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Mapping Interaction Sites on Human Chemokine Receptors by Deep Mutational Scanning

Jeremiah D. Heredia, Jihye Park, Riley J. Brubaker, Steven K. Szymanski, Kevin S. Gill and Erik Procko
J Immunol June 1, 2018, 200 (11) 3825-3839; DOI: https://doi.org/10.4049/jimmunol.1800343
Jeremiah D. Heredia
Department of Biochemistry, University of Illinois at Urbana-Champaign, Urbana, IL 61801
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  • ORCID record for Jeremiah D. Heredia
Jihye Park
Department of Biochemistry, University of Illinois at Urbana-Champaign, Urbana, IL 61801
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Riley J. Brubaker
Department of Biochemistry, University of Illinois at Urbana-Champaign, Urbana, IL 61801
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Steven K. Szymanski
Department of Biochemistry, University of Illinois at Urbana-Champaign, Urbana, IL 61801
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Kevin S. Gill
Department of Biochemistry, University of Illinois at Urbana-Champaign, Urbana, IL 61801
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Erik Procko
Department of Biochemistry, University of Illinois at Urbana-Champaign, Urbana, IL 61801
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Article Information

vol. 200 no. 11 3825-3839
DOI 
https://doi.org/10.4049/jimmunol.1800343
PubMed 
29678950

Published By 
The American Association of Immunologists, Inc.
Print ISSN 
0022-1767
Online ISSN 
1550-6606
History 
  • Received March 8, 2018
  • Accepted March 30, 2018
  • Published online May 21, 2018.

Article Versions

  • Older version (April 20, 2018 - 07:10).
  • You are viewing the most recent version of this article.
Copyright & Usage 
Copyright © 2018 by The American Association of Immunologists, Inc.

Author Information

  1. Jeremiah D. Heredia,
  2. Jihye Park,
  3. Riley J. Brubaker,
  4. Steven K. Szymanski,
  5. Kevin S. Gill and
  6. Erik Procko
  1. Department of Biochemistry, University of Illinois at Urbana-Champaign, Urbana, IL 61801
  1. Address correspondence and reprint requests to Prof. Erik Procko, University of Illinois, 419 Roger Adams Laboratory, 600 South Mathews, Urbana, IL 61801. E-mail address: procko{at}illinois.edu
  1. J.D.H. was responsible for most experiments and data analysis with assistance from E.P. J.P. and K.S.G. purified and tested gp120–CD4 proteins. S.K.S. deep sequenced transcripts from unsorted transfected cultures. R.J.B. cloned and tested receptor-Venus fusions by bimolecular fluorescence complementation. E.P. supervised the project and secured funding.

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Article usage: April 2018 to January 2021

AbstractFullPdf
Apr 2018712086
May 20187325261
Jun 20181997345
Jul 2018942927
Aug 2018943236
Sep 201893919
Oct 20181243346
Nov 20181043335
Dec 20181013328
Total 20182253294383
Jan 2019892731
Feb 2019833022
Mar 2019742116
Apr 20191002124
May 2019773236
Jun 2019172925
Jul 201983631
Aug 2019103127
Sep 2019113135
Oct 2019174035
Nov 2019135341
Dec 201934519
Total 2019502396342
Jan 2020185532
Feb 2020112937
Mar 2020285147
Apr 2020216458
May 202095241
Jun 202075828
Jul 202074851
Aug 202066355
Sep 202076759
Oct 202076056
Nov 202085770
Dec 2020145836
Total 2020143662570
Jan 2021123125
Total 2021123125
Total291013831320

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The Journal of Immunology: 200 (11)
The Journal of Immunology
Vol. 200, Issue 11
1 Jun 2018
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Mapping Interaction Sites on Human Chemokine Receptors by Deep Mutational Scanning
Jeremiah D. Heredia, Jihye Park, Riley J. Brubaker, Steven K. Szymanski, Kevin S. Gill, Erik Procko
The Journal of Immunology June 1, 2018, 200 (11) 3825-3839; DOI: 10.4049/jimmunol.1800343

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Mapping Interaction Sites on Human Chemokine Receptors by Deep Mutational Scanning
Jeremiah D. Heredia, Jihye Park, Riley J. Brubaker, Steven K. Szymanski, Kevin S. Gill, Erik Procko
The Journal of Immunology June 1, 2018, 200 (11) 3825-3839; DOI: 10.4049/jimmunol.1800343
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