The Journal of Immunology: 198 (10)

May 15, 2017; Volume 198,Issue 10

IN THIS ISSUE

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In This Issue
The Impact of Secondhand Smoke Exposure: It Runs in the Family See article p. 3815
RGC-32 Regulates Th17 Responses See article p. 3869
Cell Cycle Progress Is Gone in B Cells Lacking GON4L See article p. 3978
Targeting Tumor-Localized Myeloid Cells See article p. 4166

J Immunol May 15, 2017, 198 (10) 3763-3764; DOI: https://doi.org/10.4049/jimmunol.1790006

IMMUNOLOGY NOTES AND RESOURCES

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High-Throughput Immunogenetics for Clinical and Research Applications in Immunohematology: Potential and Challenges
Anton W. Langerak, Monika Brüggemann, Frédéric Davi, Nikos Darzentas, Jacques J. M. van Dongen, David Gonzalez, Gianni Cazzaniga, Véronique Giudicelli, Marie-Paule Lefranc, Mathieu Giraud, Elizabeth A. Macintyre, Michael Hummel, Christiane Pott, Patricia J. T. A. Groenen and Kostas Stamatopoulos

J Immunol May 15, 2017, 198 (10) 3765-3774; DOI: https://doi.org/10.4049/jimmunol.1602050
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A Consensus Definitive Classification of Scavenger Receptors and Their Roles in Health and Disease
Mercy R. PrabhuDas, Cynthia L. Baldwin, Paul L. Bollyky, Dawn M. E. Bowdish, Kurt Drickamer, Maria Febbraio, Joachim Herz, Lester Kobzik, Monty Krieger, John Loike, Benita McVicker, Terry K. Means, Soren K. Moestrup, Steven R. Post, Tatsuya Sawamura, Samuel Silverstein, Robert C. Speth, Janice C. Telfer, Geoffrey M. Thiele, Xiang-Yang Wang, Samuel D. Wright and Joseph El Khoury

J Immunol May 15, 2017, 198 (10) 3775-3789; DOI: https://doi.org/10.4049/jimmunol.1700373

BRIEF REVIEWS

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Innate Control of Adaptive Immunity: Beyond the Three-Signal Paradigm
Aakanksha Jain and Chandrashekhar Pasare

J Immunol May 15, 2017, 198 (10) 3791-3800; DOI: https://doi.org/10.4049/jimmunol.1602000

CUTTING EDGE

Open Access
Cutting Edge: Increased Autoimmunity Risk in Glycogen Storage Disease Type 1b Is Associated with a Reduced Engagement of Glycolysis in T Cells and an Impaired Regulatory T Cell Function
Author Choice Article

Daniela Melis, Fortunata Carbone, Giorgia Minopoli, Claudia La Rocca, Francesco Perna, Veronica De Rosa, Mario Galgani, Generoso Andria, Giancarlo Parenti and Giuseppe Matarese

J Immunol May 15, 2017, 198 (10) 3803-3808; DOI: https://doi.org/10.4049/jimmunol.1601946
Open Access
Cutting Edge: Selective Oral ROCK2 Inhibitor Reduces Clinical Scores in Patients with Psoriasis Vulgaris and Normalizes Skin Pathology via Concurrent Regulation of IL-17 and IL-10
Author Choice Article

Alexandra Zanin-Zhorov, Jonathan M. Weiss, Alissa Trzeciak, Wei Chen, Jingya Zhang, Melanie S. Nyuydzefe, Carmen Arencibia, Seetharam Polimera, Olivier Schueller, Judilyn Fuentes-Duculan, Kathleen M. Bonifacio, Norma Kunjravia, Inna Cueto, Jennifer Soung, Roy M. Fleischmann, Alan Kivitz, Mark Lebwohl, Margarita Nunez, Johnnie Woodson, Shondra L. Smith, Robert F. West, Mark Berger, James G. Krueger, John L. Ryan and Samuel D. Waksal

J Immunol May 15, 2017, 198 (10) 3809-3814; DOI: https://doi.org/10.4049/jimmunol.1602142

ALLERGY AND OTHER HYPERSENSITIVITIES

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Gestational Exposure to Sidestream (Secondhand) Cigarette Smoke Promotes Transgenerational Epigenetic Transmission of Exacerbated Allergic Asthma and Bronchopulmonary Dysplasia
Shashi P. Singh, Hitendra S. Chand, Raymond J. Langley, Neerad Mishra, Ted Barrett, Karin Rudolph, Carmen Tellez, Piotr T. Filipczak, Steve Belinsky, Ali I. Saeed, Aryaz Sheybani, Vernat Exil, Hemant Agarwal, Venkataramana K. Sidhaye, Thomas Sussan, Shyam Biswal and Mohan Sopori

J Immunol May 15, 2017, 198 (10) 3815-3822; DOI: https://doi.org/10.4049/jimmunol.1700014
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Blocking Allergic Reaction through Targeting Surface-Bound IgE with Low-Affinity Anti-IgE Antibodies
Ke Zhang, Jeffrey Liu, Thao Truong, Elyssa Zukin, Wendy Chen and Andrew Saxon

J Immunol May 15, 2017, 198 (10) 3823-3834; DOI: https://doi.org/10.4049/jimmunol.1602022

ANTIGEN RECOGNITION AND RESPONSES

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Varied Role of Ubiquitylation in Generating MHC Class I Peptide Ligands
Jiajie Wei, Damien Zanker, Anthony R. Di Carluccio, Margery G. Smelkinson, Kazuyo Takeda, Mina O. Seedhom, Devin Dersh, James S. Gibbs, Ning Yang, Ajit Jadhav, Weisan Chen and Jonathan W. Yewdell

J Immunol May 15, 2017, 198 (10) 3835-3845; DOI: https://doi.org/10.4049/jimmunol.1602122
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Characterization of T-Dependent and T-Independent B Cell Responses to a Virus-like Particle
Wenhua Liao, Zhaolin Hua, Can Liu, Lin Lin, Rui Chen and Baidong Hou

J Immunol May 15, 2017, 198 (10) 3846-3856; DOI: https://doi.org/10.4049/jimmunol.1601852

AUTOIMMUNITY

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CD137 Plays Both Pathogenic and Protective Roles in Type 1 Diabetes Development in NOD Mice
Matthew H. Forsberg, Ashley E. Ciecko, Kyle J. Bednar, Arata Itoh, Kritika Kachapati, William M. Ridgway and Yi-Guang Chen

J Immunol May 15, 2017, 198 (10) 3857-3868; DOI: https://doi.org/10.4049/jimmunol.1601851
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RGC-32 Promotes Th17 Cell Differentiation and Enhances Experimental Autoimmune Encephalomyelitis
Violeta Rus, Vinh Nguyen, Alexandru Tatomir, Jason R. Lees, Armugam P. Mekala, Dallas Boodhoo, Cosmin A. Tegla, Irina G. Luzina, Paul A. Antony, Cornelia D. Cudrici, Tudor C. Badea and Horea G. Rus

J Immunol May 15, 2017, 198 (10) 3869-3877; DOI: https://doi.org/10.4049/jimmunol.1602158
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The Nuclear Receptor Nr4a1 Acts as a Microglia Rheostat and Serves as a Therapeutic Target in Autoimmune-Driven Central Nervous System Inflammation
Tobias Rothe, Natacha Ipseiz, Maria Faas, Stefanie Lang, Francesc Perez-Branguli, Daniel Metzger, Hiroshi Ichinose, Beate Winner, Georg Schett and Gerhard Krönke

J Immunol May 15, 2017, 198 (10) 3878-3885; DOI: https://doi.org/10.4049/jimmunol.1600638

CLINICAL AND HUMAN IMMUNOLOGY

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Chronic Fibro-Inflammatory Responses in Autoimmune Pancreatitis Depend on IFN-α and IL-33 Produced by Plasmacytoid Dendritic Cells
Tomohiro Watanabe, Kouhei Yamashita, Yasuyuki Arai, Kosuke Minaga, Ken Kamata, Tomoyuki Nagai, Yoriaki Komeda, Mamoru Takenaka, Satoru Hagiwara, Hiroshi Ida, Toshiharu Sakurai, Naoshi Nishida, Warren Strober and Masatoshi Kudo

J Immunol May 15, 2017, 198 (10) 3886-3896; DOI: https://doi.org/10.4049/jimmunol.1700060

IMMUNE REGULATION

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CXCL17 Attenuates Imiquimod-Induced Psoriasis-like Skin Inflammation by Recruiting Myeloid-Derived Suppressor Cells and Regulatory T Cells
Tomonori Oka, Makoto Sugaya, Naomi Takahashi, Takehiro Takahashi, Sayaka Shibata, Tomomitsu Miyagaki, Yoshihide Asano and Shinichi Sato

J Immunol May 15, 2017, 198 (10) 3897-3908; DOI: https://doi.org/10.4049/jimmunol.1601607
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IL-7Rα Expression Regulates Murine Dendritic Cell Sensitivity to Thymic Stromal Lymphopoietin
Laura Kummola, Zsuzsanna Ortutay, Xi Chen, Stephane Caucheteux, Sanna Hämäläinen, Saara Aittomäki, Ryoji Yagi, Jinfang Zhu, Marko Pesu, William E. Paul and Ilkka S. Junttila

J Immunol May 15, 2017, 198 (10) 3909-3918; DOI: https://doi.org/10.4049/jimmunol.1600753
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A Novel miR-24–TCF1 Axis in Modulating Effector T Cell Responses
Sunglim Cho, Cheng-Jang Wu, Duc T. Nguyen, Ling-Li Lin, Mei-Chi Chen, Aly Azeem Khan, Bi-Huei Yang, Wenxian Fu and Li-Fan Lu

J Immunol May 15, 2017, 198 (10) 3919-3926; DOI: https://doi.org/10.4049/jimmunol.1601404
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The Histone Acetyltransferase Gcn5 Positively Regulates T Cell Activation
Beixue Gao, Qingfei Kong, Yana Zhang, Chawon Yun, Sharon Y. R. Dent, Jianxun Song, Donna D. Zhang, Yiming Wang, Xuemei Li and Deyu Fang

J Immunol May 15, 2017, 198 (10) 3927-3938; DOI: https://doi.org/10.4049/jimmunol.1600312
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mTORC1 Promotes T-bet Phosphorylation To Regulate Th1 Differentiation
Olesya Chornoguz, Robert S. Hagan, Azeb Haile, Matthew L. Arwood, Christopher J. Gamper, Arnob Banerjee and Jonathan D. Powell

J Immunol May 15, 2017, 198 (10) 3939-3948; DOI: https://doi.org/10.4049/jimmunol.1601078
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Invariant NKT Cell Activation Is Potentiated by Homotypic trans-Ly108 Interactions
Yuriy Baglaenko, Mayra Cruz Tleugabulova, Eric Gracey, Nafiseh Talaei, Kieran Patricia Manion, Nan-Hua Chang, Dario Michael Ferri, Thierry Mallevaey and Joan E. Wither

J Immunol May 15, 2017, 198 (10) 3949-3962; DOI: https://doi.org/10.4049/jimmunol.1601369

IMMUNE SYSTEM DEVELOPMENT

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Mechanisms That Shape Human Antibody Repertoire Development in Mice Transgenic for Human Ig H and L Chain Loci
Nancy S. Longo, Tobias Rogosch, Michael Zemlin, Moncef Zouali and Peter E. Lipsky

J Immunol May 15, 2017, 198 (10) 3963-3977; DOI: https://doi.org/10.4049/jimmunol.1700133
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Early B Cell Progenitors Deficient for GON4L Fail To Differentiate Due to a Block in Mitotic Cell Division
Jennifer Y. Barr, Renee X. Goodfellow, Diana F. Colgan and John D. Colgan

J Immunol May 15, 2017, 198 (10) 3978-3988; DOI: https://doi.org/10.4049/jimmunol.1602054

IMMUNOTHERAPY AND VACCINES

Open Access
Interference of the T Cell and Antigen-Presenting Cell Costimulatory Pathway Using CTLA4-Ig (Abatacept) Prevents Staphylococcal Enterotoxin B Pathology
Author Choice Article

Sarah J. C. Whitfield, Chris Taylor, Jane E. Risdall, Gareth D. Griffiths, James T. A. Jones, E. Diane Williamson, Sjoerd Rijpkema, Luisa Saraiva, Sandrine Vessillier, A. Christopher Green and Alun J. Carter

J Immunol May 15, 2017, 198 (10) 3989-3998; DOI: https://doi.org/10.4049/jimmunol.1601525
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Antibody Distance from the Cell Membrane Regulates Antibody Effector Mechanisms
Kirstie L. S. Cleary, H. T. Claude Chan, Sonja James, Martin J. Glennie and Mark S. Cragg

J Immunol May 15, 2017, 198 (10) 3999-4011; DOI: https://doi.org/10.4049/jimmunol.1601473
Open Access
Induction of an IFN-Mediated Antiviral Response by a Self-Amplifying RNA Vaccine: Implications for Vaccine Design
Author Choice Article

Timothy Pepini, Anne-Marie Pulichino, Thomas Carsillo, Alicia L. Carlson, Farid Sari-Sarraf, Katrin Ramsauer, Jason C. Debasitis, Giulietta Maruggi, Gillis R. Otten, Andrew J. Geall, Dong Yu, Jeffrey B. Ulmer and Carlo Iavarone

J Immunol May 15, 2017, 198 (10) 4012-4024; DOI: https://doi.org/10.4049/jimmunol.1601877

INFECTIOUS DISEASE AND HOST RESPONSE

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Antibody Epitopes Identified in Critical Regions of Dengue Virus Nonstructural 1 Protein in Mouse Vaccination and Natural Human Infections
Tomer Hertz, P. Robert Beatty, Zachary MacMillen, Sarah S. Killingbeck, Chunling Wang and Eva Harris

J Immunol May 15, 2017, 198 (10) 4025-4035; DOI: https://doi.org/10.4049/jimmunol.1700029
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Direct Antimicrobial Activity of IFN-β
Amber Kaplan, Michelle W. Lee, Andrea J. Wolf, Jose J. Limon, Courtney A. Becker, Minna Ding, Ramachandran Murali, Ernest Y. Lee, George Y. Liu, Gerard C. L. Wong and David M. Underhill

J Immunol May 15, 2017, 198 (10) 4036-4045; DOI: https://doi.org/10.4049/jimmunol.1601226
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Sex-Based Differences in Susceptibility to Severe Acute Respiratory Syndrome Coronavirus Infection
Rudragouda Channappanavar, Craig Fett, Matthias Mack, Patrick P. Ten Eyck, David K. Meyerholz and Stanley Perlman

J Immunol May 15, 2017, 198 (10) 4046-4053; DOI: https://doi.org/10.4049/jimmunol.1601896
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CD11c-Expressing Cells Affect Regulatory T Cell Behavior in the Meninges during Central Nervous System Infection
Carleigh A. O’Brien, Christopher Overall, Christoph Konradt, Aisling C. O’Hara Hall, Nikolas W. Hayes, Sagie Wagage, Beena John, David A. Christian, Christopher A. Hunter and Tajie H. Harris

J Immunol May 15, 2017, 198 (10) 4054-4061; DOI: https://doi.org/10.4049/jimmunol.1601581
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EBV MicroRNA BART16 Suppresses Type I IFN Signaling
Marjolein J. G. Hooykaas, Michiel van Gent, Jasper A. Soppe, Elisabeth Kruse, Ingrid G. J. Boer, Dik van Leenen, Marian J. A. Groot Koerkamp, Frank C. P. Holstege, Maaike E. Ressing, Emmanuel J. H. J. Wiertz and Robert Jan Lebbink

J Immunol May 15, 2017, 198 (10) 4062-4073; DOI: https://doi.org/10.4049/jimmunol.1501605

INNATE IMMUNITY AND INFLAMMATION

Open Access
Endothelial MAPKs Direct ICAM-1 Signaling to Divergent Inflammatory Functions
Author Choice Article

Silvia Dragoni, Natalie Hudson, Bridget-Ann Kenny, Thomas Burgoyne, Jenny A. McKenzie, Yadvinder Gill, Robert Blaber, Clare E. Futter, Peter Adamson, John Greenwood and Patric Turowski

J Immunol May 15, 2017, 198 (10) 4074-4085; DOI: https://doi.org/10.4049/jimmunol.1600823
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Raf Kinase Inhibitor Protein Preferentially Promotes TLR3-Triggered Signaling and Inflammation
Rongrong Lai, Meidi Gu, Wei Jiang, Wenlong Lin, Penglei Xu, Zhiyong Liu, He Huang, Huazhang An and Xiaojian Wang

J Immunol May 15, 2017, 198 (10) 4086-4095; DOI: https://doi.org/10.4049/jimmunol.1601672
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Microbiota-Induced Antibodies Are Essential for Host Inflammatory Responsiveness to Sterile and Infectious Stimuli
Daniel Cisalpino, Caio T. Fagundes, Camila B. Brito, Fernando R. Ascenção, Celso M. Queiroz-Junior, Angélica T. Vieira, Lirlândia P. Sousa, Flávio A. Amaral, Leda Q. Vieira, Jacques R. Nicoli, Mauro M. Teixeira and Danielle G. Souza

J Immunol May 15, 2017, 198 (10) 4096-4106; DOI: https://doi.org/10.4049/jimmunol.1600852

MUCOSAL IMMUNOLOGY

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Mucosal IgM Antibody with d-Mannose Affinity in Fugu Takifugu rubripes Is Utilized by a Monogenean Parasite Heterobothrium okamotoi for Host Recognition
Kento Igarashi, Ryohei Matsunaga, Sachi Hirakawa, Sho Hosoya, Hiroaki Suetake, Kiyoshi Kikuchi, Yuzuru Suzuki, Osamu Nakamura, Toshiaki Miyadai, Satoshi Tasumi and Shigeyuki Tsutsui

J Immunol May 15, 2017, 198 (10) 4107-4114; DOI: https://doi.org/10.4049/jimmunol.1601996
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Extravillous Trophoblast and Endothelial Cell Crosstalk Mediates Leukocyte Infiltration to the Early Remodeling Decidual Spiral Arteriole Wall
Ruhul H. Choudhury, Caroline E. Dunk, Stephen J. Lye, John D. Aplin, Lynda K. Harris and Rebecca L. Jones

J Immunol May 15, 2017, 198 (10) 4115-4128; DOI: https://doi.org/10.4049/jimmunol.1601175

TUMOR IMMUNOLOGY

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The Granulocyte Progenitor Stage Is a Key Target of IRF8-Mediated Regulation of Myeloid-Derived Suppressor Cell Production
Colleen S. Netherby, Michelle N. Messmer, Lauren Burkard-Mandel, Sean Colligan, Austin Miller, Eduardo Cortes Gomez, Jianmin Wang, Michael J. Nemeth and Scott I. Abrams

J Immunol May 15, 2017, 198 (10) 4129-4139; DOI: https://doi.org/10.4049/jimmunol.1601722
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Aminoacyl tRNA Synthetase–Interacting Multifunctional Protein 1 Activates NK Cells via Macrophages In Vitro and In Vivo
Myun Soo Kim, Ju Han Song, Edward P. Cohen, Daeho Cho and Tae Sung Kim

J Immunol May 15, 2017, 198 (10) 4140-4147; DOI: https://doi.org/10.4049/jimmunol.1601558

NOVEL IMMUNOLOGICAL METHODS

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CSReport: A New Computational Tool Designed for Automatic Analysis of Class Switch Recombination Junctions Sequenced by High-Throughput Sequencing
François Boyer, Hend Boutouil, Iman Dalloul, Zeinab Dalloul, Jeanne Cook-Moreau, Jean-Claude Aldigier, Claire Carrion, Bastien Herve, Erwan Scaon, Michel Cogné and Sophie Péron

J Immunol May 15, 2017, 198 (10) 4148-4155; DOI: https://doi.org/10.4049/jimmunol.1601924
Open Access
Antigen Receptor Galaxy: A User-Friendly, Web-Based Tool for Analysis and Visualization of T and B Cell Receptor Repertoire Data
Author Choice Article

Hanna IJspeert, Pauline A. van Schouwenburg, David van Zessen, Ingrid Pico-Knijnenburg, Andrew P. Stubbs and Mirjam van der Burg

J Immunol May 15, 2017, 198 (10) 4156-4165; DOI: https://doi.org/10.4049/jimmunol.1601921
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4PD Functionalized Dendrimers: A Flexible Tool for In Vivo Gene Silencing of Tumor-Educated Myeloid Cells
Serena Zilio, Jennifer L. Vella, Adriana C. De la Fuente, Pirouz M. Daftarian, Donald T. Weed, Angel Kaifer, Ilaria Marigo, Kevin Leone, Vincenzo Bronte and Paolo Serafini

J Immunol May 15, 2017, 198 (10) 4166-4177; DOI: https://doi.org/10.4049/jimmunol.1600833

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Table of Contents

IN THIS ISSUE

IMMUNOLOGY NOTES AND RESOURCES

BRIEF REVIEWS

CUTTING EDGE

ALLERGY AND OTHER HYPERSENSITIVITIES

ANTIGEN RECOGNITION AND RESPONSES

AUTOIMMUNITY

CLINICAL AND HUMAN IMMUNOLOGY

IMMUNE REGULATION

IMMUNE SYSTEM DEVELOPMENT

IMMUNOTHERAPY AND VACCINES

INFECTIOUS DISEASE AND HOST RESPONSE

INNATE IMMUNITY AND INFLAMMATION

MUCOSAL IMMUNOLOGY

TUMOR IMMUNOLOGY

NOVEL IMMUNOLOGICAL METHODS

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