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The Journal of Immunology

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Table of Contents

January 15, 2018; Volume 200,Issue 2

EDITORIAL

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    The Cancer Immunotherapy Revolution: Mechanistic Insights
    Pamela J. Fink
    J Immunol January 15, 2018, 200 (2) 371-372; DOI: https://doi.org/10.4049/jimmunol.1790024

IN THIS ISSUE

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    In This Issue

    Sphingosine-1 Phosphate and T Cell Migration See article p. 551

    Two Layers of CD16a Regulation in NK Cells See article p. 565

    What’s Sex Got To Do with Skin Infections? See article p. 657

    RIPK1 Mediates DC Necroptosis See article p. 737

    TLR2 Agonists in Tumor Immune Evasion See article p. 847

    J Immunol January 15, 2018, 200 (2) 373-374; DOI: https://doi.org/10.4049/jimmunol.1790025

TRANSLATING IMMUNOLOGY

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    Inhibitors of the PD-1 Pathway in Tumor Therapy
    Martin W. LaFleur, Yuki Muroyama, Charles G. Drake and Arlene H. Sharpe
    J Immunol January 15, 2018, 200 (2) 375-383; DOI: https://doi.org/10.4049/jimmunol.1701044

BRIEF REVIEWS

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    A Believer’s Overview of Cancer Immunosurveillance and Immunotherapy
    Olivera J. Finn
    J Immunol January 15, 2018, 200 (2) 385-391; DOI: https://doi.org/10.4049/jimmunol.1701302
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    Hitting the Target: How T Cells Detect and Eliminate Tumors
    Anthony E. Zamora, Jeremy Chase Crawford and Paul G. Thomas
    J Immunol January 15, 2018, 200 (2) 392-399; DOI: https://doi.org/10.4049/jimmunol.1701413
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    Metabolic Barriers to T Cell Function in Tumors
    Ayaka Sugiura and Jeffrey C. Rathmell
    J Immunol January 15, 2018, 200 (2) 400-407; DOI: https://doi.org/10.4049/jimmunol.1701041
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    Tissue-Resident Cytolytic Innate Lymphocytes in Cancer
    Briana G. Nixon and Ming O. Li
    J Immunol January 15, 2018, 200 (2) 408-414; DOI: https://doi.org/10.4049/jimmunol.1701124
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    Unlocking the Complexities of Tumor-Associated Regulatory T Cells
    Jaime L. Chao and Peter A. Savage
    J Immunol January 15, 2018, 200 (2) 415-421; DOI: https://doi.org/10.4049/jimmunol.1701188
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    Myeloid-Derived Suppressor Cells: Immune-Suppressive Cells That Impair Antitumor Immunity and Are Sculpted by Their Environment
    Suzanne Ostrand-Rosenberg and Catherine Fenselau
    J Immunol January 15, 2018, 200 (2) 422-431; DOI: https://doi.org/10.4049/jimmunol.1701019
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    Immune Cell Infiltration and Tertiary Lymphoid Structures as Determinants of Antitumor Immunity
    Victor H. Engelhard, Anthony B. Rodriguez, Ileana S. Mauldin, Amber N. Woods, J. David Peske and Craig L. Slingluff Jr.
    J Immunol January 15, 2018, 200 (2) 432-442; DOI: https://doi.org/10.4049/jimmunol.1701269
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    Dendritic Cell–Based Cancer Vaccines
    Patricia M. Santos and Lisa H. Butterfield
    J Immunol January 15, 2018, 200 (2) 443-449; DOI: https://doi.org/10.4049/jimmunol.1701024
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    Critical Interactions between Immunogenic Cancer Cell Death, Oncolytic Viruses, and the Immune System Define the Rational Design of Combination Immunotherapies
    Jacob P. van Vloten, Samuel T. Workenhe, Sarah K. Wootton, Karen L. Mossman and Byram W. Bridle
    J Immunol January 15, 2018, 200 (2) 450-458; DOI: https://doi.org/10.4049/jimmunol.1701021
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    Chimeric Antigen Receptor T Cell Therapy: Challenges to Bench-to-Bedside Efficacy
    Shivani Srivastava and Stanley R. Riddell
    J Immunol January 15, 2018, 200 (2) 459-468; DOI: https://doi.org/10.4049/jimmunol.1701155

CUTTING EDGE

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    Cutting Edge: CCR2 Is Not Required for Ly6Chi Monocyte Egress from the Bone Marrow but Is Necessary for Migration within the Brain in La Crosse Virus Encephalitis
    Clayton W. Winkler, Tyson A. Woods, Shelly J. Robertson, Kristin L. McNally, Aaron B. Carmody, Sonja M. Best and Karin E. Peterson
    J Immunol January 15, 2018, 200 (2) 471-476; DOI: https://doi.org/10.4049/jimmunol.1701230
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    Cutting Edge: Allograft Rejection Is Associated with Weak T Cell Responses to Many Different Graft Leukocyte-Derived Peptides
    Adam L. Burrack, Deepali Malhotra, Thamotharampillai Dileepan, Kevin C. Osum, Linnea A. Swanson, Brian T. Fife and Marc K. Jenkins
    J Immunol January 15, 2018, 200 (2) 477-482; DOI: https://doi.org/10.4049/jimmunol.1701434

ANTIGEN RECOGNITION AND RESPONSES

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    Role of the EHD Family of Endocytic Recycling Regulators for TCR Recycling and T Cell Function
    Fany M. Iseka, Benjamin T. Goetz, Insha Mushtaq, Wei An, Luke R. Cypher, Timothy A. Bielecki, Eric C. Tom, Priyanka Arya, Sohinee Bhattacharyya, Matthew D. Storck, Craig L. Semerad, James E. Talmadge, R. Lee Mosley, Vimla Band and Hamid Band
    J Immunol January 15, 2018, 200 (2) 483-499; DOI: https://doi.org/10.4049/jimmunol.1601793
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    A Subset of Human Autoreactive CD1c-Restricted T Cells Preferentially Expresses TRBV4-1+ TCRs
    Tingxi Guo, Ming Yin Koo, Yuki Kagoya, Mark Anczurowski, Chung-Hsi Wang, Kayoko Saso, Marcus O. Butler and Naoto Hirano
    J Immunol January 15, 2018, 200 (2) 500-511; DOI: https://doi.org/10.4049/jimmunol.1700677

AUTOIMMUNITY

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    Estrogen Receptor α Signaling Exacerbates Immune-Mediated Nephropathies through Alteration of Metabolic Activity
    Chelsea Corradetti, Neelakshi R. Jog, Matteo Cesaroni, Michael Madaio and Roberto Caricchio
    J Immunol January 15, 2018, 200 (2) 512-522; DOI: https://doi.org/10.4049/jimmunol.1700770
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    Epitope Mapping of SERCA2a Identifies an Antigenic Determinant That Induces Mainly Atrial Myocarditis in A/J Mice
    Bharathi Krishnan, Chandirasegaran Massilamany, Rakesh H. Basavalingappa, Arunakumar Gangaplara, Rajkumar A. Rajasekaran, Muhammad Z. Afzal, Vahid Khalilzad-Sharghi, You Zhou, Jean-Jack Riethoven, Shyam S. Nandi, Paras K. Mishra, Raymond A. Sobel, Jennifer L. Strande, David Steffen and Jay Reddy
    J Immunol January 15, 2018, 200 (2) 523-537; DOI: https://doi.org/10.4049/jimmunol.1701090

CLINICAL AND HUMAN IMMUNOLOGY

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    Quantitative Multiplexed Imaging Analysis Reveals a Strong Association between Immunogen-Specific B Cell Responses and Tonsillar Germinal Center Immune Dynamics in Children after Influenza Vaccination
    Donato Amodio, Nicola Cotugno, Giulia Macchiarulo, Salvatore Rocca, Yiannis Dimopoulos, Maria Rita Castrucci, Rita De Vito, Filippo M. Tucci, Adrian B. McDermott, Sandeep Narpala, Paolo Rossi, Richard A. Koup, Paolo Palma and Constantinos Petrovas
    J Immunol January 15, 2018, 200 (2) 538-550; DOI: https://doi.org/10.4049/jimmunol.1701312
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    Human Naive and Memory T Cells Display Opposite Migratory Responses to Sphingosine-1 Phosphate
    Annabelle Drouillard, Antoinette Neyra, Anne-Laure Mathieu, Antoine Marçais, Mélanie Wencker, Jacqueline Marvel, Alexandre Belot and Thierry Walzer
    J Immunol January 15, 2018, 200 (2) 551-557; DOI: https://doi.org/10.4049/jimmunol.1701278
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    Effect of IL-7 Therapy on Phospho-Ribosomal Protein S6 and TRAF1 Expression in HIV-Specific CD8 T Cells in Patients Receiving Antiretroviral Therapy
    Chao Wang, Maria I. Edilova, Lisa E. Wagar, Shariq Mujib, Meromit Singer, Nicole F. Bernard, Thérèse Croughs, Michael M. Lederman, Irini Sereti, Margaret A. Fischl, Elisabeth Kremmer, Mario Ostrowski, Jean-Pierre Routy and Tania H. Watts
    J Immunol January 15, 2018, 200 (2) 558-564; DOI: https://doi.org/10.4049/jimmunol.1601254

IMMUNE REGULATION

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    Epigenetic and Posttranscriptional Regulation of CD16 Expression during Human NK Cell Development
    Aaron R. Victor, Christoph Weigel, Steven D. Scoville, Wing Keung Chan, Kelsey Chatman, Mary M. Nemer, Charlene Mao, Karen A. Young, Jianying Zhang, Jianhua Yu, Aharon G. Freud, Christopher C. Oakes and Michael A. Caligiuri
    J Immunol January 15, 2018, 200 (2) 565-572; DOI: https://doi.org/10.4049/jimmunol.1701128
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    Teleost-Specific TLR19 Localizes to Endosome, Recognizes dsRNA, Recruits TRIF, Triggers both IFN and NF-κB Pathways, and Protects Cells from Grass Carp Reovirus Infection
    Jianfei Ji, Youliang Rao, Quanyuan Wan, Zhiwei Liao and Jianguo Su
    J Immunol January 15, 2018, 200 (2) 573-585; DOI: https://doi.org/10.4049/jimmunol.1701149
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    Foxp1 Negatively Regulates T Follicular Helper Cell Differentiation and Germinal Center Responses by Controlling Cell Migration and CTLA-4
    Bi Shi, Jianlin Geng, Yin-Hu Wang, Hairong Wei, Beth Walters, Wei Li, Xuerui Luo, Anna Stevens, Melanie Pittman, Bin Li, Sunnie R. Thompson and Hui Hu
    J Immunol January 15, 2018, 200 (2) 586-594; DOI: https://doi.org/10.4049/jimmunol.1701000

IMMUNOTHERAPY AND VACCINES

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    IL-3 Differentially Regulates Membrane and Soluble RANKL in Osteoblasts through Metalloproteases and the JAK2/STAT5 Pathway and Improves the RANKL/OPG Ratio in Adult Mice
    Kanupriya Singh, Vikrant Piprode, Suhas T. Mhaske, Amruta Barhanpurkar-Naik and Mohan R. Wani
    J Immunol January 15, 2018, 200 (2) 595-606; DOI: https://doi.org/10.4049/jimmunol.1601528

INFECTIOUS DISEASE AND HOST RESPONSE

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    Brucella abortus Triggers a cGAS-Independent STING Pathway To Induce Host Protection That Involves Guanylate-Binding Proteins and Inflammasome Activation
    Miriam M. Costa Franco, Fernanda Marim, Erika S. Guimarães, Natan R. G. Assis, Daiane M. Cerqueira, Juliana Alves-Silva, Jerome Harms, Gary Splitter, Judith Smith, Thirumala-Devi Kanneganti, Nina M. G. P. de Queiroz, Delia Gutman, Glen N. Barber and Sergio C. Oliveira
    J Immunol January 15, 2018, 200 (2) 607-622; DOI: https://doi.org/10.4049/jimmunol.1700725
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    Metformin Mediates Protection against Legionella Pneumonia through Activation of AMPK and Mitochondrial Reactive Oxygen Species
    Chiaki Kajiwara, Yu Kusaka, Soichiro Kimura, Tetsuo Yamaguchi, Yuta Nanjo, Yoshikazu Ishii, Heiichiro Udono, Theodore J. Standiford and Kazuhiro Tateda
    J Immunol January 15, 2018, 200 (2) 623-631; DOI: https://doi.org/10.4049/jimmunol.1700474
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    Osteoblasts Are Rapidly Ablated by Virus-Induced Systemic Inflammation following Lymphocytic Choriomeningitis Virus or Pneumonia Virus of Mice Infection in Mice
    Steven Maltby, Alyssa J. Lochrin, Bianca Bartlett, Hock L. Tay, Jessica Weaver, Ingrid J. Poulton, Maximilian W. Plank, Helene F. Rosenberg, Natalie A. Sims and Paul S. Foster
    J Immunol January 15, 2018, 200 (2) 632-642; DOI: https://doi.org/10.4049/jimmunol.1700927
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    Early Inhibition of Fatty Acid Synthesis Reduces Generation of Memory Precursor Effector T Cells in Chronic Infection
    Samad A. Ibitokou, Brian E. Dillon, Mala Sinha, Bartosz Szczesny, Añahi Delgadillo, Doaa Reda Abdelrahman, Csaba Szabo, Lutfi Abu-Elheiga, Craig Porter, Demidmaa Tuvdendorj and Robin Stephens
    J Immunol January 15, 2018, 200 (2) 643-656; DOI: https://doi.org/10.4049/jimmunol.1602110
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    Innate Sex Bias of Staphylococcus aureus Skin Infection Is Driven by α-Hemolysin
    Moriah J. Castleman, Srijana Pokhrel, Kathleen D. Triplett, Donna F. Kusewitt, Bradley O. Elmore, Jason A. Joyner, Jon K. Femling, Geetanjali Sharma, Helen J. Hathaway, Eric R. Prossnitz and Pamela R. Hall
    J Immunol January 15, 2018, 200 (2) 657-668; DOI: https://doi.org/10.4049/jimmunol.1700810
  • Open Access
    Induction of Immunosuppressive CD8+CD25+FOXP3+ Regulatory T Cells by Suboptimal Stimulation with Staphylococcal Enterotoxin C1

    Author Choice Article

    Juyeun Lee, Nogi Park, Joo Youn Park, Barbara L. F. Kaplan, Stephen B. Pruett, Juw Won Park, Yong Ho Park and Keun Seok Seo
    J Immunol January 15, 2018, 200 (2) 669-680; DOI: https://doi.org/10.4049/jimmunol.1602109

INNATE IMMUNITY AND INFLAMMATION

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    Time-Restricted Feeding Alters the Innate Immune Response to Bacterial Endotoxin
    Yasmine M. Cissé, Jeremy C. Borniger, Elise Lemanski, William H. Walker II and Randy J. Nelson
    J Immunol January 15, 2018, 200 (2) 681-687; DOI: https://doi.org/10.4049/jimmunol.1701136
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    Alternative Splicing Transcripts of Zebrafish LGP2 Gene Differentially Contribute to IFN Antiviral Response
    Qi-Min Zhang, Xiang Zhao, Zhi Li, Min Wu, Jian-Fang Gui and Yi-Bing Zhang
    J Immunol January 15, 2018, 200 (2) 688-703; DOI: https://doi.org/10.4049/jimmunol.1701388
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    Cytoplasmic Linker Protein CLIP170 Negatively Regulates TLR4 Signaling by Targeting the TLR Adaptor Protein TIRAP
    Padmaja Jakka, Bindu Bhargavi, Swapna Namani, Subathra Murugan, Gary Splitter and Girish Radhakrishnan
    J Immunol January 15, 2018, 200 (2) 704-714; DOI: https://doi.org/10.4049/jimmunol.1601559
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    A Role of NKR-P1A (CD161) and Lectin-like Transcript 1 in Natural Cytotoxicity against Human Articular Chondrocytes
    Agata Białoszewska, Joanna Olkowska-Truchanowicz, Katarzyna Bocian, Anna Osiecka-Iwan, Andrzej Czop, Claudine Kieda and Jacek Malejczyk
    J Immunol January 15, 2018, 200 (2) 715-724; DOI: https://doi.org/10.4049/jimmunol.1700387
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    mPGES1-Dependent Prostaglandin E2 (PGE2) Controls Antigen-Specific Th17 and Th1 Responses by Regulating T Autocrine and Paracrine PGE2 Production
    Damian Maseda, Elizabeth M. Johnson, Lindsay E. Nyhoff, Bridgette Baron, Fumiaki Kojima, Ashley J. Wilhelm, Martin R. Ward, Jerold G. Woodward, David D. Brand and Leslie J. Crofford
    J Immunol January 15, 2018, 200 (2) 725-736; DOI: https://doi.org/10.4049/jimmunol.1601808
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    Dendritic Cell RIPK1 Maintains Immune Homeostasis by Preventing Inflammation and Autoimmunity
    Joanne A. O’Donnell, Jesse Lehman, Justine E. Roderick, Dalia Martinez-Marin, Matija Zelic, Ciara Doran, Nicole Hermance, Stephen Lyle, Manolis Pasparakis, Katherine A. Fitzgerald, Ann Marshak-Rothstein and Michelle A. Kelliher
    J Immunol January 15, 2018, 200 (2) 737-748; DOI: https://doi.org/10.4049/jimmunol.1701229
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    Ca2+-Dependent Regulation of NFATc1 via KCa3.1 in Inflammatory Osteoclastogenesis
    Eva M. Grössinger, Mincheol Kang, Laura Bouchareychas, Ritu Sarin, Dominik R. Haudenschild, Laura N. Borodinsky and Iannis E. Adamopoulos
    J Immunol January 15, 2018, 200 (2) 749-757; DOI: https://doi.org/10.4049/jimmunol.1701170
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    Role of CD44 in Regulating TLR2 Activation of Human Macrophages and Downstream Expression of Proinflammatory Cytokines
    Marwa Qadri, Sara Almadani, Gregory D. Jay and Khaled A. Elsaid
    J Immunol January 15, 2018, 200 (2) 758-767; DOI: https://doi.org/10.4049/jimmunol.1700713
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    Cyclic GMP–AMP Synthase Is the Cytosolic Sensor of Plasmodium falciparum Genomic DNA and Activates Type I IFN in Malaria
    Carolina Gallego-Marin, Jacob E. Schrum, Warrison A. Andrade, Scott A. Shaffer, Lina F. Giraldo, Alvaro M. Lasso, Evelyn A. Kurt-Jones, Katherine A. Fitzgerald and Douglas T. Golenbock
    J Immunol January 15, 2018, 200 (2) 768-774; DOI: https://doi.org/10.4049/jimmunol.1701048
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    Altered Marginal Zone B Cell Selection in the Absence of IκBNS
    Monika Ádori, Gabriel K. Pedersen, Csaba Ádori, Elina Erikson, Sharesta Khoenkhoen, Julian M. Stark, Jin Huk Choi, Pia Dosenovic, Mikael C. I. Karlsson, Bruce Beutler and Gunilla B. Karlsson Hedestam
    J Immunol January 15, 2018, 200 (2) 775-787; DOI: https://doi.org/10.4049/jimmunol.1700791
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    Immunoregulatory Activity of the Natural Product Laminarin Varies Widely as a Result of Its Physical Properties
    Alyson J. Smith, Bridget Graves, Robert Child, Peter J. Rice, Zuchao Ma, Douglas W. Lowman, Harry E. Ensley, Kendal T. Ryter, Jay T. Evans and David L. Williams
    J Immunol January 15, 2018, 200 (2) 788-799; DOI: https://doi.org/10.4049/jimmunol.1701258

MUCOSAL IMMUNOLOGY

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    CCL28-Deficient Mice Have Reduced IgA Antibody–Secreting Cells and an Altered Microbiota in the Colon
    Kazuhiko Matsuo, Daisuke Nagakubo, Shinya Yamamoto, Akiko Shigeta, Shuta Tomida, Mitsugu Fujita, Takako Hirata, Ikuo Tsunoda, Takashi Nakayama and Osamu Yoshie
    J Immunol January 15, 2018, 200 (2) 800-809; DOI: https://doi.org/10.4049/jimmunol.1700037
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    Integrin α4β7 Blockade Preferentially Impacts CCR6+ Lymphocyte Subsets in Blood and Mucosal Tissues of Naive Rhesus Macaques
    Giulia Calenda, Rassamon Keawvichit, Géraldine Arrode-Brusés, Kovit Pattanapanyasat, Ines Frank, Siddappa N. Byrareddy, James Arthos, Claudia Cicala, Brooke Grasperge, James L. Blanchard, Agegnehu Gettie, Keith A. Reimann, Aftab A. Ansari and Elena Martinelli
    J Immunol January 15, 2018, 200 (2) 810-820; DOI: https://doi.org/10.4049/jimmunol.1701150

SYSTEMS IMMUNOLOGY

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    Deep Coverage Tissue and Cellular Proteomics Revealed IL-1β Can Independently Induce the Secretion of TNF-Associated Proteins from Human Synoviocytes
    Shengquan Tang, Suyuan Deng, Jiahui Guo, Xing Chen, Wanling Zhang, Yizhi Cui, Yanzhang Luo, Ziqi Yan, Qing-Yu He, Shan Shen and Tong Wang
    J Immunol January 15, 2018, 200 (2) 821-833; DOI: https://doi.org/10.4049/jimmunol.1700480

TRANSPLANTATION

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    PD-L1 Prevents the Development of Autoimmune Heart Disease in Graft-versus-Host Disease
    Kathryn W. Juchem, Faruk Sacirbegovic, Cuiling Zhang, Arlene H. Sharpe, Kerry Russell, Jennifer M. McNiff, Anthony J. Demetris, Mark J. Shlomchik and Warren D. Shlomchik
    J Immunol January 15, 2018, 200 (2) 834-846; DOI: https://doi.org/10.4049/jimmunol.1701076

TUMOR IMMUNOLOGY

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    Naive CD4+ T Cells Carrying a TLR2 Agonist Overcome TGF-β–Mediated Tumor Immune Evasion
    Mohsen Ibrahim, Davide Scozzi, Kelsey A. Toth, Donatella Ponti, Daniel Kreisel, Cecilia Menna, Elena De Falco, Antonio D’Andrilli, Erino A. Rendina, Antonella Calogero, Alexander S. Krupnick and Andrew E. Gelman
    J Immunol January 15, 2018, 200 (2) 847-856; DOI: https://doi.org/10.4049/jimmunol.1700396
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    Apoptotic Cancer Cells Suppress 5-Lipoxygenase in Tumor-Associated Macrophages
    Julia Ringleb, Elisabeth Strack, Carlo Angioni, Gerd Geisslinger, Dieter Steinhilber, Andreas Weigert and Bernhard Brüne
    J Immunol January 15, 2018, 200 (2) 857-868; DOI: https://doi.org/10.4049/jimmunol.1700609

NOVEL IMMUNOLOGICAL METHODS

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    A High-Throughput Real-Time Imaging Technique To Quantify NETosis and Distinguish Mechanisms of Cell Death in Human Neutrophils
    Sarthak Gupta, Diana W. Chan, Kristien J. Zaal and Mariana J. Kaplan
    J Immunol January 15, 2018, 200 (2) 869-879; DOI: https://doi.org/10.4049/jimmunol.1700905

CORRECTIONS

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    Correction: NFAT1 Regulates Systemic Autoimmunity through the Modulation of a Dendritic Cell Property
    J Immunol January 15, 2018, 200 (2) 880; DOI: https://doi.org/10.4049/jimmunol.1701555
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This Issue

The Journal of Immunology: 200 (2)
The Journal of Immunology
Vol. 200, Issue 2
15 Jan 2018
  • Table of Contents
  • Table of Contents (PDF)
  • About the Cover
  • Advertising (PDF)
  • Back Matter (PDF)
  • Editorial Board (PDF)
  • Front Matter (PDF)

Issue highlights

  • A Believer’s Overview of Cancer Immunosurveillance and Immunotherapy
  • Hitting the Target: How T Cells Detect and Eliminate Tumors
  • Metabolic Barriers to T Cell Function in Tumors
  • Tissue-Resident Cytolytic Innate Lymphocytes in Cancer
  • Unlocking the Complexities of Tumor-Associated Regulatory T Cells
  • Myeloid-Derived Suppressor Cells: Immune-Suppressive Cells That Impair Antitumor Immunity and Are Sculpted by Their Environment
  • Immune Cell Infiltration and Tertiary Lymphoid Structures as Determinants of Antitumor Immunity
  • Dendritic Cell–Based Cancer Vaccines
  • Critical Interactions between Immunogenic Cancer Cell Death, Oncolytic Viruses, and the Immune System Define the Rational Design of Combination Immunotherapies
  • Chimeric Antigen Receptor T Cell Therapy: Challenges to Bench-to-Bedside Efficacy
  • In This Issue
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  • EDITORIAL
  • IN THIS ISSUE
  • TRANSLATING IMMUNOLOGY
  • BRIEF REVIEWS
  • CUTTING EDGE
  • ANTIGEN RECOGNITION AND RESPONSES
  • AUTOIMMUNITY
  • CLINICAL AND HUMAN IMMUNOLOGY
  • IMMUNE REGULATION
  • IMMUNOTHERAPY AND VACCINES
  • INFECTIOUS DISEASE AND HOST RESPONSE
  • INNATE IMMUNITY AND INFLAMMATION
  • MUCOSAL IMMUNOLOGY
  • SYSTEMS IMMUNOLOGY
  • TRANSPLANTATION
  • TUMOR IMMUNOLOGY
  • NOVEL IMMUNOLOGICAL METHODS
  • CORRECTIONS
  • Highlights
  • Most Cited
  • Most Read
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Immunodominant AH1 Antigen-Deficient Necroptotic, but Not Apoptotic, Murine Cancer Cells Induce Antitumor Protection
Osteoclasts Derive Predominantly from Bone Marrow–Resident CX3CR1+ Precursor Cells in Homeostasis, whereas Circulating CX3CR1+ Cells Contribute to Osteoclast Development during Fracture Repair
Intracellular IL-1 Receptor Antagonist Isoform 1 Released from Keratinocytes upon Cell Death Acts as an Inhibitor for the Alarmin IL-1α
Polysaccharide Capsules Equip the Human Symbiont Bacteroides thetaiotaomicron to Modulate Immune Responses to a Dominant Antigen in the Intestine
Natural and Induced Tolerogenic Dendritic Cells
Cutting Edge: IL-6–Driven Immune Dysregulation Is Strictly Dependent on IL-6R α-Chain Expression

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Print ISSN 0022-1767        Online ISSN 1550-6606