The Journal of Immunology: 199 (1)

July 1, 2017; Volume 199,Issue 1

IN THIS ISSUE

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In This Issue
Glucocorticoids Find Their Target See article p. 48
Sulfatide Plays Favorites with iNKT Cells See article p. 97
Putting Complement in the Middle See article p. 278
Homing in on Homeostatic Th17 Cells See article p. 312

J Immunol July 1, 2017, 199 (1) 1-2; DOI: https://doi.org/10.4049/jimmunol.1790009

PILLARS OF IMMUNOLOGY

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Access Guide to Antigen Receptor Genes
Ranjan Sen

J Immunol July 1, 2017, 199 (1) 3-4; DOI: https://doi.org/10.4049/jimmunol.1700680
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Pillars Article: A Role for Histone Acetylation in the Developmental Regulation of V(D)J Recombination. Science. 2000. 287: 495-498
Michelle Taylor McMurry and Michael S. Krangel

J Immunol July 1, 2017, 199 (1) 5-8;

BRIEF REVIEWS

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Inducing Mucosal IgA: A Challenge for Vaccine Adjuvants and Delivery Systems
Prosper N. Boyaka

J Immunol July 1, 2017, 199 (1) 9-16; DOI: https://doi.org/10.4049/jimmunol.1601775
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Macrophage-Mediated Inflammation in Normal and Diabetic Wound Healing
Anna E. Boniakowski, Andrew S. Kimball, Benjamin N. Jacobs, Steven L. Kunkel and Katherine A. Gallagher

J Immunol July 1, 2017, 199 (1) 17-24; DOI: https://doi.org/10.4049/jimmunol.1700223

CUTTING EDGE

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Cutting Edge: Origins, Recruitment, and Regulation of CD11c⁺ Cells in Inflamed Islets of Autoimmune Diabetes Mice
Joanna E. Klementowicz, Ashley E. Mahne, Allyson Spence, Vinh Nguyen, Ansuman T. Satpathy, Kenneth M. Murphy and Qizhi Tang

J Immunol July 1, 2017, 199 (1) 27-32; DOI: https://doi.org/10.4049/jimmunol.1601062
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Cutting Edge: Dual TCRα Expression Poses an Autoimmune Hazard by Limiting Regulatory T Cell Generation
Nathaniel J. Schuldt, Jennifer L. Auger, Justin A. Spanier, Tijana Martinov, Elise R. Breed, Brian T. Fife, Kristin A. Hogquist and Bryce A. Binstadt

J Immunol July 1, 2017, 199 (1) 33-38; DOI: https://doi.org/10.4049/jimmunol.1700406

ALLERGY AND OTHER HYPERSENSITIVITIES

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Aeroallergens Induce Reactive Oxygen Species Production and DNA Damage and Dampen Antioxidant Responses in Bronchial Epithelial Cells
Tze Khee Chan, W. S. Daniel Tan, Hong Yong Peh and W. S. Fred Wong

J Immunol July 1, 2017, 199 (1) 39-47; DOI: https://doi.org/10.4049/jimmunol.1600657
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Airway Epithelial Cells Are Crucial Targets of Glucocorticoids in a Mouse Model of Allergic Asthma
Carina Klaßen, Anna Karabinskaya, Lien Dejager, Sabine Vettorazzi, Justine Van Moorleghem, Fred Lühder, Sebastiaan H. Meijsing, Jan P. Tuckermann, Hanibal Bohnenberger, Claude Libert and Holger M. Reichardt

J Immunol July 1, 2017, 199 (1) 48-61; DOI: https://doi.org/10.4049/jimmunol.1601691
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Occludin Expression in Epidermal γδ T Cells in Response to Epidermal Stress Causes Them To Migrate into Draining Lymph Nodes
Takahito Saito, Michihiro Yano, Yutaro Ohki, Michio Tomura and Naoko Nakano

J Immunol July 1, 2017, 199 (1) 62-71; DOI: https://doi.org/10.4049/jimmunol.1600848

AUTOIMMUNITY

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Critical Role of P2Y₁₂ Receptor in Regulation of Th17 Differentiation and Experimental Autoimmune Encephalomyelitis Pathogenesis
Chaoyan Qin, Jinfeng Zhou, Yuan Gao, Weiming Lai, Cuixia Yang, Yingying Cai, Shuai Chen and Changsheng Du

J Immunol July 1, 2017, 199 (1) 72-81; DOI: https://doi.org/10.4049/jimmunol.1601549
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A Novel α9 Integrin Ligand, XCL1/Lymphotactin, Is Involved in the Development of Murine Models of Autoimmune Diseases
Naoki Matsumoto, Shigeyuki Kon, Takuya Nakatsuru, Tomoe Miyashita, Kyosuke Inui, Kodai Saitoh, Yuichi Kitai, Ryuta Muromoto, Jun-ichi Kashiwakura, Toshimitsu Uede and Tadashi Matsuda

J Immunol July 1, 2017, 199 (1) 82-90; DOI: https://doi.org/10.4049/jimmunol.1601329
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Antigen-Specific T Cell Analysis Reveals That Active Immune Responses to β Cell Antigens Are Focused on a Unique Set of Epitopes
Junbao Yang, Xiaomin Wen, Hengyu Xu, Nadia Torres-Chinn, Cate Speake, Carla J. Greenbaum, Gerald T. Nepom and William W. Kwok

J Immunol July 1, 2017, 199 (1) 91-96; DOI: https://doi.org/10.4049/jimmunol.1601570

CLINICAL AND HUMAN IMMUNOLOGY

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Autoreactivity to Sulfatide by Human Invariant NKT Cells
Annelein M. Stax, Jessica Tuengel, Enrico Girardi, Naoki Kitano, Lenka L. Allan, Victor Liu, Dongjun Zheng, William J. Panenka, Joren Guillaume, Chi-Huey Wong, Serge van Calenbergh, Dirk M. Zajonc and Peter van den Elzen

J Immunol July 1, 2017, 199 (1) 97-106; DOI: https://doi.org/10.4049/jimmunol.1601976
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Controlled Human Malaria Infection Leads to Long-Lasting Changes in Innate and Innate-like Lymphocyte Populations
Maxmillian Mpina, Nicholas J. Maurice, Masanao Yajima, Chloe K. Slichter, Hannah W. Miller, Mukta Dutta, M. Juliana McElrath, Kenneth D. Stuart, Stephen C. De Rosa, John P. McNevin, Peter S. Linsley, Salim Abdulla, Marcel Tanner, Stephen L. Hoffman, Raphael Gottardo, Claudia A. Daubenberger and Martin Prlic

J Immunol July 1, 2017, 199 (1) 107-118; DOI: https://doi.org/10.4049/jimmunol.1601989

IMMUNE REGULATION

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Viral RNA–Unprimed Rig-I Restrains Stat3 Activation in the Modulation of Regulatory T Cell/Th17 Cell Balance
Hui Yang, He-Zhou Guo, Xian-Yang Li, Jian Lin, Wu Zhang, Jun-Mei Zhao, Hong-Xin Zhang, Sai-Juan Chen, Zhu Chen and Jiang Zhu

J Immunol July 1, 2017, 199 (1) 119-128; DOI: https://doi.org/10.4049/jimmunol.1700366
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T Cells Deficient in the Tyrosine Phosphatase SHP-1 Resist Suppression by Regulatory T Cells
Emily R. Mercadante and Ulrike M. Lorenz

J Immunol July 1, 2017, 199 (1) 129-137; DOI: https://doi.org/10.4049/jimmunol.1602171
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Physiologic Thymic Involution Underlies Age-Dependent Accumulation of Senescence-Associated CD4⁺ T Cells
Kyosuke Sato, Aiko Kato, Miho Sekai, Yoko Hamazaki and Nagahiro Minato

J Immunol July 1, 2017, 199 (1) 138-148; DOI: https://doi.org/10.4049/jimmunol.1602005
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SOCS1 Is a Key Molecule That Prevents Regulatory T Cell Plasticity under Inflammatory Conditions
Reiko Takahashi, Hiroko Nakatsukasa, Shunichi Shiozawa and Akihiko Yoshimura

J Immunol July 1, 2017, 199 (1) 149-158; DOI: https://doi.org/10.4049/jimmunol.1600441
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Monoclonal Invariant NKT (iNKT) Cell Mice Reveal a Role for Both Tissue of Origin and the TCR in Development of iNKT Functional Subsets
Eleanor Clancy-Thompson, Gui Zhen Chen, Paul M. Tyler, Mariah M. Servos, Marta Barisa, Patrick J. Brennan, Hidde L. Ploegh and Stephanie K. Dougan

J Immunol July 1, 2017, 199 (1) 159-171; DOI: https://doi.org/10.4049/jimmunol.1700214

IMMUNE SYSTEM DEVELOPMENT

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The Influence of MHC Class II on B Cell Defects Induced by Invariant Chain/CD74 N-Terminal Fragments
Janna Schneppenheim, Ann-Christine Loock, Susann Hüttl, Michaela Schweizer, Renate Lüllmann-Rauch, Hans-Heinrich Oberg, Philipp Arnold, Christian H. K. Lehmann, Diana Dudziak, Dieter Kabelitz, Ralph Lucius, Ana-Maria Lennon-Duménil, Paul Saftig and Bernd Schröder

J Immunol July 1, 2017, 199 (1) 172-185; DOI: https://doi.org/10.4049/jimmunol.1601533

IMMUNOTHERAPY AND VACCINES

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Bolstering the Number and Function of HSV-1–Specific CD8⁺ Effector Memory T Cells and Tissue-Resident Memory T Cells in Latently Infected Trigeminal Ganglia Reduces Recurrent Ocular Herpes Infection and Disease
Arif A. Khan, Ruchi Srivastava, Aziz A. Chentoufi, Elizabeth Kritzer, Sravya Chilukuri, Sumit Garg, David C. Yu, Hawa Vahed, Lei Huang, Sabrina A. Syed, Julie N. Furness, Tien T. Tran, Nesburn B. Anthony, Christine E. McLaren, John Sidney, Alessandro Sette, Randolph J. Noelle and Lbachir BenMohamed

J Immunol July 1, 2017, 199 (1) 186-203; DOI: https://doi.org/10.4049/jimmunol.1700145
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Enhanced Effector Functions Due to Antibody Defucosylation Depend on the Effector Cell Fcγ Receptor Profile
Christine W. Bruggeman, Gillian Dekkers, Arthur E. H. Bentlage, Louise W. Treffers, Sietse Q. Nagelkerke, Suzanne Lissenberg-Thunnissen, Carolien A. M. Koeleman, Manfred Wuhrer, Timo K. van den Berg, Theo Rispens, Gestur Vidarsson and Taco W. Kuijpers

J Immunol July 1, 2017, 199 (1) 204-211; DOI: https://doi.org/10.4049/jimmunol.1700116

INFECTIOUS DISEASE AND HOST RESPONSE

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Heme Oxygenase-1 Modulates Human Respiratory Syncytial Virus Replication and Lung Pathogenesis during Infection
Janyra A. Espinoza, Miguel A. León, Pablo F. Céspedes, Roberto S. Gómez, Gisela Canedo-Marroquín, Sebastían A. Riquelme, Francisco J. Salazar-Echegarai, Phillipe Blancou, Thomas Simon, Ignacio Anegon, Margarita K. Lay, Pablo A. González, Claudia A. Riedel, Susan M. Bueno and Alexis M. Kalergis

J Immunol July 1, 2017, 199 (1) 212-223; DOI: https://doi.org/10.4049/jimmunol.1601414
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The Role of Shed PrP^c in the Neuropathogenesis of HIV Infection
Bezawit W. Megra, Eliseo A. Eugenin and Joan W. Berman

J Immunol July 1, 2017, 199 (1) 224-232; DOI: https://doi.org/10.4049/jimmunol.1601041
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Lung CD4 Tissue-Resident Memory T Cells Mediate Adaptive Immunity Induced by Previous Infection of Mice with Bordetella pertussis
Mieszko M. Wilk, Alicja Misiak, Róisín M. McManus, Aideen C. Allen, Marina A. Lynch and Kingston H. G. Mills

J Immunol July 1, 2017, 199 (1) 233-243; DOI: https://doi.org/10.4049/jimmunol.1602051
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T Follicular Helper Cell–Derived IL-4 Is Required for IgE Production during Intestinal Helminth Infection
Alexandre P. Meli, Ghislaine Fontés, Cindy Leung Soo and Irah L. King

J Immunol July 1, 2017, 199 (1) 244-252; DOI: https://doi.org/10.4049/jimmunol.1700141

INNATE IMMUNITY AND INFLAMMATION

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CXCL4 Exposure Potentiates TLR-Driven Polarization of Human Monocyte-Derived Dendritic Cells and Increases Stimulation of T Cells
Sandra C. Silva-Cardoso, Alsya J. Affandi, Lotte Spel, Marta Cossu, Joel A. G. van Roon, Marianne Boes and Timothy R. D. J. Radstake

J Immunol July 1, 2017, 199 (1) 253-262; DOI: https://doi.org/10.4049/jimmunol.1602020
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SLC46 Family Transporters Facilitate Cytosolic Innate Immune Recognition of Monomeric Peptidoglycans
Donggi Paik, Amanda Monahan, Daniel R. Caffrey, Roland Elling, William E. Goldman and Neal Silverman

J Immunol July 1, 2017, 199 (1) 263-270; DOI: https://doi.org/10.4049/jimmunol.1600409
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Golgi-Associated Protein Kinase C-ε Is Delivered to Phagocytic Cups: Role of Phosphatidylinositol 4-Phosphate
Cheryl M. Hanes, Anna E. D’Amico, Takehiko Ueyama, Alexander C. Wong, Xuexin Zhang, W. Frederick Hynes, Margarida M. Barroso, Nathaniel C. Cady, Mohamed Trebak, Naoaki Saito and Michelle R. Lennartz

J Immunol July 1, 2017, 199 (1) 271-277; DOI: https://doi.org/10.4049/jimmunol.1700243
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TLR-Induced Murine Dendritic Cell (DC) Activation Requires DC-Intrinsic Complement
Joong-Hyuk Sheen, Michael G. Strainic, Jinbo Liu, Weijia Zhang, Zhengzi Yi, M. Edward Medof and Peter S. Heeger

J Immunol July 1, 2017, 199 (1) 278-291; DOI: https://doi.org/10.4049/jimmunol.1700339

MOLECULAR AND STRUCTURAL IMMUNOLOGY

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FHR-1 Binds to C-Reactive Protein and Enhances Rather than Inhibits Complement Activation
Ádám I. Csincsi, Zsóka Szabó, Zsófia Bánlaki, Barbara Uzonyi, Marcell Cserhalmi, Éva Kárpáti, Agustín Tortajada, Joseph J. E. Caesar, Zoltán Prohászka, T. Sakari Jokiranta, Susan M. Lea, Santiago Rodríguez de Córdoba and Mihály Józsi

J Immunol July 1, 2017, 199 (1) 292-303; DOI: https://doi.org/10.4049/jimmunol.1600483

MUCOSAL IMMUNOLOGY

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IL-6 Signaling Regulates Small Intestinal Crypt Homeostasis
Victoria Jeffery, Andrew J. Goldson, Jack R. Dainty, Marcello Chieppa and Anastasia Sobolewski

J Immunol July 1, 2017, 199 (1) 304-311; DOI: https://doi.org/10.4049/jimmunol.1600960
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Selective Induction of Homeostatic Th17 Cells in the Murine Intestine by Cholera Toxin Interacting with the Microbiota
Qing Zhao, Stacey N. Harbour, Raivo Kolde, Isabel J. Latorre, Hein M. Tun, Trenton R. Schoeb, Henrietta Turner, James J. Moon, Ehsan Khafipour, Ramnik J. Xavier, Casey T. Weaver and Charles O. Elson

J Immunol July 1, 2017, 199 (1) 312-322; DOI: https://doi.org/10.4049/jimmunol.1700171

SYSTEMS IMMUNOLOGY

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Single-Cell RNA Sequencing Reveals Expanded Clones of Islet Antigen-Reactive CD4⁺ T Cells in Peripheral Blood of Subjects with Type 1 Diabetes
Karen Cerosaletti, Fariba Barahmand-pour-Whitman, Junbao Yang, Hannah A. DeBerg, Matthew J. Dufort, Sara A. Murray, Elisabeth Israelsson, Cate Speake, Vivian H. Gersuk, James A. Eddy, Helena Reijonen, Carla J. Greenbaum, William W. Kwok, Erik Wambre, Martin Prlic, Raphael Gottardo, Gerald T. Nepom and Peter S. Linsley

J Immunol July 1, 2017, 199 (1) 323-335; DOI: https://doi.org/10.4049/jimmunol.1700172

TRANSPLANTATION

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Host-Derived CD70 Suppresses Murine Graft-versus-Host Disease by Limiting Donor T Cell Expansion and Effector Function
Nicholas D. Leigh, Rachel E. O’Neill, Wei Du, Chuan Chen, Jingxin Qiu, Jonathan D. Ashwell, Philip L. McCarthy, George L. Chen and Xuefang Cao

J Immunol July 1, 2017, 199 (1) 336-347; DOI: https://doi.org/10.4049/jimmunol.1502181

NOVEL IMMUNOLOGICAL METHODS

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Comprehensive Approach for Identifying the T Cell Subset Origin of CD3 and CD28 Antibody–Activated Chimeric Antigen Receptor–Modified T Cells
Michael Schmueck-Henneresse, Bilal Omer, Thomas Shum, Haruko Tashiro, Maksim Mamonkin, Natalia Lapteva, Sandhya Sharma, Lisa Rollins, Gianpietro Dotti, Petra Reinke, Hans-Dieter Volk and Cliona M. Rooney

J Immunol July 1, 2017, 199 (1) 348-362; DOI: https://doi.org/10.4049/jimmunol.1601494

LETTERS OF RETRACTION

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Retraction: Adora2b Adenosine Receptor Signaling Protects during Acute Kidney Injury via Inhibition of Neutrophil-Dependent TNF-α Release
J Immunol July 1, 2017, 199 (1) 363; DOI: https://doi.org/10.4049/jimmunol.1700657

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Table of Contents

IN THIS ISSUE

PILLARS OF IMMUNOLOGY

BRIEF REVIEWS

CUTTING EDGE

ALLERGY AND OTHER HYPERSENSITIVITIES

AUTOIMMUNITY

CLINICAL AND HUMAN IMMUNOLOGY

IMMUNE REGULATION

IMMUNE SYSTEM DEVELOPMENT

IMMUNOTHERAPY AND VACCINES

INFECTIOUS DISEASE AND HOST RESPONSE

INNATE IMMUNITY AND INFLAMMATION

MOLECULAR AND STRUCTURAL IMMUNOLOGY

MUCOSAL IMMUNOLOGY

SYSTEMS IMMUNOLOGY

TRANSPLANTATION

NOVEL IMMUNOLOGICAL METHODS

LETTERS OF RETRACTION

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