The Journal of Immunology: 200 (1)

January 1, 2018; Volume 200,Issue 1

IN THIS ISSUE

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In This Issue
Finding Familiarity in MHC-E See article p. 49
Oxidative Stress: The Missing Link between T1D and Viral Immunity See article p. 61
TET2 Regulates CD8⁺ T Cell Fate Decisions See article p. 82
Visualizing Multiple Checkpoint Molecules See article p. 347

J Immunol January 1, 2018, 200 (1) 1-2; DOI: https://doi.org/10.4049/jimmunol.1790023

IMMUNOLOGY NOTES AND RESOURCES

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A Beginner’s Guide to Analyzing and Visualizing Mass Cytometry Data
Abigail K. Kimball, Lauren M. Oko, Bonnie L. Bullock, Raphael A. Nemenoff, Linda F. van Dyk and Eric T. Clambey

J Immunol January 1, 2018, 200 (1) 3-22; DOI: https://doi.org/10.4049/jimmunol.1701494

PILLARS OF IMMUNOLOGY

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The Reign of Antibodies: A Celebration of and Tribute to Michael Potter and His Homogeneous Immunoglobulin Workshops
Patricia J. Gearhart, Beverly A. Mock, Rafael Casellas and Michael P. Cancro

J Immunol January 1, 2018, 200 (1) 23-26; DOI: https://doi.org/10.4049/jimmunol.1701516
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Pillars Article: Evidence for Amino Acid Sequence Differences among Proteins Resembling the L-chain Subunits of Immunoglobulins. J. Mol. Biol. 1965. 12: 81–87
J. Claude Bennett, Leroy E. Hood, William J Dreyer and Michael Potter

J Immunol January 1, 2018, 200 (1) 27-37;

BRIEF REVIEWS

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Salmonella Vaccines: Conduits for Protective Antigens
Josephine E. Clark-Curtiss and Roy Curtiss III

J Immunol January 1, 2018, 200 (1) 39-48; DOI: https://doi.org/10.4049/jimmunol.1600608

ANTIGEN RECOGNITION AND RESPONSES

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The Role of MHC-E in T Cell Immunity Is Conserved among Humans, Rhesus Macaques, and Cynomolgus Macaques
Helen L. Wu, Roger W. Wiseman, Colette M. Hughes, Gabriela M. Webb, Shaheed A. Abdulhaqq, Benjamin N. Bimber, Katherine B. Hammond, Jason S. Reed, Lina Gao, Benjamin J. Burwitz, Justin M. Greene, Fidel Ferrer, Alfred W. Legasse, Michael K. Axthelm, Byung S. Park, Simon Brackenridge, Nicholas J. Maness, Andrew J. McMichael, Louis J. Picker, David H. O’Connor, Scott G. Hansen and Jonah B. Sacha

J Immunol January 1, 2018, 200 (1) 49-60; DOI: https://doi.org/10.4049/jimmunol.1700841

AUTOIMMUNITY

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Superoxide Production by NADPH Oxidase Intensifies Macrophage Antiviral Responses during Diabetogenic Coxsackievirus Infection
Ashley R. Burg, Shaonli Das, Lindsey E. Padgett, Zachary E. Koenig and Hubert M. Tse

J Immunol January 1, 2018, 200 (1) 61-70; DOI: https://doi.org/10.4049/jimmunol.1700478
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Essential Role of CARD14 in Murine Experimental Psoriasis
Mayuri Tanaka, Kouji Kobiyama, Tetsuya Honda, Kozue Uchio-Yamada, Yayoi Natsume-Kitatani, Kenji Mizuguchi, Kenji Kabashima and Ken J. Ishii

J Immunol January 1, 2018, 200 (1) 71-81; DOI: https://doi.org/10.4049/jimmunol.1700995

IMMUNE REGULATION

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The Loss of TET2 Promotes CD8⁺ T Cell Memory Differentiation
Shannon A. Carty, Mercy Gohil, Lauren B. Banks, Renee M. Cotton, Matthew E. Johnson, Erietta Stelekati, Andrew D. Wells, E. John Wherry, Gary A. Koretzky and Martha S. Jordan

J Immunol January 1, 2018, 200 (1) 82-91; DOI: https://doi.org/10.4049/jimmunol.1700559
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Downregulation of NFAT3 Due to Lack of T-Box Transcription Factor TBX5 Is Crucial for Cytokine Expression in T Cells
Osamu Kaminuma, Noriko Kitamura, Yasumasa Nishito, Soichi Nemoto, Hideki Tatsumi, Akio Mori and Takachika Hiroi

J Immunol January 1, 2018, 200 (1) 92-100; DOI: https://doi.org/10.4049/jimmunol.1602113
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Route of Antigen Presentation Can Determine the Selection of Foxp3-Dependent or Foxp3-Independent Dominant Immune Tolerance
Ana Agua-Doce, Marta Caridade, Vanessa G. Oliveira, Lisa Bergman, Maria C. Lafaille, Juan J. Lafaille, Jocelyne Demengeot and Luis Graca

J Immunol January 1, 2018, 200 (1) 101-109; DOI: https://doi.org/10.4049/jimmunol.1601886
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STAT5B: A Differential Regulator of the Life and Death of CD4⁺ Effector Memory T Cells
Sonia S. Majri, Jill M. Fritz, Alejandro V. Villarino, Lixin Zheng, Chrysi Kanellopoulou, Benjamin Chaigne-Delalande, Juha Grönholm, Julie E. Niemela, Behdad Afzali, Matthew Biancalana, Stefania Pittaluga, Ashleigh Sun, José L. Cohen, Steven M. Holland, John J. O’Shea, Gulbu Uzel and Michael J. Lenardo

J Immunol January 1, 2018, 200 (1) 110-118; DOI: https://doi.org/10.4049/jimmunol.1701133
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Ultraviolet B–Induced Maturation of CD11b-Type Langerin⁻ Dendritic Cells Controls the Expansion of Foxp3⁺ Regulatory T Cells in the Skin
Sayuri Yamazaki, Mizuyu Odanaka, Akiko Nishioka, Saori Kasuya, Hiroaki Shime, Hiroaki Hemmi, Masaki Imai, Dieter Riethmacher, Tsuneyasu Kaisho, Naganari Ohkura, Shimon Sakaguchi and Akimichi Morita

J Immunol January 1, 2018, 200 (1) 119-129; DOI: https://doi.org/10.4049/jimmunol.1701056

IMMUNE SYSTEM DEVELOPMENT

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The Role of Macrophages in the Response to TNF Inhibition in Experimental Arthritis
Qi-Quan Huang, Robert Birkett, Renee Doyle, Bo Shi, Elyssa L. Roberts, Qinwen Mao and Richard M. Pope

J Immunol January 1, 2018, 200 (1) 130-138; DOI: https://doi.org/10.4049/jimmunol.1700229
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CXCR3/CXCL10 Axis Shapes Tissue Distribution of Memory Phenotype CD8⁺ T Cells in Nonimmunized Mice
Cécile Alanio, Rosa Barreira da Silva, David Michonneau, Philippe Bousso, Molly A. Ingersoll and Matthew L. Albert

J Immunol January 1, 2018, 200 (1) 139-146; DOI: https://doi.org/10.4049/jimmunol.1700564

IMMUNOGENETICS

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A Novel Pkhd1 Mutation Interacts with the Nonobese Diabetic Genetic Background To Cause Autoimmune Cholangitis
Wenting Huang, Daniel B. Rainbow, Yuehong Wu, David Adams, Pranavkumar Shivakumar, Leah Kottyan, Rebekah Karns, Bruce Aronow, Jorge Bezerra, M. Eric Gershwin, Laurence B. Peterson, Linda S. Wicker and William M. Ridgway

J Immunol January 1, 2018, 200 (1) 147-162; DOI: https://doi.org/10.4049/jimmunol.1701087

IMMUNOTHERAPY AND VACCINES

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Live Attenuated Leishmania donovani Centrin Gene–Deleted Parasites Induce IL-23–Dependent IL-17–Protective Immune Response against Visceral Leishmaniasis in a Murine Model
Antara Banerjee, Parna Bhattacharya, Pradeep K. Dagur, Subir Karmakar, Nevien Ismail, Amritanshu B. Joshi, Adovi D. Akue, Mark KuKuruga, John Philip McCoy Jr., Ranadhir Dey and Hira L. Nakhasi

J Immunol January 1, 2018, 200 (1) 163-176; DOI: https://doi.org/10.4049/jimmunol.1700674

INFECTIOUS DISEASE AND HOST RESPONSE

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Amplifying IFN-γ Signaling in Dendritic Cells by CD11c-Specific Loss of SOCS1 Increases Innate Immunity to Infection while Decreasing Adaptive Immunity
Alejandro F. Alice, Gwen Kramer, Shelly Bambina, Jason R. Baird, Keith S. Bahjat, Michael J. Gough and Marka R. Crittenden

J Immunol January 1, 2018, 200 (1) 177-185; DOI: https://doi.org/10.4049/jimmunol.1700909
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Toxoplasma gondii Inactivates Human Plasmacytoid Dendritic Cells by Functional Mimicry of IL-10
Piotr L. Pierog, Yanlin Zhao, Sukhwinder Singh, Jihong Dai, George S. Yap and Patricia Fitzgerald-Bocarsly

J Immunol January 1, 2018, 200 (1) 186-195; DOI: https://doi.org/10.4049/jimmunol.1701045
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NOX2-Derived Reactive Oxygen Species Control Inflammation during Leishmania amazonensis Infection by Mediating Infection-Induced Neutrophil Apoptosis
Matheus B. H. Carneiro, Eric H. Roma, Adam J. Ranson, Nicole A. Doria, Alain Debrabant, David L. Sacks, Leda Q. Vieira and Nathan C. Peters

J Immunol January 1, 2018, 200 (1) 196-208; DOI: https://doi.org/10.4049/jimmunol.1700899
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The IFN Response in Bats Displays Distinctive IFN-Stimulated Gene Expression Kinetics with Atypical RNASEL Induction
Pamela C. De La Cruz-Rivera, Mohammed Kanchwala, Hanquan Liang, Ashwani Kumar, Lin-Fa Wang, Chao Xing and John W. Schoggins

J Immunol January 1, 2018, 200 (1) 209-217; DOI: https://doi.org/10.4049/jimmunol.1701214

INNATE IMMUNITY AND INFLAMMATION

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IL-1β Induces Pathologically Activated Osteoclasts Bearing Extremely High Levels of Resorbing Activity: A Possible Pathological Subpopulation of Osteoclasts, Accompanied by Suppressed Expression of Kindlin-3 and Talin-1
Takuma Shiratori, Yukari Kyumoto-Nakamura, Akiko Kukita, Norihisa Uehara, Jingqi Zhang, Kinuko Koda, Mako Kamiya, Tamer Badawy, Erika Tomoda, Xianghe Xu, Takayoshi Yamaza, Yasuteru Urano, Kiyoshi Koyano and Toshio Kukita

J Immunol January 1, 2018, 200 (1) 218-228; DOI: https://doi.org/10.4049/jimmunol.1602035
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IL-33–Responsive Group 2 Innate Lymphoid Cells Are Regulated by Female Sex Hormones in the Uterus
Kathleen Bartemes, Chien-Chang Chen, Koji Iijima, Li Drake and Hirohito Kita

J Immunol January 1, 2018, 200 (1) 229-236; DOI: https://doi.org/10.4049/jimmunol.1602085
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Identification of IFN-γ and IL-27 as Critical Regulators of Respiratory Syncytial Virus–Induced Exacerbation of Allergic Airways Disease in a Mouse Model
Thi Hiep Nguyen, Steven Maltby, Hock L. Tay, Fiona Eyers, Paul S. Foster and Ming Yang

J Immunol January 1, 2018, 200 (1) 237-247; DOI: https://doi.org/10.4049/jimmunol.1601950
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The Activation of Human Dermal Microvascular Cells by Poly(I:C), Lipopolysaccharide, Imiquimod, and ODN2395 Is Mediated by the Fli1/FOXO3A Pathway
Lukasz Stawski, Grace Marden and Maria Trojanowska

J Immunol January 1, 2018, 200 (1) 248-259; DOI: https://doi.org/10.4049/jimmunol.1601968
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Reticulon-1 and Reduced Migration toward Chemoattractants by Macrophages Differentiated from the Bone Marrow of Ultraviolet-Irradiated and Ultraviolet-Chimeric Mice
Terence A. McGonigle, Amy R. Dwyer, Eloise L. Greenland, Naomi M. Scott, Kim W. Carter, Kevin N. Keane, Philip Newsholme, Helen S. Goodridge, Fiona J. Pixley and Prue H. Hart

J Immunol January 1, 2018, 200 (1) 260-270; DOI: https://doi.org/10.4049/jimmunol.1700760
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Embryonic Lethality and Host Immunity of RelA-Deficient Mice Are Mediated by Both Apoptosis and Necroptosis
Chengxian Xu, Xiaoxia Wu, Xixi Zhang, Qun Xie, Cunxian Fan and Haibing Zhang

J Immunol January 1, 2018, 200 (1) 271-285; DOI: https://doi.org/10.4049/jimmunol.1700859
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Rhesus Macaque Myeloid-Derived Suppressor Cells Demonstrate T Cell Inhibitory Functions and Are Transiently Increased after Vaccination
Ang Lin, Frank Liang, Elizabeth A. Thompson, Maria Vono, Sebastian Ols, Gustaf Lindgren, Kimberly Hassett, Hugh Salter, Giuseppe Ciaramella and Karin Loré

J Immunol January 1, 2018, 200 (1) 286-294; DOI: https://doi.org/10.4049/jimmunol.1701005
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Granzyme A in Human Platelets Regulates the Synthesis of Proinflammatory Cytokines by Monocytes in Aging
Robert A. Campbell, Zechariah Franks, Anish Bhatnagar, Jesse W. Rowley, Bhanu K. Manne, Mark A. Supiano, Hansjorg Schwertz, Andrew S. Weyrich and Matthew T. Rondina

J Immunol January 1, 2018, 200 (1) 295-304; DOI: https://doi.org/10.4049/jimmunol.1700885
Open Access
NFAT5-Regulated Macrophage Polarization Supports the Proinflammatory Function of Macrophages and T Lymphocytes
Author Choice Article

Mónica Tellechea, Maria Buxadé, Sonia Tejedor, Jose Aramburu and Cristina López-Rodríguez

J Immunol January 1, 2018, 200 (1) 305-315; DOI: https://doi.org/10.4049/jimmunol.1601942
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Modulation of the Alternative Pathway of Complement by Murine Factor H–Related Proteins
Alexandra H. Antonioli, Janice White, Frances Crawford, Brandon Renner, Kevin J. Marchbank, Jonathan P. Hannan, Joshua M. Thurman, Philippa Marrack and V. Michael Holers

J Immunol January 1, 2018, 200 (1) 316-326; DOI: https://doi.org/10.4049/jimmunol.1602017

MOLECULAR AND STRUCTURAL IMMUNOLOGY

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Absence of CD59 in Guinea Pigs: Analysis of the Cavia porcellus Genome Suggests the Evolution of a CD59 Pseudogene
Hani Boshra, Wioleta M. Zelek, Timothy R. Hughes, Santiago Rodriguez de Cordoba and B. Paul Morgan

J Immunol January 1, 2018, 200 (1) 327-335; DOI: https://doi.org/10.4049/jimmunol.1701238

SYSTEMS IMMUNOLOGY

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Identity and Diversity of Human Peripheral Th and T Regulatory Cells Defined by Single-Cell Mass Cytometry
Matthew A. Kunicki, Laura C. Amaya Hernandez, Kara L. Davis, Rosa Bacchetta and Maria-Grazia Roncarolo

J Immunol January 1, 2018, 200 (1) 336-346; DOI: https://doi.org/10.4049/jimmunol.1701025

NOVEL IMMUNOLOGICAL METHODS

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Eight-Color Multiplex Immunohistochemistry for Simultaneous Detection of Multiple Immune Checkpoint Molecules within the Tumor Microenvironment
Mark A. J. Gorris, Altuna Halilovic, Katrin Rabold, Anne van Duffelen, Iresha N. Wickramasinghe, Dagmar Verweij, Inge M. N. Wortel, Johannes C. Textor, I. Jolanda M. de Vries and Carl G. Figdor

J Immunol January 1, 2018, 200 (1) 347-354; DOI: https://doi.org/10.4049/jimmunol.1701262

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Table of Contents

IN THIS ISSUE

IMMUNOLOGY NOTES AND RESOURCES

PILLARS OF IMMUNOLOGY

BRIEF REVIEWS

ANTIGEN RECOGNITION AND RESPONSES

AUTOIMMUNITY

IMMUNE REGULATION

IMMUNE SYSTEM DEVELOPMENT

IMMUNOGENETICS

IMMUNOTHERAPY AND VACCINES

INFECTIOUS DISEASE AND HOST RESPONSE

INNATE IMMUNITY AND INFLAMMATION

MOLECULAR AND STRUCTURAL IMMUNOLOGY

SYSTEMS IMMUNOLOGY

NOVEL IMMUNOLOGICAL METHODS

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