The Journal of Immunology: 201 (7)

October 1, 2018; Volume 201,Issue 7

IN THIS ISSUE

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In This Issue
Function of Nod2 in Autoimmune Arthritis See article p. 1889
PGI₂ Suppresses IL-33–Driven Th2 Responses See article p. 1936
Lenalidomide Induces Th1 Responses during CLL Treatment See article p. 1967
Potent Prime-and-Trap Vaccine for P. yoelii See article p. 1984
T_Reg Expansion by an Immunocytokine See article p. 2094

J Immunol October 1, 2018, 201 (7) 1811-1812; DOI: https://doi.org/10.4049/jimmunol.1890016

IMMUNOLOGY NOTES AND RESOURCES

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Flow Cytometry: To Dump or Not To Dump
Maximilian Boesch, Antonio Cosma and Sieghart Sopper

J Immunol October 1, 2018, 201 (7) 1813-1815; DOI: https://doi.org/10.4049/jimmunol.1801037

PILLARS OF IMMUNOLOGY

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How Superantigens Bind MHC
Luc Van Kaer

J Immunol October 1, 2018, 201 (7) 1817-1818; DOI: https://doi.org/10.4049/jimmunol.1801104
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Pillars Article: Three-Dimensional Structure of a Human Class II Histocompatibility Molecule Complexed with Superantigen. Nature. 1994. 368: 711–718
Theodore S. Jardetzky, Jerry H. Brown, Joan C. Gorga, Lawrence J. Stern, Robert G. Urban, Young-in Chi, Cynthia Stauffacher, Jack L. Strominger and Don C. Wiley

J Immunol October 1, 2018, 201 (7) 1819-1826;

BRIEF REVIEWS

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Innate T Cells Govern Adipose Tissue Biology
Nelson M. LaMarche, Ayano C. Kohlgruber and Michael B. Brenner

J Immunol October 1, 2018, 201 (7) 1827-1834; DOI: https://doi.org/10.4049/jimmunol.1800556

CUTTING EDGE

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Cutting Edge: Elevated Leptin during Diet-Induced Obesity Reduces the Efficacy of Tumor Immunotherapy
Katherine A. Murphy, Britnie R. James, Frances V. Sjaastad, Tamara A. Kucaba, Hyunjoon Kim, Erik L. Brincks, Streamson C. Chua Jr., Andrew Wilber and Thomas S. Griffith

J Immunol October 1, 2018, 201 (7) 1837-1841; DOI: https://doi.org/10.4049/jimmunol.1701738

ALLERGY AND OTHER HYPERSENSITIVITIES

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Testosterone Decreases House Dust Mite–Induced Type 2 and IL-17A–Mediated Airway Inflammation
Hubaida Fuseini, Jeffrey A. Yung, Jacqueline Yvonne Cephus, Jian Zhang, Kasia Goleniewska, Vasiliy V. Polosukhin, R. Stokes Peebles Jr. and Dawn C. Newcomb

J Immunol October 1, 2018, 201 (7) 1843-1854; DOI: https://doi.org/10.4049/jimmunol.1800293
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The Canonical but Not the Noncanonical Wnt Pathway Inhibits the Development of Allergic Airway Disease
Hendrik Beckert, Helen Meyer-Martin, Roland Buhl, Christian Taube and Sebastian Reuter

J Immunol October 1, 2018, 201 (7) 1855-1864; DOI: https://doi.org/10.4049/jimmunol.1800554
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Differential Influence on Regulatory B Cells by T_H2 Cytokines Affects Protection in Allergic Airway Disease
Sophina H. Taitano, Luciën E. P. M. van der Vlugt, Molly M. Shea, Jennifer Yang, Nicholas W. Lukacs and Steven K. Lundy

J Immunol October 1, 2018, 201 (7) 1865-1874; DOI: https://doi.org/10.4049/jimmunol.1800206

ANTIGEN RECOGNITION AND RESPONSES

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Cytosolic Processing Governs TAP-Independent Presentation of a Critical Melanoma Antigen
Nathalie Vigneron, Violette Ferrari, Benoît J. Van den Eynde, Peter Cresswell and Ralf M. Leonhardt

J Immunol October 1, 2018, 201 (7) 1875-1888; DOI: https://doi.org/10.4049/jimmunol.1701479

AUTOIMMUNITY

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Nod2 Deficiency Augments Th17 Responses and Exacerbates Autoimmune Arthritis
Ruth J. Napier, Ellen J. Lee, Emily E. Vance, Paige E. Snow, Kimberly A. Samson, Clare E. Dawson, Amy E. Moran, Peter Stenzel, Michael P. Davey, Shimon Sakaguchi and Holly L. Rosenzweig

J Immunol October 1, 2018, 201 (7) 1889-1898; DOI: https://doi.org/10.4049/jimmunol.1700507
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IL-2–Anti–IL-2 Monoclonal Antibody Immune Complexes Inhibit Collagen-Induced Arthritis by Augmenting Regulatory T Cell Functions
Yuichi Yokoyama, Tsuyoshi Iwasaki, Sachie Kitano, Atsushi Satake, Shosaku Nomura, Tetsuya Furukawa, Kiyoshi Matsui and Hajime Sano

J Immunol October 1, 2018, 201 (7) 1899-1906; DOI: https://doi.org/10.4049/jimmunol.1701502
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A Hypermorphic Nfkbid Allele Contributes to Impaired Thymic Deletion of Autoreactive Diabetogenic CD8⁺ T Cells in NOD Mice
Maximiliano Presa, Jeremy J. Racine, Jennifer R. Dwyer, Deanna J. Lamont, Jeremy J. Ratiu, Vishal Kumar Sarsani, Yi-Guang Chen, Aron Geurts, Ingo Schmitz, Timothy Stearns, Jennifer Allocco, Harold D. Chapman and David V. Serreze

J Immunol October 1, 2018, 201 (7) 1907-1917; DOI: https://doi.org/10.4049/jimmunol.1800465

CLINICAL AND HUMAN IMMUNOLOGY

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Activation of NF-κB in Synovium versus Cartilage from Patients with Advanced Knee Osteoarthritis: A Potential Contributor to Inflammatory Aspects of Disease Progression
Aisha S. Ahmed, Per Gedin, Anders Hugo, Georgy Bakalkin, Alkass Kanar, David A. Hart, Henrik Druid, Camilla Svensson and Eva Kosek

J Immunol October 1, 2018, 201 (7) 1918-1927; DOI: https://doi.org/10.4049/jimmunol.1800486
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Absence of Surface IgD Does Not Impair Naive B Cell Homeostasis or Memory B Cell Formation in IGHD Haploinsufficient Humans
Jana Nechvatalova, Sophinus J. W. Bartol, Zita Chovancova, Louis Boon, Marcela Vlkova and Menno C. van Zelm

J Immunol October 1, 2018, 201 (7) 1928-1935; DOI: https://doi.org/10.4049/jimmunol.1800767

IMMUNE REGULATION

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The PGI₂ Analog Cicaprost Inhibits IL-33–Induced Th2 Responses, IL-2 Production, and CD25 Expression in Mouse CD4⁺ T Cells
Weisong Zhou, Jian Zhang, Shinji Toki, Kasia Goleniewska, Marc O. Johnson, Melissa H. Bloodworth, Dawn C. Newcomb and R. Stokes Peebles Jr.

J Immunol October 1, 2018, 201 (7) 1936-1945; DOI: https://doi.org/10.4049/jimmunol.1700605

IMMUNOGENETICS

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Characterization of an NLRP1 Inflammasome from Zebrafish Reveals a Unique Sequential Activation Mechanism Underlying Inflammatory Caspases in Ancient Vertebrates
Jiang-yuan Li, Ke Gao, Tong Shao, Dong-dong Fan, Chong-bin Hu, Cen-cen Sun, Wei-ren Dong, Ai-fu Lin, Li-xin Xiang and Jian-zhong Shao

J Immunol October 1, 2018, 201 (7) 1946-1966; DOI: https://doi.org/10.4049/jimmunol.1800498

IMMUNOTHERAPY AND VACCINES

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Activation of Th1 Immunity within the Tumor Microenvironment Is Associated with Clinical Response to Lenalidomide in Chronic Lymphocytic Leukemia
Georg Aue, Clare Sun, Delong Liu, Jae-Hyun Park, Stefania Pittaluga, Xin Tian, Elinor Lee, Susan Soto, Janet Valdez, Irina Maric, Maryalice Stetler-Stevenson, Constance Yuan, Yusuke Nakamura, Pawel Muranski and Adrian Wiestner

J Immunol October 1, 2018, 201 (7) 1967-1974; DOI: https://doi.org/10.4049/jimmunol.1800570
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Three-Dimensional Ameliorated Biologics Elicit Thymic Renewal in Tumor-Bearing Hosts
Yanna Zhang, Huanhuan Yang, Qian Li, Xiaogang Duan, Xia Zhao, Yuquan Wei and Xiancheng Chen

J Immunol October 1, 2018, 201 (7) 1975-1983; DOI: https://doi.org/10.4049/jimmunol.1701727
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Prime-and-Trap Malaria Vaccination To Generate Protective CD8⁺ Liver-Resident Memory T Cells
Tayla M. Olsen, Brad C. Stone, Vorada Chuenchob and Sean C. Murphy

J Immunol October 1, 2018, 201 (7) 1984-1993; DOI: https://doi.org/10.4049/jimmunol.1800740

INFECTIOUS DISEASE AND HOST RESPONSE

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Impaired Development and Expansion of Germinal Center Follicular Th Cells in Simian Immunodeficiency Virus–Infected Neonatal Macaques
Huanbin Xu, Widade Ziani, Jiasheng Shao, Lara A. Doyle-Meyers, Kasi E. Russell-Lodrigue, Marion S. Ratterree, Ronald S. Veazey and Xiaolei Wang

J Immunol October 1, 2018, 201 (7) 1994-2003; DOI: https://doi.org/10.4049/jimmunol.1800235
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Autocrine IL-10 Signaling Promotes Dendritic Cell Type-2 Activation and Persistence of Murine Cryptococcal Lung Infection
Seagal Teitz-Tennenbaum, Steven P. Viglianti, Jonathan A. Roussey, Stuart M. Levitz, Michal A. Olszewski and John J. Osterholzer

J Immunol October 1, 2018, 201 (7) 2004-2015; DOI: https://doi.org/10.4049/jimmunol.1800070
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Dysregulated Calcium Homeostasis in Cystic Fibrosis Neutrophils Leads to Deficient Antimicrobial Responses
Frank H. Robledo-Avila, Juan de Dios Ruiz-Rosado, Kenneth L. Brockman, Benjamin T. Kopp, Amal O. Amer, Karen McCoy, Lauren O. Bakaletz and Santiago Partida-Sanchez

J Immunol October 1, 2018, 201 (7) 2016-2027; DOI: https://doi.org/10.4049/jimmunol.1800076

INNATE IMMUNITY AND INFLAMMATION

Open Access
Human NK Cells Lyse Th2-Polarizing Dendritic Cells via NKp30 and DNAM-1
Author Choice Article

Katherine Walwyn-Brown, Karolin Guldevall, Mezida Saeed, Daniela Pende, Björn Önfelt, Andrew S. MacDonald and Daniel M. Davis

J Immunol October 1, 2018, 201 (7) 2028-2041; DOI: https://doi.org/10.4049/jimmunol.1800475
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CSF-1 in Inflammatory and Arthritic Pain Development
Reem Saleh, Ming-Chin Lee, Stella H. Khiew, Cynthia Louis, Andrew J. Fleetwood, Adrian Achuthan, Irmgard Förster, Andrew D. Cook and John A. Hamilton

J Immunol October 1, 2018, 201 (7) 2042-2053; DOI: https://doi.org/10.4049/jimmunol.1800665
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PPARγ Deficiency Suppresses the Release of IL-1β and IL-1α in Macrophages via a Type 1 IFN–Dependent Mechanism
Kassandra J. Weber, Madeline Sauer, Li He, Eric Tycksen, Gowri Kalugotla, Babak Razani and Joel D. Schilling

J Immunol October 1, 2018, 201 (7) 2054-2069; DOI: https://doi.org/10.4049/jimmunol.1800224
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IRAK1 Limits TLR3/4- and IFNAR-Driven IL-27 Production through a STAT1-Dependent Mechanism
Daniela Bruni, Adam Dignam, Susan Dunne, Devlin Wall-Coughlan, Aisling McCrudden, Karen O’Connell, Caitriona Lyons, Christopher McGuigan, Niall Tubridy and Marion P. Butler

J Immunol October 1, 2018, 201 (7) 2070-2081; DOI: https://doi.org/10.4049/jimmunol.1701373

MOLECULAR AND STRUCTURAL IMMUNOLOGY

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Crystal Structure of the Labile Complex of IL-24 with the Extracellular Domains of IL-22R1 and IL-20R2
Jacek Lubkowski, Cem Sonmez, Sergey V. Smirnov, Andriy Anishkin, Sergei V. Kotenko and Alexander Wlodawer

J Immunol October 1, 2018, 201 (7) 2082-2093; DOI: https://doi.org/10.4049/jimmunol.1800726
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Engineering a Single-Agent Cytokine/Antibody Fusion That Selectively Expands Regulatory T Cells for Autoimmune Disease Therapy
Jamie B. Spangler, Eleonora Trotta, Jakub Tomala, Ariana Peck, Tracy A. Young, Christina S. Savvides, Stephanie Silveria, Petra Votavova, Joshua Salafsky, Vijay S. Pande, Marek Kovar, Jeffrey A. Bluestone and K. Christopher Garcia

J Immunol October 1, 2018, 201 (7) 2094-2106; DOI: https://doi.org/10.4049/jimmunol.1800578
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Sialic Acid Ligand Binding of CD22 and Siglec-G Determines Distinct B Cell Functions but Is Dispensable for B Cell Tolerance Induction
Lamia Özgör, Sarah J. Meyer, Marina Korn, Klara Terörde and Lars Nitschke

J Immunol October 1, 2018, 201 (7) 2107-2116; DOI: https://doi.org/10.4049/jimmunol.1800296

SYSTEMS IMMUNOLOGY

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Differential Induction of IFN-α and Modulation of CD112 and CD54 Expression Govern the Magnitude of NK Cell IFN-γ Response to Influenza A Viruses
Lisa M. Kronstad, Christof Seiler, Rosemary Vergara, Susan P. Holmes and Catherine A. Blish

J Immunol October 1, 2018, 201 (7) 2117-2131; DOI: https://doi.org/10.4049/jimmunol.1800161
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Human Lymph Nodes Maintain TCF-1^hi Memory T Cells with High Functional Potential and Clonal Diversity throughout Life
Michelle Miron, Brahma V. Kumar, Wenzhao Meng, Tomer Granot, Dustin J. Carpenter, Takashi Senda, Dora Chen, Aaron M. Rosenfeld, Bochao Zhang, Harvey Lerner, Amy L. Friedman, Uri Hershberg, Yufeng Shen, Adeeb Rahman, Eline T. Luning Prak and Donna L. Farber

J Immunol October 1, 2018, 201 (7) 2132-2140; DOI: https://doi.org/10.4049/jimmunol.1800716

TUMOR IMMUNOLOGY

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IL-21 Selectively Protects CD62L⁺ NKT Cells and Enhances Their Effector Functions for Adoptive Immunotherapy
Ho Ngai, Gengwen Tian, Amy N. Courtney, Soodeh B. Ravari, Linjie Guo, Bin Liu, Jingling Jin, Elise T. Shen, Erica J. Di Pierro and Leonid S. Metelitsa

J Immunol October 1, 2018, 201 (7) 2141-2153; DOI: https://doi.org/10.4049/jimmunol.1800429
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Epidermal Growth Factor (EGF) Autocrine Activation of Human Platelets Promotes EGF Receptor–Dependent Oral Squamous Cell Carcinoma Invasion, Migration, and Epithelial Mesenchymal Transition
Rui Chen, Ge Jin, Wei Li and Thomas M. McIntyre

J Immunol October 1, 2018, 201 (7) 2154-2164; DOI: https://doi.org/10.4049/jimmunol.1800124
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miR-143 Regulates Memory T Cell Differentiation by Reprogramming T Cell Metabolism
Tengfei Zhang, Zhen Zhang, Feng Li, Yu Ping, Guohui Qin, Chaoqi Zhang and Yi Zhang

J Immunol October 1, 2018, 201 (7) 2165-2175; DOI: https://doi.org/10.4049/jimmunol.1800230

NOVEL IMMUNOLOGICAL METHODS

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Collateral Damage: What Effect Does Anti-CD4 and Anti-CD8α Antibody–Mediated Depletion Have on Leukocyte Populations?
So Ri Jung, Tamara Suprunenko, Thomas M. Ashhurst, Nicholas J. C. King and Markus J. Hofer

J Immunol October 1, 2018, 201 (7) 2176-2186; DOI: https://doi.org/10.4049/jimmunol.1800339

CORRECTIONS

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Correction: Influenza A Virus Negative Strand RNA Is Translated for CD8⁺ T Cell Immunosurveillance
Heather D. Hickman, Jacqueline W. Mays, James Gibbs, Ivan Kosik, Javier G. Magadán, Kazuyo Takeda, Suman Das, Glennys V. Reynoso, Barbara F. Ngudiankama, JiaJie Wei, John P. Shannon, Daniel McManus and Jonathan W. Yewdell

J Immunol October 1, 2018, 201 (7) 2187; DOI: https://doi.org/10.4049/jimmunol.1801100

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Table of Contents

IN THIS ISSUE

IMMUNOLOGY NOTES AND RESOURCES

PILLARS OF IMMUNOLOGY

BRIEF REVIEWS

CUTTING EDGE

ALLERGY AND OTHER HYPERSENSITIVITIES

ANTIGEN RECOGNITION AND RESPONSES

AUTOIMMUNITY

CLINICAL AND HUMAN IMMUNOLOGY

IMMUNE REGULATION

IMMUNOGENETICS

IMMUNOTHERAPY AND VACCINES

INFECTIOUS DISEASE AND HOST RESPONSE

INNATE IMMUNITY AND INFLAMMATION

MOLECULAR AND STRUCTURAL IMMUNOLOGY

SYSTEMS IMMUNOLOGY

TUMOR IMMUNOLOGY

NOVEL IMMUNOLOGICAL METHODS

CORRECTIONS

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