The Journal of Immunology: 200 (6)

March 15, 2018; Volume 200,Issue 6

IN THIS ISSUE

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In This Issue
Early Immune Correlates for Asthma See article p. 1995
Toward a Universal Influenza Vaccine See article p. 2057
A Peek into HPV Persistence See article p. 2076
p53 to the Rescue in Emergency Granulopoiesis See article p. 2129

J Immunol March 15, 2018, 200 (6) 1955-1956; DOI: https://doi.org/10.4049/jimmunol.1890002

TRANSLATING IMMUNOLOGY

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Passive Serum Therapy to Immunomodulation by IVIG: A Fascinating Journey of Antibodies
Cristina João, Vir Singh Negi, Michel D. Kazatchkine, Jagadeesh Bayry and Srini V. Kaveri

J Immunol March 15, 2018, 200 (6) 1957-1963; DOI: https://doi.org/10.4049/jimmunol.1701271

BRIEF REVIEWS

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Recent Insights into CD4⁺ Th Cell Differentiation in Malaria
Megan S. F. Soon and Ashraful Haque

J Immunol March 15, 2018, 200 (6) 1965-1975; DOI: https://doi.org/10.4049/jimmunol.1701316

CUTTING EDGE

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Cutting Edge: Divergent Requirement of T-Box Transcription Factors in Effector and Memory NK Cells
Sharline Madera, Clair D. Geary, Colleen M. Lau, Olga Pikovskaya, Steven L. Reiner and Joseph C. Sun

J Immunol March 15, 2018, 200 (6) 1977-1981; DOI: https://doi.org/10.4049/jimmunol.1700416
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Cutting Edge: Check Your Mice—A Point Mutation in the Ncr1 Locus Identified in CD45.1 Congenic Mice with Consequences in Mouse Susceptibility to Infection
Youngsoon Jang, Zachary J. Gerbec, Taejoon Won, Bongkum Choi, Amy Podsiad, Bethany B. Moore, Subramaniam Malarkannan and Yasmina Laouar

J Immunol March 15, 2018, 200 (6) 1982-1987; DOI: https://doi.org/10.4049/jimmunol.1701676
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Cutting Edge: De Novo Glucocorticoid Synthesis by Thymic Epithelial Cells Regulates Antigen-Specific Thymocyte Selection
Paul R. Mittelstadt, Matthew D. Taves and Jonathan D. Ashwell

J Immunol March 15, 2018, 200 (6) 1988-1994; DOI: https://doi.org/10.4049/jimmunol.1701328

ALLERGY AND OTHER HYPERSENSITIVITIES

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Development of Asthma in Inner-City Children: Possible Roles of MAIT Cells and Variation in the Home Environment
Shilpi Chandra, Gerhard Wingender, Jason A. Greenbaum, Archana Khurana, Amin M. Gholami, Anusha-Preethi Ganesan, Michael Rosenbach, Katy Jaffee, James E. Gern, Robert Wood, George O’Connor, Megan Sandel, Meyer Kattan, Leonard Bacharier, Alkis Togias, Anthony A. Horner and Mitchell Kronenberg

J Immunol March 15, 2018, 200 (6) 1995-2003; DOI: https://doi.org/10.4049/jimmunol.1701525

IMMUNE REGULATION

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Many Th Cell Subsets Have Fas Ligand–Dependent Cytotoxic Potential
Dmitri I. Kotov, Jessica A. Kotov, Michael F. Goldberg and Marc K. Jenkins

J Immunol March 15, 2018, 200 (6) 2004-2012; DOI: https://doi.org/10.4049/jimmunol.1700420
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ILDR2-Fc Is a Novel Regulator of Immune Homeostasis and Inducer of Antigen-Specific Immune Tolerance
Joseph R. Podojil, Iris Hecht, Ming-Yi Chiang, Ilan Vaknin, Inbal Barbiro, Amit Novik, Eyal Neria, Galit Rotman and Stephen D. Miller

J Immunol March 15, 2018, 200 (6) 2013-2024; DOI: https://doi.org/10.4049/jimmunol.1700326
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ILDR2 Is a Novel B7-like Protein That Negatively Regulates T Cell Responses
Iris Hecht, Amir Toporik, Joseph R. Podojil, Ilan Vaknin, Gady Cojocaru, Anat Oren, Elizabeta Aizman, Spencer C. Liang, Ling Leung, Yosef Dicken, Amit Novik, Nadav Marbach-Bar, Aziza Elmesmari, Clare Tange, Ashley Gilmour, Donna McIntyre, Mariola Kurowska-Stolarska, Kay McNamee, Judith Leitner, Shirley Greenwald, Liat Dassa, Zurit Levine, Peter Steinberger, Richard O. Williams, Stephen D. Miller, Iain B. McInnes, Eyal Neria and Galit Rotman

J Immunol March 15, 2018, 200 (6) 2025-2037; DOI: https://doi.org/10.4049/jimmunol.1700325
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Low-Dose Methotrexate Prevents Primary and Secondary Humoral Immune Responses and Induces Immune Tolerance to a Recombinant Immunotoxin
Emily M. King, Ronit Mazor, Nicolas Çuburu and Ira Pastan

J Immunol March 15, 2018, 200 (6) 2038-2045; DOI: https://doi.org/10.4049/jimmunol.1701430

IMMUNE SYSTEM DEVELOPMENT

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Differential Expression of PU.1 and Key T Lineage Transcription Factors Distinguishes Fetal and Adult T Cell Development
Encarnacion Montecino-Rodriguez, David Casero, Michael Fice, Jonathan Le and Kenneth Dorshkind

J Immunol March 15, 2018, 200 (6) 2046-2056; DOI: https://doi.org/10.4049/jimmunol.1701336

IMMUNOTHERAPY AND VACCINES

Open Access
Simultaneous Targeting of Multiple Hemagglutinins to APCs for Induction of Broad Immunity against Influenza
Author Choice Article

Ane Marie Anderson, Marta Baranowska-Hustad, Ranveig Braathen, Gunnveig Grodeland and Bjarne Bogen

J Immunol March 15, 2018, 200 (6) 2057-2066; DOI: https://doi.org/10.4049/jimmunol.1701088
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An Antigen-Free, Plasmacytoid Dendritic Cell–Targeting Immunotherapy To Bolster Memory CD8⁺ T Cells in Nonhuman Primates
Yuji Masuta, Takuya Yamamoto, Yayoi Natsume-Kitatani, Tomohiro Kanuma, Eiko Moriishi, Kouji Kobiyama, Kenji Mizuguchi, Yasuhiro Yasutomi and Ken J. Ishii

J Immunol March 15, 2018, 200 (6) 2067-2075; DOI: https://doi.org/10.4049/jimmunol.1701183

INFECTIOUS DISEASE AND HOST RESPONSE

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HPV18 Persistence Impairs Basal and DNA Ligand–Mediated IFN-β and IFN-λ₁ Production through Transcriptional Repression of Multiple Downstream Effectors of Pattern Recognition Receptor Signaling
Silvia Albertini, Irene Lo Cigno, Federica Calati, Marco De Andrea, Cinzia Borgogna, Valentina Dell’Oste, Santo Landolfo and Marisa Gariglio

J Immunol March 15, 2018, 200 (6) 2076-2089; DOI: https://doi.org/10.4049/jimmunol.1701536
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Th1, Th17, and Th1Th17 Lymphocytes during Tuberculosis: Th1 Lymphocytes Predominate and Appear as Low-Differentiated CXCR3⁺CCR6⁺ Cells in the Blood and Highly Differentiated CXCR3^+/−CCR6⁻ Cells in the Lungs
Irina Yu. Nikitina, Alexander V. Panteleev, George A. Kosmiadi, Yana V. Serdyuk, Tatiana A. Nenasheva, Alexander A. Nikolaev, Lubov A. Gorelova, Tatiana V. Radaeva, Yana Yu. Kiseleva, Vladimir K. Bozhenko and Irina V. Lyadova

J Immunol March 15, 2018, 200 (6) 2090-2103; DOI: https://doi.org/10.4049/jimmunol.1701424

INNATE IMMUNITY AND INFLAMMATION

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Carbon Monoxide Impairs CD11b⁺Ly-6C^hi Monocyte Migration from the Blood to Inflamed Pancreas via Inhibition of the CCL2/CCR2 Axis
Jinghua Wu, Ruling Zhang, Guoyong Hu, Helen He Zhu, Wei-Qiang Gao and Jing Xue

J Immunol March 15, 2018, 200 (6) 2104-2114; DOI: https://doi.org/10.4049/jimmunol.1701169
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TGF-β1 Suppresses the Type I IFN Response and Induces Mitochondrial Dysfunction in Alveolar Macrophages
Jocelyn R. Grunwell, Samantha M. Yeligar, Susan Stephenson, Xiao Du Ping, Theresa W. Gauthier, Anne M. Fitzpatrick and Lou Ann S. Brown

J Immunol March 15, 2018, 200 (6) 2115-2128; DOI: https://doi.org/10.4049/jimmunol.1701325
Open Access
TP53 Haploinsufficiency Rescues Emergency Granulopoiesis in FANCC^−/− Mice
Author Choice Article

Liping Hu, Weiqi Huang, Ling Bei, Larisa Broglie and Elizabeth A. Eklund

J Immunol March 15, 2018, 200 (6) 2129-2139; DOI: https://doi.org/10.4049/jimmunol.1700931

MOLECULAR AND STRUCTURAL IMMUNOLOGY

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Galectin-3 Interacts with the CHI3L1 Axis and Contributes to Hermansky–Pudlak Syndrome Lung Disease
Yang Zhou, Chuan Hua He, Daniel S. Yang, Tung Nguyen, Yueming Cao, Suchitra Kamle, Chang-min Lee, Bernadette R. Gochuico, William A. Gahl, Barry S. Shea, Chun Geun Lee and Jack A. Elias

J Immunol March 15, 2018, 200 (6) 2140-2153; DOI: https://doi.org/10.4049/jimmunol.1701442
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Cell-Specific Requirements for STAT Proteins and Type I IFN Receptor Signaling Discretely Regulate IL-24 and IL-10 Expression in NK Cells and Macrophages
Djeneba Dabitao, Christian M. Hedrich, Fengying Wang, Vimvara Vacharathit and Jay H. Bream

J Immunol March 15, 2018, 200 (6) 2154-2164; DOI: https://doi.org/10.4049/jimmunol.1701340
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Phospholipase D in TCR-Mediated Signaling and T Cell Activation
Minghua Zhu, Daniel P. Foreman, Sarah A. O’Brien, Yuefei Jin and Weiguo Zhang

J Immunol March 15, 2018, 200 (6) 2165-2173; DOI: https://doi.org/10.4049/jimmunol.1701291

MUCOSAL IMMUNOLOGY

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The Antimicrobial Peptide CRAMP Is Essential for Colon Homeostasis by Maintaining Microbiota Balance
Teizo Yoshimura, Mairi H. McLean, Amiran K. Dzutsev, Xiaohong Yao, Keqiang Chen, Jiaqiang Huang, Wanghua Gong, Jiamin Zhou, Yi Xiang, Jonathan H. Badger, Colm O'hUigin, Vishal Thovarai, Lino Tessarollo, Scott K. Durum, Giorgio Trinchieri, Xiu-wu Bian and Ji Ming Wang

J Immunol March 15, 2018, 200 (6) 2174-2185; DOI: https://doi.org/10.4049/jimmunol.1602073

TRANSPLANTATION

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T Cell Expression of C5a Receptor 2 Augments Murine Regulatory T Cell (T_REG) Generation and T_REG-Dependent Cardiac Allograft Survival
Divya A. Verghese, Markus Demir, Nicholas Chun, Miguel Fribourg, Paolo Cravedi, Ines Llaudo, Trent M. Woodruff, Pragya Yadav, Sergio A. Lira, M. Edward Medof and Peter S. Heeger

J Immunol March 15, 2018, 200 (6) 2186-2198; DOI: https://doi.org/10.4049/jimmunol.1701638
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High Mutation Frequency of the PIGA Gene in T Cells Results in Reconstitution of GPI Anchor⁻/CD52⁻ T Cells That Can Give Early Immune Protection after Alemtuzumab-Based T Cell–Depleted Allogeneic Stem Cell Transplantation
Floris C. Loeff, J. H. Frederik Falkenburg, Lois Hageman, Wesley Huisman, Sabrina A. J. Veld, H. M. Esther van Egmond, Marian van de Meent, Peter A. von dem Borne, Hendrik Veelken, Constantijn J. M. Halkes and Inge Jedema

J Immunol March 15, 2018, 200 (6) 2199-2208; DOI: https://doi.org/10.4049/jimmunol.1701018

NOVEL IMMUNOLOGICAL METHODS

Open Access
Csf1r-mApple Transgene Expression and Ligand Binding In Vivo Reveal Dynamics of CSF1R Expression within the Mononuclear Phagocyte System
Author Choice Article

Catherine A. Hawley, Rocio Rojo, Anna Raper, Kristin A. Sauter, Zofia M. Lisowski, Kathleen Grabert, Calum C. Bain, Gemma M. Davis, Pieter A. Louwe, Michael C. Ostrowski, David A. Hume, Clare Pridans and Stephen J. Jenkins

J Immunol March 15, 2018, 200 (6) 2209-2223; DOI: https://doi.org/10.4049/jimmunol.1701488

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Table of Contents

IN THIS ISSUE

TRANSLATING IMMUNOLOGY

BRIEF REVIEWS

CUTTING EDGE

ALLERGY AND OTHER HYPERSENSITIVITIES

IMMUNE REGULATION

IMMUNE SYSTEM DEVELOPMENT

IMMUNOTHERAPY AND VACCINES

INFECTIOUS DISEASE AND HOST RESPONSE

INNATE IMMUNITY AND INFLAMMATION

MOLECULAR AND STRUCTURAL IMMUNOLOGY

MUCOSAL IMMUNOLOGY

TRANSPLANTATION

NOVEL IMMUNOLOGICAL METHODS

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