The Journal of Immunology: 199 (9)

November 1, 2017; Volume 199,Issue 9

IN THIS ISSUE

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In This Issue
A Better Look at AID See article p. 3023
Nondeletional Roles for Nur77 See article p. 3147
Virus Wreaks Neonatal Havoc See article p. 3212
Boosting Subdominant Cancer-Specific CD8⁺ T Cells See article p. 3348

J Immunol November 1, 2017, 199 (9) 3009-3010; DOI: https://doi.org/10.4049/jimmunol.1790019

PILLARS OF IMMUNOLOGY

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Stacking the Deck: Studies of Patients with Multiple Autoimmune Diseases Propelled Our Understanding of Type 1 Diabetes as an Autoimmune Disease
Jane H. Buckner and Carla J. Greenbaum

J Immunol November 1, 2017, 199 (9) 3011-3013; DOI: https://doi.org/10.4049/jimmunol.1701299
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Pillars Article: Islet-cell Antibodies in Diabetes Mellitus with Autoimmune Polyendocrine Deficiencies. Lancet. 1974. 304: 1279-1283
Gian Franco Bottazzo, Alejo Florin-Christensen and Deborah Doniach

J Immunol November 1, 2017, 199 (9) 3014-3018; DOI: https://doi.org/10.4049/jimmunol.1701303
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Pillars Article: Antibodies to Pancreatic Islet Cells in Insulin-dependent Diabetics with Coexistent Autoimmune Disease. Lancet. 1974. 304: 1529-1531
A. C. MacCuish, W. J. Irvine, E. W. Barnes and L. J. P. Duncan

J Immunol November 1, 2017, 199 (9) 3019-3021; DOI: https://doi.org/10.4049/jimmunol.1701304

ANTIGEN RECOGNITION AND RESPONSES

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Efficient Induction of Ig Gene Hypermutation in Ex Vivo–Activated Primary B Cells
Jun Liu, Ermeng Xiong, Hanying Zhu, Hiromi Mori, Shoya Yasuda, Kazuo Kinoshita, Takeshi Tsubata and Ji-Yang Wang

J Immunol November 1, 2017, 199 (9) 3023-3030; DOI: https://doi.org/10.4049/jimmunol.1700868

AUTOIMMUNITY

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Wnt/β-Catenin Signaling Induces Integrin α4β1 in T Cells and Promotes a Progressive Neuroinflammatory Disease in Mice
Daniele Sorcini, Stefano Bruscoli, Tiziana Frammartino, Monica Cimino, Emanuela Mazzon, Maria Galuppo, Placido Bramanti, Mumna Al-Banchaabouchi, Dominika Farley, Olga Ermakova, Olga Britanova, Mark Izraelson, Dmitry Chudakov, Michele Biagioli, Paolo Sportoletti, Sara Flamini, Marcello Raspa, Ferdinando Scavizzi, Claus Nerlov, Graziella Migliorati, Carlo Riccardi and Oxana Bereshchenko

J Immunol November 1, 2017, 199 (9) 3031-3041; DOI: https://doi.org/10.4049/jimmunol.1700247
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Pathogenic Role for γδ T Cells in Autoimmune Anti-Myeloperoxidase Glomerulonephritis
Poh-Yi Gan, Takeshi Fujita, Joshua Daniel Ooi, Maliha Asghar Alikhan, Jonathan Dick, Raymond Shim, Dragana Odobasic, Kim Maree O’Sullivan, Arthur Richard Kitching and Stephen Roger Holdsworth

J Immunol November 1, 2017, 199 (9) 3042-3050; DOI: https://doi.org/10.4049/jimmunol.1602025
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NFAT1 Regulates Systemic Autoimmunity through the Modulation of a Dendritic Cell Property
Chang-Suk Chae, Gi-Cheon Kim, Eun Sil Park, Choong-Gu Lee, Ravi Verma, Hagg-Lim Cho, Chang-Duk Jun, Yung Joon Yoo and Sin-Hyeog Im

J Immunol November 1, 2017, 199 (9) 3051-3062; DOI: https://doi.org/10.4049/jimmunol.1700882
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SHIP-1 Deficiency in AID⁺ B Cells Leads to the Impaired Function of B10 Cells with Spontaneous Autoimmunity
Yingjia Chen, Fanlei Hu, Xuejiao Dong, Meng Zhao, Jing Wang, Xiaolin Sun, Tae Jin Kim, Zhanguo Li and Wanli Liu

J Immunol November 1, 2017, 199 (9) 3063-3073; DOI: https://doi.org/10.4049/jimmunol.1700138

CLINICAL AND HUMAN IMMUNOLOGY

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In Utero Exposure to Histological Chorioamnionitis Primes the Exometabolomic Profiles of Preterm CD4⁺ T Lymphocytes
Poojitha Matta, Stacy D. Sherrod, Christina C. Marasco, Daniel J. Moore, John A. McLean and Joern-Hendrik Weitkamp

J Immunol November 1, 2017, 199 (9) 3074-3085; DOI: https://doi.org/10.4049/jimmunol.1601880
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Basic Fibroblast Growth Factor 2 Is a Determinant of CD4 T Cell–Airway Smooth Muscle Cell Communication through Membrane Conduits
Soroor Farahnak, Toby K. McGovern, Rachael Kim, Michael O’Sullivan, Brian Chen, Minhyoung Lee, Haruka Yoshie, Anna Wang, Joyce Jang, Saba Al Heialy, Anne-Marie Lauzon and James G. Martin

J Immunol November 1, 2017, 199 (9) 3086-3093; DOI: https://doi.org/10.4049/jimmunol.1700164

IMMUNE REGULATION

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Myeloid-Derived Suppressor Cells Inhibit T Follicular Helper Cell Immune Response in Japanese Encephalitis Virus Infection
Chong Wang, Nan Zhang, Luting Qi, Jiaolong Yuan, Ke Wang, Kunlun Wang, Sicong Ma, Haili Wang, Wenjuan Lou, Pingdong Hu, Muhammad Awais, Shengbo Cao, Zhen F. Fu and Min Cui

J Immunol November 1, 2017, 199 (9) 3094-3105; DOI: https://doi.org/10.4049/jimmunol.1700671
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Small Nuclear Ribonucleoprotein Polypeptide A–Mediated Alternative Polyadenylation of STAT5B during Th1 Cell Differentiation
Feifei Qiu, Yonggui Fu, Chan Lu, Yuchao Feng, Qiong Wang, Zhanfeng Huo, Xin Jia, Chengyong Chen, Shangwu Chen and Anlong Xu

J Immunol November 1, 2017, 199 (9) 3106-3115; DOI: https://doi.org/10.4049/jimmunol.1601872
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Human CD22 Inhibits Murine B Cell Receptor Activation in a Human CD22 Transgenic Mouse Model
Kyle J. Bednar, Elena Shanina, Romain Ballet, Edward P. Connors, Shiteng Duan, Joana Juan, Britni M. Arlian, Michael D. Kulis, Eugene C. Butcher, Wai-Ping Fung-Leung, Tadimeti S. Rao, James C. Paulson and Matthew S. Macauley

J Immunol November 1, 2017, 199 (9) 3116-3128; DOI: https://doi.org/10.4049/jimmunol.1700898
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IL-17–Secreting γδ T Cells Are Completely Dependent upon CCR6 for Homing to Inflamed Skin
James J. Campbell, Karen Ebsworth, Linda S. Ertl, Jeffrey P. McMahon, Dale Newland, Yu Wang, Shirley Liu, Zhenhua Miao, Ton Dang, Penglie Zhang, Israel F. Charo, Rajinder Singh and Thomas J. Schall

J Immunol November 1, 2017, 199 (9) 3129-3136; DOI: https://doi.org/10.4049/jimmunol.1700826
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The Cooperative Role of CD326⁺ and CD11b⁺ Dendritic Cell Subsets for a Hapten-Induced Th2 Differentiation
Yuri Cho, Dohyeong Kwon and Suk-Jo Kang

J Immunol November 1, 2017, 199 (9) 3137-3146; DOI: https://doi.org/10.4049/jimmunol.1601262

IMMUNE SYSTEM DEVELOPMENT

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Nur77 Regulates Nondeletional Mechanisms of Tolerance in T Cells
Qian Nancy Hu, Alexander Y. W. Suen, Laura M. Henao Caviedes and Troy A. Baldwin

J Immunol November 1, 2017, 199 (9) 3147-3157; DOI: https://doi.org/10.4049/jimmunol.1701085

IMMUNOGENETICS

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H3K27 Methylation Dynamics during CD4 T Cell Activation: Regulation of JAK/STAT and IL12RB2 Expression by JMJD3
Sarah A. LaMere, Ryan C. Thompson, Xiangzhi Meng, H. Kiyomi Komori, Adam Mark and Daniel R. Salomon

J Immunol November 1, 2017, 199 (9) 3158-3175; DOI: https://doi.org/10.4049/jimmunol.1700475

INFECTIOUS DISEASE AND HOST RESPONSE

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Aging-Impaired Filamentous Actin Polymerization Signaling Reduces Alveolar Macrophage Phagocytosis of Bacteria
Zhigang Li, Yang Jiao, Erica K. Fan, Melanie J. Scott, Yuehua Li, Song Li, Timothy R. Billiar, Mark A. Wilson, Xueyin Shi and Jie Fan

J Immunol November 1, 2017, 199 (9) 3176-3186; DOI: https://doi.org/10.4049/jimmunol.1700140
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Cytomegalovirus (CMV) Epitope–Specific CD4⁺ T Cells Are Inflated in HIV⁺ CMV⁺ Subjects
Chike O. Abana, Mark A. Pilkinton, Silvana Gaudieri, Abha Chopra, Wyatt J. McDonnell, Celestine Wanjalla, Louise Barnett, Rama Gangula, Cindy Hager, Dae K. Jung, Brian G. Engelhardt, Madan H. Jagasia, Paul Klenerman, Elizabeth J. Phillips, David M. Koelle, Spyros A. Kalams and Simon A. Mallal

J Immunol November 1, 2017, 199 (9) 3187-3201; DOI: https://doi.org/10.4049/jimmunol.1700851
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Phenotypic and Functional Characterization of Circulatory, Splenic, and Hepatic NK Cells in Simian Immunodeficiency Virus–Controlling Macaques
Diego A. Vargas-Inchaustegui, Sabrina Helmold Hait, Hye Kyung Chung, Jigna Narola, Tanya Hoang and Marjorie Robert-Guroff

J Immunol November 1, 2017, 199 (9) 3202-3211; DOI: https://doi.org/10.4049/jimmunol.1700586
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CD8⁺ T Cells Prevent Lethality from Neonatal Murine Roseolovirus Infection
Swapneel J. Patel and Wayne M. Yokoyama

J Immunol November 1, 2017, 199 (9) 3212-3221; DOI: https://doi.org/10.4049/jimmunol.1700982

INNATE IMMUNITY AND INFLAMMATION

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NEMO–IKKβ Are Essential for IRF3 and NF-κB Activation in the cGAS–STING Pathway
Run Fang, Chenguang Wang, Qifei Jiang, Mengze Lv, Pengfei Gao, Xiaoyu Yu, Ping Mu, Rui Zhang, Sheng Bi, Ji-Ming Feng and Zhengfan Jiang

J Immunol November 1, 2017, 199 (9) 3222-3233; DOI: https://doi.org/10.4049/jimmunol.1700699
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Monitoring C5aR2 Expression Using a Floxed tdTomato-C5aR2 Knock-In Mouse
Christian M. Karsten, Anna V. Wiese, Fabian Mey, Julia Figge, Trent M. Woodruff, Tom Reuter, Olga Scurtu, Anna Kordowski, Larissa N. Almeida, Daria Briukhovetska, Katharina M. Quell, Jing Sun, Fanny Ender, Inken Schmudde, Tillman Vollbrandt, Yves Laumonnier and Jörg Köhl

J Immunol November 1, 2017, 199 (9) 3234-3248; DOI: https://doi.org/10.4049/jimmunol.1700710
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The PYHIN Protein p205 Regulates the Inflammasome by Controlling Asc Expression
Sreya Ghosh, Christina Wallerath, Sergio Covarrubias, Veit Hornung, Susan Carpenter and Katherine A. Fitzgerald

J Immunol November 1, 2017, 199 (9) 3249-3260; DOI: https://doi.org/10.4049/jimmunol.1700823
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Green Tea Polyphenol EGCG Upregulates Tollip Expression by Suppressing Elf-1 Expression
Motofumi Kumazoe, Mai Yamashita, Yuki Nakamura, Kanako Takamatsu, Jaehoon Bae, Shuya Yamashita, Shuhei Yamada, Hiroaki Onda, Takashi Nojiri, Kenji Kangawa and Hirofumi Tachibana

J Immunol November 1, 2017, 199 (9) 3261-3269; DOI: https://doi.org/10.4049/jimmunol.1601822
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Type III IFNs Are Commonly Induced by Bacteria-Sensing TLRs and Reinforce Epithelial Barriers during Infection
Charlotte Odendall, Andrew A. Voak and Jonathan C. Kagan

J Immunol November 1, 2017, 199 (9) 3270-3279; DOI: https://doi.org/10.4049/jimmunol.1700250
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HERP Binds TBK1 To Activate Innate Immunity and Repress Virus Replication in Response to Endoplasmic Reticulum Stress
Maolin Ge, Zhen Luo, Zhi Qiao, Yao Zhou, Xin Cheng, Qibin Geng, Yanyan Cai, Pin Wan, Ying Xiong, Fang Liu, Kailang Wu, Yingle Liu and Jianguo Wu

J Immunol November 1, 2017, 199 (9) 3280-3292; DOI: https://doi.org/10.4049/jimmunol.1700376
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Priming and Activation of Inflammasome by Canarypox Virus Vector ALVAC via the cGAS/IFI16–STING–Type I IFN Pathway and AIM2 Sensor
Fengliang Liu, Qingli Niu, Xiuzhen Fan, Connie Liu, Jie Zhang, Zhi Wei, Wei Hou, Thirumala-Devi Kanneganti, Merlin L. Robb, Jerome H. Kim, Nelson L. Michael, Jiaren Sun, Lynn Soong and Haitao Hu

J Immunol November 1, 2017, 199 (9) 3293-3305; DOI: https://doi.org/10.4049/jimmunol.1700698
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Interaction of Neutrophils with Macrophages Promotes IL-1β Maturation and Contributes to Hepatic Ischemia–Reperfusion Injury
Ai Sadatomo, Yoshiyuki Inoue, Homare Ito, Tadayoshi Karasawa, Hiroaki Kimura, Sachiko Watanabe, Yoshiko Mizushina, Jun Nakamura, Ryo Kamata, Tadashi Kasahara, Hisanaga Horie, Naohiro Sata and Masafumi Takahashi

J Immunol November 1, 2017, 199 (9) 3306-3315; DOI: https://doi.org/10.4049/jimmunol.1700717

MUCOSAL IMMUNOLOGY

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IL-22 Increases Permeability of Intestinal Epithelial Tight Junctions by Enhancing Claudin-2 Expression
Yaya Wang, John Brian Mumm, Ronald Herbst, Roland Kolbeck and Yue Wang

J Immunol November 1, 2017, 199 (9) 3316-3325; DOI: https://doi.org/10.4049/jimmunol.1700152
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Identification of IL-40, a Novel B Cell–Associated Cytokine
Jovani Catalan-Dibene, Monica I. Vazquez, Van Phi Luu, Sean-Paul Nuccio, Alborz Karimzadeh, Jenna M. Kastenschmidt, S. Armando Villalta, Irina Ushach, Egest J. Pone, Paolo Casali, Manuela Raffatellu, Amanda M. Burkhardt, Marcela Hernandez-Ruiz, Gina Heller, Peter A. Hevezi and Albert Zlotnik

J Immunol November 1, 2017, 199 (9) 3326-3335; DOI: https://doi.org/10.4049/jimmunol.1700534

SYSTEMS IMMUNOLOGY

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CD151 Expression Is Associated with a Hyperproliferative T Cell Phenotype
Lillian Seu, Christopher Tidwell, Laura Timares, Alexandra Duverger, Frederic H. Wagner, Paul A. Goepfert, Andrew O. Westfall, Steffanie Sabbaj and Olaf Kutsch

J Immunol November 1, 2017, 199 (9) 3336-3347; DOI: https://doi.org/10.4049/jimmunol.1700648

TUMOR IMMUNOLOGY

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PD-1 Blockade Promotes Epitope Spreading in Anticancer CD8⁺ T Cell Responses by Preventing Fratricidal Death of Subdominant Clones To Relieve Immunodomination
Arash Memarnejadian, Courtney E. Meilleur, Christopher R. Shaler, Khashayarsha Khazaie, Jack R. Bennink, Todd D. Schell and S. M. Mansour Haeryfar

J Immunol November 1, 2017, 199 (9) 3348-3359; DOI: https://doi.org/10.4049/jimmunol.1700643

NOVEL IMMUNOLOGICAL METHODS

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NetMHCpan-4.0: Improved Peptide–MHC Class I Interaction Predictions Integrating Eluted Ligand and Peptide Binding Affinity Data
Vanessa Jurtz, Sinu Paul, Massimo Andreatta, Paolo Marcatili, Bjoern Peters and Morten Nielsen

J Immunol November 1, 2017, 199 (9) 3360-3368; DOI: https://doi.org/10.4049/jimmunol.1700893
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Reconstructing Antibody Repertoires from Error-Prone Immunosequencing Reads
Alexander Shlemov, Sergey Bankevich, Andrey Bzikadze, Maria A. Turchaninova, Yana Safonova and Pavel A. Pevzner

J Immunol November 1, 2017, 199 (9) 3369-3380; DOI: https://doi.org/10.4049/jimmunol.1700485

CORRECTIONS

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Correction: IL-33 Signaling Regulates Innate IL-17A and IL-22 Production via Suppression of Prostaglandin E₂ during Lung Fungal Infection
Jaleesa M. Garth, Kristen M. Reeder, Matthew S. Godwin, Joseph J. Mackel, Chad W. Dunaway, Jonathan P. Blackburn and Chad Steele

J Immunol November 1, 2017, 199 (9) 3381; DOI: https://doi.org/10.4049/jimmunol.1701301

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Table of Contents

IN THIS ISSUE

PILLARS OF IMMUNOLOGY

ANTIGEN RECOGNITION AND RESPONSES

AUTOIMMUNITY

CLINICAL AND HUMAN IMMUNOLOGY

IMMUNE REGULATION

IMMUNE SYSTEM DEVELOPMENT

IMMUNOGENETICS

INFECTIOUS DISEASE AND HOST RESPONSE

INNATE IMMUNITY AND INFLAMMATION

MUCOSAL IMMUNOLOGY

SYSTEMS IMMUNOLOGY

TUMOR IMMUNOLOGY

NOVEL IMMUNOLOGICAL METHODS

CORRECTIONS

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