The Journal of Immunology: 202 (5)

March 1, 2019; Volume 202,Issue 5

IN THIS ISSUE

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In This Issue
A Better View of Abatacept See article p. 1373
A Rel-evant Mutation See article p. 1479
LRP1 Regulates Macrophage TNF Release See article p. 1501
PAT1 as a Regulator of NADPH Oxidase See article p. 1549

J Immunol March 1, 2019, 202 (5) 1313; DOI: https://doi.org/10.4049/jimmunol.1990001

PILLARS OF IMMUNOLOGY

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From RAG2 to T Cell Riches and Future Fortunes
Rebecca A. Glynn and Craig H. Bassing

J Immunol March 1, 2019, 202 (5) 1315-1316; DOI: https://doi.org/10.4049/jimmunol.1900010
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Pillars Article: Restoration of T Cell Development in RAG-2-Deficient Mice by Functional TCR Transgenes. Science. 1993. 259: 822-825
Yoichi Shinkai, Shigeo Koyasu, Kei-ichi Nakayama, Kenneth M. Murphy, Dennis Y. Loh, Ellis L. Reinherz and Frederick W. Alt

J Immunol March 1, 2019, 202 (5) 1317-1320;

BRIEF REVIEWS

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The Immune Function of Tuft Cells at Gut Mucosal Surfaces and Beyond
Hung-An Ting and Jakob von Moltke

J Immunol March 1, 2019, 202 (5) 1321-1329; DOI: https://doi.org/10.4049/jimmunol.1801069

ALLERGY AND OTHER HYPERSENSITIVITIES

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Nrf2 Suppresses Allergic Lung Inflammation by Attenuating the Type 2 Innate Lymphoid Cell Response
Ryuichi Nagashima, Hitomi Kosai, Masahiro Masuo, Keiko Izumiyama, Taketo Noshikawaji, Motoko Morimoto, Satoru Kumaki, Yasunari Miyazaki, Hozumi Motohashi, Masayuki Yamamoto and Nobuyuki Tanaka

J Immunol March 1, 2019, 202 (5) 1331-1339; DOI: https://doi.org/10.4049/jimmunol.1801180

ANTIGEN RECOGNITION AND RESPONSES

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Poor Antigen Processing of Poxvirus Particles Limits CD4⁺ T Cell Recognition and Impacts Immunogenicity of the Inactivated Vaccine
Katherine S. Forsyth, Brian DeHaven, Mark Mendonca, Sinu Paul, Alessandro Sette and Laurence C. Eisenlohr

J Immunol March 1, 2019, 202 (5) 1340-1349; DOI: https://doi.org/10.4049/jimmunol.1801099

AUTOIMMUNITY

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MYMD-1, a Novel Immunometabolic Regulator, Ameliorates Autoimmune Thyroiditis via Suppression of Th1 Responses and TNF-α Release
Giulia Di Dalmazi, Paulina Chalan and Patrizio Caturegli

J Immunol March 1, 2019, 202 (5) 1350-1362; DOI: https://doi.org/10.4049/jimmunol.1801238

CLINICAL AND HUMAN IMMUNOLOGY

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Upregulation of Chitinase 1 in Alveolar Macrophages of HIV-Infected Smokers
Eric C. Logue, C. Preston Neff, Douglas G. Mack, Allison K. Martin, Suzanne Fiorillo, James Lavelle, R. William Vandivier, Thomas B. Campbell, Brent E. Palmer and Andrew P. Fontenot

J Immunol March 1, 2019, 202 (5) 1363-1372; DOI: https://doi.org/10.4049/jimmunol.1801105
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Abatacept Targets T Follicular Helper and Regulatory T Cells, Disrupting Molecular Pathways That Regulate Their Proliferation and Maintenance
Simon Glatigny, Barbara Höllbacher, Samantha J. Motley, Cathy Tan, Christian Hundhausen, Jane H. Buckner, Dawn Smilek, Samia J. Khoury, Linna Ding, Tielin Qin, Jorge Pardo, Gerald T. Nepom, Laurence A. Turka, Kristina M. Harris, Daniel J. Campbell and Estelle Bettelli

J Immunol March 1, 2019, 202 (5) 1373-1382; DOI: https://doi.org/10.4049/jimmunol.1801425

IMMUNE REGULATION

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The B Cell Activation-Induced miR-183 Cluster Plays a Minimal Role in Canonical Primary Humoral Responses
Joseph N. Pucella, Montserrat Cols, Wei-Feng Yen, Shunbin Xu and Jayanta Chaudhuri

J Immunol March 1, 2019, 202 (5) 1383-1396; DOI: https://doi.org/10.4049/jimmunol.1800071
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The PI3K p110δ Isoform Inhibitor Idelalisib Preferentially Inhibits Human Regulatory T Cell Function
Stalin Chellappa, Kushi Kushekhar, Ludvig A. Munthe, Geir E. Tjønnfjord, Einar M. Aandahl, Klaus Okkenhaug and Kjetil Taskén

J Immunol March 1, 2019, 202 (5) 1397-1405; DOI: https://doi.org/10.4049/jimmunol.1701703
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ARTD1 in Myeloid Cells Controls the IL-12/18–IFN-γ Axis in a Model of Sterile Sepsis, Chronic Bacterial Infection, and Cancer
Friedrich A. Kunze, Michael Bauer, Juliana Komuczki, Margit Lanzinger, Kapila Gunasekera, Ann-Katrin Hopp, Mareike Lehmann, Burkhard Becher, Anne Müller and Michael O. Hottiger

J Immunol March 1, 2019, 202 (5) 1406-1416; DOI: https://doi.org/10.4049/jimmunol.1801107
Open Access
Differences in Self-Recognition between Secreted Antibody and Membrane-Bound B Cell Antigen Receptor
Author Choice Article

Joseena Iype, Moumita Datta, Ahmad Khadour, Rudolf Übelhart, Antonella Nicolò, Tim Rollenske, Marcus Dühren-von Minden, Hedda Wardemann, Palash C. Maity and Hassan Jumaa

J Immunol March 1, 2019, 202 (5) 1417-1427; DOI: https://doi.org/10.4049/jimmunol.1800690
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Involvement of Lamin B1 Reduction in Accelerated Cellular Senescence during Chronic Obstructive Pulmonary Disease Pathogenesis
Nayuta Saito, Jun Araya, Saburo Ito, Kazuya Tsubouchi, Shunsuke Minagawa, Hiromichi Hara, Akihiko Ito, Takayuki Nakano, Yusuke Hosaka, Akihiro Ichikawa, Tsukasa Kadota, Masahiro Yoshida, Yu Fujita, Hirofumi Utsumi, Yusuke Kurita, Kenji Kobayashi, Mitsuo Hashimoto, Hiroshi Wakui, Takanori Numata, Yumi Kaneko, Hisatoshi Asano, Makoto Odaka, Takashi Ohtsuka, Toshiaki Morikawa, Katsutoshi Nakayama and Kazuyoshi Kuwano

J Immunol March 1, 2019, 202 (5) 1428-1440; DOI: https://doi.org/10.4049/jimmunol.1801293
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Akt-1 and Akt-2 Differentially Regulate the Development of Experimental Autoimmune Encephalomyelitis by Controlling Proliferation of Thymus-Derived Regulatory T Cells
Song Ouyang, Qiuming Zeng, Na Tang, Hui Guo, Rong Tang, Weifan Yin, Aimin Wang, Hongyu Tang, Jiru Zhou, Hong Xie, Wallace Y. Langdon, Huan Yang and Jian Zhang

J Immunol March 1, 2019, 202 (5) 1441-1452; DOI: https://doi.org/10.4049/jimmunol.1701204

INFECTIOUS DISEASE AND HOST RESPONSE

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Resolution of Cutaneous Leishmaniasis and Persistence of Leishmania major in the Absence of Arginase 1
Katrin Paduch, Andrea Debus, Baplu Rai, Ulrike Schleicher and Christian Bogdan

J Immunol March 1, 2019, 202 (5) 1453-1464; DOI: https://doi.org/10.4049/jimmunol.1801249
Open Access
HIV, Cytomegalovirus, and Malaria Infections during Pregnancy Lead to Inflammation and Shifts in Memory B Cell Subsets in Kenyan Neonates
Author Choice Article

Kee Thai Yeo, Paula Embury, Timothy Anderson, Peter Mungai, Indu Malhotra, Christopher King, James Kazura and Arlene Dent

J Immunol March 1, 2019, 202 (5) 1465-1478; DOI: https://doi.org/10.4049/jimmunol.1801024
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Rel-Dependent Immune and Central Nervous System Mechanisms Control Viral Replication and Inflammation during Mouse Herpes Simplex Encephalitis
Mathieu Mancini, Grégory Caignard, Benoît Charbonneau, Anne Dumaine, Nila Wu, Gabriel A. Leiva-Torres, Steve Gerondakis, Angela Pearson, Salman T. Qureshi, Robert Sladek and Silvia M. Vidal

J Immunol March 1, 2019, 202 (5) 1479-1493; DOI: https://doi.org/10.4049/jimmunol.1800063
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Coexistent Helminth Infection–Mediated Modulation of Chemokine Responses in Latent Tuberculosis
Anuradha Rajamanickam, Saravanan Munisankar, Yukthi Bhootra, Chandra Kumar Dolla, Thomas B. Nutman and Subash Babu

J Immunol March 1, 2019, 202 (5) 1494-1500; DOI: https://doi.org/10.4049/jimmunol.1801190

INNATE IMMUNITY AND INFLAMMATION

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LRP1 Controls TNF Release via the TIMP-3/ADAM17 Axis in Endotoxin-Activated Macrophages
Kristin Schubert, Laura E. Collins, Patricia Green, Hideaki Nagase and Linda Troeberg

J Immunol March 1, 2019, 202 (5) 1501-1509; DOI: https://doi.org/10.4049/jimmunol.1800834
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Gα_i2 Signaling Regulates Inflammasome Priming and Cytokine Production by Biasing Macrophage Phenotype Determination
Ali Vural, Neel R. Nabar, Il-Young Hwang, Silke Sohn, Chung Park, Mikael C. I. Karlsson, Joe B. Blumer and John H. Kehrl

J Immunol March 1, 2019, 202 (5) 1510-1520; DOI: https://doi.org/10.4049/jimmunol.1801145
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Hydroxylase Inhibition Selectively Induces Cell Death in Monocytes
Bianca Crifo, Bettina Schaible, Eric Brown, Doug N. Halligan, Carsten C. Scholz, Susan F. Fitzpatrick, Anna Kirwan, Helen M. Roche, Mattia Criscuoli, Antonella Naldini, Hugh Giffney, Daniel Crean, Alfonso Blanco, Miguel A. Cavadas, Eoin P. Cummins, Zsolt Fabian and Cormac T. Taylor

J Immunol March 1, 2019, 202 (5) 1521-1530; DOI: https://doi.org/10.4049/jimmunol.1800912
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Hypercholesterolemia Induces a Mast Cell–CD4⁺ T Cell Interaction in Atherosclerosis
Eva Kritikou, Thomas van der Heijden, Maarten Swart, Janine van Duijn, Bram Slütter, Anouk Wezel, Harm J. Smeets, Pasquale Maffia, Johan Kuiper and Ilze Bot

J Immunol March 1, 2019, 202 (5) 1531-1539; DOI: https://doi.org/10.4049/jimmunol.1800648
Open Access
IL-17A Recruits Rab35 to IL-17R to Mediate PKCα-Dependent Stress Fiber Formation and Airway Smooth Muscle Contractility
Author Choice Article

Katarzyna Bulek, Xing Chen, Vandy Parron, Aparna Sundaram, Tomasz Herjan, Suidong Ouyang, Caini Liu, Alana Majors, Jarod Zepp, Ji Gao, Ashok Dongre, Malgorzata Bodaszewska-Lubas, Arnaud Echard, Mark Aronica, Julie Carman, Stavros Garantziotis, Dean Sheppard and Xiaoxia Li

J Immunol March 1, 2019, 202 (5) 1540-1548; DOI: https://doi.org/10.4049/jimmunol.1801025
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The Kinesin Light Chain–Related Protein PAT1 Promotes Superoxide Anion Production in Human Phagocytes
Riad Arabi-Derkawi, Yvonne O’Dowd, Ni Cheng, Loïc Rolas, Tarek Boussetta, Houssam Raad, Viviana Marzaioli, Coralie Pintard, Magali Fasseu, Yolande Kroviarski, Sahra A. Belambri, Pham My-Chan Dang, Richard D. Ye, Marie-Anne Gougerot-Pocidalo and Jamel El-Benna

J Immunol March 1, 2019, 202 (5) 1549-1558; DOI: https://doi.org/10.4049/jimmunol.1800610
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Signals of the Neuropilin-1–MET Axis and Cues of Mechanical Force Exertion Converge to Elicit Inflammatory Activation in Coherent Endothelial Cells
Maryam Rezaei, Ana C. Martins Cavaco, Jochen Seebach, Stephan Niland, Jana Zimmermann, Eva-Maria Hanschmann, Rupert Hallmann, Hermann Schillers and Johannes A. Eble

J Immunol March 1, 2019, 202 (5) 1559-1572; DOI: https://doi.org/10.4049/jimmunol.1801346

MOLECULAR AND STRUCTURAL IMMUNOLOGY

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DNA Breaks in Ig V Regions Are Predominantly Single Stranded and Are Generated by UNG and MSH6 DNA Repair Pathways
Kimberly J. Zanotti, Robert W. Maul, William Yang and Patricia J. Gearhart

J Immunol March 1, 2019, 202 (5) 1573-1581; DOI: https://doi.org/10.4049/jimmunol.1801183
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Fc Sialylation Prolongs Serum Half-Life of Therapeutic Antibodies
Mathilde Bas, Aurélie Terrier, Emilie Jacque, Aurélie Dehenne, Virginie Pochet-Béghin, Cécile Beghin, Anne-Sophie Dezetter, Gilles Dupont, Anaïs Engrand, Benjamin Beaufils, Philippe Mondon, Nathalie Fournier, Christophe de Romeuf, Sylvie Jorieux, Alexandre Fontayne, Lennart T. Mars and Céline Monnet

J Immunol March 1, 2019, 202 (5) 1582-1594; DOI: https://doi.org/10.4049/jimmunol.1800896
Open Access
Insertion of N-Terminal Hinge Glycosylation Enhances Interactions of the Fc Region of Human IgG1 Monomers with Glycan-Dependent Receptors and Blocks Hemagglutination by the Influenza Virus
Author Choice Article

Patricia A. Blundell, Dongli Lu, Mark Wilkinson, Anne Dell, Stuart Haslam and Richard J. Pleass

J Immunol March 1, 2019, 202 (5) 1595-1611; DOI: https://doi.org/10.4049/jimmunol.1801337

SYSTEMS IMMUNOLOGY

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Identification of Variable and Joining Germline Genes and Alleles for Rhesus Macaque from B Cell Receptor Repertoires
Wei Zhang, Xinyue Li, Longlong Wang, Jianxiang Deng, Liya Lin, Lei Tian, Jinghua Wu, Chenling Tang, Huanming Yang, Jian Wang, Ping Qiu, Tong-Ming Fu, Nitin K. Saksena, I-Ming Wang and Xiao Liu

J Immunol March 1, 2019, 202 (5) 1612-1622; DOI: https://doi.org/10.4049/jimmunol.1800342

TUMOR IMMUNOLOGY

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Tumor Microenvironment Modulates Immunological Outcomes of Myeloid Cells with mTORC1 Disruption
Chuanlin Ding, Xiaomin Sun, Caijun Wu, Xiaoling Hu, Huang-ge Zhang and Jun Yan

J Immunol March 1, 2019, 202 (5) 1623-1634; DOI: https://doi.org/10.4049/jimmunol.1801112

NOVEL IMMUNOLOGICAL METHODS

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A Multiparameter Flow Cytometry Analysis Panel to Assess CD163 mRNA and Protein in Monocyte and Macrophage Populations in Hyperinflammatory Diseases
Sherry Thornton, Rachel Tan, Alyssa Sproles, Thuy Do, Jonathan Schick, Alexei A. Grom, Monica DeLay and Grant S. Schulert

J Immunol March 1, 2019, 202 (5) 1635-1643; DOI: https://doi.org/10.4049/jimmunol.1800765

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Table of Contents

IN THIS ISSUE

PILLARS OF IMMUNOLOGY

BRIEF REVIEWS

ALLERGY AND OTHER HYPERSENSITIVITIES

ANTIGEN RECOGNITION AND RESPONSES

AUTOIMMUNITY

CLINICAL AND HUMAN IMMUNOLOGY

IMMUNE REGULATION

INFECTIOUS DISEASE AND HOST RESPONSE

INNATE IMMUNITY AND INFLAMMATION

MOLECULAR AND STRUCTURAL IMMUNOLOGY

SYSTEMS IMMUNOLOGY

TUMOR IMMUNOLOGY

NOVEL IMMUNOLOGICAL METHODS

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