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The Journal of Immunology

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Table of Contents

March 1, 2019; Volume 202,Issue 5

IN THIS ISSUE

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    In This Issue

    A Better View of Abatacept See article p. 1373

    A Rel-evant Mutation See article p. 1479

    LRP1 Regulates Macrophage TNF Release See article p. 1501

    PAT1 as a Regulator of NADPH Oxidase See article p. 1549

    J Immunol March 1, 2019, 202 (5) 1313; DOI: https://doi.org/10.4049/jimmunol.1990001

PILLARS OF IMMUNOLOGY

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    From RAG2 to T Cell Riches and Future Fortunes
    Rebecca A. Glynn and Craig H. Bassing
    J Immunol March 1, 2019, 202 (5) 1315-1316; DOI: https://doi.org/10.4049/jimmunol.1900010
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    Pillars Article: Restoration of T Cell Development in RAG-2-Deficient Mice by Functional TCR Transgenes. Science. 1993. 259: 822-825
    Yoichi Shinkai, Shigeo Koyasu, Kei-ichi Nakayama, Kenneth M. Murphy, Dennis Y. Loh, Ellis L. Reinherz and Frederick W. Alt
    J Immunol March 1, 2019, 202 (5) 1317-1320;

BRIEF REVIEWS

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    The Immune Function of Tuft Cells at Gut Mucosal Surfaces and Beyond
    Hung-An Ting and Jakob von Moltke
    J Immunol March 1, 2019, 202 (5) 1321-1329; DOI: https://doi.org/10.4049/jimmunol.1801069

ALLERGY AND OTHER HYPERSENSITIVITIES

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    Nrf2 Suppresses Allergic Lung Inflammation by Attenuating the Type 2 Innate Lymphoid Cell Response
    Ryuichi Nagashima, Hitomi Kosai, Masahiro Masuo, Keiko Izumiyama, Taketo Noshikawaji, Motoko Morimoto, Satoru Kumaki, Yasunari Miyazaki, Hozumi Motohashi, Masayuki Yamamoto and Nobuyuki Tanaka
    J Immunol March 1, 2019, 202 (5) 1331-1339; DOI: https://doi.org/10.4049/jimmunol.1801180

ANTIGEN RECOGNITION AND RESPONSES

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    Poor Antigen Processing of Poxvirus Particles Limits CD4+ T Cell Recognition and Impacts Immunogenicity of the Inactivated Vaccine
    Katherine S. Forsyth, Brian DeHaven, Mark Mendonca, Sinu Paul, Alessandro Sette and Laurence C. Eisenlohr
    J Immunol March 1, 2019, 202 (5) 1340-1349; DOI: https://doi.org/10.4049/jimmunol.1801099

AUTOIMMUNITY

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    MYMD-1, a Novel Immunometabolic Regulator, Ameliorates Autoimmune Thyroiditis via Suppression of Th1 Responses and TNF-α Release
    Giulia Di Dalmazi, Paulina Chalan and Patrizio Caturegli
    J Immunol March 1, 2019, 202 (5) 1350-1362; DOI: https://doi.org/10.4049/jimmunol.1801238

CLINICAL AND HUMAN IMMUNOLOGY

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    Upregulation of Chitinase 1 in Alveolar Macrophages of HIV-Infected Smokers
    Eric C. Logue, C. Preston Neff, Douglas G. Mack, Allison K. Martin, Suzanne Fiorillo, James Lavelle, R. William Vandivier, Thomas B. Campbell, Brent E. Palmer and Andrew P. Fontenot
    J Immunol March 1, 2019, 202 (5) 1363-1372; DOI: https://doi.org/10.4049/jimmunol.1801105
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    Abatacept Targets T Follicular Helper and Regulatory T Cells, Disrupting Molecular Pathways That Regulate Their Proliferation and Maintenance
    Simon Glatigny, Barbara Höllbacher, Samantha J. Motley, Cathy Tan, Christian Hundhausen, Jane H. Buckner, Dawn Smilek, Samia J. Khoury, Linna Ding, Tielin Qin, Jorge Pardo, Gerald T. Nepom, Laurence A. Turka, Kristina M. Harris, Daniel J. Campbell and Estelle Bettelli
    J Immunol March 1, 2019, 202 (5) 1373-1382; DOI: https://doi.org/10.4049/jimmunol.1801425

IMMUNE REGULATION

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    The B Cell Activation-Induced miR-183 Cluster Plays a Minimal Role in Canonical Primary Humoral Responses
    Joseph N. Pucella, Montserrat Cols, Wei-Feng Yen, Shunbin Xu and Jayanta Chaudhuri
    J Immunol March 1, 2019, 202 (5) 1383-1396; DOI: https://doi.org/10.4049/jimmunol.1800071
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    The PI3K p110δ Isoform Inhibitor Idelalisib Preferentially Inhibits Human Regulatory T Cell Function
    Stalin Chellappa, Kushi Kushekhar, Ludvig A. Munthe, Geir E. Tjønnfjord, Einar M. Aandahl, Klaus Okkenhaug and Kjetil Taskén
    J Immunol March 1, 2019, 202 (5) 1397-1405; DOI: https://doi.org/10.4049/jimmunol.1701703
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    ARTD1 in Myeloid Cells Controls the IL-12/18–IFN-γ Axis in a Model of Sterile Sepsis, Chronic Bacterial Infection, and Cancer
    Friedrich A. Kunze, Michael Bauer, Juliana Komuczki, Margit Lanzinger, Kapila Gunasekera, Ann-Katrin Hopp, Mareike Lehmann, Burkhard Becher, Anne Müller and Michael O. Hottiger
    J Immunol March 1, 2019, 202 (5) 1406-1416; DOI: https://doi.org/10.4049/jimmunol.1801107
  • Open Access
    Differences in Self-Recognition between Secreted Antibody and Membrane-Bound B Cell Antigen Receptor

    Author Choice Article

    Joseena Iype, Moumita Datta, Ahmad Khadour, Rudolf Übelhart, Antonella Nicolò, Tim Rollenske, Marcus Dühren-von Minden, Hedda Wardemann, Palash C. Maity and Hassan Jumaa
    J Immunol March 1, 2019, 202 (5) 1417-1427; DOI: https://doi.org/10.4049/jimmunol.1800690
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    Involvement of Lamin B1 Reduction in Accelerated Cellular Senescence during Chronic Obstructive Pulmonary Disease Pathogenesis
    Nayuta Saito, Jun Araya, Saburo Ito, Kazuya Tsubouchi, Shunsuke Minagawa, Hiromichi Hara, Akihiko Ito, Takayuki Nakano, Yusuke Hosaka, Akihiro Ichikawa, Tsukasa Kadota, Masahiro Yoshida, Yu Fujita, Hirofumi Utsumi, Yusuke Kurita, Kenji Kobayashi, Mitsuo Hashimoto, Hiroshi Wakui, Takanori Numata, Yumi Kaneko, Hisatoshi Asano, Makoto Odaka, Takashi Ohtsuka, Toshiaki Morikawa, Katsutoshi Nakayama and Kazuyoshi Kuwano
    J Immunol March 1, 2019, 202 (5) 1428-1440; DOI: https://doi.org/10.4049/jimmunol.1801293
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    Akt-1 and Akt-2 Differentially Regulate the Development of Experimental Autoimmune Encephalomyelitis by Controlling Proliferation of Thymus-Derived Regulatory T Cells
    Song Ouyang, Qiuming Zeng, Na Tang, Hui Guo, Rong Tang, Weifan Yin, Aimin Wang, Hongyu Tang, Jiru Zhou, Hong Xie, Wallace Y. Langdon, Huan Yang and Jian Zhang
    J Immunol March 1, 2019, 202 (5) 1441-1452; DOI: https://doi.org/10.4049/jimmunol.1701204

INFECTIOUS DISEASE AND HOST RESPONSE

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    Resolution of Cutaneous Leishmaniasis and Persistence of Leishmania major in the Absence of Arginase 1
    Katrin Paduch, Andrea Debus, Baplu Rai, Ulrike Schleicher and Christian Bogdan
    J Immunol March 1, 2019, 202 (5) 1453-1464; DOI: https://doi.org/10.4049/jimmunol.1801249
  • Open Access
    HIV, Cytomegalovirus, and Malaria Infections during Pregnancy Lead to Inflammation and Shifts in Memory B Cell Subsets in Kenyan Neonates

    Author Choice Article

    Kee Thai Yeo, Paula Embury, Timothy Anderson, Peter Mungai, Indu Malhotra, Christopher King, James Kazura and Arlene Dent
    J Immunol March 1, 2019, 202 (5) 1465-1478; DOI: https://doi.org/10.4049/jimmunol.1801024
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    Rel-Dependent Immune and Central Nervous System Mechanisms Control Viral Replication and Inflammation during Mouse Herpes Simplex Encephalitis
    Mathieu Mancini, Grégory Caignard, Benoît Charbonneau, Anne Dumaine, Nila Wu, Gabriel A. Leiva-Torres, Steve Gerondakis, Angela Pearson, Salman T. Qureshi, Robert Sladek and Silvia M. Vidal
    J Immunol March 1, 2019, 202 (5) 1479-1493; DOI: https://doi.org/10.4049/jimmunol.1800063
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    Coexistent Helminth Infection–Mediated Modulation of Chemokine Responses in Latent Tuberculosis
    Anuradha Rajamanickam, Saravanan Munisankar, Yukthi Bhootra, Chandra Kumar Dolla, Thomas B. Nutman and Subash Babu
    J Immunol March 1, 2019, 202 (5) 1494-1500; DOI: https://doi.org/10.4049/jimmunol.1801190

INNATE IMMUNITY AND INFLAMMATION

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    LRP1 Controls TNF Release via the TIMP-3/ADAM17 Axis in Endotoxin-Activated Macrophages
    Kristin Schubert, Laura E. Collins, Patricia Green, Hideaki Nagase and Linda Troeberg
    J Immunol March 1, 2019, 202 (5) 1501-1509; DOI: https://doi.org/10.4049/jimmunol.1800834
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    Gαi2 Signaling Regulates Inflammasome Priming and Cytokine Production by Biasing Macrophage Phenotype Determination
    Ali Vural, Neel R. Nabar, Il-Young Hwang, Silke Sohn, Chung Park, Mikael C. I. Karlsson, Joe B. Blumer and John H. Kehrl
    J Immunol March 1, 2019, 202 (5) 1510-1520; DOI: https://doi.org/10.4049/jimmunol.1801145
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    Hydroxylase Inhibition Selectively Induces Cell Death in Monocytes
    Bianca Crifo, Bettina Schaible, Eric Brown, Doug N. Halligan, Carsten C. Scholz, Susan F. Fitzpatrick, Anna Kirwan, Helen M. Roche, Mattia Criscuoli, Antonella Naldini, Hugh Giffney, Daniel Crean, Alfonso Blanco, Miguel A. Cavadas, Eoin P. Cummins, Zsolt Fabian and Cormac T. Taylor
    J Immunol March 1, 2019, 202 (5) 1521-1530; DOI: https://doi.org/10.4049/jimmunol.1800912
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    Hypercholesterolemia Induces a Mast Cell–CD4+ T Cell Interaction in Atherosclerosis
    Eva Kritikou, Thomas van der Heijden, Maarten Swart, Janine van Duijn, Bram Slütter, Anouk Wezel, Harm J. Smeets, Pasquale Maffia, Johan Kuiper and Ilze Bot
    J Immunol March 1, 2019, 202 (5) 1531-1539; DOI: https://doi.org/10.4049/jimmunol.1800648
  • Open Access
    IL-17A Recruits Rab35 to IL-17R to Mediate PKCα-Dependent Stress Fiber Formation and Airway Smooth Muscle Contractility

    Author Choice Article

    Katarzyna Bulek, Xing Chen, Vandy Parron, Aparna Sundaram, Tomasz Herjan, Suidong Ouyang, Caini Liu, Alana Majors, Jarod Zepp, Ji Gao, Ashok Dongre, Malgorzata Bodaszewska-Lubas, Arnaud Echard, Mark Aronica, Julie Carman, Stavros Garantziotis, Dean Sheppard and Xiaoxia Li
    J Immunol March 1, 2019, 202 (5) 1540-1548; DOI: https://doi.org/10.4049/jimmunol.1801025
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    The Kinesin Light Chain–Related Protein PAT1 Promotes Superoxide Anion Production in Human Phagocytes
    Riad Arabi-Derkawi, Yvonne O’Dowd, Ni Cheng, Loïc Rolas, Tarek Boussetta, Houssam Raad, Viviana Marzaioli, Coralie Pintard, Magali Fasseu, Yolande Kroviarski, Sahra A. Belambri, Pham My-Chan Dang, Richard D. Ye, Marie-Anne Gougerot-Pocidalo and Jamel El-Benna
    J Immunol March 1, 2019, 202 (5) 1549-1558; DOI: https://doi.org/10.4049/jimmunol.1800610
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    Signals of the Neuropilin-1–MET Axis and Cues of Mechanical Force Exertion Converge to Elicit Inflammatory Activation in Coherent Endothelial Cells
    Maryam Rezaei, Ana C. Martins Cavaco, Jochen Seebach, Stephan Niland, Jana Zimmermann, Eva-Maria Hanschmann, Rupert Hallmann, Hermann Schillers and Johannes A. Eble
    J Immunol March 1, 2019, 202 (5) 1559-1572; DOI: https://doi.org/10.4049/jimmunol.1801346

MOLECULAR AND STRUCTURAL IMMUNOLOGY

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    DNA Breaks in Ig V Regions Are Predominantly Single Stranded and Are Generated by UNG and MSH6 DNA Repair Pathways
    Kimberly J. Zanotti, Robert W. Maul, William Yang and Patricia J. Gearhart
    J Immunol March 1, 2019, 202 (5) 1573-1581; DOI: https://doi.org/10.4049/jimmunol.1801183
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    Fc Sialylation Prolongs Serum Half-Life of Therapeutic Antibodies
    Mathilde Bas, Aurélie Terrier, Emilie Jacque, Aurélie Dehenne, Virginie Pochet-Béghin, Cécile Beghin, Anne-Sophie Dezetter, Gilles Dupont, Anaïs Engrand, Benjamin Beaufils, Philippe Mondon, Nathalie Fournier, Christophe de Romeuf, Sylvie Jorieux, Alexandre Fontayne, Lennart T. Mars and Céline Monnet
    J Immunol March 1, 2019, 202 (5) 1582-1594; DOI: https://doi.org/10.4049/jimmunol.1800896
  • Open Access
    Insertion of N-Terminal Hinge Glycosylation Enhances Interactions of the Fc Region of Human IgG1 Monomers with Glycan-Dependent Receptors and Blocks Hemagglutination by the Influenza Virus

    Author Choice Article

    Patricia A. Blundell, Dongli Lu, Mark Wilkinson, Anne Dell, Stuart Haslam and Richard J. Pleass
    J Immunol March 1, 2019, 202 (5) 1595-1611; DOI: https://doi.org/10.4049/jimmunol.1801337

SYSTEMS IMMUNOLOGY

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    Identification of Variable and Joining Germline Genes and Alleles for Rhesus Macaque from B Cell Receptor Repertoires
    Wei Zhang, Xinyue Li, Longlong Wang, Jianxiang Deng, Liya Lin, Lei Tian, Jinghua Wu, Chenling Tang, Huanming Yang, Jian Wang, Ping Qiu, Tong-Ming Fu, Nitin K. Saksena, I-Ming Wang and Xiao Liu
    J Immunol March 1, 2019, 202 (5) 1612-1622; DOI: https://doi.org/10.4049/jimmunol.1800342

TUMOR IMMUNOLOGY

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    Tumor Microenvironment Modulates Immunological Outcomes of Myeloid Cells with mTORC1 Disruption
    Chuanlin Ding, Xiaomin Sun, Caijun Wu, Xiaoling Hu, Huang-ge Zhang and Jun Yan
    J Immunol March 1, 2019, 202 (5) 1623-1634; DOI: https://doi.org/10.4049/jimmunol.1801112

NOVEL IMMUNOLOGICAL METHODS

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    A Multiparameter Flow Cytometry Analysis Panel to Assess CD163 mRNA and Protein in Monocyte and Macrophage Populations in Hyperinflammatory Diseases
    Sherry Thornton, Rachel Tan, Alyssa Sproles, Thuy Do, Jonathan Schick, Alexei A. Grom, Monica DeLay and Grant S. Schulert
    J Immunol March 1, 2019, 202 (5) 1635-1643; DOI: https://doi.org/10.4049/jimmunol.1800765
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This Issue

The Journal of Immunology: 202 (5)
The Journal of Immunology
Vol. 202, Issue 5
1 Mar 2019
  • Table of Contents
  • Table of Contents (PDF)
  • About the Cover
  • Back Matter (PDF)
  • Editorial Board (PDF)
  • Front Matter (PDF)

Issue highlights

  • In This Issue
  • The Immune Function of Tuft Cells at Gut Mucosal Surfaces and Beyond
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  • IN THIS ISSUE
  • PILLARS OF IMMUNOLOGY
  • BRIEF REVIEWS
  • ALLERGY AND OTHER HYPERSENSITIVITIES
  • ANTIGEN RECOGNITION AND RESPONSES
  • AUTOIMMUNITY
  • CLINICAL AND HUMAN IMMUNOLOGY
  • IMMUNE REGULATION
  • INFECTIOUS DISEASE AND HOST RESPONSE
  • INNATE IMMUNITY AND INFLAMMATION
  • MOLECULAR AND STRUCTURAL IMMUNOLOGY
  • SYSTEMS IMMUNOLOGY
  • TUMOR IMMUNOLOGY
  • NOVEL IMMUNOLOGICAL METHODS
  • Highlights
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Immunodominant AH1 Antigen-Deficient Necroptotic, but Not Apoptotic, Murine Cancer Cells Induce Antitumor Protection
Osteoclasts Derive Predominantly from Bone Marrow–Resident CX3CR1+ Precursor Cells in Homeostasis, whereas Circulating CX3CR1+ Cells Contribute to Osteoclast Development during Fracture Repair
Intracellular IL-1 Receptor Antagonist Isoform 1 Released from Keratinocytes upon Cell Death Acts as an Inhibitor for the Alarmin IL-1α
Polysaccharide Capsules Equip the Human Symbiont Bacteroides thetaiotaomicron to Modulate Immune Responses to a Dominant Antigen in the Intestine
Natural and Induced Tolerogenic Dendritic Cells
Cutting Edge: IL-6–Driven Immune Dysregulation Is Strictly Dependent on IL-6R α-Chain Expression

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