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The Journal of Immunology

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Table of Contents

September 15, 2016; Volume 197,Issue 6

IN THIS ISSUE

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    In This Issue

    Tracking Down Trex1 Target Cells See article p. 2157

    Managing Stress during T Cell Development See article p. 2280

    Learning from Your Mother See article p. 2290

    Tracking Down Antitumor T Cells See article p. 2509

    Metabolic Exhaustion in Leukemia See article p. 2532

    J Immunol September 15, 2016, 197 (6) 2043-2044; DOI: https://doi.org/10.4049/jimmunol.1690014

TRANSLATING IMMUNOLOGY

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    Costimulation Blockade in Autoimmunity and Transplantation: The CD28 Pathway
    Andrew B. Adams, Mandy L. Ford and Christian P. Larsen
    J Immunol September 15, 2016, 197 (6) 2045-2050; DOI: https://doi.org/10.4049/jimmunol.1601135

BRIEF REVIEWS

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    Novel Evasion Mechanisms of the Classical Complement Pathway
    Brandon L. Garcia, Seline A. Zwarthoff, Suzan H. M. Rooijakkers and Brian V. Geisbrecht
    J Immunol September 15, 2016, 197 (6) 2051-2060; DOI: https://doi.org/10.4049/jimmunol.1600863

CUTTING EDGE

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    Cutting Edge: Marginal Zone Macrophages Regulate Antigen Transport by B Cells to the Follicle in the Spleen via CD21
    Kajsa E. Prokopec, Anna-Maria Georgoudaki, Silke Sohn, Fredrik Wermeling, Hans Grönlund, Emma Lindh, Michael C. Carroll and Mikael C. I. Karlsson
    J Immunol September 15, 2016, 197 (6) 2063-2068; DOI: https://doi.org/10.4049/jimmunol.1502282

ALLERGY AND OTHER HYPERSENSITIVITIES

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    Leukotriene B4 Receptor 2 Is Critical for the Synthesis of Vascular Endothelial Growth Factor in Allergen-Stimulated Mast Cells
    A-Jin Lee, MyungJa Ro and Jae-Hong Kim
    J Immunol September 15, 2016, 197 (6) 2069-2078; DOI: https://doi.org/10.4049/jimmunol.1502565

ANTIGEN RECOGNITION AND RESPONSES

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    Adhesion- and Degranulation-Promoting Adapter Protein Promotes CD8 T Cell Differentiation and Resident Memory Formation and Function during an Acute Infection
    Jessica K. Fiege, Lalit K. Beura, Brandon J. Burbach and Yoji Shimizu
    J Immunol September 15, 2016, 197 (6) 2079-2089; DOI: https://doi.org/10.4049/jimmunol.1501805
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    Dynein Separately Partners with NDE1 and Dynactin To Orchestrate T Cell Focused Secretion
    Shubhankar Nath, Laura Christian, Sarah Youngsun Tan, Sanghee Ki, Lauren I. R. Ehrlich and Martin Poenie
    J Immunol September 15, 2016, 197 (6) 2090-2101; DOI: https://doi.org/10.4049/jimmunol.1600180
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    Diverse HLA-I Peptide Repertoires of the APC Lines MUTZ3-Derived Immature and Mature Dendritic Cells and THP1-Derived Macrophages
    Lydon Wainaina Nyambura, Saulius Jarmalavicius, Renato Brito Baleeiro and Peter Walden
    J Immunol September 15, 2016, 197 (6) 2102-2109; DOI: https://doi.org/10.4049/jimmunol.1600762

AUTOIMMUNITY

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    TLR Tolerance as a Treatment for Central Nervous System Autoimmunity
    Emily J. Anstadt, Mai Fujiwara, Nicholas Wasko, Frank Nichols and Robert B. Clark
    J Immunol September 15, 2016, 197 (6) 2110-2118; DOI: https://doi.org/10.4049/jimmunol.1600876
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    New Murine Model of Early Onset Autoimmune Thyroid Disease/Hypothyroidism and Autoimmune Exocrinopathy of the Salivary Gland
    Timothy Daniel Kayes, Gary A. Weisman, Jean M. Camden, Lucas T. Woods, Cole Bredehoeft, Edward F. Downey, James Cole and Helen Braley-Mullen
    J Immunol September 15, 2016, 197 (6) 2119-2130; DOI: https://doi.org/10.4049/jimmunol.1600133
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    IL-35 Decelerates the Inflammatory Process by Regulating Inflammatory Cytokine Secretion and M1/M2 Macrophage Ratio in Psoriasis
    Junfeng Zhang, Yi Lin, Chunlei Li, Xiaomei Zhang, Lin Cheng, Lei Dai, Youcui Wang, Fangfang Wang, Gang Shi, Yiming Li, Qianmei Yang, Xueliang Cui, Yi Liu, Huiling Wang, Shuang Zhang, Yang Yang, Rong Xiang, Jiong Li, Dechao Yu, Yuquan Wei and Hongxin Deng
    J Immunol September 15, 2016, 197 (6) 2131-2144; DOI: https://doi.org/10.4049/jimmunol.1600446
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    Transient Expression of Transgenic IL-12 in Mouse Liver Triggers Unremitting Inflammation Mimicking Human Autoimmune Hepatitis
    Irene Gil-Farina, Marianna Di Scala, Eduardo Salido, Esperanza López-Franco, Estefania Rodríguez-García, Mercedes Blasi, Juana Merino, Rafael Aldabe, Jesús Prieto and Gloria Gonzalez-Aseguinolaza
    J Immunol September 15, 2016, 197 (6) 2145-2156; DOI: https://doi.org/10.4049/jimmunol.1600228
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    Loss of Trex1 in Dendritic Cells Is Sufficient To Trigger Systemic Autoimmunity
    Katrin Peschke, Martin Achleitner, Kathrin Frenzel, Alexander Gerbaulet, Servi Remzi Ada, Nicolas Zeller, Stefan Lienenklaus, Mathias Lesche, Claire Poulet, Ronald Naumann, Andreas Dahl, Ursula Ravens, Claudia Günther, Werner Müller, Klaus-Peter Knobeloch, Marco Prinz, Axel Roers and Rayk Behrendt
    J Immunol September 15, 2016, 197 (6) 2157-2166; DOI: https://doi.org/10.4049/jimmunol.1600722
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    Essential Requirement for IFN Regulatory Factor 7 in Autoantibody Production but Not Development of Nephritis in Murine Lupus
    Fumi Miyagawa, Yutaka Tagaya, Keiko Ozato and Hideo Asada
    J Immunol September 15, 2016, 197 (6) 2167-2176; DOI: https://doi.org/10.4049/jimmunol.1502445
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    Osteopontin in Spontaneous Germinal Centers Inhibits Apoptotic Cell Engulfment and Promotes Anti-Nuclear Antibody Production in Lupus-Prone Mice
    Keiko Sakamoto, Yuji Fukushima, Koyu Ito, Michiyuki Matsuda, Shigekazu Nagata, Nagahiro Minato and Masakazu Hattori
    J Immunol September 15, 2016, 197 (6) 2177-2186; DOI: https://doi.org/10.4049/jimmunol.1600987
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    Opposing Roles of Tyrosine Kinase Receptors Mer and Axl Determine Clinical Outcomes in Experimental Immune-Mediated Nephritis
    Yuxuan Zhen, Stephen O. Priest and Wen-Hai Shao
    J Immunol September 15, 2016, 197 (6) 2187-2194; DOI: https://doi.org/10.4049/jimmunol.1600793

CLINICAL AND HUMAN IMMUNOLOGY

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    Unconventional Human T Cells Accumulate at the Site of Infection in Response to Microbial Ligands and Induce Local Tissue Remodeling

    Author Choice Article

    Anna Rita Liuzzi, Ann Kift-Morgan, Melisa Lopez-Anton, Ida M. Friberg, Jingjing Zhang, Amy C. Brook, Gareth W. Roberts, Kieron L. Donovan, Chantal S. Colmont, Mark A. Toleman, Timothy Bowen, David W. Johnson, Nicholas Topley, Bernhard Moser, Donald J. Fraser and Matthias Eberl
    J Immunol September 15, 2016, 197 (6) 2195-2207; DOI: https://doi.org/10.4049/jimmunol.1600990

IMMUNE REGULATION

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    Regulatory T Cell Numbers in Inflamed Skin Are Controlled by Local Inflammatory Cues That Upregulate CD25 and Facilitate Antigen-Driven Local Proliferation
    Alison C. Billroth-MacLurg, Jill Ford, Alexander Rosenberg, Jim Miller and Deborah J. Fowell
    J Immunol September 15, 2016, 197 (6) 2208-2218; DOI: https://doi.org/10.4049/jimmunol.1502575
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    MicroRNA-17 Suppresses TNF-α Signaling by Interfering with TRAF2 and cIAP2 Association in Rheumatoid Arthritis Synovial Fibroblasts
    Nahid Akhtar, Anil Kumar Singh and Salahuddin Ahmed
    J Immunol September 15, 2016, 197 (6) 2219-2228; DOI: https://doi.org/10.4049/jimmunol.1600360
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    Folate Receptor β Regulates Integrin CD11b/CD18 Adhesion of a Macrophage Subset to Collagen
    Christian Machacek, Verena Supper, Vladimir Leksa, Goran Mitulovic, Andreas Spittler, Karel Drbal, Miloslav Suchanek, Anna Ohradanova-Repic and Hannes Stockinger
    J Immunol September 15, 2016, 197 (6) 2229-2238; DOI: https://doi.org/10.4049/jimmunol.1501878

IMMUNE SYSTEM DEVELOPMENT

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    IL-36–Induced Toxicity in Neonatal Mice Involves TNF-α Production by Liver Myeloid Cells
    Jennifer Palomo, Beatris Mastelic-Gavillet, Estelle Woldt, Sabina Troccaz, Emiliana Rodriguez, Gaby Palmer, Claire-Anne Siegrist and Cem Gabay
    J Immunol September 15, 2016, 197 (6) 2239-2249; DOI: https://doi.org/10.4049/jimmunol.1600700
  • Open Access
    Conditional Disruption of Raptor Reveals an Essential Role for mTORC1 in B Cell Development, Survival, and Metabolism

    Author Choice Article

    Terri N. Iwata, Julita A. Ramírez, Mark Tsang, Heon Park, Daciana H. Margineantu, David M. Hockenbery and Brian M. Iritani
    J Immunol September 15, 2016, 197 (6) 2250-2260; DOI: https://doi.org/10.4049/jimmunol.1600492
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    lck-Driven Cre Expression Alters T Cell Development in the Thymus and the Frequencies and Functions of Peripheral T Cell Subsets
    Berit Carow, Yu Gao, Jonathan Coquet, Marie Reilly and Martin E. Rottenberg
    J Immunol September 15, 2016, 197 (6) 2261-2268; DOI: https://doi.org/10.4049/jimmunol.1600827
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    A Histone Methyltransferase ESET Is Critical for T Cell Development
    Shoichi Takikita, Ryunosuke Muro, Toshiyuki Takai, Takeshi Otsubo, Yuki I. Kawamura, Taeko Dohi, Hiroyo Oda, Masayuki Kitajima, Kenshiro Oshima, Masahira Hattori, Takaho A. Endo, Tetsuro Toyoda, John Weis, Yoichi Shinkai and Harumi Suzuki
    J Immunol September 15, 2016, 197 (6) 2269-2279; DOI: https://doi.org/10.4049/jimmunol.1502486
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    Rpl22 Loss Selectively Impairs αβ T Cell Development by Dysregulating Endoplasmic Reticulum Stress Signaling
    Nehal R. Solanki, Jason E. Stadanlick, Yong Zhang, Ann-Cecile Duc, Sang-Yun Lee, Jens Peter Holst Lauritsen, Zhiqiang Zhang and David L. Wiest
    J Immunol September 15, 2016, 197 (6) 2280-2289; DOI: https://doi.org/10.4049/jimmunol.1600815
  • Open Access
    Maternal Milk T Cells Drive Development of Transgenerational Th1 Immunity in Offspring Thymus

    Author Choice Article

    Mrinal K. Ghosh, Virginia Nguyen, H. Konrad Muller and Ameae M. Walker
    J Immunol September 15, 2016, 197 (6) 2290-2296; DOI: https://doi.org/10.4049/jimmunol.1502483
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    A Csf1r-EGFP Transgene Provides a Novel Marker for Monocyte Subsets in Sheep

    Author Choice Article

    Clare Pridans, Gemma M. Davis, Kristin A. Sauter, Zofia M. Lisowski, Yolanda Corripio-Miyar, Anna Raper, Lucas Lefevre, Rachel Young, Mary E. McCulloch, Simon Lillico, Elspeth Milne, Bruce Whitelaw and David A. Hume
    J Immunol September 15, 2016, 197 (6) 2297-2305; DOI: https://doi.org/10.4049/jimmunol.1502336

IMMUNOGENETICS

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    Diversified Anchoring Features the Peptide Presentation of DLA-88*50801: First Structural Insight into Domestic Dog MHC Class I
    Jin Xiao, Wangzhen Xiang, Yan Chai, Joel Haywood, Jianxun Qi, Limin Ba, Peng Qi, Ming Wang, Jun Liu and George F. Gao
    J Immunol September 15, 2016, 197 (6) 2306-2315; DOI: https://doi.org/10.4049/jimmunol.1600887

IMMUNOTHERAPY AND VACCINES

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    B Cell Responses Associated with Vaccine-Induced Delayed SIVmac251 Acquisition in Female Rhesus Macaques
    Venkatramanan Mohanram, Thorsten Demberg, Thomas Musich, Iskra Tuero, Diego A. Vargas-Inchaustegui, Leia Miller-Novak, David Venzon and Marjorie Robert-Guroff
    J Immunol September 15, 2016, 197 (6) 2316-2324; DOI: https://doi.org/10.4049/jimmunol.1600544

INFECTIOUS DISEASE AND HOST RESPONSE

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    Expansion and Protection by a Virus-Specific NK Cell Subset Lacking Expression of the Inhibitory NKR-P1B Receptor during Murine Cytomegalovirus Infection
    Mir Munir A. Rahim, Andrew Wight, Ahmad Bakur Mahmoud, Oscar A. Aguilar, Seung-Hwan Lee, Silvia M. Vidal, James R. Carlyle and Andrew P. Makrigiannis
    J Immunol September 15, 2016, 197 (6) 2325-2337; DOI: https://doi.org/10.4049/jimmunol.1600776
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    Herpesvirus-Associated Lymphadenitis Distorts Fibroblastic Reticular Cell Microarchitecture and Attenuates CD8 T Cell Responses to Neurotropic Infection in Mice Lacking the STING-IFNα/β Defense Pathways
    Derek J. Royer, Christopher D. Conrady and Daniel J. J. Carr
    J Immunol September 15, 2016, 197 (6) 2338-2352; DOI: https://doi.org/10.4049/jimmunol.1600574

INNATE IMMUNITY AND INFLAMMATION

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    Complement Destabilizes Cardiomyocyte Function In Vivo after Polymicrobial Sepsis and In Vitro
    Miriam Kalbitz, Fatemeh Fattahi, Todd J. Herron, Jamison J. Grailer, Lawrence Jajou, Hope Lu, Markus Huber-Lang, Firas S. Zetoune, J. Vidya Sarma, Sharlene M. Day, Mark W. Russell, José Jalife and Peter A. Ward
    J Immunol September 15, 2016, 197 (6) 2353-2361; DOI: https://doi.org/10.4049/jimmunol.1600091
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    Resolvin D3 Is Dysregulated in Arthritis and Reduces Arthritic Inflammation
    Hildur H. Arnardottir, Jesmond Dalli, Lucy V. Norling, Romain A. Colas, Mauro Perretti and Charles N. Serhan
    J Immunol September 15, 2016, 197 (6) 2362-2368; DOI: https://doi.org/10.4049/jimmunol.1502268
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    Soluble IL-6 Receptor and IL-27 Subunit p28 Protein Complex Mediate the Antiviral Response through the Type III IFN Pathway
    Xiaodan Yang, Hua Hao, Zhangchuan Xia, Gang Xu, Zhongying Cao, Xueyuan Chen, Shi Liu and Ying Zhu
    J Immunol September 15, 2016, 197 (6) 2369-2381; DOI: https://doi.org/10.4049/jimmunol.1600627
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    Charon Mediates Immune Deficiency–Driven PARP-1–Dependent Immune Responses in Drosophila
    Yingbiao Ji, Colin Thomas, Nikita Tulin, Niraj Lodhi, Ernest Boamah, Vladimir Kolenko and Alexei V. Tulin
    J Immunol September 15, 2016, 197 (6) 2382-2389; DOI: https://doi.org/10.4049/jimmunol.1600994
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    Blood-Borne Lipopolysaccharide Is Rapidly Eliminated by Liver Sinusoidal Endothelial Cells via High-Density Lipoprotein
    Zhili Yao, Jessica M. Mates, Alana M. Cheplowitz, Lindsay P. Hammer, Andrei Maiseyeu, Gary S. Phillips, Mark D. Wewers, Murugesan V. S. Rajaram, John M. Robinson, Clark L. Anderson and Latha P. Ganesan
    J Immunol September 15, 2016, 197 (6) 2390-2399; DOI: https://doi.org/10.4049/jimmunol.1600702
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    IL-17 Promotes Neutrophil-Mediated Immunity by Activating Microvascular Pericytes and Not Endothelium
    Rebecca Liu, Holly M. Lauridsen, Robert A. Amezquita, Richard W. Pierce, Dan Jane-wit, Caodi Fang, Amanda S. Pellowe, Nancy C. Kirkiles-Smith, Anjelica L. Gonzalez and Jordan S. Pober
    J Immunol September 15, 2016, 197 (6) 2400-2408; DOI: https://doi.org/10.4049/jimmunol.1600138
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    TLR2 Activation Limits Rhinovirus-Stimulated CXCL-10 by Attenuating IRAK-1–Dependent IL-33 Receptor Signaling in Human Bronchial Epithelial Cells
    Shyamala Ganesan, Duc Pham, Yaxun Jing, Mohammad Farazuddin, Magdalena H. Hudy, Benjamin Unger, Adam T. Comstock, David Proud, Adam S. Lauring and Uma S. Sajjan
    J Immunol September 15, 2016, 197 (6) 2409-2420; DOI: https://doi.org/10.4049/jimmunol.1502702
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    Efficacy and Pharmacology of the NLRP3 Inflammasome Inhibitor CP-456,773 (CRID3) in Murine Models of Dermal and Pulmonary Inflammation
    Michael J. Primiano, Bruce A. Lefker, Michael R. Bowman, Andrea G. Bree, Cedric Hubeau, Paul D. Bonin, Matthew Mangan, Ken Dower, Brian G. Monks, Leah Cushing, Stephen Wang, Julia Guzova, Aiping Jiao, Lih-Ling Lin, Eicke Latz, David Hepworth and J. Perry Hall
    J Immunol September 15, 2016, 197 (6) 2421-2433; DOI: https://doi.org/10.4049/jimmunol.1600035
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    IL-12 Signals through the TCR To Support CD8 Innate Immune Responses
    Nicholas P. Goplen, Vikas Saxena, Karin M. Knudson, Adam G. Schrum, Diana Gil, Mark A. Daniels, Rose Zamoyska and Emma Teixeiro
    J Immunol September 15, 2016, 197 (6) 2434-2443; DOI: https://doi.org/10.4049/jimmunol.1600037
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    Local Microenvironment Controls the Compartmentalization of NK Cell Responses during Systemic Inflammation in Mice
    Orhan Rasid, Ioana Sonya Ciulean, Catherine Fitting, Noelle Doyen and Jean-Marc Cavaillon
    J Immunol September 15, 2016, 197 (6) 2444-2454; DOI: https://doi.org/10.4049/jimmunol.1601040
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    Human Invariant NKT Cells Induce IL-1β Secretion by Peripheral Blood Monocytes via a P2X7-Independent Pathway
    Laura E. Felley, Akshat Sharma, Erin Theisen, James C. Romero-Masters, John-Demian Sauer and Jenny E. Gumperz
    J Immunol September 15, 2016, 197 (6) 2455-2464; DOI: https://doi.org/10.4049/jimmunol.1600790

MOLECULAR AND STRUCTURAL IMMUNOLOGY

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    The ETS Family Transcription Factors Etv5 and PU.1 Function in Parallel To Promote Th9 Cell Development
    Byunghee Koh, Matthew M. Hufford, Duy Pham, Matthew R. Olson, Tong Wu, Rukhsana Jabeen, Xin Sun and Mark H. Kaplan
    J Immunol September 15, 2016, 197 (6) 2465-2472; DOI: https://doi.org/10.4049/jimmunol.1502383
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    Endocytosis of Cytotoxic Granules Is Essential for Multiple Killing of Target Cells by T Lymphocytes
    Hsin-Fang Chang, Hawraa Bzeih, Claudia Schirra, Praneeth Chitirala, Mahantappa Halimani, Emmanuelle Cordat, Elmar Krause, Jens Rettig and Varsha Pattu
    J Immunol September 15, 2016, 197 (6) 2473-2484; DOI: https://doi.org/10.4049/jimmunol.1600828

MUCOSAL IMMUNOLOGY

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    NFIL3 Expression Distinguishes Tissue-Resident NK Cells and Conventional NK-like Cells in the Mouse Submandibular Glands
    Timothy K. Erick, Courtney K. Anderson, Emma C. Reilly, Jack R. Wands and Laurent Brossay
    J Immunol September 15, 2016, 197 (6) 2485-2491; DOI: https://doi.org/10.4049/jimmunol.1601099

SYSTEMS IMMUNOLOGY

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    Unsupervised HLA Peptidome Deconvolution Improves Ligand Prediction Accuracy and Predicts Cooperative Effects in Peptide–HLA Interactions
    Michal Bassani-Sternberg and David Gfeller
    J Immunol September 15, 2016, 197 (6) 2492-2499; DOI: https://doi.org/10.4049/jimmunol.1600808
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    Systems Analysis of the Complement-Induced Priming Phase of Liver Regeneration
    Jun S. Min, Robert A. DeAngelis, Edimara S. Reis, Shakti Gupta, Mano R. Maurya, Charles Evans, Arun Das, Charles Burant, John D. Lambris and Shankar Subramaniam
    J Immunol September 15, 2016, 197 (6) 2500-2508; DOI: https://doi.org/10.4049/jimmunol.1600628

TUMOR IMMUNOLOGY

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    Immunotherapy Expands and Maintains the Function of High-Affinity Tumor-Infiltrating CD8 T Cells In Situ
    Amy E. Moran, Fanny Polesso and Andrew D. Weinberg
    J Immunol September 15, 2016, 197 (6) 2509-2521; DOI: https://doi.org/10.4049/jimmunol.1502659
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    Functional Differences between IgM and IgD Signaling in Chronic Lymphocytic Leukemia
    Elisa ten Hacken, Mariela Sivina, Ekaterina Kim, Susan O’Brien, William G. Wierda, Alessandra Ferrajoli, Zeev Estrov, Michael J. Keating, Thomas Oellerich, Cristina Scielzo, Paolo Ghia, Federico Caligaris-Cappio and Jan A. Burger
    J Immunol September 15, 2016, 197 (6) 2522-2531; DOI: https://doi.org/10.4049/jimmunol.1600915
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    Suppression of Glut1 and Glucose Metabolism by Decreased Akt/mTORC1 Signaling Drives T Cell Impairment in B Cell Leukemia
    Peter J. Siska, Gerritje J. W. van der Windt, Rigel J. Kishton, Sivan Cohen, William Eisner, Nancie J. MacIver, Arnon P. Kater, J. Brice Weinberg and Jeffrey C. Rathmell
    J Immunol September 15, 2016, 197 (6) 2532-2540; DOI: https://doi.org/10.4049/jimmunol.1502464
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    MAGE-C2–Specific TCRs Combined with Epigenetic Drug-Enhanced Antigenicity Yield Robust and Tumor-Selective T Cell Responses
    Andre Kunert, Mandy van Brakel, Sabine van Steenbergen-Langeveld, Marvin da Silva, Pierre G. Coulie, Cor Lamers, Stefan Sleijfer and Reno Debets
    J Immunol September 15, 2016, 197 (6) 2541-2552; DOI: https://doi.org/10.4049/jimmunol.1502024
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This Issue

The Journal of Immunology: 197 (6)
The Journal of Immunology
Vol. 197, Issue 6
15 Sep 2016
  • Table of Contents
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  • Back Matter (PDF)
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  • IN THIS ISSUE
  • TRANSLATING IMMUNOLOGY
  • BRIEF REVIEWS
  • CUTTING EDGE
  • ALLERGY AND OTHER HYPERSENSITIVITIES
  • ANTIGEN RECOGNITION AND RESPONSES
  • AUTOIMMUNITY
  • CLINICAL AND HUMAN IMMUNOLOGY
  • IMMUNE REGULATION
  • IMMUNE SYSTEM DEVELOPMENT
  • IMMUNOGENETICS
  • IMMUNOTHERAPY AND VACCINES
  • INFECTIOUS DISEASE AND HOST RESPONSE
  • INNATE IMMUNITY AND INFLAMMATION
  • MOLECULAR AND STRUCTURAL IMMUNOLOGY
  • MUCOSAL IMMUNOLOGY
  • SYSTEMS IMMUNOLOGY
  • TUMOR IMMUNOLOGY
  • Highlights
  • Most Cited
  • Most Read
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Immunodominant AH1 Antigen-Deficient Necroptotic, but Not Apoptotic, Murine Cancer Cells Induce Antitumor Protection
Osteoclasts Derive Predominantly from Bone Marrow–Resident CX3CR1+ Precursor Cells in Homeostasis, whereas Circulating CX3CR1+ Cells Contribute to Osteoclast Development during Fracture Repair
Intracellular IL-1 Receptor Antagonist Isoform 1 Released from Keratinocytes upon Cell Death Acts as an Inhibitor for the Alarmin IL-1α
Polysaccharide Capsules Equip the Human Symbiont Bacteroides thetaiotaomicron to Modulate Immune Responses to a Dominant Antigen in the Intestine
Natural and Induced Tolerogenic Dendritic Cells
Cutting Edge: IL-6–Driven Immune Dysregulation Is Strictly Dependent on IL-6R α-Chain Expression

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Print ISSN 0022-1767        Online ISSN 1550-6606