The Journal of Immunology: 199 (12)

December 15, 2017; Volume 199,Issue 12

IN THIS ISSUE

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In This Issue
CD28 Drives T_FR Differentiation and Function See article p. 3972
Sinking Teeth into Periodontitis See article p. 4023
Protective IL-22 Binding Protein See article p. 4078
Capturing Plasmablasts To Study Vaccine Responses See article p. 4180

J Immunol December 15, 2017, 199 (12) 3927-3928; DOI: https://doi.org/10.4049/jimmunol.1790022

CUTTING EDGE

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Cutting Edge: c-Maf Is Required for Regulatory T Cells To Adopt RORγt⁺ and Follicular Phenotypes
Joshua D. Wheaton, Chen-Hao Yeh and Maria Ciofani

J Immunol December 15, 2017, 199 (12) 3931-3936; DOI: https://doi.org/10.4049/jimmunol.1701134
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Cutting Edge: Processing of Oxidized Peptides in Macrophages Regulates T Cell Activation and Development of Autoimmune Arthritis
Min Yang, Claus Haase, Johan Viljanen, Bingze Xu, Changrong Ge, Jan Kihlberg and Rikard Holmdahl

J Immunol December 15, 2017, 199 (12) 3937-3942; DOI: https://doi.org/10.4049/jimmunol.1700774

ALLERGY AND OTHER HYPERSENSITIVITIES

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Lung-Infiltrating Foxp3⁺ Regulatory T Cells Are Quantitatively and Qualitatively Different during Eosinophilic and Neutrophilic Allergic Airway Inflammation but Essential To Control the Inflammation
Eunjung Jang, Quang Tam Nguyen, Sohee Kim, Dongkyun Kim, Thi Hong Nga Le, Karen Keslar, Nina Dvorina, Mark A. Aronica and Booki Min

J Immunol December 15, 2017, 199 (12) 3943-3951; DOI: https://doi.org/10.4049/jimmunol.1700211
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Endogenous Calcitriol Synthesis Controls the Humoral IgE Response in Mice
Juliane Lindner, Sebastian Rausch, Sandra Treptow, Kerstin Geldmeyer-Hilt, Tina Krause, René St-Arnaud, Alice Arabian, Andreas Radbruch, Susanne Hartmann, Margitta Worm and Guido Heine

J Immunol December 15, 2017, 199 (12) 3952-3958; DOI: https://doi.org/10.4049/jimmunol.1602080

ANTIGEN RECOGNITION AND RESPONSES

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Mode of Tolerance Induction and Requirement for Aire Are Governed by the Cell Types That Express Self-Antigen and Those That Present Antigen
Yasuhiro Mouri, Yoshihiro Ueda, Tomoyoshi Yamano, Minoru Matsumoto, Koichi Tsuneyama, Tatsuo Kinashi and Mitsuru Matsumoto

J Immunol December 15, 2017, 199 (12) 3959-3971; DOI: https://doi.org/10.4049/jimmunol.1700892

AUTOIMMUNITY

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B Cells Drive Autoimmunity in Mice with CD28-Deficient Regulatory T Cells
Ruan Zhang, Peter T. Sage, Kelsey Finn, Alexandria Huynh, Bruce R. Blazar, Francesco Marangoni, Thorsten R. Mempel, Arlene H. Sharpe and Laurence A. Turka

J Immunol December 15, 2017, 199 (12) 3972-3980; DOI: https://doi.org/10.4049/jimmunol.1700409
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Broad Susceptibility of Nucleolar Proteins and Autoantigens to Complement C1 Protease Degradation
Yitian Cai, Seng Yin Kelly Wee, Junjie Chen, Boon Heng Dennis Teo, Yee Leng Carol Ng, Khai Pang Leong and Jinhua Lu

J Immunol December 15, 2017, 199 (12) 3981-3990; DOI: https://doi.org/10.4049/jimmunol.1700728
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The Type 1 Diabetes–Resistance Locus Idd22 Controls Trafficking of Autoreactive CTLs into the Pancreatic Islets of NOD Mice
Robert L. Whitener, Lisa Gallo Knight, Jianwei Li, Sarah Knapp, Shuyao Zhang, Mani Annamalai, Vadim M. Pliner, Dongtao Fu, Ilian Radichev, Christina Amatya, Alexei Savinov, Arif Yurdagul Jr., Shuai Yuan, John Glawe, Christopher G. Kevil, Jing Chen, Scott E. Stimpson and Clayton E. Mathews

J Immunol December 15, 2017, 199 (12) 3991-4000; DOI: https://doi.org/10.4049/jimmunol.1602037
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Mer Receptor Tyrosine Kinase Signaling Prevents Self-Ligand Sensing and Aberrant Selection in Germinal Centers
Stephanie L. Schell, Chetna Soni, Melinda J. Fasnacht, Phillip P. Domeier, Timothy K. Cooper and Ziaur S. M. Rahman

J Immunol December 15, 2017, 199 (12) 4001-4015; DOI: https://doi.org/10.4049/jimmunol.1700611
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SATB1 Conditional Knockout Results in Sjögren’s Syndrome in Mice
Yuriko Tanaka, Takehiko Sotome, Akiko Inoue, Takanori Mukozu, Taku Kuwabara, Tetuo Mikami, Terumi Kowhi-Shigematsu and Motonari Kondo

J Immunol December 15, 2017, 199 (12) 4016-4022; DOI: https://doi.org/10.4049/jimmunol.1700550

CLINICAL AND HUMAN IMMUNOLOGY

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Gingival Tissue Inflammation Promotes Increased Matrix Metalloproteinase-12 Production by CD200R^low Monocyte-Derived Cells in Periodontitis
Sofia Björnfot Holmström, Reuben Clark, Stephanie Zwicker, Daniela Bureik, Egle Kvedaraite, Eric Bernasconi, Anh Thu Nguyen Hoang, Gunnar Johannsen, Benjamin J. Marsland, Elisabeth A. Boström and Mattias Svensson

J Immunol December 15, 2017, 199 (12) 4023-4035; DOI: https://doi.org/10.4049/jimmunol.1700672
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Disruption of Thrombocyte and T Lymphocyte Development by a Mutation in ARPC1B
Raz Somech, Atar Lev, Yu Nee Lee, Amos J. Simon, Ortal Barel, Ginette Schiby, Camila Avivi, Iris Barshack, Michele Rhodes, Jiejing Yin, Minshi Wang, Yibin Yang, Jennifer Rhodes, Nufar Marcus, Ben-Zion Garty, Jerry Stein, Ninette Amariglio, Gideon Rechavi, David L. Wiest and Yong Zhang

J Immunol December 15, 2017, 199 (12) 4036-4045; DOI: https://doi.org/10.4049/jimmunol.1700460
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Proinflammatory T Cell Status Associated with Early Life Adversity
Martha M. C. Elwenspoek, Xenia Hengesch, Fleur A. D. Leenen, Anna Schritz, Krystel Sias, Violetta K. Schaan, Sophie B. Mériaux, Stephanie Schmitz, Fanny Bonnemberger, Hartmut Schächinger, Claus Vögele, Jonathan D. Turner and Claude P. Muller

J Immunol December 15, 2017, 199 (12) 4046-4055; DOI: https://doi.org/10.4049/jimmunol.1701082

IMMUNE REGULATION

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Glycogen Synthase Kinase-3 Modulates Cbl-b and Constrains T Cell Activation
Charles W. Tran, Samuel D. Saibil, Thierry Le Bihan, Sara R. Hamilton, Karl S. Lang, Han You, Amy E. Lin, Kristine M. Garza, Alisha R. Elford, Kelly Tai, Michael E. Parsons, Kip Wigmore, Mitchell G. Vainberg, Josef M. Penninger, James R. Woodgett, Tak W. Mak and Pamela S. Ohashi

J Immunol December 15, 2017, 199 (12) 4056-4065; DOI: https://doi.org/10.4049/jimmunol.1600396
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Regnase-1 and Roquin Nonredundantly Regulate Th1 Differentiation Causing Cardiac Inflammation and Fibrosis
Xiaotong Cui, Takashi Mino, Masanori Yoshinaga, Yoshinari Nakatsuka, Fabian Hia, Daichi Yamasoba, Tohru Tsujimura, Keizo Tomonaga, Yutaka Suzuki, Takuya Uehata and Osamu Takeuchi

J Immunol December 15, 2017, 199 (12) 4066-4077; DOI: https://doi.org/10.4049/jimmunol.1701211
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A Protective Function of IL-22BP in Ischemia Reperfusion and Acetaminophen-Induced Liver Injury
Dörte Kleinschmidt, Anastasios D. Giannou, Heather M. McGee, Jan Kempski, Babett Steglich, Francis Jessica Huber, Thomas Michael Ernst, Ahmad Mustafa Shiri, Claudia Wegscheid, Elena Tasika, Peter Hübener, Philipp Huber, Tanja Bedke, Niklas Steffens, Theodora Agalioti, Tobias Fuchs, Jill Noll, Hannelore Lotter, Gisa Tiegs, Ansgar W. Lohse, Jonathan H. Axelrod, Eithan Galun, Richard A. Flavell, Nicola Gagliani and Samuel Huber

J Immunol December 15, 2017, 199 (12) 4078-4090; DOI: https://doi.org/10.4049/jimmunol.1700587
Open Access
TIM-3 Engagement Promotes Effector Memory T Cell Differentiation of Human Antigen-Specific CD8 T Cells by Activating mTORC1
Author Choice Article

Nina Chi Sabins, Olesya Chornoguz, Karen Leander, Fred Kaplan, Richard Carter, Michelle Kinder, Kurtis Bachman, Raluca Verona, Shixue Shen, Vipul Bhargava and Sandra Santulli-Marotto

J Immunol December 15, 2017, 199 (12) 4091-4102; DOI: https://doi.org/10.4049/jimmunol.1701030

IMMUNOTHERAPY AND VACCINES

Open Access
IgG1 Is Required for Optimal Protection after Immunization with the Purified Porin OmpD from Salmonella Typhimurium
Author Choice Article

Yang Zhang, Coral Dominguez-Medina, Nicola J. Cumley, Jennifer N. Heath, Sarah J. Essex, Saeeda Bobat, Anna Schager, Margaret Goodall, Sven Kracker, Christopher D. Buckley, Robin C. May, Robert A. Kingsley, Calman A. MacLennan, Constantino López-Macías, Adam F. Cunningham and Kai-Michael Toellner

J Immunol December 15, 2017, 199 (12) 4103-4109; DOI: https://doi.org/10.4049/jimmunol.1700952
Open Access
CD27-Mediated Regulatory T Cell Depletion and Effector T Cell Costimulation Both Contribute to Antitumor Efficacy
Author Choice Article

Anna Wasiuk, James Testa, Jeff Weidlick, Crystal Sisson, Laura Vitale, Jenifer Widger, Andrea Crocker, Lawrence J. Thomas, Joel Goldstein, Henry C. Marsh, Tibor Keler and Li-Zhen He

J Immunol December 15, 2017, 199 (12) 4110-4123; DOI: https://doi.org/10.4049/jimmunol.1700606

INNATE IMMUNITY AND INFLAMMATION

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Serum IgA Immune Complexes Promote Proinflammatory Cytokine Production by Human Macrophages, Monocytes, and Kupffer Cells through FcαRI–TLR Cross-Talk
Ivo S. Hansen, Willianne Hoepel, Sebastiaan A. J. Zaat, Dominique L. P. Baeten and Jeroen den Dunnen

J Immunol December 15, 2017, 199 (12) 4124-4131; DOI: https://doi.org/10.4049/jimmunol.1700883
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Copper Regulates Maturation and Expression of an MITF:Tryptase Axis in Mast Cells
Jun Mei Hu Frisk, Lena Kjellén, Stephen G. Kaler, Gunnar Pejler and Helena Öhrvik

J Immunol December 15, 2017, 199 (12) 4132-4141; DOI: https://doi.org/10.4049/jimmunol.1700786

MOLECULAR AND STRUCTURAL IMMUNOLOGY

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Ubc9 Binds to ADAP and Is Required for Rap1 Membrane Recruitment, Rac1 Activation, and Integrin-Mediated T Cell Adhesion
Yiwei Xiong, Chengjin Ye, Naiqi Yang, Madanqi Li and Hebin Liu

J Immunol December 15, 2017, 199 (12) 4142-4154; DOI: https://doi.org/10.4049/jimmunol.1700572

SYSTEMS IMMUNOLOGY

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Virtual Sorting Has a Distinctive Advantage in Identification of Anticorrelated Genes and Further Negative Regulators of Immune Cell Subpopulations
Pingzhang Wang, Wenling Han and Dalong Ma

J Immunol December 15, 2017, 199 (12) 4155-4164; DOI: https://doi.org/10.4049/jimmunol.1700946

NOVEL IMMUNOLOGICAL METHODS

Open Access
Development of a Novel CD4⁺ TCR Transgenic Line That Reveals a Dominant Role for CD8⁺ Dendritic Cells and CD40 Signaling in the Generation of Helper and CTL Responses to Blood-Stage Malaria
Author Choice Article

Daniel Fernandez-Ruiz, Lei Shong Lau, Nazanin Ghazanfari, Claerwen M. Jones, Wei Yi Ng, Gayle M. Davey, Dorothee Berthold, Lauren Holz, Yu Kato, Matthias H. Enders, Ganchimeg Bayarsaikhan, Sanne H. Hendriks, Lianne I. M. Lansink, Jessica A. Engel, Megan S. F. Soon, Kylie R. James, Anton Cozijnsen, Vanessa Mollard, Alessandro D. Uboldi, Christopher J. Tonkin, Tania F. de Koning-Ward, Paul R. Gilson, Tsuneyasu Kaisho, Ashraful Haque, Brendan S. Crabb, Francis R. Carbone, Geoffrey I. McFadden and William R. Heath

J Immunol December 15, 2017, 199 (12) 4165-4179; DOI: https://doi.org/10.4049/jimmunol.1700186
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Isolation and Characterization of Antigen-Specific Plasmablasts Using a Novel Flow Cytometry–Based Ig Capture Assay
Christopher L. Pinder, Sven Kratochvil, Deniz Cizmeci, Luke Muir, Yanping Guo, Robin J. Shattock and Paul F. McKay

J Immunol December 15, 2017, 199 (12) 4180-4188; DOI: https://doi.org/10.4049/jimmunol.1701253

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Table of Contents

IN THIS ISSUE

CUTTING EDGE

ALLERGY AND OTHER HYPERSENSITIVITIES

ANTIGEN RECOGNITION AND RESPONSES

AUTOIMMUNITY

CLINICAL AND HUMAN IMMUNOLOGY

IMMUNE REGULATION

IMMUNOTHERAPY AND VACCINES

INNATE IMMUNITY AND INFLAMMATION

MOLECULAR AND STRUCTURAL IMMUNOLOGY

SYSTEMS IMMUNOLOGY

NOVEL IMMUNOLOGICAL METHODS

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