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Ketogenic diet activates protective γδ T cell responses against influenza virus infection

Emily Lauren Goldberg, Ryan Molony, Sviatoslav Sidorov, Eriko Kudo, Vishwa Deep Dixit and Akiko Iwasaki
J Immunol May 1, 2019, 202 (1 Supplement) 62.7;
Emily Lauren Goldberg
1Yale Sch. of Med.
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Ryan Molony
1Yale Sch. of Med.
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Sviatoslav Sidorov
1Yale Sch. of Med.
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Eriko Kudo
1Yale Sch. of Med.
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Vishwa Deep Dixit
1Yale Sch. of Med.
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Akiko Iwasaki
1Yale Sch. of Med.
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Abstract

Influenza A virus (IAV) infection-associated morbidity and mortality are a key global healthcare concern, necessitating the identification of novel therapies capable of reducing the severity of IAV infections. In this study, we show that the consumption of a low-carbohydrate, high-fat ketogenic diet (KD) protects mice from lethal IAV infection and disease. KD feeding resulted in an expansion of γδ T cells in the lung that improved barrier functions, thereby enhancing anti-viral resistance. Expansion of these protective γδ T cells required metabolic adaptation to a ketogenic diet, as neither feeding mice a high-fat high-carbohydrate diet nor providing chemical ketone body substrate that bypasses hepatic ketogenesis protected against infection. Therefore, KD mediated immune-metabolic integration represents a viable avenue towards preventing or alleviating influenza disease.

  • Copyright © 2019 by The American Association of Immunologists, Inc.
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The Journal of Immunology
Vol. 202, Issue 1 Supplement
1 May 2019
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Ketogenic diet activates protective γδ T cell responses against influenza virus infection
Emily Lauren Goldberg, Ryan Molony, Sviatoslav Sidorov, Eriko Kudo, Vishwa Deep Dixit, Akiko Iwasaki
The Journal of Immunology May 1, 2019, 202 (1 Supplement) 62.7;

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Ketogenic diet activates protective γδ T cell responses against influenza virus infection
Emily Lauren Goldberg, Ryan Molony, Sviatoslav Sidorov, Eriko Kudo, Vishwa Deep Dixit, Akiko Iwasaki
The Journal of Immunology May 1, 2019, 202 (1 Supplement) 62.7;
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Print ISSN 0022-1767        Online ISSN 1550-6606