The Journal of Immunology: 200 (7)

April 1, 2018; Volume 200,Issue 7

IN THIS ISSUE

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In This Issue
Idelalisib in Chronic Lymphocytic Leukemia See article p. 2304
Alternative NF-κB Pathway in Treg Homeostasis and Function See article p. 2362
Plasmid-Based Gene Editing in Primary T Cells See article p. 2489

J Immunol April 1, 2018, 200 (7) 2227-2228; DOI: https://doi.org/10.4049/jimmunol.1890003

PILLARS OF IMMUNOLOGY

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NKG2D–MICA Interaction: A Paradigm Shift in Innate Recognition
Mathieu Bléry and Eric Vivier

J Immunol April 1, 2018, 200 (7) 2229-2230; DOI: https://doi.org/10.4049/jimmunol.1800176
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Pillars Article: Activation of NK Cells and T Cells by NKG2D, a Receptor for Stress-Inducible MICA. Science. 1999. 285: 727–729
Stefan Bauer, Veronika Groh, Jun Wu, Alexander Steinle, Joseph H. Phillips, Lewis L. Lanier and Thomas Spies

J Immunol April 1, 2018, 200 (7) 2231-2233;

BRIEF REVIEWS

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Development, Homeostasis, and Functions of Intestinal Intraepithelial Lymphocytes
Luc Van Kaer and Danyvid Olivares-Villagómez

J Immunol April 1, 2018, 200 (7) 2235-2244; DOI: https://doi.org/10.4049/jimmunol.1701704

CUTTING EDGE

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Cutting Edge: A New Player in the Alternative Complement Pathway, MASP-1 Is Essential for LPS-Induced, but Not for Zymosan-Induced, Alternative Pathway Activation
Katalin Paréj, Andrea Kocsis, Csenge Enyingi, Ráhel Dani, Gábor Oroszlán, László Beinrohr, József Dobó, Péter Závodszky, Gábor Pál and Péter Gál

J Immunol April 1, 2018, 200 (7) 2247-2252; DOI: https://doi.org/10.4049/jimmunol.1701421

ALLERGY AND OTHER HYPERSENSITIVITIES

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Elevated Expression of IL-33 and TSLP in the Airways of Human Asthmatics In Vivo: A Potential Biomarker of Severe Refractory Disease
Yan Li, Wei Wang, Zhe Lv, Yun Li, Yan Chen, Kewu Huang, Chris J. Corrigan and Sun Ying

J Immunol April 1, 2018, 200 (7) 2253-2262; DOI: https://doi.org/10.4049/jimmunol.1701455

ANTIGEN RECOGNITION AND RESPONSES

Open Access
Peptide–MHC Class I Tetramers Can Fail To Detect Relevant Functional T Cell Clonotypes and Underestimate Antigen-Reactive T Cell Populations
Author Choice Article

Cristina Rius, Meriem Attaf, Katie Tungatt, Valentina Bianchi, Mateusz Legut, Amandine Bovay, Marco Donia, Per thor Straten, Mark Peakman, Inge Marie Svane, Sascha Ott, Tom Connor, Barbara Szomolay, Garry Dolton and Andrew K. Sewell

J Immunol April 1, 2018, 200 (7) 2263-2279; DOI: https://doi.org/10.4049/jimmunol.1700242

AUTOIMMUNITY

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FHR5 Binds to Laminins, Uses Separate C3b and Surface-Binding Sites, and Activates Complement on Malondialdehyde-Acetaldehyde Surfaces
Ramona B. Rudnick, Qian Chen, Emma Diletta Stea, Andrea Hartmann, Nikolina Papac-Milicevic, Fermin Person, Michael Wiesener, Christoph J. Binder, Thorsten Wiech, Christine Skerka and Peter F. Zipfel

J Immunol April 1, 2018, 200 (7) 2280-2290; DOI: https://doi.org/10.4049/jimmunol.1701641

CLINICAL AND HUMAN IMMUNOLOGY

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Human Binge Alcohol Intake Inhibits TLR4–MyD88 and TLR4–TRIF Responses but Not the TLR3–TRIF Pathway: HspA1A and PP1 Play Selective Regulatory Roles
Sujatha Muralidharan, Arlene Lim, Donna Catalano and Pranoti Mandrekar

J Immunol April 1, 2018, 200 (7) 2291-2303; DOI: https://doi.org/10.4049/jimmunol.1600924
Open Access
The PI3Kδ-Selective Inhibitor Idelalisib Minimally Interferes with Immune Effector Function Mediated by Rituximab or Obinutuzumab and Significantly Augments B Cell Depletion In Vivo
Author Choice Article

Adam Palazzo, Sylvia Herter, Laura Grosmaire, Randy Jones, Christian R. Frey, Florian Limani, Marina Bacac, Pablo Umana, Robert J. Oldham, Michael J. E. Marshall, Kerry L. Cox, Anna H. Turaj, Mark S. Cragg, Christian Klein, Matthew J. Carter and Stacey Tannheimer

J Immunol April 1, 2018, 200 (7) 2304-2312; DOI: https://doi.org/10.4049/jimmunol.1700323

IMMUNE REGULATION

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Reciprocal Regulation of Glycolysis-Driven Th17 Pathogenicity and Regulatory T Cell Stability by Cdc42
Khalid W. Kalim, Jun-Qi Yang, Yuan Li, Yan Meng, Yi Zheng and Fukun Guo

J Immunol April 1, 2018, 200 (7) 2313-2326; DOI: https://doi.org/10.4049/jimmunol.1601765
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A Novel Biological Role for Peptidyl-Arginine Deiminases: Citrullination of Cathelicidin LL-37 Controls the Immunostimulatory Potential of Cell-Free DNA
Alicia Wong, Danuta Bryzek, Ewelina Dobosz, Carsten Scavenius, Pavel Svoboda, Maria Rapala-Kozik, Adam Lesner, Ivo Frydrych, Jan Enghild, Piotr Mydel, Jan Pohl, Paul R. Thompson, Jan Potempa and Joanna Koziel

J Immunol April 1, 2018, 200 (7) 2327-2340; DOI: https://doi.org/10.4049/jimmunol.1701391
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TLR2 Stimulation Strengthens Intrahepatic Myeloid-Derived Cell-Mediated T Cell Tolerance through Inducing Kupffer Cell Expansion and IL-10 Production
Jia Liu, Qing Yu, Weimin Wu, Xuan Huang, Ruth Broering, Melanie Werner, Michael Roggendorf, Dongliang Yang and Mengji Lu

J Immunol April 1, 2018, 200 (7) 2341-2351; DOI: https://doi.org/10.4049/jimmunol.1700540

IMMUNE SYSTEM DEVELOPMENT

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Bruton’s Tyrosine Kinase Is Not Essential for B Cell Survival beyond Early Developmental Stages
Lindsay E. Nyhoff, Emily S. Clark, Bridgette L. Barron, Rachel H. Bonami, Wasif N. Khan and Peggy L. Kendall

J Immunol April 1, 2018, 200 (7) 2352-2361; DOI: https://doi.org/10.4049/jimmunol.1701489
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The Alternative NF-κB Pathway in Regulatory T Cell Homeostasis and Suppressive Function
Yenkel Grinberg-Bleyer, Rachel Caron, John J. Seeley, Nilushi S. De Silva, Christian W. Schindler, Matthew S. Hayden, Ulf Klein and Sankar Ghosh

J Immunol April 1, 2018, 200 (7) 2362-2371; DOI: https://doi.org/10.4049/jimmunol.1800042

IMMUNOGENETICS

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HLA Class II–Triggered Signaling Cascades Cause Endothelial Cell Proliferation and Migration: Relevance to Antibody-Mediated Transplant Rejection
Yi-Ping Jin, Nicole M. Valenzuela, Xiaohai Zhang, Enrique Rozengurt and Elaine F. Reed

J Immunol April 1, 2018, 200 (7) 2372-2390; DOI: https://doi.org/10.4049/jimmunol.1701259

INFECTIOUS DISEASE AND HOST RESPONSE

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Inflammatory Monocytes Drive Influenza A Virus–Mediated Lung Injury in Juvenile Mice
Bria M. Coates, Kelly L. Staricha, Clarissa M. Koch, Yuan Cheng, Dale K. Shumaker, G. R. Scott Budinger, Harris Perlman, Alexander V. Misharin and Karen M. Ridge

J Immunol April 1, 2018, 200 (7) 2391-2404; DOI: https://doi.org/10.4049/jimmunol.1701543
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IL-12+IL-18 Cosignaling in Human Macrophages and Lung Epithelial Cells Activates Cathelicidin and Autophagy, Inhibiting Intracellular Mycobacterial Growth
Rui Yang, Enzhuo Yang, Ling Shen, Robert L. Modlin, Hongbo Shen and Zheng W. Chen

J Immunol April 1, 2018, 200 (7) 2405-2417; DOI: https://doi.org/10.4049/jimmunol.1701073
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Septic Shock Shapes B Cell Response toward an Exhausted-like/Immunoregulatory Profile in Patients
Claude-Alexandre Gustave, Morgane Gossez, Julie Demaret, Thomas Rimmelé, Alain Lepape, Christophe Malcus, Françoise Poitevin-Later, Laurent Jallades, Julien Textoris, Guillaume Monneret and Fabienne Venet

J Immunol April 1, 2018, 200 (7) 2418-2425; DOI: https://doi.org/10.4049/jimmunol.1700929

INNATE IMMUNITY AND INFLAMMATION

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α_Mβ₂ Is Antiatherogenic in Female but Not Male Mice
Dorota Szpak, Lahoucine Izem, Dmitriy Verbovetskiy, Dmitry A. Soloviev, Valentin P. Yakubenko and Elzbieta Pluskota

J Immunol April 1, 2018, 200 (7) 2426-2438; DOI: https://doi.org/10.4049/jimmunol.1700313
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PARP14 Controls the Nuclear Accumulation of a Subset of Type I IFN–Inducible Proteins
Greta Caprara, Elena Prosperini, Viviana Piccolo, Gianluca Sigismondo, Alessia Melacarne, Alessandro Cuomo, Mark Boothby, Maria Rescigno, Tiziana Bonaldi and Gioacchino Natoli

J Immunol April 1, 2018, 200 (7) 2439-2454; DOI: https://doi.org/10.4049/jimmunol.1701117

MOLECULAR AND STRUCTURAL IMMUNOLOGY

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c-Src–Dependent and –Independent Functions of Matk in Osteoclasts and Osteoblasts
Jung Ha Kim, Kabsun Kim, Inyoung Kim, Semun Seong and Nacksung Kim

J Immunol April 1, 2018, 200 (7) 2455-2463; DOI: https://doi.org/10.4049/jimmunol.1700582
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Statistical Validation of Rare Complement Variants Provides Insights into the Molecular Basis of Atypical Hemolytic Uremic Syndrome and C3 Glomerulopathy
Amy J. Osborne, Matteo Breno, Nicolo Ghiringhelli Borsa, Fengxiao Bu, Véronique Frémeaux-Bacchi, Daniel P. Gale, Lambertus P. van den Heuvel, David Kavanagh, Marina Noris, Sheila Pinto, Pavithra M. Rallapalli, Giuseppe Remuzzi, Santiago Rodríguez de Cordoba, Angela Ruiz, Richard J. H. Smith, Paula Vieira-Martins, Elena Volokhina, Valerie Wilson, Timothy H. J. Goodship and Stephen J. Perkins

J Immunol April 1, 2018, 200 (7) 2464-2478; DOI: https://doi.org/10.4049/jimmunol.1701695

TRANSPLANTATION

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Blockade of Host β2-Adrenergic Receptor Enhances Graft-versus-Tumor Effect through Modulating APCs
Hemn Mohammadpour, Rachel O’Neil, Jingxin Qiu, Philip L. McCarthy, Elizabeth A. Repasky and Xuefang Cao

J Immunol April 1, 2018, 200 (7) 2479-2488; DOI: https://doi.org/10.4049/jimmunol.1701752

NOVEL IMMUNOLOGICAL METHODS

Open Access
Highly Efficient and Versatile Plasmid-Based Gene Editing in Primary T Cells
Author Choice Article

Mara Kornete, Romina Marone and Lukas T. Jeker

J Immunol April 1, 2018, 200 (7) 2489-2501; DOI: https://doi.org/10.4049/jimmunol.1701121

CORRECTIONS

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Correction: Green Tea Polyphenol EGCG Upregulates Tollip Expression by Suppressing Elf-1 Expression
Motofumi Kumazoe, Mai Yamashita, Yuki Nakamura, Kanako Takamatsu, Jaehoon Bae, Shuya Yamashita, Shuhei Yamada, Hiroaki Onda, Takashi Nojiri, Kenji Kangawa and Hirofumi Tachibana

J Immunol April 1, 2018, 200 (7) 2502-2504; DOI: https://doi.org/10.4049/jimmunol.1800143
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Correction: B Cells Drive Autoimmunity in Mice with CD28-Deficient Regulatory T Cells
Ruan Zhang, Peter T. Sage, Kelsey Finn, Alexandria Huynh, Bruce R. Blazar, Francesco Marangoni, Thorsten R. Mempel, Arlene H. Sharpe and Laurence A. Turka

J Immunol April 1, 2018, 200 (7) 2505-2506; DOI: https://doi.org/10.4049/jimmunol.1800150
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Correction: A Fusion Protein Encoding the Second Extracellular Domain of CCR5 Arrests Chemokine-Induced Cosignaling and Effectively Suppresses Ongoing Experimental Autoimmune Encephalomyelitis
Yair Sapir, Alon Vitenshtein, Yiftah Barsheshet, Yaniv Zohar, Gizi Wildbaum and Nathan Karin

J Immunol April 1, 2018, 200 (7) 2507-2508; DOI: https://doi.org/10.4049/jimmunol.1800166
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Correction: Predominant Expression of CCL2 at the Tumor Site of Prostate Cancer Patients Directs a Selective Loss of Immunological Tolerance to CCL2 That Could Be Amplified in a Beneficial Manner
Liat Izhak, Gizi Wildbaum, Uri Weinberg, Yuval Shaked, Jennifer Alami, Daniel Dumont, Boris Friedman, Avi Stein and Nathan Karin

J Immunol April 1, 2018, 200 (7) 2509-2510; DOI: https://doi.org/10.4049/jimmunol.1800167

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Table of Contents

IN THIS ISSUE

PILLARS OF IMMUNOLOGY

BRIEF REVIEWS

CUTTING EDGE

ALLERGY AND OTHER HYPERSENSITIVITIES

ANTIGEN RECOGNITION AND RESPONSES

AUTOIMMUNITY

CLINICAL AND HUMAN IMMUNOLOGY

IMMUNE REGULATION

IMMUNE SYSTEM DEVELOPMENT

IMMUNOGENETICS

INFECTIOUS DISEASE AND HOST RESPONSE

INNATE IMMUNITY AND INFLAMMATION

MOLECULAR AND STRUCTURAL IMMUNOLOGY

TRANSPLANTATION

NOVEL IMMUNOLOGICAL METHODS

CORRECTIONS

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