The Journal of Immunology: 201 (2)

July 15, 2018; Volume 201,Issue 2

IN THIS ISSUE

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In This Issue
Blunting NK Cell Responses with Systemic IL-15 See article p. 493
Recruiting Dendritic Cell Progenitors See article p. 516
IL-36γ Contributes to Influenza Immunity See article p. 573
Probing Phagolysosome Integrity during Cryptococcal Infection See article p. 583
IL-36 Plays Protective Role during Oral Fungal Infection See article p. 627
ATXN3 Promotes Antiviral Defenses See article p. 675

J Immunol July 15, 2018, 201 (2) 323-324; DOI: https://doi.org/10.4049/jimmunol.1890011

BRIEF REVIEWS

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Immune Cells at the Fetomaternal Interface: How the Microenvironment Modulates Immune Cells To Foster Fetal Development
Anne Schumacher, David J. Sharkey, Sarah A. Robertson and Ana C. Zenclussen

J Immunol July 15, 2018, 201 (2) 325-334; DOI: https://doi.org/10.4049/jimmunol.1800058

CUTTING EDGE

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Cutting Edge: Evidence for Nonvascular Route of Visceral Organ Immunosurveillance by T Cells
Elizabeth M. Steinert, Emily A. Thompson, Lalit K. Beura, Omar A. Adam, Jason S. Mitchell, Mengdi Guo, Elise R. Breed, Frances V. Sjaastad, Vaiva Vezys and David Masopust

J Immunol July 15, 2018, 201 (2) 337-342; DOI: https://doi.org/10.4049/jimmunol.1800279

ALLERGY AND OTHER HYPERSENSITIVITIES

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Naturally Occurring Missense MRGPRX2 Variants Display Loss of Function Phenotype for Mast Cell Degranulation in Response to Substance P, Hemokinin-1, Human β-Defensin-3, and Icatibant
Ibrahim Alkanfari, Kshitij Gupta, Tahsin Jahan and Hydar Ali

J Immunol July 15, 2018, 201 (2) 343-349; DOI: https://doi.org/10.4049/jimmunol.1701793

ANTIGEN RECOGNITION AND RESPONSES

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Deep Sequencing Reveals Transient Segregation of T Cell Repertoires in Splenic T Cell Zones during an Immune Response
Johannes Textor, Anke Fähnrich, Martin Meinhardt, Cornelia Tune, Sebastian Klein, Rene Pagel, Peter König, Kathrin Kalies and Jürgen Westermann

J Immunol July 15, 2018, 201 (2) 350-358; DOI: https://doi.org/10.4049/jimmunol.1800091

AUTOIMMUNITY

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Transcription Factor NFAT5 Promotes Migration and Invasion of Rheumatoid Synoviocytes via Coagulation Factor III and CCL2
Saseong Lee, Jin-Sun Kong, Sungyong You, H. Moo Kwon, Seung-Ah Yoo, Chul-Soo Cho and Wan-Uk Kim

J Immunol July 15, 2018, 201 (2) 359-370; DOI: https://doi.org/10.4049/jimmunol.1701097
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mTORC2 Activity Disrupts Lysosome Acidification in Systemic Lupus Erythematosus by Impairing Caspase-1 Cleavage of Rab39a
Andrew J. Monteith, Heather A. Vincent, SunAh Kang, Patrick Li, Tauris M. Claiborne, Zenon Rajfur, Ken Jacobson, Nathaniel J. Moorman and Barbara J. Vilen

J Immunol July 15, 2018, 201 (2) 371-382; DOI: https://doi.org/10.4049/jimmunol.1701712
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CK2 Controls Th17 and Regulatory T Cell Differentiation Through Inhibition of FoxO1
Sara A. Gibson, Wei Yang, Zhaoqi Yan, Hongwei Qin and Etty N. Benveniste

J Immunol July 15, 2018, 201 (2) 383-392; DOI: https://doi.org/10.4049/jimmunol.1701592
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TLR7-Mediated Lupus Nephritis Is Independent of Type I IFN Signaling
Sonya J. Wolf, Jonathan Theros, Tammi J. Reed, Jianhua Liu, Irina L. Grigorova, Giovanny Martínez-Colón, Chaim O. Jacob, Jeffrey B. Hodgin and J. Michelle Kahlenberg

J Immunol July 15, 2018, 201 (2) 393-405; DOI: https://doi.org/10.4049/jimmunol.1701588
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TAPP Adaptors Control B Cell Metabolism by Modulating the Phosphatidylinositol 3-Kinase Signaling Pathway: A Novel Regulatory Circuit Preventing Autoimmunity
Nipun Jayachandran, Edgard M. Mejia, Kimia Sheikholeslami, Affan A. Sher, Sen Hou, Grant M. Hatch and Aaron J. Marshall

J Immunol July 15, 2018, 201 (2) 406-416; DOI: https://doi.org/10.4049/jimmunol.1701440

CLINICAL AND HUMAN IMMUNOLOGY

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In Rheumatoid Arthritis, Synovitis at Different Inflammatory Sites Is Dominated by Shared but Patient-Specific T Cell Clones
Anne Musters, Paul L. Klarenbeek, Marieke E. Doorenspleet, Giulia Balzaretti, Rebecca E. E. Esveldt, Barbera D. C. van Schaik, Aldo Jongejan, Sander W. Tas, Antoine H. C. van Kampen, Frank Baas and Niek de Vries

J Immunol July 15, 2018, 201 (2) 417-422; DOI: https://doi.org/10.4049/jimmunol.1800421
Open Access
HLA-DQA1, -DQB1, and -DRB1 Alleles Associated with Acute Tubulointerstitial Nephritis in a Chinese Population: A Single-Center Cohort Study
Author Choice Article

Yan Jia, Tao Su, Yanghui Gu, Cui Li, Xujie Zhou, Jianqun Su, Pingping Sun, Jiawei Tang, Liu Yang, Gang Liu and Li Yang

J Immunol July 15, 2018, 201 (2) 423-431; DOI: https://doi.org/10.4049/jimmunol.1800237
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Developmental Regulation of Effector and Resident Memory T Cell Generation during Pediatric Viral Respiratory Tract Infection
Thomas J. Connors, J. Scott Baird, Margot C. Yopes, Kyra D. Zens, Kalpana Pethe, Thyyar M. Ravindranath, Siu-hong Ho and Donna L. Farber

J Immunol July 15, 2018, 201 (2) 432-439; DOI: https://doi.org/10.4049/jimmunol.1800396

IMMUNE REGULATION

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PRMT1 Plays a Critical Role in Th17 Differentiation by Regulating Reciprocal Recruitment of STAT3 and STAT5
Subha Sen, Zhiheng He, Shubhamoy Ghosh, Kenneth J. Dery, Lu Yang, Jing Zhang and Zuoming Sun

J Immunol July 15, 2018, 201 (2) 440-450; DOI: https://doi.org/10.4049/jimmunol.1701654
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Tumor Suppressor p14ARF Enhances IFN-γ–Activated Immune Response by Inhibiting PIAS1 via SUMOylation
Jennifer Alagu, Yoko Itahana, Faizal Sim, Sheng-Hao Chao, Xuezhi Bi and Koji Itahana

J Immunol July 15, 2018, 201 (2) 451-464; DOI: https://doi.org/10.4049/jimmunol.1800327
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Identification of the First Teleost CD5 Molecule: Additional Evidence on Phenotypical and Functional Similarities between Fish IgM⁺ B Cells and Mammalian B1 Cells
Beatriz Abós, Steve Bird, Aitor G. Granja, Esther Morel, Juan A. More Bayona, Daniel R. Barreda and Carolina Tafalla

J Immunol July 15, 2018, 201 (2) 465-480; DOI: https://doi.org/10.4049/jimmunol.1701546
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mTOR Complex 1 Signaling Regulates the Generation and Function of Central and Effector Foxp3⁺ Regulatory T Cells
Im-Hong Sun, Min-Hee Oh, Liang Zhao, Chirag H. Patel, Matthew L. Arwood, Wei Xu, Ada J. Tam, Richard L. Blosser, Jiayu Wen and Jonathan D. Powell

J Immunol July 15, 2018, 201 (2) 481-492; DOI: https://doi.org/10.4049/jimmunol.1701477
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Emergence of NK Cell Hyporesponsiveness after Two IL-15 Stimulation Cycles
Marie Frutoso, Sébastien Morisseau, Fella Tamzalit, Agnès Quéméner, Dihia Meghnem, Isabelle Leray, Yannick Jacques and Erwan Mortier

J Immunol July 15, 2018, 201 (2) 493-506; DOI: https://doi.org/10.4049/jimmunol.1800086
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Myeloid-Derived Suppressor Cells Contribute to Susceptibility to Trypanosoma congolense Infection by Suppressing CD4⁺ T Cell Proliferation and IFN-γ Production
Chukwunonso Onyilagha, Shiby Kuriakose, Nnamdi Ikeogu, Ping Jia and Jude Uzonna

J Immunol July 15, 2018, 201 (2) 507-515; DOI: https://doi.org/10.4049/jimmunol.1800180

IMMUNE SYSTEM DEVELOPMENT

Open Access
Formation of the Intrathymic Dendritic Cell Pool Requires CCL21-Mediated Recruitment of CCR7⁺ Progenitors to the Thymus
Author Choice Article

Emilie J. Cosway, Izumi Ohigashi, Karin Schauble, Sonia M. Parnell, William E. Jenkinson, Sanjiv Luther, Yousuke Takahama and Graham Anderson

J Immunol July 15, 2018, 201 (2) 516-523; DOI: https://doi.org/10.4049/jimmunol.1800348
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Retinoic Acid Signaling in Thymic Epithelial Cells Regulates Thymopoiesis
Kerstin Wendland, Kristoffer Niss, Knut Kotarsky, Nikita Y. H. Wu, Andrea J. White, Johan Jendholm, Aymeric Rivollier, Jose M. G. Izarzugaza, Søren Brunak, Georg A. Holländer, Graham Anderson, Katarzyna M. Sitnik and William W. Agace

J Immunol July 15, 2018, 201 (2) 524-532; DOI: https://doi.org/10.4049/jimmunol.1800418

INFECTIOUS DISEASE AND HOST RESPONSE

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Porcine Circovirus Type 2 Suppresses IL-12p40 Induction via Capsid/gC1qR-Mediated MicroRNAs and Signalings
Qian Du, Xingchen Wu, Tongtong Wang, Xuefeng Yang, Zhenyu Wang, Yingying Niu, Xiaomin Zhao, Shan-Lu Liu, Dewen Tong and Yong Huang

J Immunol July 15, 2018, 201 (2) 533-547; DOI: https://doi.org/10.4049/jimmunol.1800250
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Giardia Infection of the Small Intestine Induces Chronic Colitis in Genetically Susceptible Hosts
Sara M. Dann, Christine H. Y. Le, Elaine M. Hanson, Matthew C. Ross and Lars Eckmann

J Immunol July 15, 2018, 201 (2) 548-559; DOI: https://doi.org/10.4049/jimmunol.1700824
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Exacerbated Staphylococcus aureus Foot Infections in Obese/Diabetic Mice Are Associated with Impaired Germinal Center Reactions, Ig Class Switching, and Humoral Immunity
Christopher W. Farnsworth, Eric M. Schott, Abigail Benvie, Stephen L. Kates, Edward M. Schwarz, Steven R. Gill, Michael J. Zuscik and Robert A. Mooney

J Immunol July 15, 2018, 201 (2) 560-572; DOI: https://doi.org/10.4049/jimmunol.1800253
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IL-36γ Protects against Severe Influenza Infection by Promoting Lung Alveolar Macrophage Survival and Limiting Viral Replication
Alexander N. Wein, Paul R. Dunbar, Sean R. McMaster, Zheng-Rong Tiger Li, Timothy L. Denning and Jacob E. Kohlmeier

J Immunol July 15, 2018, 201 (2) 573-582; DOI: https://doi.org/10.4049/jimmunol.1701796
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The Outcome of the Cryptococcus neoformans–Macrophage Interaction Depends on Phagolysosomal Membrane Integrity
Carlos M. De Leon-Rodriguez, Diego C. P. Rossi, Man Shun Fu, Quigly Dragotakes, Carolina Coelho, Ignacio Guerrero Ros, Benjamin Caballero, Sabrina J. Nolan and Arturo Casadevall

J Immunol July 15, 2018, 201 (2) 583-603; DOI: https://doi.org/10.4049/jimmunol.1700958
Open Access
Cysteine-Reactive Free ISG15 Generates IL-1β–Producing CD8α⁺ Dendritic Cells at the Site of Infection
Author Choice Article

Anna Napolitano, Annemarthe G. van der Veen, Monique Bunyan, Annabel Borg, David Frith, Steven Howell, Svend Kjaer, Antje Beling, Ambrosius P. Snijders, Klaus-Peter Knobeloch and Eva-Maria Frickel

J Immunol July 15, 2018, 201 (2) 604-614; DOI: https://doi.org/10.4049/jimmunol.1701322
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Regulation and Role of Chitotriosidase during Lung Infection with Klebsiella pneumoniae
Lokesh Sharma, Alyssa K. Amick, Swathy Vasudevan, Sei Won Lee, Chad R. Marion, Wei Liu, Virginia Brady, Ashley Losier, Santos D. Bermejo, Clemente J. Britto, Chun Geun Lee, Jack A. Elias and Charles S. Dela Cruz

J Immunol July 15, 2018, 201 (2) 615-626; DOI: https://doi.org/10.4049/jimmunol.1701782
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IL-36 and IL-1/IL-17 Drive Immunity to Oral Candidiasis via Parallel Mechanisms
Akash H. Verma, Hanna Zafar, Nicole O. Ponde, Olivia W. Hepworth, Diksha Sihra, Felix E. Y. Aggor, Joseph S. Ainscough, Jemima Ho, Jonathan P. Richardson, Bianca M. Coleman, Bernhard Hube, Martin Stacey, Mandy J. McGeachy, Julian R. Naglik, Sarah L. Gaffen and David L. Moyes

J Immunol July 15, 2018, 201 (2) 627-634; DOI: https://doi.org/10.4049/jimmunol.1800515

INNATE IMMUNITY AND INFLAMMATION

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Macrophages Switch Their Phenotype by Regulating Maf Expression during Different Phases of Inflammation
Kenta Kikuchi, Mayumi Iida, Naoki Ikeda, Shigetaka Moriyama, Michito Hamada, Satoru Takahashi, Hiroshi Kitamura, Takashi Watanabe, Yoshinori Hasegawa, Koji Hase, Takeshi Fukuhara, Hideyo Sato, Eri H. Kobayashi, Takafumi Suzuki, Masayuki Yamamoto, Masato Tanaka and Kenichi Asano

J Immunol July 15, 2018, 201 (2) 635-651; DOI: https://doi.org/10.4049/jimmunol.1800040
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SLC15A2 and SLC15A4 Mediate the Transport of Bacterially Derived Di/Tripeptides To Enhance the Nucleotide-Binding Oligomerization Domain–Dependent Immune Response in Mouse Bone Marrow–Derived Macrophages
Yongjun Hu, Feifeng Song, Huidi Jiang, Gabriel Nuñez and David E. Smith

J Immunol July 15, 2018, 201 (2) 652-662; DOI: https://doi.org/10.4049/jimmunol.1800210
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Myeloid Cell–Restricted STAT3 Signaling Controls a Cell-Autonomous Antifibrotic Repair Program
Nhu-Nguyen Do, Sebastian Willenborg, Beate Eckes, Christian Jüngst, Gerhard Sengle, Frank Zaucke and Sabine A. Eming

J Immunol July 15, 2018, 201 (2) 663-674; DOI: https://doi.org/10.4049/jimmunol.1701791
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ATXN3 Positively Regulates Type I IFN Antiviral Response by Deubiquitinating and Stabilizing HDAC3
Qian Feng, Ying Miao, Jun Ge, Yukang Yuan, Yibo Zuo, Liping Qian, Jin Liu, Qiao Cheng, Tingting Guo, Liting Zhang, Zhengyuan Yu and Hui Zheng

J Immunol July 15, 2018, 201 (2) 675-687; DOI: https://doi.org/10.4049/jimmunol.1800285
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Opposing Effects of IL-1Ra and IL-36Ra on Innate Immune Response to Pseudomonas aeruginosa Infection in C57BL/6 Mouse Corneas
Nan Gao, Rao Me, Chenyang Dai, Berhane Seyoum and Fu-shin X. Yu

J Immunol July 15, 2018, 201 (2) 688-699; DOI: https://doi.org/10.4049/jimmunol.1800046

MOLECULAR AND STRUCTURAL IMMUNOLOGY

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C2 Domains of Munc13-4 Are Crucial for Ca²⁺-Dependent Degranulation and Cytotoxicity in NK Cells
Na-Ryum Bin, Ke Ma, Chi-Wei Tien, Siyan Wang, Dan Zhu, Seungmee Park, Ekaterina Turlova, Kyoko Sugita, Ryutaro Shirakawa, Peter van der Sluijs, Hisanori Horiuchi, Hong-Shuo Sun, Philippe P. Monnier, Herbert Y. Gaisano and Shuzo Sugita

J Immunol July 15, 2018, 201 (2) 700-713; DOI: https://doi.org/10.4049/jimmunol.1800426
Open Access
Evidence for the Existence of a CXCL17 Receptor Distinct from GPR35
Author Choice Article

Nurul A. S. Binti Mohd Amir, Amanda E. Mackenzie, Laura Jenkins, Karim Boustani, Marston C. Hillier, Tomoko Tsuchiya, Graeme Milligan and James E. Pease

J Immunol July 15, 2018, 201 (2) 714-724; DOI: https://doi.org/10.4049/jimmunol.1700884

MUCOSAL IMMUNOLOGY

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Bcl2L12 Contributes to Th2-Biased Inflammation in the Intestinal Mucosa by Regulating CD4⁺ T Cell Activities
Mao-Gang Li, Xiao-Yu Liu, Zhi-Qiang Liu, Jing-Yi Hong, Jiang-Qi Liu, Cai-Jie Zhou, Tian-Yong Hu, Xiao-Jun Xiao, Pi-Xin Ran, Peng-Yuan Zheng, Zhi-Gang Liu and Ping-Chang Yang

J Immunol July 15, 2018, 201 (2) 725-733; DOI: https://doi.org/10.4049/jimmunol.1800139
Open Access
Mucosal Immunity in the Female Murine Mammary Gland
Author Choice Article

Courtney B. Betts, Nathan D. Pennock, Breanna P. Caruso, Brian Ruffell, Virginia F. Borges and Pepper Schedin

J Immunol July 15, 2018, 201 (2) 734-746; DOI: https://doi.org/10.4049/jimmunol.1800023
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Epithelial IL-15 Is a Critical Regulator of γδ Intraepithelial Lymphocyte Motility within the Intestinal Mucosa
Madeleine D. Hu, Alexander D. Ethridge, Rebecca Lipstein, Sushil Kumar, Yitang Wang, Bana Jabri, Jerrold R. Turner and Karen L. Edelblum

J Immunol July 15, 2018, 201 (2) 747-756; DOI: https://doi.org/10.4049/jimmunol.1701603

SYSTEMS IMMUNOLOGY

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Dual Roles for Ikaros in Regulation of Macrophage Chromatin State and Inflammatory Gene Expression
Kyu-Seon Oh, Rachel A. Gottschalk, Nicolas W. Lounsbury, Jing Sun, Michael G. Dorrington, Songjoon Baek, Guangping Sun, Ze Wang, Kathleen S. Krauss, Joshua D. Milner, Bhaskar Dutta, Gordon L. Hager, Myong-Hee Sung and Iain D. C. Fraser

J Immunol July 15, 2018, 201 (2) 757-771; DOI: https://doi.org/10.4049/jimmunol.1800158

TRANSPLANTATION

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Leukocyte-Associated Ig-like Receptor 1 Inhibits T_h1 Responses but Is Required for Natural and Induced Monocyte-Dependent T_h17 Responses
Vrushali V. Agashe, Ewa Jankowska-Gan, Melissa Keller, Jeremy A. Sullivan, Lynn D. Haynes, John F. Kernien, Jose R. Torrealba, Drew Roenneburg, Melanie Dart, Marco Colonna, David S. Wilkes and William J. Burlingham

J Immunol July 15, 2018, 201 (2) 772-781; DOI: https://doi.org/10.4049/jimmunol.1701753

TUMOR IMMUNOLOGY

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A_2A Adenosine Receptor Gene Deletion or Synthetic A_2A Antagonist Liberate Tumor-Reactive CD8⁺ T Cells from Tumor-Induced Immunosuppression
Jorgen Kjaergaard, Stephen Hatfield, Graham Jones, Akio Ohta and Michail Sitkovsky

J Immunol July 15, 2018, 201 (2) 782-791; DOI: https://doi.org/10.4049/jimmunol.1700850
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PD-1 Blockade Unleashes Effector Potential of Both High- and Low-Affinity Tumor-Infiltrating T Cells
Amaia Martínez-Usatorre, Alena Donda, Dietmar Zehn and Pedro Romero

J Immunol July 15, 2018, 201 (2) 792-803; DOI: https://doi.org/10.4049/jimmunol.1701644
Open Access
Early Generated B-1–Derived B Cells Have the Capacity To Progress To Become Mantle Cell Lymphoma–like Neoplasia in Aged Mice
Author Choice Article

Kyoko Hayakawa, Anthony M. Formica, Yuka Nakao, Daiju Ichikawa, Susan A. Shinton, Joni Brill-Dashoff, Mitchell R. Smith, Herbert C. Morse III and Richard R. Hardy

J Immunol July 15, 2018, 201 (2) 804-813; DOI: https://doi.org/10.4049/jimmunol.1800400
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Human Naive T Cells Express Functional CXCL8 and Promote Tumorigenesis
Joel Crespo, Ke Wu, Wei Li, Ilona Kryczek, Tomasz Maj, Linda Vatan, Shuang Wei, Anthony W. Opipari and Weiping Zou

J Immunol July 15, 2018, 201 (2) 814-820; DOI: https://doi.org/10.4049/jimmunol.1700755

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Table of Contents

IN THIS ISSUE

BRIEF REVIEWS

CUTTING EDGE

ALLERGY AND OTHER HYPERSENSITIVITIES

ANTIGEN RECOGNITION AND RESPONSES

AUTOIMMUNITY

CLINICAL AND HUMAN IMMUNOLOGY

IMMUNE REGULATION

IMMUNE SYSTEM DEVELOPMENT

INFECTIOUS DISEASE AND HOST RESPONSE

INNATE IMMUNITY AND INFLAMMATION

MOLECULAR AND STRUCTURAL IMMUNOLOGY

MUCOSAL IMMUNOLOGY

SYSTEMS IMMUNOLOGY

TRANSPLANTATION

TUMOR IMMUNOLOGY

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