The Journal of Immunology: 198 (7)

April 1, 2017; Volume 198,Issue 7

IN THIS ISSUE

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In This Issue
Tracing tTreg Transitions See article p. 2612
The Shocking Truth about IL-17A See article p. 2805
Self Help for Arthritis See article p. 2876
Transformers Protect the Sea Urchin See article p. 2957
Virus-Specific TILs May Muddle Diagnostics See article p. 2979

J Immunol April 1, 2017, 198 (7) 2517-2518; DOI: https://doi.org/10.4049/jimmunol.1790003

PILLARS OF IMMUNOLOGY

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The Cloning of GM-CSF
Glenn Dranoff

J Immunol April 1, 2017, 198 (7) 2519-2521; DOI: https://doi.org/10.4049/jimmunol.1700182
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Pillars Article: Molecular Cloning of cDNA Encoding a Murine Haematopoietic Growth Regulator, Granulocyte—Macrophage Colony Stimulating Factor. Nature. 1984. 309: 763–767
Nicholas M. Gough, Jill Gough, Donald Metcalf, Anne Kelso, Dianne Grail, Nicos A. Nicola, Antony W. Burgess and Ashley R. Dunn

J Immunol April 1, 2017, 198 (7) 2522-2526;

BRIEF REVIEWS

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Relationship between CD4 Regulatory T Cells and Anergy In Vivo
Lokesh A. Kalekar and Daniel L. Mueller

J Immunol April 1, 2017, 198 (7) 2527-2533; DOI: https://doi.org/10.4049/jimmunol.1602031
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Two Strikes and You’re Out? The Pathogenic Interplay of Coinhibitor Deficiency and Lymphopenia-Induced Proliferation
Kristofor K. Ellestad and Colin C. Anderson

J Immunol April 1, 2017, 198 (7) 2534-2541; DOI: https://doi.org/10.4049/jimmunol.1601884

ALLERGY AND OTHER HYPERSENSITIVITIES

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Expression of IL-22 in the Skin Causes Th2-Biased Immunity, Epidermal Barrier Dysfunction, and Pruritus via Stimulating Epithelial Th2 Cytokines and the GRP Pathway
Hongfei Lou, Jingning Lu, Eun Byul Choi, Min Hee Oh, Mingeum Jeong, Sara Barmettler, Zhou Zhu and Tao Zheng

J Immunol April 1, 2017, 198 (7) 2543-2555; DOI: https://doi.org/10.4049/jimmunol.1600126

ANTIGEN RECOGNITION AND RESPONSES

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The Activating Human NK Cell Receptor KIR2DS2 Recognizes a β₂-Microglobulin–Independent Ligand on Cancer Cells
Lavanya Thiruchelvam-Kyle, Sigurd E. Hoelsbrekken, Per C. Saether, Elisabeth Gyllensten Bjørnsen, Daniela Pende, Sigbjørn Fossum, Michael R. Daws and Erik Dissen

J Immunol April 1, 2017, 198 (7) 2556-2567; DOI: https://doi.org/10.4049/jimmunol.1600930

AUTOIMMUNITY

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CD74 Deficiency Mitigates Systemic Lupus Erythematosus–like Autoimmunity and Pathological Findings in Mice
Yi Zhou, Huimei Chen, Li Liu, Xueqing Yu, Galina K. Sukhova, Min Yang, Lijun Zhang, Vasileios C. Kyttaris, George C. Tsokos, Isaac E. Stillman, Takaharu Ichimura, Joseph V. Bonventre, Peter Libby and Guo-Ping Shi

J Immunol April 1, 2017, 198 (7) 2568-2577; DOI: https://doi.org/10.4049/jimmunol.1600028
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Disruption of Pathogenic Cellular Networks by IL-21 Blockade Leads to Disease Amelioration in Murine Lupus
Jin-Young Choi, Abhinav Seth, Michael Kashgarian, Sonia Terrillon, Emma Fung, Lili Huang, Li Chun Wang and Joe Craft

J Immunol April 1, 2017, 198 (7) 2578-2588; DOI: https://doi.org/10.4049/jimmunol.1601687
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Dependence of Glomerulonephritis Induction on Novel Intraglomerular Alternatively Activated Bone Marrow–Derived Macrophages and Mac-1 and PD-L1 in Lupus-Prone NZM2328 Mice
Sun-sang J. Sung, Yan Ge, Chao Dai, Hongyang Wang, Shu Man Fu, Rahul Sharma, Young S. Hahn, Jing Yu, Thu H. Le, Mark D. Okusa, Warren K. Bolton and Jessica R. Lawler

J Immunol April 1, 2017, 198 (7) 2589-2601; DOI: https://doi.org/10.4049/jimmunol.1601565
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BAFF Induces Tertiary Lymphoid Structures and Positions T Cells within the Glomeruli during Lupus Nephritis
SunAh Kang, Yuri Fedoriw, Ethan K. Brenneman, Young K. Truong, Kristine Kikly and Barbara J. Vilen

J Immunol April 1, 2017, 198 (7) 2602-2611; DOI: https://doi.org/10.4049/jimmunol.1600281
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Activation and Functional Specialization of Regulatory T Cells Lead to the Generation of Foxp3 Instability
Zhongmei Zhang, Wei Zhang, Jie Guo, Qianchong Gu, Xueping Zhu and Xuyu Zhou

J Immunol April 1, 2017, 198 (7) 2612-2625; DOI: https://doi.org/10.4049/jimmunol.1601409
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MicroRNA-15b Suppresses Th17 Differentiation and Is Associated with Pathogenesis of Multiple Sclerosis by Targeting O-GlcNAc Transferase
Ruiqiong Liu, Xiaofeng Ma, Li Chen, Yang Yang, Yi Zeng, Jie Gao, Wei Jiang, Fang Zhang, Daojing Li, Bin Han, Ranran Han, Rongfang Qiu, Wei Huang, Yan Wang and Junwei Hao

J Immunol April 1, 2017, 198 (7) 2626-2639; DOI: https://doi.org/10.4049/jimmunol.1601727

CLINICAL AND HUMAN IMMUNOLOGY

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β2 Glycoprotein I Recognition Drives Th1 Inflammation in Atherosclerotic Plaques of Patients with Primary Antiphospholipid Syndrome
Marisa Benagiano, Maria Gerosa, Jacopo Romagnoli, Michael Mahler, Maria O. Borghi, Alessia Grassi, Chiara Della Bella, Giacomo Emmi, Amedeo Amedei, Elena Silvestri, Lorenzo Emmi, Domenico Prisco, Pier Luigi Meroni and Mario M. D’Elios

J Immunol April 1, 2017, 198 (7) 2640-2648; DOI: https://doi.org/10.4049/jimmunol.1600305

IMMUNE REGULATION

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The Bacterial Peptidoglycan-Sensing Molecules NOD1 and NOD2 Promote CD8⁺ Thymocyte Selection
Marianne M. Martinic, Irina Caminschi, Meredith O’Keeffe, Therese C. Thinnes, Raelene Grumont, Steve Gerondakis, Dianne B. McKay, David Nemazee and Amanda L. Gavin

J Immunol April 1, 2017, 198 (7) 2649-2660; DOI: https://doi.org/10.4049/jimmunol.1601462
Open Access
Metformin Suppresses Systemic Autoimmunity in Roquin^san/san Mice through Inhibiting B Cell Differentiation into Plasma Cells via Regulation of AMPK/mTOR/STAT3
Author Choice Article

Seon-Yeong Lee, Su-Jin Moon, Eun-Kyung Kim, Hyeon-Beom Seo, Eun-Ji Yang, Hye-Jin Son, Jae-Kyung Kim, Jun-Ki Min, Sung-Hwan Park and Mi-La Cho

J Immunol April 1, 2017, 198 (7) 2661-2670; DOI: https://doi.org/10.4049/jimmunol.1403088
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Antigen Density Dictates Immune Responsiveness following Red Blood Cell Transfusion
Connie M. Arthur, Seema R. Patel, Nicole H. Smith, Ashley Bennett, Nourine A. Kamili, Amanda Mener, Christian Gerner-Smidt, Harold C. Sullivan, J. Scott Hale, Andreas Wieland, Benjamin Youngblood, James C. Zimring, Jeanne E. Hendrickson and Sean R. Stowell

J Immunol April 1, 2017, 198 (7) 2671-2680; DOI: https://doi.org/10.4049/jimmunol.1601736
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IL-13–Mediated Regulation of Learning and Memory
Tiroyaone M. Brombacher, Justin K. Nono, Keisha S. De Gouveia, Nokuthula Makena, Matthew Darby, Jacqueline Womersley, Ousman Tamgue and Frank Brombacher

J Immunol April 1, 2017, 198 (7) 2681-2688; DOI: https://doi.org/10.4049/jimmunol.1601546
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Exopolysaccharide from Bacillus subtilis Induces Anti-Inflammatory M2 Macrophages That Prevent T Cell–Mediated Disease
Mallory L. Paynich, Sara E. Jones-Burrage and Katherine L. Knight

J Immunol April 1, 2017, 198 (7) 2689-2698; DOI: https://doi.org/10.4049/jimmunol.1601641
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Inducible T Cell Kinase Regulates the Acquisition of Cytolytic Capacity and Degranulation in CD8⁺ CTLs
Senta M. Kapnick, Jane C. Stinchcombe, Gillian M. Griffiths and Pamela L. Schwartzberg

J Immunol April 1, 2017, 198 (7) 2699-2711; DOI: https://doi.org/10.4049/jimmunol.1601202
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Epigenetic Component p66a Modulates Myeloid-Derived Suppressor Cells by Modifying STAT3
Jiaxuan Xin, Zhiqian Zhang, Xiaomin Su, Liyang Wang, Yuan Zhang and Rongcun Yang

J Immunol April 1, 2017, 198 (7) 2712-2720; DOI: https://doi.org/10.4049/jimmunol.1601712
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Normal Thymocyte Egress, T Cell Trafficking, and CD4⁺ T Cell Homeostasis Require Interactions between RGS Proteins and Gα_i2
Il-Young Hwang, Chung Park, Kathleen Harrison and John H. Kehrl

J Immunol April 1, 2017, 198 (7) 2721-2734; DOI: https://doi.org/10.4049/jimmunol.1601433
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Inhibiting Oxidative Phosphorylation In Vivo Restrains Th17 Effector Responses and Ameliorates Murine Colitis
Luigi Franchi, Ivan Monteleone, Ling-Yang Hao, Mark A. Spahr, Wenpu Zhao, Xikui Liu, Kellie Demock, Aditi Kulkarni, Chuck A. Lesch, Brian Sanchez, Laura Carter, Irene Marafini, Xiao Hu, Oksana Mashadova, Min Yuan, John M. Asara, Harinder Singh, Costas A. Lyssiotis, Giovanni Monteleone, Anthony W. Opipari and Gary D. Glick

J Immunol April 1, 2017, 198 (7) 2735-2746; DOI: https://doi.org/10.4049/jimmunol.1600810

IMMUNE SYSTEM DEVELOPMENT

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Roquin Paralogs Differentially Regulate Functional NKT Cell Subsets
Christoph Drees, J. Christoph Vahl, Sabrina Bortoluzzi, Klaus D. Heger, Julius C. Fischer, F. Thomas Wunderlich, Christian Peschel and Marc Schmidt-Supprian

J Immunol April 1, 2017, 198 (7) 2747-2759; DOI: https://doi.org/10.4049/jimmunol.1601732

IMMUNOTHERAPY AND VACCINES

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Peripherally Generated Foxp3⁺ Regulatory T Cells Mediate the Immunomodulatory Effects of IVIg in Allergic Airways Disease
Amir H. Massoud, Gabriel N. Kaufman, Di Xue, Marianne Béland, Marieme Dembele, Ciriaco A. Piccirillo, Walid Mourad and Bruce D. Mazer

J Immunol April 1, 2017, 198 (7) 2760-2771; DOI: https://doi.org/10.4049/jimmunol.1502361
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Novel Adjuvant Based on the Pore-Forming Protein Sticholysin II Encapsulated into Liposomes Effectively Enhances the Antigen-Specific CTL-Mediated Immune Response
Rady J. Laborde, Oraly Sanchez-Ferras, María C. Luzardo, Yoelys Cruz-Leal, Audry Fernández, Circe Mesa, Liliana Oliver, Liem Canet, Liane Abreu-Butin, Catarina V. Nogueira, Mayra Tejuca, Fabiola Pazos, Carlos Álvarez, María E. Alonso, Ieda M. Longo-Maugéri, Michael N. Starnbach, Darren E. Higgins, Luis E. Fernández and María E. Lanio

J Immunol April 1, 2017, 198 (7) 2772-2784; DOI: https://doi.org/10.4049/jimmunol.1600310
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Targeting Influenza Virus Hemagglutinin to Xcr1⁺ Dendritic Cells in the Absence of Receptor-Mediated Endocytosis Enhances Protective Antibody Responses
Arnar Gudjonsson, Anna Lysén, Sreekumar Balan, Vibeke Sundvold-Gjerstad, Catharina Arnold-Schrauf, Lisa Richter, Espen S. Bækkevold, Marc Dalod, Bjarne Bogen and Even Fossum

J Immunol April 1, 2017, 198 (7) 2785-2795; DOI: https://doi.org/10.4049/jimmunol.1601881

INFECTIOUS DISEASE AND HOST RESPONSE

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Monocytes Are the Predominant Cell Type Associated with Listeria monocytogenes in the Gut, but They Do Not Serve as an Intracellular Growth Niche
Grant S. Jones and Sarah E. F. D’Orazio

J Immunol April 1, 2017, 198 (7) 2796-2804; DOI: https://doi.org/10.4049/jimmunol.1602076
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Rapid and Rigorous IL-17A Production by a Distinct Subpopulation of Effector Memory T Lymphocytes Constitutes a Novel Mechanism of Toxic Shock Syndrome Immunopathology
Peter A. Szabo, Ankur Goswami, Delfina M. Mazzuca, Kyoungok Kim, David B. O’Gorman, David A. Hess, Ian D. Welch, Howard A. Young, Bhagirath Singh, John K. McCormick and S. M. Mansour Haeryfar

J Immunol April 1, 2017, 198 (7) 2805-2818; DOI: https://doi.org/10.4049/jimmunol.1601366
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IL-6 Production by TLR-Activated APC Broadly Enhances Aged Cognate CD4 Helper and B Cell Antibody Responses In Vivo
Vinayak Brahmakshatriya, Yi Kuang, Priyadharshini Devarajan, Jingya Xia, Wenliang Zhang, Allen Minh Vong and Susan L. Swain

J Immunol April 1, 2017, 198 (7) 2819-2833; DOI: https://doi.org/10.4049/jimmunol.1601119

INNATE IMMUNITY AND INFLAMMATION

Open Access
Monocyte Subsets Coregulate Inflammatory Responses by Integrated Signaling through TNF and IL-6 at the Endothelial Cell Interface
Author Choice Article

Myriam Chimen, Clara M. Yates, Helen M. McGettrick, Lewis S. C. Ward, Matthew J. Harrison, Bonita Apta, Lea H. Dib, Beat A. Imhof, Paul Harrison, Gerard B. Nash and G. Ed Rainger

J Immunol April 1, 2017, 198 (7) 2834-2843; DOI: https://doi.org/10.4049/jimmunol.1601281
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DNA Repair Interacts with Autophagy To Regulate Inflammatory Responses to Pulmonary Hyperoxia
Yan Ye, Ping Lin, Weidong Zhang, Shirui Tan, Xikun Zhou, Rongpeng Li, Qinqin Pu, Jonathan L. Koff, Archana Dhasarathy, Feng Ma, Xin Deng, Jianxin Jiang and Min Wu

J Immunol April 1, 2017, 198 (7) 2844-2853; DOI: https://doi.org/10.4049/jimmunol.1601001
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Reactive Oxygen Species–Producing Myeloid Cells Act as a Bone Marrow Niche for Sterile Inflammation–Induced Reactive Granulopoiesis
Haiyan Zhu, Hyun-Jeong Kwak, Peng Liu, Besnik Bajrami, Yuanfu Xu, Shin-Young Park, Cesar Nombela-Arrieta, Subhanjan Mondal, Hiroto Kambara, Hongbo Yu, Li Chai, Leslie E. Silberstein, Tao Cheng and Hongbo R. Luo

J Immunol April 1, 2017, 198 (7) 2854-2864; DOI: https://doi.org/10.4049/jimmunol.1602006
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Local TNFR1 Signaling Licenses Murine Neutrophils for Increased TLR-Dependent Cytokine and Eicosanoid Production
Jacques Deguine, Jessica Wei, Roman Barbalat, Karsten Gronert and Gregory M. Barton

J Immunol April 1, 2017, 198 (7) 2865-2875; DOI: https://doi.org/10.4049/jimmunol.1601465
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Identification of Novel Chondroprotective Mediators in Resolving Inflammatory Exudates
Magdalena K. Kaneva, Karin V. Greco, Sarah E. Headland, Trinidad Montero-Melendez, Prashant Mori, Kevin Greenslade, Costantino Pitzalis, Adrian Moore and Mauro Perretti

J Immunol April 1, 2017, 198 (7) 2876-2885; DOI: https://doi.org/10.4049/jimmunol.1601111
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Neutrophil Microparticles Deliver Active Myeloperoxidase to Injured Mucosa To Inhibit Epithelial Wound Healing
Thomas W. Slater, Ariel Finkielsztein, Lorraine A. Mascarenhas, Lindsey C. Mehl, Veronika Butin-Israeli and Ronen Sumagin

J Immunol April 1, 2017, 198 (7) 2886-2897; DOI: https://doi.org/10.4049/jimmunol.1601810
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Surfactant Protein A Inhibits Growth and Adherence of Uropathogenic Escherichia coli To Protect the Bladder from Infection
Jiro Hashimoto, Motoko Takahashi, Atsushi Saito, Masaki Murata, Yuichiro Kurimura, Chiaki Nishitani, Rina Takamiya, Yasuaki Uehara, Yoshihiro Hasegawa, Yoshiki Hiyama, Norimasa Sawada, Satoshi Takahashi, Naoya Masumori, Yoshio Kuroki and Shigeru Ariki

J Immunol April 1, 2017, 198 (7) 2898-2905; DOI: https://doi.org/10.4049/jimmunol.1502626
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Inhibition of Inflammatory Gene Transcription by IL-10 Is Associated with Rapid Suppression of Lipopolysaccharide-Induced Enhancer Activation
Evan A. Conaway, Dalila C. de Oliveira, Christine M. McInnis, Scott B. Snapper and Bruce H. Horwitz

J Immunol April 1, 2017, 198 (7) 2906-2915; DOI: https://doi.org/10.4049/jimmunol.1601781
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Deficiency in IL-1 Receptor Type 2 Aggravates K/BxN Serum Transfer-Induced Arthritis in Mice but Has No Impact on Systemic Inflammatory Responses
Praxedis Martin, Gaby Palmer, Emiliana Rodriguez, Christian Alexander Seemayer, Jennifer Palomo, Dominique Talabot-Ayer and Cem Gabay

J Immunol April 1, 2017, 198 (7) 2916-2926; DOI: https://doi.org/10.4049/jimmunol.1600855
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IL-6 Regulates M2 Polarization and Local Proliferation of Adipose Tissue Macrophages in Obesity
Julia Braune, Ulrike Weyer, Constance Hobusch, Jan Mauer, Jens C. Brüning, Ingo Bechmann and Martin Gericke

J Immunol April 1, 2017, 198 (7) 2927-2934; DOI: https://doi.org/10.4049/jimmunol.1600476
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An Infectious Disease–Associated Il12b Polymorphism Regulates IL-12/23 p40 Transcription Involving Poly(ADP-Ribose) Polymerase 1
Quanju Zhao, Qinglin Du, Fang Wei, Jianping Xie and Xiaojing Ma

J Immunol April 1, 2017, 198 (7) 2935-2942; DOI: https://doi.org/10.4049/jimmunol.1601894

MOLECULAR AND STRUCTURAL IMMUNOLOGY

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Immature Lymphocytes Inhibit Rag1 and Rag2 Transcription and V(D)J Recombination in Response to DNA Double-Strand Breaks
Megan R. Fisher, Adrian Rivera-Reyes, Noah B. Bloch, David G. Schatz and Craig H. Bassing

J Immunol April 1, 2017, 198 (7) 2943-2956; DOI: https://doi.org/10.4049/jimmunol.1601639
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Multitasking Immune Sp185/333 Protein, rSpTransformer-E1, and Its Recombinant Fragments Undergo Secondary Structural Transformation upon Binding Targets
Cheng Man Lun, Barney M. Bishop and L. Courtney Smith

J Immunol April 1, 2017, 198 (7) 2957-2966; DOI: https://doi.org/10.4049/jimmunol.1601795
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Rab11-FIP3 Regulation of Lck Endosomal Traffic Controls TCR Signal Transduction
Jérôme Bouchet, Iratxe del Río-Iñiguez, Elena Vázquez-Chávez, Rémi Lasserre, Sonia Agüera-González, Céline Cuche, Mary W. McCaffrey, Vincenzo Di Bartolo and Andrés Alcover

J Immunol April 1, 2017, 198 (7) 2967-2978; DOI: https://doi.org/10.4049/jimmunol.1600671

TUMOR IMMUNOLOGY

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Virus-Specific CD8⁺ T Cells Infiltrate Melanoma Lesions and Retain Function Independently of PD-1 Expression
Dan A. Erkes, Corinne J. Smith, Nicole A. Wilski, Sofia Caldeira-Dantas, Toktam Mohgbeli and Christopher M. Snyder

J Immunol April 1, 2017, 198 (7) 2979-2988; DOI: https://doi.org/10.4049/jimmunol.1601064
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The Ribosomal Protein S19 Suppresses Antitumor Immune Responses via the Complement C5a Receptor 1
Maciej M. Markiewski, Surya Kumari Vadrevu, Sharad K. Sharma, Navin Kumar Chintala, Shanawaz Ghouse, Jun-Hung Cho, David P. Fairlie, Yvonne Paterson, Aristotelis Astrinidis and Magdalena Karbowniczek

J Immunol April 1, 2017, 198 (7) 2989-2999; DOI: https://doi.org/10.4049/jimmunol.1602057

CORRECTIONS

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Correction: GM-CSF Induces Inflammatory Macrophages by Regulating Glycolysis and Lipid Metabolism
Yi Rang Na, Gyo Jeong Gu, Daun Jung, Young Won Kim, Juri Na, Jin Sun Woo, Joo Youn Cho, Hyewon Youn and Seung Hyeok Seok

J Immunol April 1, 2017, 198 (7) 3000; DOI: https://doi.org/10.4049/jimmunol.1700174

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Table of Contents

IN THIS ISSUE

PILLARS OF IMMUNOLOGY

BRIEF REVIEWS

ALLERGY AND OTHER HYPERSENSITIVITIES

ANTIGEN RECOGNITION AND RESPONSES

AUTOIMMUNITY

CLINICAL AND HUMAN IMMUNOLOGY

IMMUNE REGULATION

IMMUNE SYSTEM DEVELOPMENT

IMMUNOTHERAPY AND VACCINES

INFECTIOUS DISEASE AND HOST RESPONSE

INNATE IMMUNITY AND INFLAMMATION

MOLECULAR AND STRUCTURAL IMMUNOLOGY

TUMOR IMMUNOLOGY

CORRECTIONS

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