The Journal of Immunology: 199 (6)

September 15, 2017; Volume 199,Issue 6

IN THIS ISSUE

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In This Issue
DC Notch Knocks Down Th17 Differentiation See article p. 1989
Macrophages Lock Up γδ T Cells in Lymph Nodes See article p. 1998
Suppression of Neonatal Immunity by CD71⁺ Cells See article p. 2081

J Immunol September 15, 2017, 199 (6) 1947-1948; DOI: https://doi.org/10.4049/jimmunol.1790015

BRIEF REVIEWS

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Cytokine-Mediated Regulation of Human Lymphocyte Development and Function: Insights from Primary Immunodeficiencies
Stuart G. Tangye, Simon J. Pelham, Elissa K. Deenick and Cindy S. Ma

J Immunol September 15, 2017, 199 (6) 1949-1958; DOI: https://doi.org/10.4049/jimmunol.1700842

CUTTING EDGE

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Cutting Edge: 2B4-Mediated Coinhibition of CD4⁺ T Cells Underlies Mortality in Experimental Sepsis
Ching-wen Chen, Rohit Mittal, Nathan J. Klingensmith, Eileen M. Burd, Cox Terhorst, Greg S. Martin, Craig M. Coopersmith and Mandy L. Ford

J Immunol September 15, 2017, 199 (6) 1961-1966; DOI: https://doi.org/10.4049/jimmunol.1700375
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Cutting Edge: IL-2–Induced Expression of the Amino Acid Transporters SLC1A5 and CD98 Is a Prerequisite for NKG2D-Mediated Activation of Human NK Cells
Helle Jensen, Marc Potempa, Dagmar Gotthardt and Lewis L. Lanier

J Immunol September 15, 2017, 199 (6) 1967-1972; DOI: https://doi.org/10.4049/jimmunol.1700497
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Cutting Edge: Murine NK Cells Degranulate and Retain Cytotoxic Function without Store-Operated Calcium Entry
Jacquelyn Freund-Brown, Ruth Choa, Brenal K. Singh, Tanner Ford Robertson, Gabrielle M. Ferry, Eric Viver, Hamid Bassiri, Janis K. Burkhardt and Taku Kambayashi

J Immunol September 15, 2017, 199 (6) 1973-1978; DOI: https://doi.org/10.4049/jimmunol.1700340

AUTOIMMUNITY

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IFN-α Negatively Regulates the Expression of Endothelial Nitric Oxide Synthase and Nitric Oxide Production: Implications for Systemic Lupus Erythematosus
Joy Jones Buie, Ludivine L. Renaud, Robin Muise-Helmericks and Jim C. Oates

J Immunol September 15, 2017, 199 (6) 1979-1988; DOI: https://doi.org/10.4049/jimmunol.1600108
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Notch Balances Th17 and Induced Regulatory T Cell Functions in Dendritic Cells by Regulating Aldh1a2 Expression
Taskia Sultana Zaman, Hideki Arimochi, Satoshi Maruyama, Chieko Ishifune, Shin-ichi Tsukumo, Akiko Kitamura and Koji Yasutomo

J Immunol September 15, 2017, 199 (6) 1989-1997; DOI: https://doi.org/10.4049/jimmunol.1700645

IMMUNE REGULATION

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Macrophages Induce Long-Term Trapping of γδ T Cells with Innate-like Properties within Secondary Lymphoid Organs in the Steady State
Alexandra Audemard-Verger, Matthieu Rivière, Aurélie Durand, Elisa Peranzoni, Vincent Guichard, Pauline Hamon, Nelly Bonilla, Thomas Guilbert, Alexandre Boissonnas, Cédric Auffray, Gérard Eberl, Bruno Lucas and Bruno Martin

J Immunol September 15, 2017, 199 (6) 1998-2007; DOI: https://doi.org/10.4049/jimmunol.1700430
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Lamtor1 Is Critically Required for CD4⁺ T Cell Proliferation and Regulatory T Cell Suppressive Function
Takashi Hosokawa, Tetsuya Kimura, Shigeyuki Nada, Tatsusada Okuno, Daisuke Ito, Sujin Kang, Satoshi Nojima, Kazuya Yamashita, Takeshi Nakatani, Yoshitomo Hayama, Yasuhiro Kato, Yuhei Kinehara, Masayuki Nishide, Norihisa Mikami, Syohei Koyama, Hyota Takamatsu, Daisuke Okuzaki, Naganari Ohkura, Shimon Sakaguchi, Masato Okada and Atsushi Kumanogoh

J Immunol September 15, 2017, 199 (6) 2008-2019; DOI: https://doi.org/10.4049/jimmunol.1700157
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PD-L2 Regulates B-1 Cell Antibody Production against Phosphorylcholine through an IL-5–Dependent Mechanism
Jerome T. McKay, Marcela A. Haro, Christina A. Daly, Rama D. Yammani, Bing Pang, W. Edward Swords and Karen M. Haas

J Immunol September 15, 2017, 199 (6) 2020-2029; DOI: https://doi.org/10.4049/jimmunol.1700555

IMMUNOGENETICS

Open Access
α3-Deletion Isoform of HLA-A11 Modulates Cytotoxicity of NK Cells: Correlations with HIV-1 Infection of Cells
Author Choice Article

Xi-He Zhang, Xiao-Dong Lian, Zheng-Xi Dai, Hong-Yi Zheng, Xin Chen and Yong-Tang Zheng

J Immunol September 15, 2017, 199 (6) 2030-2042; DOI: https://doi.org/10.4049/jimmunol.1602183

INFECTIOUS DISEASE AND HOST RESPONSE

Open Access
Resolvin D1 Improves the Resolution of Inflammation via Activating NF-κB p50/p50–Mediated Cyclooxygenase-2 Expression in Acute Respiratory Distress Syndrome
Author Choice Article

Ye Gao, Huawei Zhang, Lingchun Luo, Jing Lin, Dan Li, Sisi Zheng, Hua Huang, Songfan Yan, Jingxiang Yang, Yu Hao, Hui Li, Fang Gao Smith and Shengwei Jin

J Immunol September 15, 2017, 199 (6) 2043-2054; DOI: https://doi.org/10.4049/jimmunol.1700315
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Dectin-1 Activation during Leishmania amazonensis Phagocytosis Prompts Syk-Dependent Reactive Oxygen Species Production To Trigger Inflammasome Assembly and Restriction of Parasite Replication
Djalma S. Lima-Junior, Tiago W. P. Mineo, Vera L. G. Calich and Dario S. Zamboni

J Immunol September 15, 2017, 199 (6) 2055-2068; DOI: https://doi.org/10.4049/jimmunol.1700258
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HIV-1 Infection Is Associated with Depletion and Functional Impairment of Mycobacterium tuberculosis–Specific CD4 T Cells in Individuals with Latent Tuberculosis Infection
Cheryl L. Day, Deborah A. Abrahams, Levelle D. Harris, Michele van Rooyen, Lynnett Stone, Marwou de Kock and Willem A. Hanekom

J Immunol September 15, 2017, 199 (6) 2069-2080; DOI: https://doi.org/10.4049/jimmunol.1700558
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Erythroid Suppressor Cells Compromise Neonatal Immune Response against Bordetella pertussis
Garett Dunsmore, Najmeh Bozorgmehr, Cole Delyea, Petya Koleva, Afshin Namdar and Shokrollah Elahi

J Immunol September 15, 2017, 199 (6) 2081-2095; DOI: https://doi.org/10.4049/jimmunol.1700742

INNATE IMMUNITY AND INFLAMMATION

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The Lipid Kinase PIKfyve Coordinates the Neutrophil Immune Response through the Activation of the Rac GTPase
Roya M. Dayam, Chun X. Sun, Christopher H. Choy, Gemma Mancuso, Michael Glogauer and Roberto J. Botelho

J Immunol September 15, 2017, 199 (6) 2096-2105; DOI: https://doi.org/10.4049/jimmunol.1601466
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Extracellular MicroRNAs Induce Potent Innate Immune Responses via TLR7/MyD88-Dependent Mechanisms
Yan Feng, Lin Zou, Dan Yan, Hongliang Chen, Ganqiong Xu, Wenling Jian, Ping Cui and Wei Chao

J Immunol September 15, 2017, 199 (6) 2106-2117; DOI: https://doi.org/10.4049/jimmunol.1700730
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DOCK8 Drives Src-Dependent NK Cell Effector Function
Conor J. Kearney, Stephin J. Vervoort, Kelly M. Ramsbottom, Andrew J. Freeman, Jessica Michie, Jane Peake, Jean-Laurent Casanova, Capucine Picard, Stuart G. Tangye, Cindy S. Ma, Ricky W. Johnstone, Katrina L. Randall and Jane Oliaro

J Immunol September 15, 2017, 199 (6) 2118-2127; DOI: https://doi.org/10.4049/jimmunol.1700751
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Integrin-Linked Kinase Expression in Myeloid Cells Promotes Inflammatory Signaling during Experimental Colitis
Afsar U. Ahmed, Howard C. H. Yim, Mariah Alorro, Matthias Ernst and Bryan R. G. Williams

J Immunol September 15, 2017, 199 (6) 2128-2139; DOI: https://doi.org/10.4049/jimmunol.1700125
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IL-33 Signaling Regulates Innate IL-17A and IL-22 Production via Suppression of Prostaglandin E₂ during Lung Fungal Infection
Jaleesa M. Garth, Kristen M. Reeder, Matthew S. Godwin, Joseph J. Mackel, Chad W. Dunaway, Jonathan P. Blackburn and Chad Steele

J Immunol September 15, 2017, 199 (6) 2140-2148; DOI: https://doi.org/10.4049/jimmunol.1602186
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Oxidized Low-Density Lipoprotein Loading of Macrophages Downregulates TLR-Induced Proinflammatory Responses in a Gene-Specific and Temporal Manner through Transcriptional Control
Jenny Jongstra-Bilen, Cindy X. Zhang, Timothy Wisnicki, Mengyi K. Li, Samantha White-Alfred, Ragave Ilaalagan, Dario M. Ferri, Ashley Deonarain, Mark H. Wan, Sharon J. Hyduk, Carolyn L. Cummins and Myron I. Cybulsky

J Immunol September 15, 2017, 199 (6) 2149-2157; DOI: https://doi.org/10.4049/jimmunol.1601363

MOLECULAR AND STRUCTURAL IMMUNOLOGY

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Analysis of Factor D Isoforms in Malpuech–Michels–Mingarelli–Carnevale Patients Highlights the Role of MASP-3 as a Maturase in the Alternative Pathway of Complement
Rasmus Pihl, Lisbeth Jensen, Annette G. Hansen, Ida B. Thøgersen, Stephanie Andres, Frederik Dagnæs-Hansen, Konrad Oexle, Jan J. Enghild and Steffen Thiel

J Immunol September 15, 2017, 199 (6) 2158-2170; DOI: https://doi.org/10.4049/jimmunol.1700518

SYSTEMS IMMUNOLOGY

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Deep Immune Profiling of an Arginine-Enriched Nutritional Intervention in Patients Undergoing Surgery
Nima Aghaeepour, Cindy Kin, Edward A. Ganio, Kent P. Jensen, Dyani K. Gaudilliere, Martha Tingle, Amy Tsai, Hope L. Lancero, Benjamin Choisy, Leslie S. McNeil, Robin Okada, Andrew A. Shelton, Garry P. Nolan, Martin S. Angst and Brice L. Gaudilliere

J Immunol September 15, 2017, 199 (6) 2171-2180; DOI: https://doi.org/10.4049/jimmunol.1700421

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Table of Contents

IN THIS ISSUE

BRIEF REVIEWS

CUTTING EDGE

AUTOIMMUNITY

IMMUNE REGULATION

IMMUNOGENETICS

INFECTIOUS DISEASE AND HOST RESPONSE

INNATE IMMUNITY AND INFLAMMATION

MOLECULAR AND STRUCTURAL IMMUNOLOGY

SYSTEMS IMMUNOLOGY

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