p. 2535
Epitope Editing Affects T Cell Responses in Celiac Disease See article p. 2558
Skin Wounding Sparks Monocytes See article p. 2720
Deep Dive into Dimethyl Fumarate See article p. 2737
Early Immune Cascade of Pulmonary Fibrosis See article p. 2760
CTLA-4: The Next Target in Chronic Lymphocytic Leukemia? See article p. 2806

J Immunol May 1, 2019, 202 (9) 2515-2516; DOI: https://doi.org/10.4049/jimmunol.1990005

PILLARS OF IMMUNOLOGY

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Unmasking the Mysteries of MYC
Rajeev M. Nepal and Alberto Martin

J Immunol May 1, 2019, 202 (9) 2517-2518; DOI: https://doi.org/10.4049/jimmunol.1900186

BRIEF REVIEWS

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Friend or Foe: The Protective and Pathological Roles of Inducible Bronchus-Associated Lymphoid Tissue in Pulmonary Diseases
Nancy D. Marin, Micah D. Dunlap, Deepak Kaushal and Shabaana A. Khader

J Immunol May 1, 2019, 202 (9) 2519-2526; DOI: https://doi.org/10.4049/jimmunol.1801135

CUTTING EDGE

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Cutting Edge: BCAP Promotes Lupus-like Disease and TLR-Mediated Type I IFN Induction in Plasmacytoid Dendritic Cells
Talyn Chu, Minjian Ni, Chunmo Chen, Shreeram Akilesh and Jessica A. Hamerman

J Immunol May 1, 2019, 202 (9) 2529-2534; DOI: https://doi.org/10.4049/jimmunol.1801267

ANTIGEN RECOGNITION AND RESPONSES

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TCR Affinity Biases Th Cell Differentiation by Regulating CD25, Eef1e1, and Gbp2
Dmitri I. Kotov, Jason S. Mitchell, Thomas Pengo, Christiane Ruedl, Sing Sing Way, Ryan A. Langlois, Brian T. Fife and Marc K. Jenkins

J Immunol May 1, 2019, 202 (9) 2535-2545; DOI: https://doi.org/10.4049/jimmunol.1801609
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Essential Role of NADPH Oxidase–Dependent Production of Reactive Oxygen Species in Maintenance of Sustained B Cell Receptor Signaling and B Cell Proliferation
Yang-Yang Feng, Miao Tang, Mitsuhiro Suzuki, Chinthika Gunasekara, Yuki Anbe, Yuichi Hiraoka, Jun Liu, Helmut Grasberger, Mamoru Ohkita, Yasuo Matsumura, Ji-Yang Wang and Takeshi Tsubata

J Immunol May 1, 2019, 202 (9) 2546-2557; DOI: https://doi.org/10.4049/jimmunol.1800443
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Epitope Selection for HLA-DQ2 Presentation: Implications for Celiac Disease and Viral Defense
Shu-Chen Hung, Tieying Hou, Wei Jiang, Nan Wang, Shuo-Wang Qiao, I-Ting Chow, Xiaodan Liu, Sjoerd H. van der Burg, David M. Koelle, William W. Kwok, Ludvig M. Sollid and Elizabeth D. Mellins

J Immunol May 1, 2019, 202 (9) 2558-2569; DOI: https://doi.org/10.4049/jimmunol.1801454

AUTOIMMUNITY

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Nanoparticles Bearing TSH Receptor Protein and a Tolerogenic Molecule Do Not Induce Immune Tolerance but Exacerbate Thyroid Autoimmunity in hTSHR/NOD.H2^h4 Mice
Sandra M. McLachlan, Holly A. Aliesky and Basil Rapoport

J Immunol May 1, 2019, 202 (9) 2570-2577; DOI: https://doi.org/10.4049/jimmunol.1900038

CLINICAL AND HUMAN IMMUNOLOGY

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Expanded CD14^hiCD16⁻ Immunosuppressive Monocytes Predict Disease Severity in Patients with Acute Pancreatitis
Ruling Zhang, Juanjuan Shi, Rulin Zhang, Jianbo Ni, Aida Habtezion, Xingpeng Wang, Guoyong Hu and Jing Xue

J Immunol May 1, 2019, 202 (9) 2578-2584; DOI: https://doi.org/10.4049/jimmunol.1801194
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Effector and Activated T Cells Induce Preterm Labor and Birth That Is Prevented by Treatment with Progesterone
Marcia Arenas-Hernandez, Roberto Romero, Yi Xu, Bogdan Panaitescu, Valeria Garcia-Flores, Derek Miller, Hyunyoung Ahn, Bogdan Done, Sonia S. Hassan, Chaur-Dong Hsu, Adi L. Tarca, Carmen Sanchez-Torres and Nardhy Gomez-Lopez

J Immunol May 1, 2019, 202 (9) 2585-2608; DOI: https://doi.org/10.4049/jimmunol.1801350
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Cholecystokinin Downregulates Psoriatic Inflammation by Its Possible Self-Regulatory Effect on Epidermal Keratinocytes
Atsuko Funakoshi, Kazuki Tatsuno, Takatoshi Shimauchi, Toshiharu Fujiyama, Taisuke Ito and Yoshiki Tokura

J Immunol May 1, 2019, 202 (9) 2609-2615; DOI: https://doi.org/10.4049/jimmunol.1801426

IMMUNE REGULATION

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Stromal Interaction Molecule Deficiency in T Cells Promotes Spontaneous Follicular Helper T Cell Development and Causes Type 2 Immune Disorders
Masatsugu Oh-hora, Xiuyuan Lu, Moe Shiokawa, Hiroshi Takayanagi and Sho Yamasaki

J Immunol May 1, 2019, 202 (9) 2616-2627; DOI: https://doi.org/10.4049/jimmunol.1700610
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Negligible Role for Deletion Mediated by cDC1 in CD8⁺ T Cell Tolerance
Brendan W. MacNabb, Douglas E. Kline, Annie R. Albright, Xiufen Chen, Daniel S. Leventhal, Peter A. Savage and Justin Kline

J Immunol May 1, 2019, 202 (9) 2628-2635; DOI: https://doi.org/10.4049/jimmunol.1801621

IMMUNOGENETICS

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Diversity of KIR, HLA Class I, and Their Interactions in Seven Populations of Sub-Saharan Africans
Neda Nemat-Gorgani, Lisbeth A. Guethlein, Brenna M. Henn, Steven J. Norberg, Jacques Chiaroni, Martin Sikora, Lluis Quintana-Murci, Joanna L. Mountain, Paul J. Norman and Peter Parham

J Immunol May 1, 2019, 202 (9) 2636-2647; DOI: https://doi.org/10.4049/jimmunol.1801586

INFECTIOUS DISEASE AND HOST RESPONSE

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Identification and Characterization of Functional Human Monoclonal Antibodies to Plasmodium vivax Duffy-Binding Protein
Lenore L. Carias, Sebastien Dechavanne, Vanessa C. Nicolete, Sokunthea Sreng, Seila Suon, Chanaki Amaratunga, Rick M. Fairhurst, Celia Dechavanne, Samantha Barnes, Benoit Witkowski, Jean Popovici, Camille Roesch, Edwin Chen, Marcelo U. Ferreira, Niraj H. Tolia, John H. Adams and Christopher L. King

J Immunol May 1, 2019, 202 (9) 2648-2660; DOI: https://doi.org/10.4049/jimmunol.1801631
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Dragotcytosis: Elucidation of the Mechanism for Cryptococcus neoformans Macrophage-to-Macrophage Transfer
Quigly Dragotakes, Man Shun Fu and Arturo Casadevall

J Immunol May 1, 2019, 202 (9) 2661-2670; DOI: https://doi.org/10.4049/jimmunol.1801118
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Brucella abortus Cyclic Dinucleotides Trigger STING-Dependent Unfolded Protein Response That Favors Bacterial Replication
Erika S. Guimarães, Marco Túlio R. Gomes, Priscila C. Campos, Daniel S. Mansur, Adara A. dos Santos, Jerome Harms, Gary Splitter, Judith A. Smith, Glen N. Barber and Sergio C. Oliveira

J Immunol May 1, 2019, 202 (9) 2671-2681; DOI: https://doi.org/10.4049/jimmunol.1801233
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Shifting Dynamics of Intestinal Macrophages during Simian Immunodeficiency Virus Infection in Adult Rhesus Macaques
Naofumi Takahashi, Chie Sugimoto, Carolina Allers, Xavier Alvarez, Woong-Ki Kim, Elizabeth S. Didier and Marcelo J. Kuroda

J Immunol May 1, 2019, 202 (9) 2682-2689; DOI: https://doi.org/10.4049/jimmunol.1801457
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Systemic Antibiotic Therapy Reduces Circulating Inflammatory Dendritic Cells and Treg–Th17 Plasticity in Periodontitis
Mythilypriya Rajendran, Stephen Looney, Nagendra Singh, Mahmoud Elashiry, Mohamed M. Meghil, Ahmed R. El-Awady, Omnia Tawfik, Cristiano Susin, Roger M. Arce and Christopher W. Cutler

J Immunol May 1, 2019, 202 (9) 2690-2699; DOI: https://doi.org/10.4049/jimmunol.1900046

INNATE IMMUNITY AND INFLAMMATION

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Distinctive Effects of GM-CSF and M-CSF on Proliferation and Polarization of Two Major Pulmonary Macrophage Populations
Christina Draijer, Loka Raghu Kumar Penke and Marc Peters-Golden

J Immunol May 1, 2019, 202 (9) 2700-2709; DOI: https://doi.org/10.4049/jimmunol.1801387
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Identification of Residues Critical for FPR2 Activation by the Cryptic Peptide Mitocryptide-2 Originating from the Mitochondrial DNA–Encoded Cytochrome b
Simon Lind, Michael Gabl, André Holdfeldt, Jonas Mårtensson, Martina Sundqvist, Kodai Nishino, Claes Dahlgren, Hidehito Mukai and Huamei Forsman

J Immunol May 1, 2019, 202 (9) 2710-2719; DOI: https://doi.org/10.4049/jimmunol.1900060
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Skin Wounding–Induced Monocyte Expansion in Mice Is Not Abrogated by IL-1 Receptor 1 Deficiency
Pijus K. Barman, Jingbo Pang, Norifumi Urao and Timothy J. Koh

J Immunol May 1, 2019, 202 (9) 2720-2727; DOI: https://doi.org/10.4049/jimmunol.1801481
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Leptin Promotes Monosodium Urate Crystal–Induced Inflammation in Human and Murine Models of Gout
Yiyun Yu, Jie Yang, Sisi Fu, Yu Xue, Minrui Liang, Dandan Xuan, Xiaoxia Zhu, Weiguo Wan, Ling Lv and Hejian Zou

J Immunol May 1, 2019, 202 (9) 2728-2736; DOI: https://doi.org/10.4049/jimmunol.1801097
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Dimethyl Fumarate Disrupts Human Innate Immune Signaling by Targeting the IRAK4–MyD88 Complex
Balyn W. Zaro, Ekaterina V. Vinogradova, Daniel C. Lazar, Megan M. Blewett, Radu M. Suciu, Junichiro Takaya, Sean Studer, Juan Carlos de la Torre, Jean-Laurent Casanova, Benjamin F. Cravatt and John R. Teijaro

J Immunol May 1, 2019, 202 (9) 2737-2746; DOI: https://doi.org/10.4049/jimmunol.1801627
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The Immune Deficiency Pathway Regulates Metabolic Homeostasis in Drosophila
Saeideh Davoodi, Anthony Galenza, Andrew Panteluk, Rujuta Deshpande, Meghan Ferguson, Savraj Grewal and Edan Foley

J Immunol May 1, 2019, 202 (9) 2747-2759; DOI: https://doi.org/10.4049/jimmunol.1801632
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Epithelial Expression of an Interstitial Lung Disease–Associated Mutation in Surfactant Protein-C Modulates Recruitment and Activation of Key Myeloid Cell Populations in Mice
Alessandro Venosa, Jeremy Katzen, Yaniv Tomer, Meghan Kopp, Sarita Jamil, Scott J. Russo, Surafel Mulugeta and Michael F. Beers

J Immunol May 1, 2019, 202 (9) 2760-2771; DOI: https://doi.org/10.4049/jimmunol.1900039
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Imbalance of Ly-6C^hi and Ly-6C^lo Monocytes/Macrophages Worsens Hyperoxia-Induced Lung Injury and Is Rescued by IFN-γ
Laurie C. Eldredge, Rane S. Creasy, Shigeru Tanaka, Jen-Feng Lai and Steven F. Ziegler

J Immunol May 1, 2019, 202 (9) 2772-2781; DOI: https://doi.org/10.4049/jimmunol.1801374

MOLECULAR AND STRUCTURAL IMMUNOLOGY

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Integrin β1 Promotes the Interaction of Murine IgG3 with Effector Cells
Carolyn Saylor Hawk, Carolina Coelho, Diane Sthefany Lima de Oliveira, Verenice Paredes, Patrícia Albuquerque, Anamélia Lorenzetti Bocca, Ananésia Correa dos Santos, Victoria Rusakova, Heather Holemon, Ildinete Silva-Pereira, Maria Sueli Soares Felipe, Hideo Yagita, André Moraes Nicola and Arturo Casadevall

J Immunol May 1, 2019, 202 (9) 2782-2794; DOI: https://doi.org/10.4049/jimmunol.1701795

TRANSPLANTATION

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Dendritic Cell Expression of Retinal Aldehyde Dehydrogenase-2 Controls Graft-versus-Host Disease Lethality
Govindarajan Thangavelu, Yu-Chi Lee, Michael Loschi, K. Melanie Schaechter, Colby J. Feser, Brent H. Koehn, Elizabeth C. Nowak, Robert Zeiser, Jonathan S. Serody, William J. Murphy, David H. Munn, Pierre Chambon, Randolph J. Noelle and Bruce R. Blazar

J Immunol May 1, 2019, 202 (9) 2795-2805; DOI: https://doi.org/10.4049/jimmunol.1800899

TUMOR IMMUNOLOGY

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Leukemic B Cell CTLA-4 Suppresses Costimulation of T Cells
Priscilla Do, Kyle A. Beckwith, Carolyn Cheney, Minh Tran, Larry Beaver, Brittany G. Griffin, Xiaokui Mo, Yang Liu, Rosa Lapalombella, Erin Hertlein, Natarajan Muthusamy and John C. Byrd

J Immunol May 1, 2019, 202 (9) 2806-2816; DOI: https://doi.org/10.4049/jimmunol.1801359

CORRECTIONS

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Correction: Abrogation of Lupus Nephritis in Somatic Hypermutation–Deficient B6.MRL-Fas^lpr mice/J Mice
Fengqi Hao, Miaomiao Tian, Yunpeng Feng, Chao Quan, Yixi Chen, Shuai Chen and Min Wei

J Immunol May 1, 2019, 202 (9) 2817; DOI: https://doi.org/10.4049/jimmunol.1900198

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Table of Contents

IN THIS ISSUE

PILLARS OF IMMUNOLOGY

BRIEF REVIEWS

CUTTING EDGE

ANTIGEN RECOGNITION AND RESPONSES

AUTOIMMUNITY

CLINICAL AND HUMAN IMMUNOLOGY

IMMUNE REGULATION

IMMUNOGENETICS

INFECTIOUS DISEASE AND HOST RESPONSE

INNATE IMMUNITY AND INFLAMMATION

MOLECULAR AND STRUCTURAL IMMUNOLOGY

TRANSPLANTATION

TUMOR IMMUNOLOGY

CORRECTIONS

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