The Journal of Immunology: 199 (8)

October 15, 2017; Volume 199,Issue 8

IN THIS ISSUE

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In This Issue
Exhaustive Elucidation of HLA-Bound Peptides See article p. 2639
Finding Flexibility in the Formation of γδ T cells See article p. 2668
cPLA2α Controls Neutrophil Transit See article p. 2873
HVEM Helps T Cells Maintain Memory See article p. 2968

J Immunol October 15, 2017, 199 (8) 2609-2610; DOI: https://doi.org/10.4049/jimmunol.1790018

CUTTING EDGE

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Cutting Edge: Genetic Association between IFI16 Single Nucleotide Polymorphisms and Resistance to Genital Herpes Correlates with IFI16 Expression Levels and HSV-2–Induced IFN-β Expression
Kristina Eriksson, Alexandra Svensson, Alon S. Hait, Kerstin Schlüter, Petra Tunbäck, Inger Nordström, Leonid Padyukov, Jan-Åke Liljeqvist, Trine H. Mogensen and Søren R. Paludan

J Immunol October 15, 2017, 199 (8) 2613-2617; DOI: https://doi.org/10.4049/jimmunol.1700385
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Cutting Edge: Endogenous IFN-β Regulates Survival and Development of Transitional B Cells
Jennie A. Hamilton, Qi Wu, PingAr Yang, Bao Luo, Shanrun Liu, Huixian Hong, Jun Li, Mark R. Walter, Eleanor N. Fish, Hui-Chen Hsu and John D. Mountz

J Immunol October 15, 2017, 199 (8) 2618-2623; DOI: https://doi.org/10.4049/jimmunol.1700888
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Cutting Edge: A Critical Role of Lesional T Follicular Helper Cells in the Pathogenesis of IgG4-Related Disease
Ryuta Kamekura, Kenichi Takano, Motohisa Yamamoto, Koji Kawata, Katsunori Shigehara, Sumito Jitsukawa, Tomonori Nagaya, Fumie Ito, Akinori Sato, Noriko Ogasawara, Chieko Tsubomatsu, Hiroki Takahashi, Hiroshi Nakase, Tetsuo Himi and Shingo Ichimiya

J Immunol October 15, 2017, 199 (8) 2624-2629; DOI: https://doi.org/10.4049/jimmunol.1601507

ANTIGEN RECOGNITION AND RESPONSES

Open Access
Activation of Human Mucosal-Associated Invariant T Cells Induces CD40L-Dependent Maturation of Monocyte-Derived and Primary Dendritic Cells
Author Choice Article

Mariolina Salio, Olivier Gasser, Claudia Gonzalez-Lopez, Anne Martens, Natacha Veerapen, Uzi Gileadi, Jacob G. Verter, Giorgio Napolitani, Regan Anderson, Gavin Painter, Gurdyal S. Besra, Ian F. Hermans and Vincenzo Cerundolo

J Immunol October 15, 2017, 199 (8) 2631-2638; DOI: https://doi.org/10.4049/jimmunol.1700615
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Unveiling the Peptide Motifs of HLA-C and HLA-G from Naturally Presented Peptides and Generation of Binding Prediction Matrices
Moreno Di Marco, Heiko Schuster, Linus Backert, Michael Ghosh, Hans-Georg Rammensee and Stefan Stevanović

J Immunol October 15, 2017, 199 (8) 2639-2651; DOI: https://doi.org/10.4049/jimmunol.1700938
Open Access
Integration of Kinase and Calcium Signaling at the Level of Chromatin Underlies Inducible Gene Activation in T Cells
Author Choice Article

Ruth Brignall, Pierre Cauchy, Sarah L. Bevington, Bethany Gorman, Angela O. Pisco, James Bagnall, Christopher Boddington, William Rowe, Hazel England, Kevin Rich, Lorraine Schmidt, Nigel P. Dyer, Mark A. Travis, Sascha Ott, Dean A. Jackson, Peter N. Cockerill and Pawel Paszek

J Immunol October 15, 2017, 199 (8) 2652-2667; DOI: https://doi.org/10.4049/jimmunol.1602033

AUTOIMMUNITY

Open Access
IL-1β and IL-23 Promote Extrathymic Commitment of CD27⁺CD122⁻ γδ T Cells to γδT17 Cells
Author Choice Article

Andreas Muschaweckh, Franziska Petermann and Thomas Korn

J Immunol October 15, 2017, 199 (8) 2668-2679; DOI: https://doi.org/10.4049/jimmunol.1700287
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NFM Cross-Reactivity to MOG Does Not Expand a Critical Threshold Level of High-Affinity T Cells Necessary for Onset of Demyelinating Disease
Lori Blanchfield, Joseph J. Sabatino Jr., Laurel Lawrence and Brian D. Evavold

J Immunol October 15, 2017, 199 (8) 2680-2691; DOI: https://doi.org/10.4049/jimmunol.1700792
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The Role of Leukocyte-Associated Ig-like Receptor-1 in Suppressing Collagen-Induced Arthritis
Seunghyun Kim, Ellis R. Easterling, Lauren C. Price, Savannah L. Smith, John E. Coligan, Jeoung-Eun Park, David D. Brand, Edward F. Rosloniec, John M. Stuart, Andrew H. Kang and Linda K. Myers

J Immunol October 15, 2017, 199 (8) 2692-2700; DOI: https://doi.org/10.4049/jimmunol.1700271

IMMUNE REGULATION

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Sublethal Total Body Irradiation Causes Long-Term Deficits in Thymus Function by Reducing Lymphoid Progenitors
Shiyun Xiao, Ivo D. Shterev, Wen Zhang, Lauren Young, Jae-Hung Shieh, Malcolm Moore, Marcel van den Brink, Gregory D. Sempowski and Nancy R. Manley

J Immunol October 15, 2017, 199 (8) 2701-2712; DOI: https://doi.org/10.4049/jimmunol.1600934
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Peripheral Deletion of CD8 T Cells Requires p38 MAPK in Cross-Presenting Dendritic Cells
Trevor Smith, Xiaotian Lin, Marielle Mello, Kristi Marquardt, Jocelyn Cheung, Binfeng Lu, Linda A. Sherman and Grégory Verdeil

J Immunol October 15, 2017, 199 (8) 2713-2720; DOI: https://doi.org/10.4049/jimmunol.1700427
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Regulatory T Cell–Mediated Suppression of Inflammation Induced by DR3 Signaling Is Dependent on Galectin-9
Shravan Madireddi, So-Young Eun, Amit K. Mehta, Aruna Birta, Dirk M. Zajonc, Toshiro Niki, Mitsuomi Hirashima, Eckhard R. Podack, Taylor H. Schreiber and Michael Croft

J Immunol October 15, 2017, 199 (8) 2721-2728; DOI: https://doi.org/10.4049/jimmunol.1700575
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Maternal Pregravid Obesity Remodels the DNA Methylation Landscape of Cord Blood Monocytes Disrupting Their Inflammatory Program
Suhas Sureshchandra, Randall M. Wilson, Maham Rais, Nicole E. Marshall, Jonathan Q. Purnell, Kent L. Thornburg and Ilhem Messaoudi

J Immunol October 15, 2017, 199 (8) 2729-2744; DOI: https://doi.org/10.4049/jimmunol.1700434
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T Cells Regulate Peripheral Naive Mature B Cell Survival by Cell–Cell Contact Mediated through SLAMF6 and SAP
Lihi Radomir, Sivan Cohen, Matthias P. Kramer, Eszter Bakos, Hadas Lewinsky, Avital Barak, Ziv Porat, Richard Bucala, Polina Stepensky, Shirly Becker-Herman and Idit Shachar

J Immunol October 15, 2017, 199 (8) 2745-2757; DOI: https://doi.org/10.4049/jimmunol.1700557

IMMUNE SYSTEM DEVELOPMENT

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Grb2-Mediated Recruitment of USP9X to LAT Enhances Themis Stability following Thymic Selection
Anne Garreau, Gaëtan Blaize, Jérémy Argenty, Nelly Rouquié, Audrey Tourdès, Stephen A. Wood, Abdelhadi Saoudi and Renaud Lesourne

J Immunol October 15, 2017, 199 (8) 2758-2766; DOI: https://doi.org/10.4049/jimmunol.1700566
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IL-4/IL-13 Signaling Inhibits the Potential of Early Thymic Progenitors To Commit to the T Cell Lineage
Subhasis Barik, Mindy M. Miller, Alexis N. Cattin-Roy, Tobechukwu K. Ukah, Weirong Chen and Habib Zaghouani

J Immunol October 15, 2017, 199 (8) 2767-2776; DOI: https://doi.org/10.4049/jimmunol.1700498
Open Access
Fate Decision Between Group 3 Innate Lymphoid and Conventional NK Cell Lineages by Notch Signaling in Human Circulating Hematopoietic Progenitors
Author Choice Article

Seishi Kyoizumi, Yoshiko Kubo, Junko Kajimura, Kengo Yoshida, Tomonori Hayashi, Kei Nakachi, Malcolm A. Moore, Marcel R. M. van den Brink and Yoichiro Kusunoki

J Immunol October 15, 2017, 199 (8) 2777-2793; DOI: https://doi.org/10.4049/jimmunol.1601711

IMMUNOTHERAPY AND VACCINES

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Enhancing Vaccine Efficacy by Engineering a Complex Synthetic Peptide To Become a Super Immunogen
Therése Nordström, Manisha Pandey, Ainslie Calcutt, Jessica Powell, Zachary N. Phillips, Grace Yeung, Ashwini K. Giddam, Yun Shi, Thomas Haselhorst, Mark von Itzstein, Michael R. Batzloff and Michael F. Good

J Immunol October 15, 2017, 199 (8) 2794-2802; DOI: https://doi.org/10.4049/jimmunol.1700836

INFECTIOUS DISEASE AND HOST RESPONSE

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Complexity of Complement Resistance Factors Expressed by Acinetobacter baumannii Needed for Survival in Human Serum
Amaro F. Sanchez-Larrayoz, Noha M. Elhosseiny, Marc G. Chevrette, Yang Fu, Peter Giunta, Raúl G. Spallanzani, Keerthikka Ravi, Gerald B. Pier, Stephen Lory and Tomás Maira-Litrán

J Immunol October 15, 2017, 199 (8) 2803-2814; DOI: https://doi.org/10.4049/jimmunol.1700877
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IL-21 Receptor Signaling Is Essential for Optimal CD4⁺ T Cell Function and Control of Mycobacterium tuberculosis Infection in Mice
Satyanarayana Swamy Cheekatla, Deepak Tripathi, Sambasivan Venkatasubramanian, Padmaja Paidipally, Elwyn Welch, Amy R. Tvinnereim, Roza Nurieva and Ramakrishna Vankayalapati

J Immunol October 15, 2017, 199 (8) 2815-2822; DOI: https://doi.org/10.4049/jimmunol.1601231
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An Anti-Inflammatory Role for NLRP10 in Murine Cutaneous Leishmaniasis
Gwendolyn M. Clay, Diogo G. Valadares, Joel W. Graff, Tyler K. Ulland, Richard E. Davis, Breanna M. Scorza, Bayan Sudan Zhanbolat, Yani Chen, Fayyaz S. Sutterwala and Mary E. Wilson

J Immunol October 15, 2017, 199 (8) 2823-2833; DOI: https://doi.org/10.4049/jimmunol.1500832
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Therapeutic Effects of Monoclonal Antibody against Dengue Virus NS1 in a STAT1 Knockout Mouse Model of Dengue Infection
Shu-Wen Wan, Pei-Wei Chen, Chin-Yu Chen, Yen-Chung Lai, Ya-Ting Chu, Chia-Yi Hung, Han Lee, Hsuan Franziska Wu, Yung-Chun Chuang, Jessica Lin, Chih-Peng Chang, Shuying Wang, Ching-Chuan Liu, Tzong-Shiann Ho, Chiou-Feng Lin, Chien-Kuo Lee, Betty A. Wu-Hsieh, Robert Anderson, Trai-Ming Yeh and Yee-Shin Lin

J Immunol October 15, 2017, 199 (8) 2834-2844; DOI: https://doi.org/10.4049/jimmunol.1601523
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A Chlamydia-Specific TCR-Transgenic Mouse Demonstrates Th1 Polyfunctionality with Enhanced Effector Function
Taylor B. Poston, Yanyan Qu, Jenna Girardi, Catherine M. O’Connell, Lauren C. Frazer, Ali N. Russell, McKensie Wall, Uma M. Nagarajan and Toni Darville

J Immunol October 15, 2017, 199 (8) 2845-2854; DOI: https://doi.org/10.4049/jimmunol.1700914
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NLRP3 and Potassium Efflux Drive Rapid IL-1β Release from Primary Human Monocytes during Toxoplasma gondii Infection
Lanny Gov, Christine A. Schneider, Tatiane S. Lima, William Pandori and Melissa B. Lodoen

J Immunol October 15, 2017, 199 (8) 2855-2864; DOI: https://doi.org/10.4049/jimmunol.1700245

INNATE IMMUNITY AND INFLAMMATION

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NKG2D Signaling between Human NK Cells Enhances TACE-Mediated TNF-α Release
Neekun Sharma, Camille V. Trinidad, Andrew P. Trembath and Mary A. Markiewicz

J Immunol October 15, 2017, 199 (8) 2865-2872; DOI: https://doi.org/10.4049/jimmunol.1700647
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Neutrophil-Derived Cytosolic PLA2α Contributes to Bacterial-Induced Neutrophil Transepithelial Migration
Lael M. Yonker, Michael A. Pazos, Bernard B. Lanter, Hongmei Mou, Kengyeh K. Chu, Alexander D. Eaton, Joseph V. Bonventre, Guillermo J. Tearney, Jayaraj Rajagopal and Bryan P. Hurley

J Immunol October 15, 2017, 199 (8) 2873-2884; DOI: https://doi.org/10.4049/jimmunol.1700539
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Viral Infection Sensitizes Human Fetal Membranes to Bacterial Lipopolysaccharide by MERTK Inhibition and Inflammasome Activation
Sarah N. Cross, Julie A. Potter, Paulomi Aldo, Ja Young Kwon, Mary Pitruzzello, Mancy Tong, Seth Guller, Carla V. Rothlin, Gil Mor and Vikki M. Abrahams

J Immunol October 15, 2017, 199 (8) 2885-2895; DOI: https://doi.org/10.4049/jimmunol.1700870
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The Scaffolding Protein IQGAP1 Interacts with NLRC3 and Inhibits Type I IFN Production
Aaron M. Tocker, Emily Durocher, Kimberly D. Jacob, Kate E. Trieschman, Suzanna M. Talento, Alma A. Rechnitzer, David M. Roberts and Beckley K. Davis

J Immunol October 15, 2017, 199 (8) 2896-2909; DOI: https://doi.org/10.4049/jimmunol.1601370
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Cyclodextrin Reduces Cholesterol Crystal–Induced Inflammation by Modulating Complement Activation
Siril S. Bakke, Marie H. Aune, Nathalie Niyonzima, Katrine Pilely, Liv Ryan, Mona Skjelland, Peter Garred, Pål Aukrust, Bente Halvorsen, Eicke Latz, Jan K. Damås, Tom E. Mollnes and Terje Espevik

J Immunol October 15, 2017, 199 (8) 2910-2920; DOI: https://doi.org/10.4049/jimmunol.1700302
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IL-17A Produced by Innate Lymphoid Cells Is Essential for Intestinal Ischemia-Reperfusion Injury
Mayya Geha, Maria G. Tsokos, Robin E. Bosse, Tatyana Sannikova, Yoichiro Iwakura, Jurandir J. Dalle Lucca, Rene De Waal Malefyt and George C. Tsokos

J Immunol October 15, 2017, 199 (8) 2921-2929; DOI: https://doi.org/10.4049/jimmunol.1700655
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Activated Protein C Attenuates Severe Inflammation by Targeting VLA-3^high Neutrophil Subpopulation in Mice
Pranita P. Sarangi, Hyun-wook Lee, Yelena V. Lerman, Alissa Trzeciak, Eric J. Harrower, Alireza R. Rezaie and Minsoo Kim

J Immunol October 15, 2017, 199 (8) 2930-2936; DOI: https://doi.org/10.4049/jimmunol.1700541
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Anti-Inflammatory Role of Langerhans Cells and Apoptotic Keratinocytes in Ultraviolet-B–Induced Cutaneous Inflammation
Mayumi Hatakeyama, Atsushi Fukunaga, Ken Washio, Kumiko Taguchi, Yoshiko Oda, Kanako Ogura and Chikako Nishigori

J Immunol October 15, 2017, 199 (8) 2937-2947; DOI: https://doi.org/10.4049/jimmunol.1601681

MOLECULAR AND STRUCTURAL IMMUNOLOGY

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The Neurobeachin-like 2 Protein Regulates Mast Cell Homeostasis
Sebastian Drube, Randy Grimlowski, Carsten Deppermann, Julia Fröbel, Florian Kraft, Nico Andreas, David Stegner, Jan Dudeck, Franziska Weber, Mandy Rödiger, Christiane Göpfert, Julia Drube, Daniela Reich, Bernhard Nieswandt, Anne Dudeck and Thomas Kamradt

J Immunol October 15, 2017, 199 (8) 2948-2957; DOI: https://doi.org/10.4049/jimmunol.1700556
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The Orphan Nuclear Receptor NR4A3 Is Involved in the Function of Dendritic Cells
Masanori Nagaoka, Takuya Yashiro, Yuna Uchida, Tomoaki Ando, Mutsuko Hara, Hajime Arai, Hideoki Ogawa, Ko Okumura, Kazumi Kasakura and Chiharu Nishiyama

J Immunol October 15, 2017, 199 (8) 2958-2967; DOI: https://doi.org/10.4049/jimmunol.1601911

MUCOSAL IMMUNOLOGY

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HVEM Imprints Memory Potential on Effector CD8 T Cells Required for Protective Mucosal Immunity
Pritesh Desai, Georges Abboud, Jessica Stanfield, Paul G. Thomas, Jianxun Song, Carl F. Ware, Michael Croft and Shahram Salek-Ardakani

J Immunol October 15, 2017, 199 (8) 2968-2975; DOI: https://doi.org/10.4049/jimmunol.1700959
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Microbial-Derived Butyrate Promotes Epithelial Barrier Function through IL-10 Receptor–Dependent Repression of Claudin-2
Leon Zheng, Caleb J. Kelly, Kayla D. Battista, Rachel Schaefer, Jordi M. Lanis, Erica E. Alexeev, Ruth X. Wang, Joseph C. Onyiah, Douglas J. Kominsky and Sean P. Colgan

J Immunol October 15, 2017, 199 (8) 2976-2984; DOI: https://doi.org/10.4049/jimmunol.1700105

SYSTEMS IMMUNOLOGY

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Learning the High-Dimensional Immunogenomic Features That Predict Public and Private Antibody Repertoires
Victor Greiff, Cédric R. Weber, Johannes Palme, Ulrich Bodenhofer, Enkelejda Miho, Ulrike Menzel and Sai T. Reddy

J Immunol October 15, 2017, 199 (8) 2985-2997; DOI: https://doi.org/10.4049/jimmunol.1700594

NOVEL IMMUNOLOGICAL METHODS

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New Methods To Analyze B Cell Immune Responses to Thymus-Dependent Antigen Sheep Red Blood Cells
Ellen J. McAllister, John R. Apgar, Charlotte R. Leung, Robert C. Rickert and Julia Jellusova

J Immunol October 15, 2017, 199 (8) 2998-3003; DOI: https://doi.org/10.4049/jimmunol.1700454

CORRECTIONS

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Correction: PRMT5-Selective Inhibitors Suppress Inflammatory T Cell Responses and Experimental Autoimmune Encephalomyelitis
Lindsay M. Webb, Stephanie A. Amici, Kyle A. Jablonski, Himanshu Savardekar, Amanda R. Panfil, Linsen Li, Wei Zhou, Kevin Peine, Vrajesh Karkhanis, Eric M. Bachelder, Kristy M. Ainslie, Patrick L. Green, Chenglong Li, Robert A. Baiocchi and Mireia Guerau-de-Arellano

J Immunol October 15, 2017, 199 (8) 3004; DOI: https://doi.org/10.4049/jimmunol.1701237
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Correction: Cutting Edge: Helminth Coinfection Blocks Effector Differentiation of CD8 T Cells through Alternate Host Th2- and IL-10–Mediated Responses
Andrew Marple, Wenhui Wu, Suhagi Shah, Yanlin Zhao, Peicheng Du, William C. Gause and George S. Yap

J Immunol October 15, 2017, 199 (8) 3005; DOI: https://doi.org/10.4049/jimmunol.1701193

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Table of Contents

IN THIS ISSUE

CUTTING EDGE

ANTIGEN RECOGNITION AND RESPONSES

AUTOIMMUNITY

IMMUNE REGULATION

IMMUNE SYSTEM DEVELOPMENT

IMMUNOTHERAPY AND VACCINES

INFECTIOUS DISEASE AND HOST RESPONSE

INNATE IMMUNITY AND INFLAMMATION

MOLECULAR AND STRUCTURAL IMMUNOLOGY

MUCOSAL IMMUNOLOGY

SYSTEMS IMMUNOLOGY

NOVEL IMMUNOLOGICAL METHODS

CORRECTIONS

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