The Journal of Immunology: 198 (11)

June 1, 2017; Volume 198,Issue 11

IN THIS ISSUE

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In This Issue
C1q Controls IC Uptake by Splenic APCs In Vivo See article p. 4235
Blocking B Cell AID Protects from T1D See article p. 4255
Ent Eats Iron To Neutralize Neutrophils See article p. 4293
Dual Functions Daunt SIV See article p. 4403

J Immunol June 1, 2017, 198 (11) 4181-4182; DOI: https://doi.org/10.4049/jimmunol.1790007

LETTERS TO THE EDITOR

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Comment on “The Common R71H-G230A-R293Q Human TMEM173 Is a Null Allele”
Kelsey E. Sivick, Natalie H. Surh, Anthony L. Desbien, Eric P. Grewal, George E. Katibah, Sarah M. McWhirter and Thomas W. Dubensky Jr.

J Immunol June 1, 2017, 198 (11) 4183-4185; DOI: https://doi.org/10.4049/jimmunol.1700294
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Response to Comment on “The Common R71H-G230A-R293Q Human TMEM173 Is a Null Allele”
Seema Patel, Steven M. Blaauboer, Heidi R. Tucker, Samira Mansouri, Juan Sebastian Ruiz-Moreno, Lutz Hamann, Ralf R. Schumann, Bastian Opitz and Lei Jin

J Immunol June 1, 2017, 198 (11) 4185-4188; DOI: https://doi.org/10.4049/jimmunol.1700322
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Comment on “Diet-Derived Short Chain Fatty Acids Stimulate Intestinal Epithelial Cells To Induce Mucosal Tolerogenic Dendritic Cells”
Margherita T. Cantorna

J Immunol June 1, 2017, 198 (11) 4188; DOI: https://doi.org/10.4049/jimmunol.1700411
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Response to Comment on “Diet-Derived Short Chain Fatty Acids Stimulate Intestinal Epithelial Cells To Induce Mucosal Tolerogenic Dendritic Cells”
Gera Goverse, Martje Erkelens and Reina Mebius

J Immunol June 1, 2017, 198 (11) 4188; DOI: https://doi.org/10.4049/jimmunol.1700466

PILLARS OF IMMUNOLOGY

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Monocyte-Derived Dendritic Cells: A Transendothelial Trip Launches the Quest To Understand Heterogeneity in the APC Family
Gabrielle T. Belz

J Immunol June 1, 2017, 198 (11) 4189-4190; DOI: https://doi.org/10.4049/jimmunol.1700527
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Pillars Article: Differentiation of Monocytes into Dendritic Cells in a Model of Transendothelial Trafficking. Science. 1998. 282: 480–483
Gwendalyn J. Randolph, Sylvie Beaulieu, Serge Lebecque, Ralph M. Steinman and William A. Muller

J Immunol June 1, 2017, 198 (11) 4191-4194;

BRIEF REVIEWS

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Passive Immunization of Farmed Fish
Binoy Rajan, Guro Løkka, Erling Olaf Koppang and Lars Austbø

J Immunol June 1, 2017, 198 (11) 4195-4202; DOI: https://doi.org/10.4049/jimmunol.1700154

CUTTING EDGE

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Cutting Edge: A Dual TLR2 and TLR7 Ligand Induces Highly Potent Humoral and Cell-Mediated Immune Responses
Alice Gutjahr, Laura Papagno, Francesco Nicoli, Alain Lamoureux, Fabienne Vernejoul, Thierry Lioux, Emma Gostick, David A. Price, Gérard Tiraby, Eric Perouzel, Victor Appay, Bernard Verrier and Stéphane Paul

J Immunol June 1, 2017, 198 (11) 4205-4209; DOI: https://doi.org/10.4049/jimmunol.1602131
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Cutting Edge: Distinct Regulatory Mechanisms Control Proinflammatory Cytokines IL-18 and IL-1β
Qifan Zhu and Thirumala-Devi Kanneganti

J Immunol June 1, 2017, 198 (11) 4210-4215; DOI: https://doi.org/10.4049/jimmunol.1700352

ANTIGEN RECOGNITION AND RESPONSES

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Definition of the Nature and Hapten Threshold of the β-Lactam Antigen Required for T Cell Activation In Vitro and in Patients
Xiaoli Meng, Zaid Al-Attar, Fiazia S. Yaseen, Rosalind Jenkins, Caroline Earnshaw, Paul Whitaker, Daniel Peckham, Neil S. French, Dean J. Naisbitt and B. Kevin Park

J Immunol June 1, 2017, 198 (11) 4217-4227; DOI: https://doi.org/10.4049/jimmunol.1700209
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The Juxtamembrane Domain of Butyrophilin BTN3A1 Controls Phosphoantigen-Mediated Activation of Human Vγ9Vδ2 T Cells
Cassie-Marie Peigné, Alexandra Léger, Marie-Claude Gesnel, Fabienne Konczak, Daniel Olive, Marc Bonneville, Richard Breathnach and Emmanuel Scotet

J Immunol June 1, 2017, 198 (11) 4228-4234; DOI: https://doi.org/10.4049/jimmunol.1601910
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C1q-Dependent Dendritic Cell Cross-Presentation of In Vivo–Formed Antigen–Antibody Complexes
Nataschja I. Ho, Marcel G. M. Camps, Edwin F. E. de Haas, Leendert A. Trouw, J. Sjef Verbeek and Ferry Ossendorp

J Immunol June 1, 2017, 198 (11) 4235-4243; DOI: https://doi.org/10.4049/jimmunol.1602169

AUTOIMMUNITY

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Protein Kinase CK2 Controls the Fate between Th17 Cell and Regulatory T Cell Differentiation
Sara A. Gibson, Wei Yang, Zhaoqi Yan, Yudong Liu, Amber L. Rowse, Amy S. Weinmann, Hongwei Qin and Etty N. Benveniste

J Immunol June 1, 2017, 198 (11) 4244-4254; DOI: https://doi.org/10.4049/jimmunol.1601912
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Genetic and Small Molecule Disruption of the AID/RAD51 Axis Similarly Protects Nonobese Diabetic Mice from Type 1 Diabetes through Expansion of Regulatory B Lymphocytes
Jeremy J. Ratiu, Jeremy J. Racine, Muneer G. Hasham, Qiming Wang, Jane A. Branca, Harold D. Chapman, Jing Zhu, Nina Donghia, Vivek Philip, William H. Schott, Clive Wasserfall, Mark A. Atkinson, Kevin D. Mills, Caroline M. Leeth and David V. Serreze

J Immunol June 1, 2017, 198 (11) 4255-4267; DOI: https://doi.org/10.4049/jimmunol.1700024
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Downregulation of miR-200a-3p, Targeting CtBP2 Complex, Is Involved in the Hypoproduction of IL-2 in Systemic Lupus Erythematosus–Derived T Cells
Eri Katsuyama, Minglu Yan, Katsue Sunahori Watanabe, Syun Matsushima, Yuriko Yamamura, Sumie Hiramatsu, Keiji Ohashi, Haruki Watanabe, Takayuki Katsuyama, Sonia Zeggar, Nobuya Yoshida, Vaishali R. Moulton, George C. Tsokos, Ken-Ei Sada and Jun Wada

J Immunol June 1, 2017, 198 (11) 4268-4276; DOI: https://doi.org/10.4049/jimmunol.1601705

CLINICAL AND HUMAN IMMUNOLOGY

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Oil-Soluble Contrast Medium (OSCM) for Hysterosalpingography Modulates Dendritic Cell and Regulatory T Cell Profiles in the Peritoneal Cavity: A Possible Mechanism by Which OSCM Enhances Fertility
Gentaro Izumi, Kaori Koga, Masashi Takamura, Wang Bo, Miwako Nagai, Mariko Miyashita, Miyuki Harada, Tetsuya Hirata, Yasushi Hirota, Osamu Yoshino, Tomoyuki Fujii and Yutaka Osuga

J Immunol June 1, 2017, 198 (11) 4277-4284; DOI: https://doi.org/10.4049/jimmunol.1600498
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High SYK Expression Drives Constitutive Activation of CD21^low B Cells
Baerbel Keller, Ina Stumpf, Valentina Strohmeier, Susanne Usadel, Els Verhoeyen, Hermann Eibel and Klaus Warnatz

J Immunol June 1, 2017, 198 (11) 4285-4292; DOI: https://doi.org/10.4049/jimmunol.1700079

IMMUNE REGULATION

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Bacterial Siderophores Hijack Neutrophil Functions
Piu Saha, Beng San Yeoh, Rodrigo A. Olvera, Xia Xiao, Vishal Singh, Deepika Awasthi, Bhagawat C. Subramanian, Qiuyan Chen, Madhu Dikshit, Yanming Wang, Carole A. Parent and Matam Vijay-Kumar

J Immunol June 1, 2017, 198 (11) 4293-4303; DOI: https://doi.org/10.4049/jimmunol.1700261
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Lis1 Regulates Germinal Center B Cell Antigen Acquisition and Affinity Maturation
Jingjing Chen, Zhenming Cai, Le Zhang, Yuye Yin, Xufeng Chen, Chao Chen, Yang Zhang, Sulan Zhai, Xuehui Long, Xiaolong Liu and Xiaoming Wang

J Immunol June 1, 2017, 198 (11) 4304-4311; DOI: https://doi.org/10.4049/jimmunol.1700159
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Induction of Adaptive Immunity Leads to Nigrostriatal Disease Progression in MPTP Mouse Model of Parkinson’s Disease
Goutam Chandra, Avik Roy, Suresh B. Rangasamy and Kalipada Pahan

J Immunol June 1, 2017, 198 (11) 4312-4326; DOI: https://doi.org/10.4049/jimmunol.1700149
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Characterization of the Micro-Environment of the Testis that Shapes the Phenotype and Function of Testicular Macrophages
Ming Wang, Monika Fijak, Hamid Hossain, Melanie Markmann, Rolf M. Nüsing, Günter Lochnit, Michaela F. Hartmann, Stefan A. Wudy, Lizong Zhang, Huanpeng Gu, Lutz Konrad, Trinad Chakraborty, Andreas Meinhardt and Sudhanshu Bhushan

J Immunol June 1, 2017, 198 (11) 4327-4340; DOI: https://doi.org/10.4049/jimmunol.1700162
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IL-1R Type 1–Deficient Mice Demonstrate an Impaired Host Immune Response against Cutaneous Vaccinia Virus Infection
Tian Tian, Michelle Qiushuang Jin, Krista Dubin, Sandra L. King, Wolfram Hoetzenecker, George F. Murphy, Chen Amy Chen, Thomas S. Kupper and Robert C. Fuhlbrigge

J Immunol June 1, 2017, 198 (11) 4341-4351; DOI: https://doi.org/10.4049/jimmunol.1500106
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Paracrine IL-2 Is Required for Optimal Type 2 Effector Cytokine Production
Matthew R. Olson, Benjamin J. Ulrich, Sarah A. Hummel, Ibrahim Khan, Brice Meuris, Yesesri Cherukuri, Alexander L. Dent, Sarath Chandra Janga and Mark H. Kaplan

J Immunol June 1, 2017, 198 (11) 4352-4359; DOI: https://doi.org/10.4049/jimmunol.1601792

IMMUNE SYSTEM DEVELOPMENT

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Tolerogenic versus Immunogenic Lipidomic Profiles of CD11c⁺ Immune Cells and Control of Immunogenic Dendritic Cell Ceramide Dynamics
Carlos Ocaña-Morgner, Susanne Sales, Manuela Rothe, Andrej Shevchenko and Rolf Jessberger

J Immunol June 1, 2017, 198 (11) 4360-4372; DOI: https://doi.org/10.4049/jimmunol.1601928

INFECTIOUS DISEASE AND HOST RESPONSE

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IL-20 Signaling in Activated Human Neutrophils Inhibits Neutrophil Migration and Function
Portia Gough, Sundar Ganesan and Sandip K. Datta

J Immunol June 1, 2017, 198 (11) 4373-4382; DOI: https://doi.org/10.4049/jimmunol.1700253
Open Access
AIM2 Inflammasome Is Critical for Influenza-Induced Lung Injury and Mortality
Author Choice Article

Hongbo Zhang, Jiadi Luo, John F. Alcorn, Kong Chen, Songqing Fan, Joseph Pilewski, Aizhong Liu, Wei Chen, Jay K. Kolls and Jieru Wang

J Immunol June 1, 2017, 198 (11) 4383-4393; DOI: https://doi.org/10.4049/jimmunol.1600714
Open Access
Egr2 and 3 Inhibit T-bet–Mediated IFN-γ Production in T Cells
Author Choice Article

Randeep Singh, Tizong Miao, Alistair L. J. Symonds, Becky Omodho, Suling Li and Ping Wang

J Immunol June 1, 2017, 198 (11) 4394-4402; DOI: https://doi.org/10.4049/jimmunol.1602010
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Cytotoxic T Cell Functions Accumulate When CD4 Is Downregulated by CD4⁺ T Cells in African Green Monkeys
Carol L. Vinton, Alexandra M. Ortiz, Nina Calantone, Joseph C. Mudd, Claire Deleage, David R. Morcock, Sonya Whitted, Jacob D. Estes, Vanessa M. Hirsch and Jason M. Brenchley

J Immunol June 1, 2017, 198 (11) 4403-4412; DOI: https://doi.org/10.4049/jimmunol.1700136
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Concomitant Disruption of CD4 and CD8 Genes Facilitates the Development of Double Negative αβ TCR⁺ Peripheral T Cells That Respond Robustly to Staphylococcal Superantigen
Vaidehi R. Chowdhary, Ashton Krogman, Ashenafi Y. Tilahun, Mariam P. Alexander, Chella S. David and Govindarajan Rajagopalan

J Immunol June 1, 2017, 198 (11) 4413-4424; DOI: https://doi.org/10.4049/jimmunol.1601991
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Determination of a Key Antigen for Immunological Intervention To Target the Latent Stage of Toxoplasma gondii
Qila Sa, Eri Ochiai, Ashish Tiwari, Jeremi Mullins, Nilabh Shastri, Corinne Mercier, Marie-France Cesbron-Delauw and Yasuhiro Suzuki

J Immunol June 1, 2017, 198 (11) 4425-4434; DOI: https://doi.org/10.4049/jimmunol.1700062

INNATE IMMUNITY AND INFLAMMATION

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Kinase Activities of RIPK1 and RIPK3 Can Direct IFN-β Synthesis Induced by Lipopolysaccharide
Danish Saleh, Malek Najjar, Matija Zelic, Saumil Shah, Shoko Nogusa, Apostolos Polykratis, Michelle K. Paczosa, Peter J. Gough, John Bertin, Michael Whalen, Katherine A. Fitzgerald, Nikolai Slavov, Manolis Pasparakis, Siddharth Balachandran, Michelle Kelliher, Joan Mecsas and Alexei Degterev

J Immunol June 1, 2017, 198 (11) 4435-4447; DOI: https://doi.org/10.4049/jimmunol.1601717
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Group B Streptococci Induce Proinflammatory Responses via a Protein Kinase D1–Dependent Pathway
Kirtikumar Upadhyay, Jeoung-Eun Park, Tae Won Yoon, Priyanka Halder, Young-In Kim, Victoria Metcalfe, Ajay J. Talati, B. Keith English and Ae-Kyung Yi

J Immunol June 1, 2017, 198 (11) 4448-4457; DOI: https://doi.org/10.4049/jimmunol.1601089
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Galectin-3: A Positive Regulator of Leukocyte Recruitment in the Inflamed Microcirculation
Beatrice R. Gittens, Jennifer V. Bodkin, Sussan Nourshargh, Mauro Perretti and Dianne Cooper

J Immunol June 1, 2017, 198 (11) 4458-4469; DOI: https://doi.org/10.4049/jimmunol.1600709
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AKT2 Regulates Pulmonary Inflammation and Fibrosis via Modulating Macrophage Activation
Yunjuan Nie, Lei Sun, Yaxian Wu, Yaoyao Yang, Jun Wang, Huiqiong He, Yudong Hu, Yanhua Chang, Qing Liang, Jianwei Zhu, Richard D. Ye, John W. Christman and Feng Qian

J Immunol June 1, 2017, 198 (11) 4470-4480; DOI: https://doi.org/10.4049/jimmunol.1601503

MOLECULAR AND STRUCTURAL IMMUNOLOGY

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Novel Molecular Mechanism of Regulation of CD40 Ligand by the Transcription Factor GLI2
Weiguo Han, David A. Jackson, Stephan J. Matissek, Jason A. Misurelli, Matthew S. Neil, Brandon Sklavanitis, Nansalmaa Amarsaikhan and Sherine F. Elsawa

J Immunol June 1, 2017, 198 (11) 4481-4489; DOI: https://doi.org/10.4049/jimmunol.1601490

SYSTEMS IMMUNOLOGY

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CD40L-Dependent Pathway Is Active at Various Stages of Rheumatoid Arthritis Disease Progression
Yanxia Guo, Alice M. Walsh, Ursula Fearon, Malcolm D. Smith, Mihir D. Wechalekar, Xuefeng Yin, Suzanne Cole, Carl Orr, Trudy McGarry, Mary Canavan, Stephan Kelly, Tai-An Lin, Xuejun Liu, Susanna M. Proudman, Douglas J. Veale, Costantino Pitzalis and Sunil Nagpal

J Immunol June 1, 2017, 198 (11) 4490-4501; DOI: https://doi.org/10.4049/jimmunol.1601988

TUMOR IMMUNOLOGY

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Murinization and H Chain Isotype Matching of the Anti-GITR Antibody DTA-1 Reduces Immunogenicity-Mediated Anaphylaxis in C57BL/6 Mice
Nicole A. Belmar, Sarah W. Chan, Melvin I. Fox, Josue A. Samayoa, Marcia M. Stickler, Ninian N. Tran, Yoshiko Akamatsu, Diane Hollenbaugh, Fiona A. Harding and Hamsell M. Alvarez

J Immunol June 1, 2017, 198 (11) 4502-4512; DOI: https://doi.org/10.4049/jimmunol.1601512
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Type 1 Immune Mechanisms Driven by the Response to Infection with Attenuated Rabies Virus Result in Changes in the Immune Bias of the Tumor Microenvironment and Necrosis of Mouse GL261 Brain Tumors
Emily K. Bongiorno, Samantha A. Garcia, Sami Sauma and D. Craig Hooper

J Immunol June 1, 2017, 198 (11) 4513-4523; DOI: https://doi.org/10.4049/jimmunol.1601444

NOVEL IMMUNOLOGICAL METHODS

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Nature and Clonality of the Fluoresceinated Secondary Antibody in Luminex Multiplex Bead Assays Are Critical Factors for Reliable Monitoring of Serum HLA Antibody Levels in Patients for Donor Organ Selection, Desensitization Therapy, and Assessment of the Risk for Graft Loss
Mepur H. Ravindranath, Vadim Jucaud, Nubia Banuelos, Matthew J. Everly, Junchao Cai, Anh Nguyen and Paul I. Terasaki

J Immunol June 1, 2017, 198 (11) 4524-4538; DOI: https://doi.org/10.4049/jimmunol.1700050
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Using Visualization of t-Distributed Stochastic Neighbor Embedding To Identify Immune Cell Subsets in Mouse Tumors
Nicole V. Acuff and Joel Linden

J Immunol June 1, 2017, 198 (11) 4539-4546; DOI: https://doi.org/10.4049/jimmunol.1602077

CORRECTIONS

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Correction: The Common R71H-G230A-R293Q Human TMEM173 Is a Null Allele
Seema Patel, Steven M. Blaauboer, Heidi R. Tucker, Samira Mansouri, Juan Sebastian Ruiz-Moreno, Lutz Hamann, Ralf R. Schumann, Bastian Opitz and Lei Jin

J Immunol June 1, 2017, 198 (11) 4547; DOI: https://doi.org/10.4049/jimmunol.1700477

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Table of Contents

IN THIS ISSUE

LETTERS TO THE EDITOR

PILLARS OF IMMUNOLOGY

BRIEF REVIEWS

CUTTING EDGE

ANTIGEN RECOGNITION AND RESPONSES

AUTOIMMUNITY

CLINICAL AND HUMAN IMMUNOLOGY

IMMUNE REGULATION

IMMUNE SYSTEM DEVELOPMENT

INFECTIOUS DISEASE AND HOST RESPONSE

INNATE IMMUNITY AND INFLAMMATION

MOLECULAR AND STRUCTURAL IMMUNOLOGY

SYSTEMS IMMUNOLOGY

TUMOR IMMUNOLOGY

NOVEL IMMUNOLOGICAL METHODS

CORRECTIONS

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