The Journal of Immunology: 198 (9)

May 1, 2017; Volume 198,Issue 9

IN THIS ISSUE

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In This Issue
SUMOylation Supports SP Thymocytes See article p. 3461
Accelerated Aging in Young Rabbits Models Old Bone Marrow See article p. 3471
MARCO Modulates Mononuclear Cells See article p. 3548
cGAS Activity Starts at the Very Beginning See article p. 3627

J Immunol May 1, 2017, 198 (9) 3369-3370; DOI: https://doi.org/10.4049/jimmunol.1790005

LETTERS TO THE EDITOR

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Comment on “A Database of Human Immune Receptor Alleles Recovered from Population Sequencing Data”
Corey T. Watson, Frederick A. Matsen IV, Katherine J. L. Jackson, Ali Bashir, Melissa Laird Smith, Jacob Glanville, Felix Breden, Steven H. Kleinstein, Andrew M. Collins and Christian E. Busse

J Immunol May 1, 2017, 198 (9) 3371-3373; DOI: https://doi.org/10.4049/jimmunol.1700306
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Response to Comment on “A Database of Human Immune Receptor Alleles Recovered from Population Sequencing Data”
Yaxuan Yu, Rhodri Ceredig and Cathal Seoighe

J Immunol May 1, 2017, 198 (9) 3373-3374; DOI: https://doi.org/10.4049/jimmunol.1700349

IMMUNOLOGY NOTES AND RESOURCES

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JingleBells: A Repository of Immune-Related Single-Cell RNA–Sequencing Datasets
Hadas Ner-Gaon, Ariel Melchior, Nili Golan, Yael Ben-Haim and Tal Shay

J Immunol May 1, 2017, 198 (9) 3375-3379; DOI: https://doi.org/10.4049/jimmunol.1700272

PILLARS OF IMMUNOLOGY

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T Cell–Transfer Experimental Autoimmune Encephalomyelitis: Pillar of Multiple Sclerosis and Autoimmunity
Reinhard Hohlfeld and Lawrence Steinman

J Immunol May 1, 2017, 198 (9) 3381-3383; DOI: https://doi.org/10.4049/jimmunol.1700346
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Pillars Article: The Rapid Isolation of Clonable Antigen-specific T Lymphocyte Lines Capable of Mediating Autoimmune Encephalomyelitis. Eur J Immunol. 1981.11: 195-199
Avraham Ben-Nun, Hartmut Wekerle and Irun R. Cohen

J Immunol May 1, 2017, 198 (9) 3384-3388;

BRIEF REVIEWS

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Essential Neuroscience in Immunology
Sangeeta S. Chavan and Kevin J. Tracey

J Immunol May 1, 2017, 198 (9) 3389-3397; DOI: https://doi.org/10.4049/jimmunol.1601613

CUTTING EDGE

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Cutting Edge: Class II–like Structural Features and Strong Receptor Binding of the Nonclassical HLA-G2 Isoform Homodimer
Kimiko Kuroki, Kazuhiro Mio, Ami Takahashi, Haruki Matsubara, Yoshiyuki Kasai, Sachie Manaka, Masahide Kikkawa, Daizo Hamada, Chikara Sato and Katsumi Maenaka

J Immunol May 1, 2017, 198 (9) 3399-3403; DOI: https://doi.org/10.4049/jimmunol.1601296
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Cutting Edge: β-Catenin–Interacting Tcf1 Isoforms Are Essential for Thymocyte Survival but Dispensable for Thymic Maturation Transitions
Zhe Xu, Shaojun Xing, Qiang Shan, Jodi A. Gullicksrud, Thomas B. Bair, Yubin Du, Chengyu Liu and Hai-Hui Xue

J Immunol May 1, 2017, 198 (9) 3404-3409; DOI: https://doi.org/10.4049/jimmunol.1602139
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Cutting Edge: Loss of T Cell RIAM Precludes Conjugate Formation with APC and Prevents Immune-Mediated Diabetes
Frederic Lagarrigue, Frank B. Gertler, Mark H. Ginsberg and Joseph M. Cantor

J Immunol May 1, 2017, 198 (9) 3410-3415; DOI: https://doi.org/10.4049/jimmunol.1601743

CLINICAL AND HUMAN IMMUNOLOGY

Open Access
Antigen-Presenting Human γδ T Cells Promote Intestinal CD4⁺ T Cell Expression of IL-22 and Mucosal Release of Calprotectin
Author Choice Article

Christopher J. Tyler, Neil E. McCarthy, James O. Lindsay, Andrew J. Stagg, Bernhard Moser and Matthias Eberl

J Immunol May 1, 2017, 198 (9) 3417-3425; DOI: https://doi.org/10.4049/jimmunol.1700003
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Lipopolysaccharide-Elicited TSLPR Expression Enriches a Functionally Discrete Subset of Human CD14⁺ CD1c⁺ Monocytes
Francesco Borriello, Raffaella Iannone, Sarah Di Somma, Viviana Vastolo, Giuseppe Petrosino, Feliciano Visconte, Maddalena Raia, Giulia Scalia, Stefania Loffredo, Gilda Varricchi, Maria Rosaria Galdiero, Francescopaolo Granata, Luigi Del Vecchio, Giuseppe Portella and Gianni Marone

J Immunol May 1, 2017, 198 (9) 3426-3435; DOI: https://doi.org/10.4049/jimmunol.1601497

IMMUNE REGULATION

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Def6 Restrains Osteoclastogenesis and Inflammatory Bone Resorption
Nikolaus Binder, Christine Miller, Masaki Yoshida, Kazuki Inoue, Shinichi Nakano, Xiaoyu Hu, Lionel B. Ivashkiv, Georg Schett, Alessandra Pernis, Steven R. Goldring, F. Patrick Ross and Baohong Zhao

J Immunol May 1, 2017, 198 (9) 3436-3447; DOI: https://doi.org/10.4049/jimmunol.1601716
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Retinoic Acid Regulates Immune Responses by Promoting IL-22 and Modulating S100 Proteins in Viral Hepatitis
Zuliang Jie, Yuejin Liang, Panpan Yi, Hui Tang, Lynn Soong, Yingzi Cong, Kangling Zhang and Jiaren Sun

J Immunol May 1, 2017, 198 (9) 3448-3460; DOI: https://doi.org/10.4049/jimmunol.1601891

IMMUNE SYSTEM DEVELOPMENT

Open Access
Ubc9 Is Required for Positive Selection and Late-Stage Maturation of Thymocytes
Author Choice Article

Aibo Wang, Xiao Ding, Maud Demarque, Xindong Liu, Deng Pan, Huawei Xin, Bo Zhong, Xiaohu Wang, Anne Dejean, Wei Jin and Chen Dong

J Immunol May 1, 2017, 198 (9) 3461-3470; DOI: https://doi.org/10.4049/jimmunol.1600980
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Inflammatory Changes in Bone Marrow Microenvironment Associated with Declining B Lymphopoiesis
Domenick E. Kennedy and Katherine L. Knight

J Immunol May 1, 2017, 198 (9) 3471-3479; DOI: https://doi.org/10.4049/jimmunol.1601643

IMMUNOGENETICS

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Bonobos Maintain Immune System Diversity with Three Functional Types of MHC-B
Emily E. Wroblewski, Lisbeth A. Guethlein, Paul J. Norman, Yingying Li, Christiana M. Shaw, Alex S. Han, Jean-Bosco N. Ndjango, Steve Ahuka-Mundeke, Alexander V. Georgiev, Martine Peeters, Beatrice H. Hahn and Peter Parham

J Immunol May 1, 2017, 198 (9) 3480-3493; DOI: https://doi.org/10.4049/jimmunol.1601955

IMMUNOTHERAPY AND VACCINES

Open Access
Low Antigen Dose in Adjuvant-Based Vaccination Selectively Induces CD4 T Cells with Enhanced Functional Avidity and Protective Efficacy
Author Choice Article

Rolf Billeskov, Yichuan Wang, Shahram Solaymani-Mohammadi, Blake Frey, Shweta Kulkarni, Peter Andersen, Else Marie Agger, Yongjun Sui and Jay A. Berzofsky

J Immunol May 1, 2017, 198 (9) 3494-3506; DOI: https://doi.org/10.4049/jimmunol.1600965
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Prime-Boost Immunization Eliminates Metastatic Colorectal Cancer by Producing High-Avidity Effector CD8⁺ T Cells
Bo Xiang, Trevor R. Baybutt, Lisa Berman-Booty, Michael S. Magee, Scott A. Waldman, Vitali Y. Alexeev and Adam E. Snook

J Immunol May 1, 2017, 198 (9) 3507-3514; DOI: https://doi.org/10.4049/jimmunol.1502672

INFECTIOUS DISEASE AND HOST RESPONSE

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The Interaction of Pneumocystis with the C-Type Lectin Receptor Mincle Exerts a Significant Role in Host Defense against Infection
Theodore J. Kottom, Deanne M. Hebrink, Paige E. Jenson, Vijayalakshmi Nandakumar, Marcel Wüthrich, Huafeng Wang, Bruce Klein, Sho Yamasaki, Bernd Lepenies and Andrew H. Limper

J Immunol May 1, 2017, 198 (9) 3515-3525; DOI: https://doi.org/10.4049/jimmunol.1600744
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Adaptive Immune Responses to Zika Virus Are Important for Controlling Virus Infection and Preventing Infection in Brain and Testes
Clayton W. Winkler, Lara M. Myers, Tyson A. Woods, Ronald J. Messer, Aaron B. Carmody, Kristin L. McNally, Dana P. Scott, Kim J. Hasenkrug, Sonja M. Best and Karin E. Peterson

J Immunol May 1, 2017, 198 (9) 3526-3535; DOI: https://doi.org/10.4049/jimmunol.1601949
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IL-24 Promotes Pseudomonas aeruginosa Keratitis in C57BL/6 Mouse Corneas
Bing X. Ross, Nan Gao, Xinhan Cui, Theodore J. Standiford, Jianjiang Xu and Fu-shin X. Yu

J Immunol May 1, 2017, 198 (9) 3536-3547; DOI: https://doi.org/10.4049/jimmunol.1602087
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Scavenger Receptor MARCO Orchestrates Early Defenses and Contributes to Fungal Containment during Cryptococcal Infection
Jintao Xu, Adam Flaczyk, Lori M. Neal, Zhenzong Fa, Alison J. Eastman, Antoni N. Malachowski, Daphne Cheng, Bethany B. Moore, Jeffrey L. Curtis, John J. Osterholzer and Michal A. Olszewski

J Immunol May 1, 2017, 198 (9) 3548-3557; DOI: https://doi.org/10.4049/jimmunol.1700057

INNATE IMMUNITY AND INFLAMMATION

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The Induction of Pro–IL-1β by Lipopolysaccharide Requires Endogenous Prostaglandin E₂ Production
Zbigniew Zasłona, Eva M. Pålsson-McDermott, Deepthi Menon, Moritz Haneklaus, Ewelina Flis, Hannah Prendeville, Sarah E. Corcoran, Marc Peters-Golden and Luke A. J. O’Neill

J Immunol May 1, 2017, 198 (9) 3558-3564; DOI: https://doi.org/10.4049/jimmunol.1602072
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G-CSF Receptor Blockade Ameliorates Arthritic Pain and Disease
Ming-Chin Lee, James A. McCubbin, Anne D. Christensen, Daniel P. Poole, Pradeep Rajasekhar, TinaMarie Lieu, Nigel W. Bunnett, Sonia Garcia-Caraballo, Andelain Erickson, Stuart M. Brierley, Reem Saleh, Adrian Achuthan, Andrew J. Fleetwood, Robin L. Anderson, John A. Hamilton and Andrew D. Cook

J Immunol May 1, 2017, 198 (9) 3565-3575; DOI: https://doi.org/10.4049/jimmunol.1602127
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Cell-Specific Variation in E-Selectin Ligand Expression among Human Peripheral Blood Mononuclear Cells: Implications for Immunosurveillance and Pathobiology
Mariana Silva, Ronald Kam Fai Fung, Conor Brian Donnelly, Paula Alexandra Videira and Robert Sackstein

J Immunol May 1, 2017, 198 (9) 3576-3587; DOI: https://doi.org/10.4049/jimmunol.1601636
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Prolonged Ischemia Triggers Necrotic Depletion of Tissue-Resident Macrophages To Facilitate Inflammatory Immune Activation in Liver Ischemia Reperfusion Injury
Shi Yue, Haoming Zhou, Xuehao Wang, Ronald W. Busuttil, Jerzy W. Kupiec-Weglinski and Yuan Zhai

J Immunol May 1, 2017, 198 (9) 3588-3595; DOI: https://doi.org/10.4049/jimmunol.1601428
Open Access
Targeting Neutrophilic Inflammation Using Polymersome-Mediated Cellular Delivery
Author Choice Article

James D. Robertson, Jon R. Ward, Milagros Avila-Olias, Giuseppe Battaglia and Stephen A. Renshaw

J Immunol May 1, 2017, 198 (9) 3596-3604; DOI: https://doi.org/10.4049/jimmunol.1601901
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The AP-1 Transcription Factor c-Jun Promotes Arthritis by Regulating Cyclooxygenase-2 and Arginase-1 Expression in Macrophages
Nicole Hannemann, Jutta Jordan, Sushmita Paul, Stephen Reid, Hanns-Wolf Baenkler, Sophia Sonnewald, Tobias Bäuerle, Julio Vera, Georg Schett and Aline Bozec

J Immunol May 1, 2017, 198 (9) 3605-3614; DOI: https://doi.org/10.4049/jimmunol.1601330
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Activation of Myeloid TLR4 Mediates T Lymphocyte Polarization after Traumatic Brain Injury
Molly Braun, Kumar Vaibhav, Nancy Saad, Sumbul Fatima, Darrell W. Brann, John R. Vender, Lei P. Wang, Md Nasrul Hoda, Babak Baban and Krishnan M. Dhandapani

J Immunol May 1, 2017, 198 (9) 3615-3626; DOI: https://doi.org/10.4049/jimmunol.1601948
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Nonspecific DNA Binding of cGAS N Terminus Promotes cGAS Activation
Jianli Tao, Xiao-Wei Zhang, Jianshi Jin, Xiao-Xia Du, Tengfei Lian, Jing Yang, Xiang Zhou, Zhengfan Jiang and Xiao-Dong Su

J Immunol May 1, 2017, 198 (9) 3627-3636; DOI: https://doi.org/10.4049/jimmunol.1601909
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IFN Regulatory Factor 3 Potentiates Emphysematous Aggravation by Lipopolysaccharide
Takashi Ishii, Keisuke Hosoki, Yuichi Nikura, Naohide Yamashita, Takahide Nagase and Naomi Yamashita

J Immunol May 1, 2017, 198 (9) 3637-3649; DOI: https://doi.org/10.4049/jimmunol.1601069
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IL-26 Confers Proinflammatory Properties to Extracellular DNA
Caroline Poli, Jean François Augusto, Jonathan Dauvé, Clément Adam, Laurence Preisser, Vincent Larochette, Pascale Pignon, Ariel Savina, Simon Blanchard, Jean François Subra, Alain Chevailler, Vincent Procaccio, Anne Croué, Christophe Créminon, Alain Morel, Yves Delneste, Helmut Fickenscher and Pascale Jeannin

J Immunol May 1, 2017, 198 (9) 3650-3661; DOI: https://doi.org/10.4049/jimmunol.1600594
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Vigilin Regulates the Expression of the Stress-Induced Ligand MICB by Interacting with Its 5′ Untranslated Region
Orit Berhani, Daphna Nachmani, Rachel Yamin, Dominik Schmiedel, Yotam Bar-On and Ofer Mandelboim

J Immunol May 1, 2017, 198 (9) 3662-3670; DOI: https://doi.org/10.4049/jimmunol.1601589
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Limited Presence of IL-22 Binding Protein, a Natural IL-22 Inhibitor, Strengthens Psoriatic Skin Inflammation
Jérôme C. Martin, Kerstin Wolk, Gaëlle Bériou, Ahmed Abidi, Ellen Witte-Händel, Cédric Louvet, Georgios Kokolakis, Lucile Drujont, Laure Dumoutier, Jean-Christophe Renauld, Robert Sabat and Régis Josien

J Immunol May 1, 2017, 198 (9) 3671-3678; DOI: https://doi.org/10.4049/jimmunol.1700021
Open Access
Hydrogen Peroxide Triggers a Dual Signaling Axis To Selectively Suppress Activated Human T Lymphocyte Migration
Author Choice Article

Jennifer A. Ball, Isabella Vlisidou, Matthew D. Blunt, Will Wood and Stephen G. Ward

J Immunol May 1, 2017, 198 (9) 3679-3689; DOI: https://doi.org/10.4049/jimmunol.1600868
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Inducible TAP1 Negatively Regulates the Antiviral Innate Immune Response by Targeting the TAK1 Complex
Zhangchuan Xia, Gang Xu, Xiaodan Yang, Nanfang Peng, Qi Zuo, Shengli Zhu, Hua Hao, Shi Liu and Ying Zhu

J Immunol May 1, 2017, 198 (9) 3690-3704; DOI: https://doi.org/10.4049/jimmunol.1601588

MOLECULAR AND STRUCTURAL IMMUNOLOGY

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Identification of C3b-Binding Small-Molecule Complement Inhibitors Using Cheminformatics
Brandon L. Garcia, D. Andrew Skaff, Arindam Chatterjee, Anders Hanning, John K. Walker, Gerald J. Wyckoff and Brian V. Geisbrecht

J Immunol May 1, 2017, 198 (9) 3705-3718; DOI: https://doi.org/10.4049/jimmunol.1601932

MUCOSAL IMMUNOLOGY

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Characterization of the B Cell Receptor Repertoire in the Intestinal Mucosa and of Tumor-Infiltrating Lymphocytes in Colorectal Adenoma and Carcinoma
Wei Zhang, Qiang Feng, Changxi Wang, Xiaojing Zeng, Yuanping Du, Liya Lin, Jinghua Wu, Longfei Fu, Kai Yang, Xiaoying Xu, Hanshi Xu, Yi Zhao, Xuemei Li, Ursula Huber Schoenauer, Andreas Stadlmayr, Nitin K. Saksena, Herbert Tilg, Christian Datz and Xiao Liu

J Immunol May 1, 2017, 198 (9) 3719-3728; DOI: https://doi.org/10.4049/jimmunol.1602039
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Rip2 Is Required for Nod2-Mediated Lysozyme Sorting in Paneth Cells
Haifang Wang, Xinwen Zhang, Zhanguang Zuo, Qin Zhang, Ying Pan, Benhua Zeng, Wenxia Li, Hong Wei and Zhihua Liu

J Immunol May 1, 2017, 198 (9) 3729-3736; DOI: https://doi.org/10.4049/jimmunol.1601583

SYSTEMS IMMUNOLOGY

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Identification of Novel STAT6-Regulated Proteins in Mouse B Cells by Comparative Transcriptome and Proteome Analysis
Lavanya Mokada-Gopal, Alexander Boeser, Christian H. K. Lehmann, Friedel Drepper, Diana Dudziak, Bettina Warscheid and David Voehringer

J Immunol May 1, 2017, 198 (9) 3737-3745; DOI: https://doi.org/10.4049/jimmunol.1601838

TRANSPLANTATION

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Azacitidine Mitigates Graft-versus-Host Disease via Differential Effects on the Proliferation of T Effectors and Natural Regulatory T Cells In Vivo
Matthew L. Cooper, Jaebok Choi, Darja Karpova, Kiran Vij, Julie Ritchey, Mark A. Schroeder and John F. DiPersio

J Immunol May 1, 2017, 198 (9) 3746-3754; DOI: https://doi.org/10.4049/jimmunol.1502399

CORRECTIONS

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Correction: Disruption of Nrf2 Impairs the Resolution of Hyperoxia-Induced Acute Lung Injury and Inflammation in Mice
Narsa M. Reddy, Steven R. Kleeberger, Thomas W. Kensler, Masayuki Yamamoto, Paul M. Hassoun and Sekhar P. Reddy

J Immunol May 1, 2017, 198 (9) 3755; DOI: https://doi.org/10.4049/jimmunol.1700291
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Correction: Cutting Edge: Integrin α₄ Is Required for Regulatory B Cell Control of Experimental Autoimmune Encephalomyelitis
Simon Glatigny, Catriona A. Wagner and Estelle Bettelli

J Immunol May 1, 2017, 198 (9) 3756; DOI: https://doi.org/10.4049/jimmunol.1700283
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Correction: Key Residues at Third CDR3β Position Impact Structure and Antigen Recognition of Human Invariant NK TCRs
Kenji Chamoto, Tingxi Guo, Stephen W. Scally, Yuki Kagoya, Mark Anczurowski, Chung-Hsi Wang, Muhammed A. Rahman, Kayoko Saso, Marcus O. Butler, Priscilla P. L. Chiu, Jean-Philippe Julien and Naoto Hirano

J Immunol May 1, 2017, 198 (9) 3757; DOI: https://doi.org/10.4049/jimmunol.1700296
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Correction: A Database of Human Immune Receptor Alleles Recovered from Population Sequencing Data
Yaxuan Yu, Rhodri Ceredig and Cathal Seoighe

J Immunol May 1, 2017, 198 (9) 3758; DOI: https://doi.org/10.4049/jimmunol.1700301
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Correction: Prevention of Vγ9Vδ2 T Cell Activation by a Vγ9Vδ2 TCR Nanobody
Renée C. G. de Bruin, Anita G. M. Stam, Anna Vangone, Paul M. P. van Bergen en Henegouwen, Henk M. W. Verheul, Zsolt Sebestyén, Jürgen Kuball, Alexandre M. J. J. Bonvin, Tanja D. de Gruijl and Hans J. van der Vliet

J Immunol May 1, 2017, 198 (9) 3759; DOI: https://doi.org/10.4049/jimmunol.1700317

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Table of Contents

IN THIS ISSUE

LETTERS TO THE EDITOR

IMMUNOLOGY NOTES AND RESOURCES

PILLARS OF IMMUNOLOGY

BRIEF REVIEWS

CUTTING EDGE

CLINICAL AND HUMAN IMMUNOLOGY

IMMUNE REGULATION

IMMUNE SYSTEM DEVELOPMENT

IMMUNOGENETICS

IMMUNOTHERAPY AND VACCINES

INFECTIOUS DISEASE AND HOST RESPONSE

INNATE IMMUNITY AND INFLAMMATION

MOLECULAR AND STRUCTURAL IMMUNOLOGY

MUCOSAL IMMUNOLOGY

SYSTEMS IMMUNOLOGY

TRANSPLANTATION

CORRECTIONS

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