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Novel Anti-Inflammatory Peptides Based on Chemokine–Glycosaminoglycan Interactions Reduce Leukocyte Migration and Disease Severity in a Model of Rheumatoid Arthritis

Emily F. McNaughton, Andrew D. Eustace, Sophie King, Richard B. Sessions, Alasdair Kay, Michele Farris, Robert Broadbridge, Oksana Kehoe, Andreas J. Kungl and Jim Middleton
J Immunol May 1, 2018, 200 (9) 3201-3217; DOI: https://doi.org/10.4049/jimmunol.1701187
Emily F. McNaughton
*School of Oral and Dental Sciences, Faculty of Health Sciences, University of Bristol, Bristol BS1 2LY, United Kingdom;
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Andrew D. Eustace
*School of Oral and Dental Sciences, Faculty of Health Sciences, University of Bristol, Bristol BS1 2LY, United Kingdom;
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Sophie King
*School of Oral and Dental Sciences, Faculty of Health Sciences, University of Bristol, Bristol BS1 2LY, United Kingdom;
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Richard B. Sessions
†School of Biochemistry, Faculty of Biomedical Sciences, University of Bristol, Bristol BS8 1TD, United Kingdom;
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Alasdair Kay
‡Leopold Muller Arthritis Research Centre, Institute for Science and Technology in Medicine, Robert Jones and Agnes Hunt Orthopaedic Hospital, Medical School, Keele University, Keele SY10 7AG, United Kingdom;
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Michele Farris
§Peptide Protein Research Ltd., Bishop's Waltham SO32 1QD, United Kingdom; and
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Robert Broadbridge
§Peptide Protein Research Ltd., Bishop's Waltham SO32 1QD, United Kingdom; and
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Oksana Kehoe
‡Leopold Muller Arthritis Research Centre, Institute for Science and Technology in Medicine, Robert Jones and Agnes Hunt Orthopaedic Hospital, Medical School, Keele University, Keele SY10 7AG, United Kingdom;
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Andreas J. Kungl
¶Karl-Franzens University, Graz 8010, Austria
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Jim Middleton
*School of Oral and Dental Sciences, Faculty of Health Sciences, University of Bristol, Bristol BS1 2LY, United Kingdom;
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Article Information

vol. 200 no. 9 3201-3217
DOI 
https://doi.org/10.4049/jimmunol.1701187
PubMed 
29572348

Published By 
The American Association of Immunologists, Inc.
Print ISSN 
0022-1767
Online ISSN 
1550-6606
History 
  • Received August 22, 2017
  • Accepted February 22, 2018
  • Published online April 23, 2018.

Article Versions

  • Older version (March 23, 2018 - 08:02).
  • You are viewing the most recent version of this article.
Copyright & Usage 
Copyright © 2018 by The American Association of Immunologists, Inc.

Author Information

  1. Emily F. McNaughton*,
  2. Andrew D. Eustace*,
  3. Sophie King*,
  4. Richard B. Sessions†,
  5. Alasdair Kay‡,
  6. Michele Farris§,
  7. Robert Broadbridge§,
  8. Oksana Kehoe‡,
  9. Andreas J. Kungl¶ and
  10. Jim Middleton*
  1. *School of Oral and Dental Sciences, Faculty of Health Sciences, University of Bristol, Bristol BS1 2LY, United Kingdom;
  2. †School of Biochemistry, Faculty of Biomedical Sciences, University of Bristol, Bristol BS8 1TD, United Kingdom;
  3. ‡Leopold Muller Arthritis Research Centre, Institute for Science and Technology in Medicine, Robert Jones and Agnes Hunt Orthopaedic Hospital, Medical School, Keele University, Keele SY10 7AG, United Kingdom;
  4. §Peptide Protein Research Ltd., Bishop's Waltham SO32 1QD, United Kingdom; and
  5. ¶Karl-Franzens University, Graz 8010, Austria
  1. Address correspondence and reprint requests to Prof. Jim Middleton, School of Oral and Dental Sciences, Faculty of Health Sciences, University of Bristol, Bristol BS1 2LY, U.K. E-mail address: jim.middleton{at}bristol.ac.uk
  1. J.M. conceived and designed the study. E.F.M., A.D.E., S.K., O.K., and A.K. performed experiments and analyzed data. R.B.S. assisted with peptide modeling and design. M.F. and R.B. provided peptide synthesis facilities and peptide chemistry consultation. A.J.K. advised and contributed to isothermal fluorescent titration data by providing facilities at Karl-Franzens University. E.F.M. and J.M. wrote the manuscript.

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Mar 2018787082
Apr 20187085255
May 20182825428
Jun 20181164115
Jul 2018701216
Aug 2018381814
Sep 20185826
Oct 2018801316
Nov 201862810
Dec 20185455
Total 20182255205247
Jan 20194976
Feb 201940415
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Apr 2019318142
May 2019202417
Jun 2019192112
Jul 2019112325
Aug 2019253023
Sep 2019212720
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Total 2019330235327
Jan 202017198
Feb 2020191338
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Jul 2020201714
Aug 2020387
Sep 2020252413
Oct 2020353920
Nov 202031615
Dec 2020181014
Total 2020241238212
Jan 202121719
Total 202121719
Total2828695805

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The Journal of Immunology: 200 (9)
The Journal of Immunology
Vol. 200, Issue 9
1 May 2018
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Novel Anti-Inflammatory Peptides Based on Chemokine–Glycosaminoglycan Interactions Reduce Leukocyte Migration and Disease Severity in a Model of Rheumatoid Arthritis
Emily F. McNaughton, Andrew D. Eustace, Sophie King, Richard B. Sessions, Alasdair Kay, Michele Farris, Robert Broadbridge, Oksana Kehoe, Andreas J. Kungl, Jim Middleton
The Journal of Immunology May 1, 2018, 200 (9) 3201-3217; DOI: 10.4049/jimmunol.1701187

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Novel Anti-Inflammatory Peptides Based on Chemokine–Glycosaminoglycan Interactions Reduce Leukocyte Migration and Disease Severity in a Model of Rheumatoid Arthritis
Emily F. McNaughton, Andrew D. Eustace, Sophie King, Richard B. Sessions, Alasdair Kay, Michele Farris, Robert Broadbridge, Oksana Kehoe, Andreas J. Kungl, Jim Middleton
The Journal of Immunology May 1, 2018, 200 (9) 3201-3217; DOI: 10.4049/jimmunol.1701187
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