The Journal of Immunology: 199 (5)

September 1, 2017; Volume 199,Issue 5

IN THIS ISSUE

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In This Issue
Muted mTOR Modulates Metabolism in Sepsis See article p. 1606
Langerhans Cells Trigger CTL Choices See article p. 1626
Thpok/LRF: Not Just for Conventional T Cells Anymore See article p. 1716
Stromal Cells Respond to Self-Serving IL-17 Made by LSK⁻ Cells See article p. 1783
Finding Steady-State LTi and Macrophage Friendships through the Microbiota See article p. 1912

J Immunol September 1, 2017, 199 (5) 1529-1530; DOI: https://doi.org/10.4049/jimmunol.1790014

PILLARS OF IMMUNOLOGY

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SAP and Lessons Learned from a Primary Immunodeficiency
Jennifer L. Cannons and Pamela L. Schwartzberg

J Immunol September 1, 2017, 199 (5) 1531-1533; DOI: https://doi.org/10.4049/jimmunol.1701007
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Pillars Article: The X-Linked Lymphoproliferative Disease Gene Product SAP Regulates Signals Induced through the Co-Receptor SLAM. Nature. 1998. 395: 462–469
J. Sayos, C. Wu, M. Morra, N. Wang, X. Zhang, D. Allen, S. van Schaik, L. Notarangelo, R. Geha, M. G. Roncarolo, H. Oettgen, J. E. De Vries, G. Aversa and C. Terhorst

J Immunol September 1, 2017, 199 (5) 1534-1541;

BRIEF REVIEWS

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Role of Substance P Neuropeptide in Inflammation, Wound Healing, and Tissue Homeostasis
Susmit Suvas

J Immunol September 1, 2017, 199 (5) 1543-1552; DOI: https://doi.org/10.4049/jimmunol.1601751

CUTTING EDGE

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Cutting Edge: CD3 ITAM Diversity Is Required for Optimal TCR Signaling and Thymocyte Development
Matthew L. Bettini, Po-Chein Chou, Clifford S. Guy, Thomas Lee, Kate M. Vignali and Dario A. A. Vignali

J Immunol September 1, 2017, 199 (5) 1555-1560; DOI: https://doi.org/10.4049/jimmunol.1700069
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Cutting Edge: TRAF6 Mediates TLR/IL-1R Signaling–Induced Nontranscriptional Priming of the NLRP3 Inflammasome
Yue Xing, Xiaomin Yao, Hua Li, Guang Xue, Qiuhong Guo, Guiwen Yang, Liguo An, Yan Zhang and Guangxun Meng

J Immunol September 1, 2017, 199 (5) 1561-1566; DOI: https://doi.org/10.4049/jimmunol.1700175
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Cutting Edge: NKG2D Signaling Enhances NK Cell Responses but Alone Is Insufficient To Drive Expansion during Mouse Cytomegalovirus Infection
Tsukasa Nabekura, Dagmar Gotthardt, Kouta Niizuma, Tihana Trsan, Tina Jenus, Stipan Jonjic and Lewis L. Lanier

J Immunol September 1, 2017, 199 (5) 1567-1571; DOI: https://doi.org/10.4049/jimmunol.1700799

ALLERGY AND OTHER HYPERSENSITIVITIES

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Estrogen Signaling Contributes to Sex Differences in Macrophage Polarization during Asthma
Aleksander Keselman, Xi Fang, Preston B. White and Nicola M. Heller

J Immunol September 1, 2017, 199 (5) 1573-1583; DOI: https://doi.org/10.4049/jimmunol.1601975

AUTOIMMUNITY

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Efficiency and Safety of CRAC Inhibitors in Human Rheumatoid Arthritis Xenograft Models
Shuang Liu, Hitoshi Hasegawa, Erika Takemasa, Yasuyuki Suzuki, Keizou Oka, Takeshi Kiyoi, Hiroyuki Takeda, Tomio Ogasawara, Tatsuya Sawasaki, Masaki Yasukawa and Kazutaka Maeyama

J Immunol September 1, 2017, 199 (5) 1584-1595; DOI: https://doi.org/10.4049/jimmunol.1700192
Open Access
Autoimmunity to Vimentin Is Associated with Outcomes of Patients with Idiopathic Pulmonary Fibrosis
Author Choice Article

Fu Jun Li, Ranu Surolia, Huashi Li, Zheng Wang, Tejaswini Kulkarni, Gang Liu, Joao A. de Andrade, Daniel J. Kass, Victor J. Thannickal, Steven R. Duncan and Veena B. Antony

J Immunol September 1, 2017, 199 (5) 1596-1605; DOI: https://doi.org/10.4049/jimmunol.1700473

CLINICAL AND HUMAN IMMUNOLOGY

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IL-7 Restores T Lymphocyte Immunometabolic Failure in Septic Shock Patients through mTOR Activation
Fabienne Venet, Julie Demaret, Benjamin J. Blaise, Christelle Rouget, Thibaut Girardot, Estellie Idealisoa, Thomas Rimmelé, François Mallet, Alain Lepape, Julien Textoris and Guillaume Monneret

J Immunol September 1, 2017, 199 (5) 1606-1615; DOI: https://doi.org/10.4049/jimmunol.1700127
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Induction of Regulatory T Cells and Its Regulation with Insulin-like Growth Factor/Insulin-like Growth Factor Binding Protein-4 by Human Mesenchymal Stem Cells
Ippei Miyagawa, Shingo Nakayamada, Kazuhisa Nakano, Kaoru Yamagata, Kei Sakata, Kunihiro Yamaoka and Yoshiya Tanaka

J Immunol September 1, 2017, 199 (5) 1616-1625; DOI: https://doi.org/10.4049/jimmunol.1600230

IMMUNE REGULATION

Open Access
Neoantigen Expression in Steady-State Langerhans Cells Induces CTL Tolerance
Author Choice Article

Helen Strandt, Douglas Florindo Pinheiro, Daniel H. Kaplan, Dagmar Wirth, Iris Karina Gratz, Peter Hammerl, Josef Thalhamer and Angelika Stoecklinger

J Immunol September 1, 2017, 199 (5) 1626-1634; DOI: https://doi.org/10.4049/jimmunol.1602098
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sIgM–FcμR Interactions Regulate Early B Cell Activation and Plasma Cell Development after Influenza Virus Infection
Trang T. T. Nguyen, Beth A. Graf, Troy D. Randall and Nicole Baumgarth

J Immunol September 1, 2017, 199 (5) 1635-1646; DOI: https://doi.org/10.4049/jimmunol.1700560
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ORMDL3 Facilitates the Survival of Splenic B Cells via an ATF6α–Endoplasmic Reticulum Stress–Beclin1 Autophagy Regulatory Pathway
Jie Dang, Xianli Bian, Xiaochun Ma, Jiangxia Li, Feng Long, Shan Shan, Qianqian Yuan, Qian Xin, Yan Li, Fei Gao, Yaoqin Gong and Qiji Liu

J Immunol September 1, 2017, 199 (5) 1647-1659; DOI: https://doi.org/10.4049/jimmunol.1602124
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CXCL1 and CXCL2 Regulate NLRP3 Inflammasome Activation via G-Protein–Coupled Receptor CXCR2
Monoranjan Boro and Kithiganahalli Narayanaswamy Balaji

J Immunol September 1, 2017, 199 (5) 1660-1671; DOI: https://doi.org/10.4049/jimmunol.1700129
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Impaired Transmigration of Myeloid-Derived Suppressor Cells across Human Sinusoidal Endothelium Is Associated with Decreased Expression of CD13
Yazid J. Resheq, Ann-Katrin Menzner, Jacobus Bosch, Joseph Tickle, Ka-Kit Li, Annika Wilhelm, Elizabeth Hepburn, Gillian Murihead, Stephen T. Ward, Stuart M. Curbishley, Henning W. Zimmermann, Tony Bruns, Daniel F. Gilbert, Philipp Tripal, Andreas Mackensen, David H. Adams and Chris J. Weston

J Immunol September 1, 2017, 199 (5) 1672-1681; DOI: https://doi.org/10.4049/jimmunol.1600466
Open Access
The Small Rho GTPase TC10 Modulates B Cell Immune Responses
Author Choice Article

Marianne Burbage, Selina J. Keppler, Beatriz Montaner, Pieta K. Mattila and Facundo D. Batista

J Immunol September 1, 2017, 199 (5) 1682-1695; DOI: https://doi.org/10.4049/jimmunol.1602167

IMMUNE SYSTEM DEVELOPMENT

Open Access
Adaptive from Innate: Human IFN-γ⁺CD4⁺ T Cells Can Arise Directly from CXCL8-Producing Recent Thymic Emigrants in Babies and Adults
Author Choice Article

Abhishek Das, Kevin Rouault-Pierre, Shraddha Kamdar, Iria Gomez-Tourino, Kristie Wood, Ian Donaldson, Charles A. Mein, Dominique Bonnet, Adrian C. Hayday and Deena L. Gibbons

J Immunol September 1, 2017, 199 (5) 1696-1705; DOI: https://doi.org/10.4049/jimmunol.1700551
Open Access
Zebrafish B Cell Development without a Pre–B Cell Stage, Revealed by CD79 Fluorescence Reporter Transgenes
Author Choice Article

Xingjun Liu, Yue-Sheng Li, Susan A. Shinton, Jennifer Rhodes, Lingjuan Tang, Hui Feng, Cicely A. Jette, A. Thomas Look, Kyoko Hayakawa and Richard R. Hardy

J Immunol September 1, 2017, 199 (5) 1706-1715; DOI: https://doi.org/10.4049/jimmunol.1700552
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Control of Regulatory T Cell Differentiation by the Transcription Factors Thpok and LRF
Andrea C. Carpenter, Elizabeth Wohlfert, Laura B. Chopp, Melanie S. Vacchio, Jia Nie, Yongmei Zhao, Jyoti Shetty, Qi Xiao, Callie Deng, Bao Tran, Margaret Cam, Matthias M. Gaida, Yasmine Belkaid and Rémy Bosselut

J Immunol September 1, 2017, 199 (5) 1716-1728; DOI: https://doi.org/10.4049/jimmunol.1700181
Open Access
Lactation-Based Maternal Educational Immunity Crosses MHC Class I Barriers and Can Impart Th1 Immunity to Th2-Biased Recipients
Author Choice Article

Mrinal K. Ghosh, H. Konrad Muller and Ameae M. Walker

J Immunol September 1, 2017, 199 (5) 1729-1736; DOI: https://doi.org/10.4049/jimmunol.1601375

IMMUNOTHERAPY AND VACCINES

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Immune Protection by a Cytomegalovirus Vaccine Vector Expressing a Single Low-Avidity Epitope
Lisa Borkner, Katarzyna M. Sitnik, Iryna Dekhtiarenko, Ann-Kathrin Pulm, Ronny Tao, Ingo Drexler and Luka Cicin-Sain

J Immunol September 1, 2017, 199 (5) 1737-1747; DOI: https://doi.org/10.4049/jimmunol.1602115

INFECTIOUS DISEASE AND HOST RESPONSE

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Manipulating Glucose Metabolism during Different Stages of Viral Pathogenesis Can Have either Detrimental or Beneficial Effects
Siva Karthik Varanasi, Dallas Donohoe, Ujjaldeep Jaggi and Barry T. Rouse

J Immunol September 1, 2017, 199 (5) 1748-1761; DOI: https://doi.org/10.4049/jimmunol.1700472
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Trypanosoma musculi Infection in Mice Critically Relies on Mannose Receptor–Mediated Arginase Induction by a TbKHC1 Kinesin H Chain Homolog
Romaric Nzoumbou-Boko, Géraldine De Muylder, Silla Semballa, Laurence Lecordier, Fréderic-Antoine Dauchy, Alain P. Gobert, Philippe Holzmuller, Jean-Loup Lemesre, Rachel Bras-Gonçalves, Christian Barnabé, Pierrette Courtois, Sylvie Daulouède, Alain Beschin, Etienne Pays and Philippe Vincendeau

J Immunol September 1, 2017, 199 (5) 1762-1771; DOI: https://doi.org/10.4049/jimmunol.1700179
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α-Toxin Regulates Local Granulocyte Expansion from Hematopoietic Stem and Progenitor Cells in Staphylococcus aureus–Infected Wounds
Patrick C. Falahee, Leif S. Anderson, Mack B. Reynolds, Mauricio Pirir, Bridget E. McLaughlin, Carly A. Dillen, Ambrose L. Cheung, Lloyd S. Miller and Scott I. Simon

J Immunol September 1, 2017, 199 (5) 1772-1782; DOI: https://doi.org/10.4049/jimmunol.1700649
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IL-17 Promotes Differentiation of Splenic LSK⁻ Lymphoid Progenitors into B Cells following Plasmodium yoelii Infection
Debopam Ghosh, Susie L. Brown and Jason S. Stumhofer

J Immunol September 1, 2017, 199 (5) 1783-1795; DOI: https://doi.org/10.4049/jimmunol.1601972
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Modulation of Roquin Function in Myeloid Cells Reduces Mycobacterium tuberculosis–Induced Inflammation
Gayathri Nagalingam, Carola G. Vinuesa, Warwick J. Britton and Bernadette M. Saunders

J Immunol September 1, 2017, 199 (5) 1796-1804; DOI: https://doi.org/10.4049/jimmunol.1602069
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Nitric Oxide Modulates Macrophage Responses to Mycobacterium tuberculosis Infection through Activation of HIF-1α and Repression of NF-κB
Jonathan Braverman and Sarah A. Stanley

J Immunol September 1, 2017, 199 (5) 1805-1816; DOI: https://doi.org/10.4049/jimmunol.1700515

INNATE IMMUNITY AND INFLAMMATION

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PALLD Regulates Phagocytosis by Enabling Timely Actin Polymerization and Depolymerization
Hai-Min Sun, Xin-Lei Chen, Xin-Jie Chen, Jin Liu, Lie Ma, Hai-Yan Wu, Qiu-Hua Huang, Xiao-Dong Xi, Tong Yin, Jiang Zhu, Zhu Chen and Sai-Juan Chen

J Immunol September 1, 2017, 199 (5) 1817-1826; DOI: https://doi.org/10.4049/jimmunol.1602018
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Arginase1 Deficiency in Monocytes/Macrophages Upregulates Inducible Nitric Oxide Synthase To Promote Cutaneous Contact Hypersensitivity
Jutamas Suwanpradid, Michael Shih, Lauren Pontius, Bin Yang, Anastasiya Birukova, Emma Guttman-Yassky, David L. Corcoran, Loretta G. Que, Robert M. Tighe and Amanda S. MacLeod

J Immunol September 1, 2017, 199 (5) 1827-1834; DOI: https://doi.org/10.4049/jimmunol.1700739
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Deconstructing the Lectin Pathway in the Pathogenesis of Experimental Inflammatory Arthritis: Essential Role of the Lectin Ficolin B and Mannose-Binding Protein–Associated Serine Protease 2
Nirmal K. Banda, Sumitra Acharya, Robert I. Scheinman, Gaurav Mehta, Minoru Takahashi, Yuichi Endo, Wuding Zhou, Conrad A. Farrar, Steven H. Sacks, Teizo Fujita, Hideharu Sekine and V. Michael Holers

J Immunol September 1, 2017, 199 (5) 1835-1845; DOI: https://doi.org/10.4049/jimmunol.1700119
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PACT Facilitates RNA-Induced Activation of MDA5 by Promoting MDA5 Oligomerization
Pak-Yin Lui, Lok-Yin Roy Wong, Ting-Hin Ho, Shannon Wing Ngor Au, Chi-Ping Chan, Kin-Hang Kok and Dong-Yan Jin

J Immunol September 1, 2017, 199 (5) 1846-1855; DOI: https://doi.org/10.4049/jimmunol.1601493
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TRIM8 Negatively Regulates TLR3/4-Mediated Innate Immune Response by Blocking TRIF–TBK1 Interaction
Wen Ye, Ming-Ming Hu, Cao-Qi Lei, Qian Zhou, Heng Lin, Ming-Shun Sun and Hong-Bing Shu

J Immunol September 1, 2017, 199 (5) 1856-1864; DOI: https://doi.org/10.4049/jimmunol.1601647
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The STAT4/MLL1 Epigenetic Axis Regulates the Antimicrobial Functions of Murine Macrophages
William F. Carson IV, Karen A. Cavassani, Elyara M. Soares, Soichiro Hirai, Nicolai A. Kittan, Matthew A. Schaller, Melissa M. Scola, Amrita Joshi, Akihiro Matsukawa, David M. Aronoff, Craig N. Johnson, Yali Dou, Katherine A. Gallagher and Steven L. Kunkel

J Immunol September 1, 2017, 199 (5) 1865-1874; DOI: https://doi.org/10.4049/jimmunol.1601272

MOLECULAR AND STRUCTURAL IMMUNOLOGY

Open Access
Evidence for Ig Light Chain Isotype Exclusion in Shark B Lymphocytes Suggests Ordered Mechanisms
Author Choice Article

Anna Iacoangeli, Anita Lui, Ashley Haines, Yuko Ohta, Martin Flajnik and Ellen Hsu

J Immunol September 1, 2017, 199 (5) 1875-1885; DOI: https://doi.org/10.4049/jimmunol.1700762

MUCOSAL IMMUNOLOGY

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Epithelial TNF Receptor Signaling Promotes Mucosal Repair in Inflammatory Bowel Disease
Emily M. Bradford, Stacy H. Ryu, Ajay Pal Singh, Goo Lee, Tatiana Goretsky, Preetika Sinh, David B. Williams, Amber L. Cloud, Elias Gounaris, Vihang Patel, Olivia F. Lamping, Evan B. Lynch, Mary Pat Moyer, Isabelle G. De Plaen, David J. Shealy, Guang-Yu Yang and Terrence A. Barrett

J Immunol September 1, 2017, 199 (5) 1886-1897; DOI: https://doi.org/10.4049/jimmunol.1601066
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The Neonatal Fc Receptor and Complement Fixation Facilitate Prophylactic Vaccine-Mediated Humoral Protection against Viral Infection in the Ocular Mucosa
Derek J. Royer, Meghan M. Carr, Hem R. Gurung, William P. Halford and Daniel J. J. Carr

J Immunol September 1, 2017, 199 (5) 1898-1911; DOI: https://doi.org/10.4049/jimmunol.1700316
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The Development of Steady-State Activation Hubs between Adult LTi ILC3s and Primed Macrophages in Small Intestine
Adam K. Savage, Hong-Erh Liang and Richard M. Locksley

J Immunol September 1, 2017, 199 (5) 1912-1922; DOI: https://doi.org/10.4049/jimmunol.1700155
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Modified Vaccinia Virus Ankara Vector Induces Specific Cellular and Humoral Responses in the Female Reproductive Tract, the Main HIV Portal of Entry
Romain Marlin, Marie-Thérèse Nugeyre, Nicolas Tchitchek, Matteo Parenti, Hakim Hocini, Fahd Benjelloun, Claude Cannou, Nathalie Dereuddre-Bosquet, Yves Levy, Françoise Barré-Sinoussi, Gabriella Scarlatti, Roger Le Grand and Elisabeth Menu

J Immunol September 1, 2017, 199 (5) 1923-1932; DOI: https://doi.org/10.4049/jimmunol.1700320

TUMOR IMMUNOLOGY

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Versican-Derived Matrikines Regulate Batf3–Dendritic Cell Differentiation and Promote T Cell Infiltration in Colorectal Cancer
Chelsea Hope, Philip B. Emmerich, Athanasios Papadas, Adam Pagenkopf, Kristina A. Matkowskyj, Dana R. Van De Hey, Susan N. Payne, Linda Clipson, Natalie S. Callander, Peiman Hematti, Shigeki Miyamoto, Michael G. Johnson, Dustin A. Deming and Fotis Asimakopoulos

J Immunol September 1, 2017, 199 (5) 1933-1941; DOI: https://doi.org/10.4049/jimmunol.1700529

LETTERS OF RETRACTION

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Retraction: Hypoxia-Inducible Factor-1α–Dependent Protection from Intestinal Ischemia/Reperfusion Injury Involves Ecto-5′-Nucleotidase (CD73) and the A2B Adenosine Receptor
Melanie L. Hart, Iris C. Gorzolla, Jens Schittenhelm, Julee H. Dalton and Holger K. Eltzschig

J Immunol September 1, 2017, 199 (5) 1942; DOI: https://doi.org/10.4049/jimmunol.1700997

CORRECTIONS

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Correction: A CD80-Biased CTLA4-Ig Fusion Protein with Superior In Vivo Efficacy by Simultaneous Engineering of Affinity, Selectivity, Stability, and FcRn Binding
Julie Douthwaite, Jacques Moisan, Cyril Privezentzev, Blagoje Soskic, Shereen Sabbah, Suzanne Cohen, Andie Collinson, Elizabeth England, Catherine Huntington, Ben Kemp, Li Zhuang, Suzanne Hudak, D. Gareth Rees, Debbie Goldberg, Chris Barton, Linda Chang, Inna Vainshtein, Meina Liang, Laurie Iciek, Philip Ambery, Mark Peakman, Tristan J. Vaughan, Tim I. M. Tree, David M. Sansom, Michael A. Bowen, Ralph R. Minter and Lutz Jermutus

J Immunol September 1, 2017, 199 (5) 1943; DOI: https://doi.org/10.4049/jimmunol.1790013
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Correction: Macrophage Mitochondrial and Stress Response to Ingestion of Cryptococcus neoformans
Carolina Coelho, Ana Camila Oliveira Souza, Lorena da Silveira Derengowski, Carlos de Leon-Rodriguez, Bo Wang, Rosiris Leon-Rivera, Anamelia Lorenzetti Bocca, Teresa Gonçalves and Arturo Casadevall

J Immunol September 1, 2017, 199 (5) 1944; DOI: https://doi.org/10.4049/jimmunol.1700948

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Table of Contents

IN THIS ISSUE

PILLARS OF IMMUNOLOGY

BRIEF REVIEWS

CUTTING EDGE

ALLERGY AND OTHER HYPERSENSITIVITIES

AUTOIMMUNITY

CLINICAL AND HUMAN IMMUNOLOGY

IMMUNE REGULATION

IMMUNE SYSTEM DEVELOPMENT

IMMUNOTHERAPY AND VACCINES

INFECTIOUS DISEASE AND HOST RESPONSE

INNATE IMMUNITY AND INFLAMMATION

MOLECULAR AND STRUCTURAL IMMUNOLOGY

MUCOSAL IMMUNOLOGY

TUMOR IMMUNOLOGY

LETTERS OF RETRACTION

CORRECTIONS

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