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Functional Anti-TIGIT Antibodies Regulate Development of Autoimmunity and Antitumor Immunity

Karen O. Dixon, Michelle Schorer, James Nevin, Yassaman Etminan, Zohreh Amoozgar, Takaaki Kondo, Sema Kurtulus, Nasim Kassam, Raymond A. Sobel, Dai Fukumura, Rakesh K. Jain, Ana C. Anderson, Vijay K. Kuchroo and Nicole Joller
J Immunol April 15, 2018, 200 (8) 3000-3007; DOI: https://doi.org/10.4049/jimmunol.1700407
Karen O. Dixon
*Evergrande Center for Immunologic Diseases at Harvard Medical School and Brigham and Women’s Hospital, Ann Romney Center for Neurologic Diseases, Boston, MA 02115;
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Michelle Schorer
†Institute of Experimental Immunology, University of Zurich, Zurich CH-8057, Switzerland;
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James Nevin
*Evergrande Center for Immunologic Diseases at Harvard Medical School and Brigham and Women’s Hospital, Ann Romney Center for Neurologic Diseases, Boston, MA 02115;
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Yassaman Etminan
*Evergrande Center for Immunologic Diseases at Harvard Medical School and Brigham and Women’s Hospital, Ann Romney Center for Neurologic Diseases, Boston, MA 02115;
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Zohreh Amoozgar
‡Edwin L. Steele Laboratories, Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114;
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Takaaki Kondo
*Evergrande Center for Immunologic Diseases at Harvard Medical School and Brigham and Women’s Hospital, Ann Romney Center for Neurologic Diseases, Boston, MA 02115;
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Sema Kurtulus
*Evergrande Center for Immunologic Diseases at Harvard Medical School and Brigham and Women’s Hospital, Ann Romney Center for Neurologic Diseases, Boston, MA 02115;
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Nasim Kassam
*Evergrande Center for Immunologic Diseases at Harvard Medical School and Brigham and Women’s Hospital, Ann Romney Center for Neurologic Diseases, Boston, MA 02115;
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Raymond A. Sobel
§Palo Alto Veterans Administration Health Care System, Palo Alto, CA 94304; and
¶Department of Pathology, Stanford University School of Medicine, Stanford, CA 94304
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Dai Fukumura
‡Edwin L. Steele Laboratories, Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114;
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Rakesh K. Jain
‡Edwin L. Steele Laboratories, Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114;
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Ana C. Anderson
*Evergrande Center for Immunologic Diseases at Harvard Medical School and Brigham and Women’s Hospital, Ann Romney Center for Neurologic Diseases, Boston, MA 02115;
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Vijay K. Kuchroo
*Evergrande Center for Immunologic Diseases at Harvard Medical School and Brigham and Women’s Hospital, Ann Romney Center for Neurologic Diseases, Boston, MA 02115;
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Nicole Joller
*Evergrande Center for Immunologic Diseases at Harvard Medical School and Brigham and Women’s Hospital, Ann Romney Center for Neurologic Diseases, Boston, MA 02115;
†Institute of Experimental Immunology, University of Zurich, Zurich CH-8057, Switzerland;
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Article Information

vol. 200 no. 8 3000-3007
DOI 
https://doi.org/10.4049/jimmunol.1700407
PubMed 
29500245

Published By 
The American Association of Immunologists, Inc.
Print ISSN 
0022-1767
Online ISSN 
1550-6606
History 
  • Received March 20, 2017
  • Accepted January 31, 2018
  • Published online April 9, 2018.

Article Versions

  • Older version (March 2, 2018 - 08:14).
  • You are viewing the most recent version of this article.
Copyright & Usage 
Copyright © 2018 by The American Association of Immunologists, Inc.

Author Information

  1. Karen O. Dixon*,1,
  2. Michelle Schorer†,1,
  3. James Nevin*,
  4. Yassaman Etminan*,
  5. Zohreh Amoozgar‡,
  6. Takaaki Kondo*,2,
  7. Sema Kurtulus*,
  8. Nasim Kassam*,
  9. Raymond A. Sobel§,¶,
  10. Dai Fukumura‡,
  11. Rakesh K. Jain‡,
  12. Ana C. Anderson*,
  13. Vijay K. Kuchroo*,3 and
  14. Nicole Joller*,†,3
  1. *Evergrande Center for Immunologic Diseases at Harvard Medical School and Brigham and Women’s Hospital, Ann Romney Center for Neurologic Diseases, Boston, MA 02115;
  2. †Institute of Experimental Immunology, University of Zurich, Zurich CH-8057, Switzerland;
  3. ‡Edwin L. Steele Laboratories, Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114;
  4. §Palo Alto Veterans Administration Health Care System, Palo Alto, CA 94304; and
  5. ¶Department of Pathology, Stanford University School of Medicine, Stanford, CA 94304
  1. Address correspondence and reprint requests to Prof. Nicole Joller or Prof. Vijay K. Kuchroo, Institute of Experimental Immunology, University of Zurich, Winterthurerstrasse 190, Y36L68, CH-8057 Zurich, Switzerland (N.J.) or Evergrande Center for Immunologic Diseases, Harvard Medical School and Brigham and Women's Hospital, 60 Fenwood Road, BTM 10016F, Boston, MA 02115-5817 (V.K.K.). E-mail addresses: nicole.joller{at}immunology.uzh.ch (N.J.) or vkuchroo{at}evergrande.hms.harvard.edu (V.K.K.)
  1. ↵1 K.O.D. and M.S. contributed equally to this work.

  2. ↵3 V.K.K. and N.J. contributed equally to this work.

  • ↵2 Current address: Mitsubishi Tanabe Pharma Corp., Yokohama, Japan.

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Article usage

Article usage: March 2018 to July 2022

AbstractFullPdf
Mar 201820940420
Apr 2018767215172
May 2018382120115
Jun 201827690138
Jul 201836298134
Aug 201827196114
Sep 201831151119
Oct 201826759106
Nov 201825150110
Dec 20181583064
Total 201851398091492
Jan 20192143574
Feb 20191924479
Mar 20191665491
Apr 2019136127144
May 201930119123
Jun 20192910686
Jul 201936103117
Aug 2019337787
Sep 2019189766
Oct 20193313280
Nov 2019217062
Dec 2019207366
Total 201992810371075
Jan 2020258159
Feb 2020297181
Mar 2020348158
Apr 202036191112
May 20203113492
Jun 20202711891
Jul 20204010079
Aug 2020308678
Sep 20204612185
Oct 2020319787
Nov 202041108120
Dec 2020386883
Total 202040812561025
Jan 202142112100
Feb 2021499877
Mar 20213910165
Apr 2021379675
May 2021379085
Jun 20214311194
Jul 20213722998
Aug 20212710680
Sep 20214210588
Oct 2021179978
Nov 20212310283
Dec 20212112895
Total 202141413771018
Jan 20222412087
Feb 20221912778
Mar 20221715071
Apr 20221412288
May 202227135112
Jun 202218143113
Jul 2022177861
Total 2022136875610
Total702553545220

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The Journal of Immunology: 200 (8)
The Journal of Immunology
Vol. 200, Issue 8
15 Apr 2018
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Functional Anti-TIGIT Antibodies Regulate Development of Autoimmunity and Antitumor Immunity
Karen O. Dixon, Michelle Schorer, James Nevin, Yassaman Etminan, Zohreh Amoozgar, Takaaki Kondo, Sema Kurtulus, Nasim Kassam, Raymond A. Sobel, Dai Fukumura, Rakesh K. Jain, Ana C. Anderson, Vijay K. Kuchroo, Nicole Joller
The Journal of Immunology April 15, 2018, 200 (8) 3000-3007; DOI: 10.4049/jimmunol.1700407

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Functional Anti-TIGIT Antibodies Regulate Development of Autoimmunity and Antitumor Immunity
Karen O. Dixon, Michelle Schorer, James Nevin, Yassaman Etminan, Zohreh Amoozgar, Takaaki Kondo, Sema Kurtulus, Nasim Kassam, Raymond A. Sobel, Dai Fukumura, Rakesh K. Jain, Ana C. Anderson, Vijay K. Kuchroo, Nicole Joller
The Journal of Immunology April 15, 2018, 200 (8) 3000-3007; DOI: 10.4049/jimmunol.1700407
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Print ISSN 0022-1767        Online ISSN 1550-6606