The Journal of Immunology: 197 (7)

October 1, 2016; Volume 197,Issue 7

IN THIS ISSUE

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In This Issue
No Air? HIF Can Help! See article p. 2646
Letting Lymphoid Progenitors In See article p. 2665
A GAP in Transendothelial Migration See article p. 2807
Blood-Borne RNA Correlates with Disease Severity in SLE See article p. 2854

J Immunol October 1, 2016, 197 (7) 2555-2556; DOI: https://doi.org/10.4049/jimmunol.1690015

LETTERS TO THE EDITOR

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Comment on “A Cytokine-Independent Approach To Identify Antigen-Specific Human Germinal Center T Follicular Helper Cells and Rare Antigen-Specific CD4⁺ T Cells in Blood”
Laura Cook, John J. Zaunders and Anthony D. Kelleher

J Immunol October 1, 2016, 197 (7) 2557-2558; DOI: https://doi.org/10.4049/jimmunol.1601311
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Response to Comment on “A Cytokine-Independent Approach To Identify Antigen-Specific Human Germinal Center T Follicular Helper Cells and Rare Antigen-Specific CD4⁺ T Cells in Blood”
Jennifer M. Dan, Colin Havenar-Daughton, Guido Silvestri, Alessandro Sette and Shane Crotty

J Immunol October 1, 2016, 197 (7) 2558; DOI: https://doi.org/10.4049/jimmunol.1601321

PILLARS OF IMMUNOLOGY

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TLR4: The Winding Road to the Discovery of the LPS Receptor
Jessica L. Murdock and Gabriel Núñez

J Immunol October 1, 2016, 197 (7) 2561-2562; DOI: https://doi.org/10.4049/jimmunol.1601400
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Pillars Article: Cutting Edge: Toll-Like Receptor 4 (TLR4)-Deficient Mice Are Hyporesponsive to Lipopolysaccharide: Evidence for TLR4 as the Lps Gene Product. J. Immunol. 1999. 162: 3749–3752
Katsuaki Hoshino, Osamu Takeuchi, Taro Kawai, Hideki Sanjo, Tomohiko Ogawa, Yoshifumi Takeda, Kiyoshi Takeda and Shizuo Akira

J Immunol October 1, 2016, 197 (7) 2563-2566;

BRIEF REVIEWS

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Role of Metabolism in the Immunobiology of Regulatory T Cells
Mario Galgani, Veronica De Rosa, Antonio La Cava and Giuseppe Matarese

J Immunol October 1, 2016, 197 (7) 2567-2575; DOI: https://doi.org/10.4049/jimmunol.1600242

CUTTING EDGE

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Cutting Edge: Direct Sensing of TLR7 Ligands and Type I IFN by the Common Myeloid Progenitor Promotes mTOR/PI3K-Dependent Emergency Myelopoiesis
Matthew B. Buechler, Holly M. Akilesh and Jessica A. Hamerman

J Immunol October 1, 2016, 197 (7) 2577-2582; DOI: https://doi.org/10.4049/jimmunol.1600813
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Cutting Edge: IgE Plays an Active Role in Tumor Immunosurveillance in Mice
Elisa A. Nigro, Anna T. Brini, Vijay A. Yenagi, Lorena M. Ferreira, Gertrude Achatz-Straussberger, Alessandro Ambrosi, Francesca Sanvito, Elisa Soprana, Eelco van Anken, Gernot Achatz, Antonio G. Siccardi and Luca Vangelista

J Immunol October 1, 2016, 197 (7) 2583-2588; DOI: https://doi.org/10.4049/jimmunol.1601026

AUTOIMMUNITY

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Influence of Extracellular RNAs, Released by Rheumatoid Arthritis Synovial Fibroblasts, on Their Adhesive and Invasive Properties
Birgit Zimmermann-Geller, Sina Köppert, Silvia Fischer, Hector A. Cabrera-Fuentes, Stephanie Lefèvre, Markus Rickert, Jürgen Steinmeyer, Stefan Rehart, Thomas Umscheid, Markus Schönburg, Ulf Müller-Ladner, Klaus T. Preissner, Klaus W. Frommer and Elena Neumann

J Immunol October 1, 2016, 197 (7) 2589-2597; DOI: https://doi.org/10.4049/jimmunol.1501580
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ERβ-Dependent Direct Suppression of Human and Murine Th17 Cells and Treatment of Established Central Nervous System Autoimmunity by a Neurosteroid
Maria Aggelakopoulou, Evangelia Kourepini, Nikolaos Paschalidis, Davina C. M. Simoes, Dimitra Kalavrizioti, Nikolaos Dimisianos, Panagiotis Papathanasopoulos, Athanasia Mouzaki and Vily Panoutsakopoulou

J Immunol October 1, 2016, 197 (7) 2598-2609; DOI: https://doi.org/10.4049/jimmunol.1601038

CLINICAL AND HUMAN IMMUNOLOGY

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Augmentation of Circulating Follicular Helper T Cells and Their Impact on Autoreactive B Cells in Myasthenia Gravis
Cun-Jin Zhang, Ye Gong, Wenli Zhu, Yuan Qi, Chun-Sheng Yang, Ying Fu, Guoqiang Chang, Yujing Li, Samuel Shi, Kristofer Wood, Shafeeq Ladha, Fu-Dong Shi, Qiang Liu and Yaping Yan

J Immunol October 1, 2016, 197 (7) 2610-2617; DOI: https://doi.org/10.4049/jimmunol.1500725

IMMUNE REGULATION

Open Access
Selective Memory to Apoptotic Cell–Derived Self-Antigens with Implications for Systemic Lupus Erythematosus Development
Author Choice Article

Amanda Duhlin, Yunying Chen, Fredrik Wermeling, Saikiran K. Sedimbi, Emma Lindh, Rahul Shinde, Marie Jo Halaby, Ylva Kaiser, Ola Winqvist, Tracy L. McGaha and Mikael C. I. Karlsson

J Immunol October 1, 2016, 197 (7) 2618-2626; DOI: https://doi.org/10.4049/jimmunol.1401129
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Functions of Smad Transcription Factors in TGF-β1–Induced Selectin Ligand Expression on Murine CD4 Th Cells
Mark E. Ebel and Geoffrey S. Kansas

J Immunol October 1, 2016, 197 (7) 2627-2634; DOI: https://doi.org/10.4049/jimmunol.1600723
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A 33D1⁺ Dendritic Cell/Autoreactive CD4⁺ T Cell Circuit Maintains IL-2–Dependent Regulatory T Cells in the Spleen
J. Michael Stolley and Daniel J. Campbell

J Immunol October 1, 2016, 197 (7) 2635-2645; DOI: https://doi.org/10.4049/jimmunol.1600974
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Transcription Factor HIF-1α Controls Expression of the Cytokine IL-22 in CD4 T Cells
Scott A. Budda, Alanson Girton, Jacob G. Henderson and Lauren A. Zenewicz

J Immunol October 1, 2016, 197 (7) 2646-2652; DOI: https://doi.org/10.4049/jimmunol.1600250
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Allergen-Induced IL-6 Regulates IL-9/IL-17A Balance in CD4⁺ T Cells in Allergic Airway Inflammation
Nicole Schütze, Stefanie Trojandt, Stephanie Kuhn, Janina M. Tomm, Martin von Bergen, Jan C. Simon and Tobias Polte

J Immunol October 1, 2016, 197 (7) 2653-2664; DOI: https://doi.org/10.4049/jimmunol.1501599

IMMUNE SYSTEM DEVELOPMENT

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Lymphotoxin β Receptor Controls T Cell Progenitor Entry to the Thymus
Author Choice Article

Beth Lucas, Kieran D. James, Emilie J. Cosway, Sonia M. Parnell, Alexi V. Tumanov, Carl F. Ware, William E. Jenkinson and Graham Anderson

J Immunol October 1, 2016, 197 (7) 2665-2672; DOI: https://doi.org/10.4049/jimmunol.1601189
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The RNA-Binding Proteins Zfp36l1 and Zfp36l2 Enforce the Thymic β-Selection Checkpoint by Limiting DNA Damage Response Signaling and Cell Cycle Progression
Katharina U. Vogel, Lewis S. Bell, Alison Galloway, Helena Ahlfors and Martin Turner

J Immunol October 1, 2016, 197 (7) 2673-2685; DOI: https://doi.org/10.4049/jimmunol.1600854
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Nestin-Expressing Precursors Give Rise to Both Endothelial as well as Nonendothelial Lymph Node Stromal Cells
Jasper J. Koning, Tanja Konijn, Kim A. Lakeman, Tom O’Toole, Keane J. G. Kenswil, Marc H. G. P. Raaijmakers, Tatyana V. Michurina, Grigori Enikolopov and Reina E. Mebius

J Immunol October 1, 2016, 197 (7) 2686-2694; DOI: https://doi.org/10.4049/jimmunol.1501162

IMMUNOGENETICS

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Characterization of Lamprey BAFF-like Gene: Evolutionary Implications
Sabyasachi Das, Yoichi Sutoh, Masayuki Hirano, Qifeng Han, Jianxu Li, Max D. Cooper and Brantley R. Herrin

J Immunol October 1, 2016, 197 (7) 2695-2703; DOI: https://doi.org/10.4049/jimmunol.1600799

IMMUNOTHERAPY AND VACCINES

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The Lymphatic Immune Response Induced by the Adjuvant AS01: A Comparison of Intramuscular and Subcutaneous Immunization Routes
Melanie R. Neeland, Wei Shi, Catherine Collignon, Nadine Taubenheim, Els N. T. Meeusen, Arnaud M. Didierlaurent and Michael J. de Veer

J Immunol October 1, 2016, 197 (7) 2704-2714; DOI: https://doi.org/10.4049/jimmunol.1600817
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CLEC12A-Mediated Antigen Uptake and Cross-Presentation by Human Dendritic Cell Subsets Efficiently Boost Tumor-Reactive T Cell Responses
Tim J. A. Hutten, Soley Thordardottir, Hanny Fredrix, Lisanne Janssen, Rob Woestenenk, Jurjen Tel, Ben Joosten, Alessandra Cambi, Mirjam H. M. Heemskerk, Gerben M. Franssen, Otto C. Boerman, Lex B. H. Bakker, Joop H. Jansen, Nicolaas Schaap, Harry Dolstra and Willemijn Hobo

J Immunol October 1, 2016, 197 (7) 2715-2725; DOI: https://doi.org/10.4049/jimmunol.1600011
Open Access
Boosting of ALVAC-SIV Vaccine-Primed Macaques with the CD4-SIVgp120 Fusion Protein Elicits Antibodies to V2 Associated with a Decreased Risk of SIV_mac251 Acquisition
Author Choice Article

Shari N. Gordon, Namal P. M. Liyanage, Melvin N. Doster, Monica Vaccari, Diego A. Vargas-Inchaustegui, Poonam Pegu, Luca Schifanella, Xiaoying Shen, Georgia D. Tomaras, Mangala Rao, Erik A. Billings, Jennifer Schwartz, Ilia Prado, Kathryn Bobb, Wenlei Zhang, David C. Montefiori, Kathryn E. Foulds, Guido Ferrari, Marjorie Robert-Guroff, Mario Roederer, Tran B. Phan, Donald N. Forthal, Donald M. Stablein, Sanjay Phogat, David J. Venzon, Timothy Fouts and Genoveffa Franchini

J Immunol October 1, 2016, 197 (7) 2726-2737; DOI: https://doi.org/10.4049/jimmunol.1600674
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Inclusion of Epitopes That Expand High-Avidity CD4⁺ T Cells Transforms Subprotective Vaccines to Efficacious Immunogens against Virulent Francisella tularensis
Lydia M. Roberts, Deborah D. Crane, Tara D. Wehrly, Joshua R. Fletcher, Bradley D. Jones and Catharine M. Bosio

J Immunol October 1, 2016, 197 (7) 2738-2747; DOI: https://doi.org/10.4049/jimmunol.1600879
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A Recombinant Chimeric Ad5/3 Vector Expressing a Multistage Plasmodium Antigen Induces Protective Immunity in Mice Using Heterologous Prime-Boost Immunization Regimens
Monica Cabrera-Mora, Jairo Andres Fonseca, Balwan Singh, Chunxia Zhao, Natalia Makarova, Igor Dmitriev, David T. Curiel, Jerry Blackwell and Alberto Moreno

J Immunol October 1, 2016, 197 (7) 2748-2761; DOI: https://doi.org/10.4049/jimmunol.1501926

INFECTIOUS DISEASE AND HOST RESPONSE

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NK Cell Responses to Human Tick-Borne Encephalitis Virus Infection
Kim Blom, Monika Braun, Jolita Pakalniene, Sebastian Lunemann, Monika Enqvist, Laura Dailidyte, Marie Schaffer, Lars Lindquist, Aukse Mickiene, Jakob Michaëlsson, Hans-Gustaf Ljunggren and Sara Gredmark-Russ

J Immunol October 1, 2016, 197 (7) 2762-2771; DOI: https://doi.org/10.4049/jimmunol.1600950
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Allergic Sensitization Underlies Hyperreactive Antigen-Specific CD4⁺ T Cell Responses in Coincident Filarial Infection
Pedro H. Gazzinelli-Guimarães, Sandra Bonne-Année, Ricardo T. Fujiwara, Helton C. Santiago and Thomas B. Nutman

J Immunol October 1, 2016, 197 (7) 2772-2779; DOI: https://doi.org/10.4049/jimmunol.1600829
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Dendritic Cells Are Dispensable for T Cell Priming and Control of Acute Lymphocytic Choriomeningitis Virus Infection
Cornelia Hilpert, Selina Sitte, Alexander Matthies and David Voehringer

J Immunol October 1, 2016, 197 (7) 2780-2786; DOI: https://doi.org/10.4049/jimmunol.1502582
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Preservation of Lymphopoietic Potential and Virus Suppressive Capacity by CD8⁺ T Cells in HIV-2–Infected Controllers
Mathieu Angin, Glenn Wong, Laura Papagno, Pierre Versmisse, Annie David, Charles Bayard, Bénédicte Charmeteau-De Muylder, Amel Besseghir, Rodolphe Thiébaut, Faroudy Boufassa, Gianfranco Pancino, Delphine Sauce, Olivier Lambotte, Françoise Brun-Vézinet, Sophie Matheron, Sarah L. Rowland-Jones, Rémi Cheynier, Asier Sáez-Cirión and Victor Appay

J Immunol October 1, 2016, 197 (7) 2787-2795; DOI: https://doi.org/10.4049/jimmunol.1600693
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Resolvin E1 Reverses Experimental Periodontitis and Dysbiosis
Chun-Teh Lee, Ricardo Teles, Alpdogan Kantarci, Tsute Chen, Jon McCafferty, Jacqueline R. Starr, Luciana Carla Neves Brito, Bruce J. Paster and Thomas E. Van Dyke

J Immunol October 1, 2016, 197 (7) 2796-2806; DOI: https://doi.org/10.4049/jimmunol.1600859

INNATE IMMUNITY AND INFLAMMATION

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Rac GTPase Activating Protein ARHGAP25 Regulates Leukocyte Transendothelial Migration in Mice
Roland Csépányi-Kömi, Éva Wisniewski, Balázs Bartos, Petra Lévai, Tamás Németh, Bernadett Balázs, Angela R. M. Kurz, Susanne Bierschenk, Markus Sperandio and Erzsébet Ligeti

J Immunol October 1, 2016, 197 (7) 2807-2815; DOI: https://doi.org/10.4049/jimmunol.1502342
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Mincle Signaling Promotes Con A Hepatitis
Stephanie H. Greco, Alejandro Torres-Hernandez, Aleksandr Kalabin, Clint Whiteman, Rae Rokosh, Sushma Ravirala, Atsuo Ochi, Johana Gutierrez, Muhammad Atif Salyana, Vishnu R. Mani, Savitha V. Nagaraj, Michael Deutsch, Lena Seifert, Donnele Daley, Rocky Barilla, Mautin Hundeyin, Yuriy Nikifrov, Karla Tejada, Bruce E. Gelb, Steven C. Katz and George Miller

J Immunol October 1, 2016, 197 (7) 2816-2827; DOI: https://doi.org/10.4049/jimmunol.1600598
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A Critical Role for P2X₇ Receptor–Induced VCAM-1 Shedding and Neutrophil Infiltration during Acute Lung Injury
Amarjit Mishra, Yujie Guo, Li Zhang, Sunil More, Tingting Weng, Narendranath Reddy Chintagari, Chaoqun Huang, Yurong Liang, Samuel Pushparaj, Deming Gou, Melanie Breshears and Lin Liu

J Immunol October 1, 2016, 197 (7) 2828-2837; DOI: https://doi.org/10.4049/jimmunol.1501041
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Differential Production of Type I IFN Determines the Reciprocal Levels of IL-10 and Proinflammatory Cytokines Produced by C57BL/6 and BALB/c Macrophages
Author Choice Article

Ashleigh Howes, Christina Taubert, Simon Blankley, Natasha Spink, Xuemei Wu, Christine M. Graham, Jiawen Zhao, Margarida Saraiva, Paola Ricciardi-Castagnoli, Gregory J. Bancroft and Anne O’Garra

J Immunol October 1, 2016, 197 (7) 2838-2853; DOI: https://doi.org/10.4049/jimmunol.1501923
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Blood-Borne RNA Correlates with Disease Activity and IFN-Stimulated Gene Expression in Systemic Lupus Erythematosus
John R. Doedens, Wendell D. Jones, Kay Hill, Michael J. Mason, Vivian H. Gersuk, Philip J. Mease, Maria Dall’Era, Cynthia Aranow, Richard W. Martin, Stanley B. Cohen, Roy M. Fleischmann, Alan J. Kivitz, Daniel J. Burge, Damien Chaussabel, Keith B. Elkon and James A. Posada

J Immunol October 1, 2016, 197 (7) 2854-2863; DOI: https://doi.org/10.4049/jimmunol.1601142
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Nrf2 Modulates Host Defense during Streptococcus pneumoniae Pneumonia in Mice
John C. Gomez, Hong Dang, Jessica R. Martin and Claire M. Doerschuk

J Immunol October 1, 2016, 197 (7) 2864-2879; DOI: https://doi.org/10.4049/jimmunol.1600043
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PFKFB3-Driven Macrophage Glycolytic Metabolism Is a Crucial Component of Innate Antiviral Defense
Hui Jiang, Hengfei Shi, Man Sun, Yafeng Wang, Qingzhou Meng, Panpan Guo, Yanlan Cao, Jiong Chen, Xiang Gao, Erguang Li and Jianghuai Liu

J Immunol October 1, 2016, 197 (7) 2880-2890; DOI: https://doi.org/10.4049/jimmunol.1600474
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Killer Cell Lectin-like Receptor G1 Inhibits NK Cell Function through Activation of Adenosine 5′-Monophosphate–Activated Protein Kinase
Bojana Müller-Durovic, Alessio Lanna, Luciana Polaco Covre, Rachel S. Mills, Sian M. Henson and Arne N. Akbar

J Immunol October 1, 2016, 197 (7) 2891-2899; DOI: https://doi.org/10.4049/jimmunol.1600590
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Aging-Associated TNF Production Primes Inflammasome Activation and NLRP3-Related Metabolic Disturbances
Franz Bauernfeind, Sven Niepmann, Percy A. Knolle and Veit Hornung

J Immunol October 1, 2016, 197 (7) 2900-2908; DOI: https://doi.org/10.4049/jimmunol.1501336
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Lactic Acid Suppresses IL-33–Mediated Mast Cell Inflammatory Responses via Hypoxia-Inducible Factor-1α–Dependent miR-155 Suppression
Daniel Abebayehu, Andrew J. Spence, Amina Abdul Qayum, Marcela T. Taruselli, Jamie J. A. McLeod, Heather L. Caslin, Alena P. Chumanevich, Elizabeth Motunrayo Kolawole, Anuya Paranjape, Bianca Baker, Victor S. Ndaw, Brian O. Barnstein, Carole A. Oskeritzian, Scott A. Sell and John J. Ryan

J Immunol October 1, 2016, 197 (7) 2909-2917; DOI: https://doi.org/10.4049/jimmunol.1600651

MOLECULAR AND STRUCTURAL IMMUNOLOGY

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The DNA Damage Response Regulates RAG1/2 Expression in Pre–B Cells through ATM-FOXO1 Signaling
Katarina Ochodnicka-Mackovicova, Mahnoush Bahjat, Chiel Maas, Amélie van der Veen, Timon A. Bloedjes, Alexander M. de Bruin, Harmen van Andel, Carol E. Schrader, Rudi W. Hendriks, Els Verhoeyen, Richard J. Bende, Carel J. M. van Noesel and Jeroen E. J. Guikema

J Immunol October 1, 2016, 197 (7) 2918-2929; DOI: https://doi.org/10.4049/jimmunol.1501989
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Class-Switch Recombination in the Absence of the IgH 3′ Regulatory Region
Ahrom Kim, Li Han, Gabriel E. Santiago, Ramiro E. Verdun and Kefei Yu

J Immunol October 1, 2016, 197 (7) 2930-2935; DOI: https://doi.org/10.4049/jimmunol.1600530
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IgG Binding Characteristics of Rhesus Macaque FcγR
Ying N. Chan, Austin W. Boesch, Nana Y. Osei-Owusu, Ali Emileh, Andrew R. Crowley, Sarah L. Cocklin, Samantha L. Finstad, Caitlyn H. Linde, Rebecca A. Howell, Isaac Zentner, Simon Cocklin, Adam R. Miles, Joshua W. Eckman, Galit Alter, Joern E. Schmitz and Margaret E. Ackerman

J Immunol October 1, 2016, 197 (7) 2936-2947; DOI: https://doi.org/10.4049/jimmunol.1502252

MUCOSAL IMMUNOLOGY

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Downregulation of the Syk Signaling Pathway in Intestinal Dendritic Cells Is Sufficient To Induce Dendritic Cells That Inhibit Colitis
Long Hang, Arthur M. Blum, Sangeeta Kumar, Joseph F. Urban Jr., Makedonka Mitreva, Timothy G. Geary, Armando Jardim, Mary M. Stevenson, Clifford A. Lowell and Joel V. Weinstock

J Immunol October 1, 2016, 197 (7) 2948-2957; DOI: https://doi.org/10.4049/jimmunol.1600063

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Table of Contents

IN THIS ISSUE

LETTERS TO THE EDITOR

PILLARS OF IMMUNOLOGY

BRIEF REVIEWS

CUTTING EDGE

AUTOIMMUNITY

CLINICAL AND HUMAN IMMUNOLOGY

IMMUNE REGULATION

IMMUNE SYSTEM DEVELOPMENT

IMMUNOGENETICS

IMMUNOTHERAPY AND VACCINES

INFECTIOUS DISEASE AND HOST RESPONSE

INNATE IMMUNITY AND INFLAMMATION

MOLECULAR AND STRUCTURAL IMMUNOLOGY

MUCOSAL IMMUNOLOGY

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