The Journal of Immunology: 197 (1)

July 1, 2016; Volume 197,Issue 1

IN THIS ISSUE

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In This Issue
Gut Microbiota Shape Lung Immunity See article p. 97
Ron Regulates Reparative Macrophages See article p. 256
Clarifying Complement with Crystals See article p. 337
Nod2 Needed To Curb Intestinal Inflammation See article p. 345

J Immunol July 1, 2016, 197 (1) 1-2; DOI: https://doi.org/10.4049/jimmunol.1690009

PILLARS OF IMMUNOLOGY

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TCGF: How Much? Oh, and by the Way, How Many?
Frank W. Fitch

J Immunol July 1, 2016, 197 (1) 3-4; DOI: https://doi.org/10.4049/jimmunol.1600803
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Pillars Article: T Cell Growth Factor: Parameters of Production and a Quantitative Microassay for Activity. J. Immunol. 1978. 120: 2027–2032
Steven Gillis, Mary M. Ferm, Winny Ou and Kendall A. Smith

J Immunol July 1, 2016, 197 (1) 5-10;

BRIEF REVIEWS

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Evolution of Cytokine Receptor Signaling
Clifford Liongue, Robert Sertori and Alister C. Ward

J Immunol July 1, 2016, 197 (1) 11-18; DOI: https://doi.org/10.4049/jimmunol.1600372

CUTTING EDGE

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Cutting Edge: A Cullin-5–TRAF6 Interaction Promotes TRAF6 Polyubiquitination and Lipopolysaccharide Signaling
Ziyan Zhu, Lili Wang, Rui Hao, Bo Zhao, Lei Sun and Richard D. Ye

J Immunol July 1, 2016, 197 (1) 21-26; DOI: https://doi.org/10.4049/jimmunol.1600447

AUTOIMMUNITY

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Regulatory T Cells Control Th2-Dominant Murine Autoimmune Gastritis
Jessica Harakal, Claudia Rival, Hui Qiao and Kenneth S. Tung

J Immunol July 1, 2016, 197 (1) 27-41; DOI: https://doi.org/10.4049/jimmunol.1502344
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Type I IFNs Regulate Inflammation, Vasculopathy, and Fibrosis in Chronic Cutaneous Graft-versus-Host Disease
Tracy A. Delaney, Chris Morehouse, P. Zachary Brohawn, Christopher Groves, Marco Colonna, Yihong Yao, Miguel Sanjuan and Anthony J. Coyle

J Immunol July 1, 2016, 197 (1) 42-50; DOI: https://doi.org/10.4049/jimmunol.1502190
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Lung Injury Combined with Loss of Regulatory T Cells Leads to De Novo Lung-Restricted Autoimmunity
Stephen Chiu, Ramiro Fernandez, Vijay Subramanian, Haiying Sun, Malcolm M. DeCamp, Daniel Kreisel, Harris Perlman, G. R. Scott Budinger, Thalachallour Mohanakumar and Ankit Bharat

J Immunol July 1, 2016, 197 (1) 51-57; DOI: https://doi.org/10.4049/jimmunol.1502539
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Enhanced Expression of Bruton’s Tyrosine Kinase in B Cells Drives Systemic Autoimmunity by Disrupting T Cell Homeostasis
Odilia B. J. Corneth, Marjolein J. W. de Bruijn, Jasper Rip, Patrick S. Asmawidjaja, Laurens P. Kil and Rudi W. Hendriks

J Immunol July 1, 2016, 197 (1) 58-67; DOI: https://doi.org/10.4049/jimmunol.1600208

CLINICAL AND HUMAN IMMUNOLOGY

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Direct TLR-2 Costimulation Unmasks the Proinflammatory Potential of Neonatal CD4⁺ T Cells
Brian D. Sinnott, Byung Park, Mardi C. Boer, Deborah A. Lewinsohn and Christina L. Lancioni

J Immunol July 1, 2016, 197 (1) 68-77; DOI: https://doi.org/10.4049/jimmunol.1501297
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Human Lymphoid Tissues Harbor a Distinct CD69⁺CXCR6⁺ NK Cell Population
Gertjan Lugthart, Janine E. Melsen, Carly Vervat, Monique M. van Ostaijen-ten Dam, Willem E. Corver, Dave L. Roelen, Jeroen van Bergen, Maarten J. D. van Tol, Arjan C. Lankester and Marco W. Schilham

J Immunol July 1, 2016, 197 (1) 78-84; DOI: https://doi.org/10.4049/jimmunol.1502603

IMMUNE REGULATION

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IL-21–Induced MHC Class II⁺ NK Cells Promote the Expansion of Human Uncommitted CD4⁺ Central Memory T Cells in a Macrophage Migration Inhibitory Factor–Dependent Manner
Romain Loyon, Emilie Picard, Olivier Mauvais, Lise Queiroz, Virginie Mougey, Jean-René Pallandre, Jeanne Galaine, Patricia Mercier-Letondal, Guillaume Kellerman, Nathalie Chaput, John Wijdenes, Olivier Adotévi, Christophe Ferrand, Pedro Romero, Yann Godet and Christophe Borg

J Immunol July 1, 2016, 197 (1) 85-96; DOI: https://doi.org/10.4049/jimmunol.1501147
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Pulmonary Th17 Antifungal Immunity Is Regulated by the Gut Microbiome
Jeremy P. McAleer, Nikki L. H. Nguyen, Kong Chen, Pawan Kumar, David M. Ricks, Matthew Binnie, Rachel A. Armentrout, Derek A. Pociask, Aaron Hein, Amy Yu, Amit Vikram, Kyle Bibby, Yoshinori Umesaki, Amariliz Rivera, Dean Sheppard, Wenjun Ouyang, Lora V. Hooper and Jay K. Kolls

J Immunol July 1, 2016, 197 (1) 97-107; DOI: https://doi.org/10.4049/jimmunol.1502566
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LFA-1/ICAM-1 Ligation in Human T Cells Promotes Th1 Polarization through a GSK3β Signaling–Dependent Notch Pathway
Navin K. Verma, M. H. U. Turabe Fazil, Seow Theng Ong, Madhavi Latha S. Chalasani, Jian Hui Low, Amuthavalli Kottaiswamy, Praseetha P, Atish Kizhakeyil, Sunil Kumar, Aditya K. Panda, Michael Freeley, Sinead M. Smith, Bernhard O. Boehm and Dermot Kelleher

J Immunol July 1, 2016, 197 (1) 108-118; DOI: https://doi.org/10.4049/jimmunol.1501264
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LAG-3 Confers a Competitive Disadvantage upon Antiviral CD8⁺ T Cell Responses
Kevin D. Cook and Jason K. Whitmire

J Immunol July 1, 2016, 197 (1) 119-127; DOI: https://doi.org/10.4049/jimmunol.1401594
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Ly49C Impairs NK Cell Memory in Mouse Cytomegalovirus Infection
Catherine A. Forbes, Anthony A. Scalzo, Mariapia A. Degli-Esposti and Jerome D. Coudert

J Immunol July 1, 2016, 197 (1) 128-140; DOI: https://doi.org/10.4049/jimmunol.1600199

IMMUNE SYSTEM DEVELOPMENT

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mTORC2 in Thymic Epithelial Cells Controls Thymopoiesis and T Cell Development
Hong-Xia Wang, Joyce S. Cheng, Shuai Chu, Yu-Rong Qiu and Xiao-Ping Zhong

J Immunol July 1, 2016, 197 (1) 141-150; DOI: https://doi.org/10.4049/jimmunol.1502698

IMMUNOGENETICS

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Characterization of SIGIRR/IL-1R8 Homolog from Zebrafish Provides New Insights into Its Inhibitory Role in Hepatic Inflammation
Wei Feng, Yi-Feng Gu, Li Nie, Dong-Yang Guo, Li-xin Xiang and Jian-zhong Shao

J Immunol July 1, 2016, 197 (1) 151-167; DOI: https://doi.org/10.4049/jimmunol.1502334

IMMUNOTHERAPY AND VACCINES

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IL-15 Trans-Signaling with the Superagonist RLI Promotes Effector/Memory CD8⁺ T Cell Responses and Enhances Antitumor Activity of PD-1 Antagonists
Mélanie Desbois, Pauline Le Vu, Clélia Coutzac, Elie Marcheteau, Coralie Béal, Magali Terme, Alain Gey, Sébastien Morisseau, Géraldine Teppaz, Lisa Boselli, Yannick Jacques, David Béchard, Eric Tartour, Lydie Cassard and Nathalie Chaput

J Immunol July 1, 2016, 197 (1) 168-178; DOI: https://doi.org/10.4049/jimmunol.1600019
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CSF-1R–Dependent Lethal Hepatotoxicity When Agonistic CD40 Antibody Is Given before but Not after Chemotherapy
Katelyn T. Byrne, Nathan H. Leisenring, David L. Bajor and Robert H. Vonderheide

J Immunol July 1, 2016, 197 (1) 179-187; DOI: https://doi.org/10.4049/jimmunol.1600146
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Low-Dose IL-2 Induces Regulatory T Cell–Mediated Control of Experimental Food Allergy
Benjamin Bonnet, James Vigneron, Béatrice Levacher, Thomas Vazquez, Fabien Pitoiset, Faustine Brimaud, Guillaume Churlaud, David Klatzmann and Bertrand Bellier

J Immunol July 1, 2016, 197 (1) 188-198; DOI: https://doi.org/10.4049/jimmunol.1501271

INFECTIOUS DISEASE AND HOST RESPONSE

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MSX1 Modulates RLR-Mediated Innate Antiviral Signaling by Facilitating Assembly of TBK1-Associated Complexes
Liu-Ting Chen, Ming-Ming Hu, Zhi-Sheng Xu, Yu Liu and Hong-Bing Shu

J Immunol July 1, 2016, 197 (1) 199-207; DOI: https://doi.org/10.4049/jimmunol.1600039
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IL-27 Induced by Select Candida spp. via TLR7/NOD2 Signaling and IFN-β Production Inhibits Fungal Clearance
Author Choice Article

Emmanuel C. Patin, Adam V. Jones, Aiysha Thompson, Mathew Clement, Chia-Te Liao, James S. Griffiths, Leah E. Wallace, Clare E. Bryant, Roland Lang, Philip Rosenstiel, Ian R. Humphreys, Philip R. Taylor, Gareth W. Jones and Selinda J. Orr

J Immunol July 1, 2016, 197 (1) 208-221; DOI: https://doi.org/10.4049/jimmunol.1501204
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Imatinib Triggers Phagolysosome Acidification and Antimicrobial Activity against Mycobacterium bovis Bacille Calmette–Guérin in Glucocorticoid-Treated Human Macrophages
Julia Steiger, Alexander Stephan, Megan S. Inkeles, Susan Realegeno, Heiko Bruns, Philipp Kröll, Juliana de Castro Kroner, Andrea Sommer, Marina Batinica, Lena Pitzler, Rainer Kalscheuer, Pia Hartmann, Georg Plum, Steffen Stenger, Matteo Pellegrini, Bent Brachvogel, Robert L. Modlin and Mario Fabri

J Immunol July 1, 2016, 197 (1) 222-232; DOI: https://doi.org/10.4049/jimmunol.1502407
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Multiple Inhibitory Pathways Contribute to Lung CD8⁺ T Cell Impairment and Protect against Immunopathology during Acute Viral Respiratory Infection
John J. Erickson, Meredith C. Rogers, Sharon J. Tollefson, Kelli L. Boyd and John V. Williams

J Immunol July 1, 2016, 197 (1) 233-243; DOI: https://doi.org/10.4049/jimmunol.1502115
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Human Xenobiotic Nuclear Receptor PXR Augments Mycobacterium tuberculosis Survival
Ella Bhagyaraj, Ravikanth Nanduri, Ankita Saini, Hedwin Kitdorlang Dkhar, Nancy Ahuja, Vemika Chandra, Sahil Mahajan, Rashi Kalra, Drishti Tiwari, Charu Sharma, Ashok Kumar Janmeja and Pawan Gupta

J Immunol July 1, 2016, 197 (1) 244-255; DOI: https://doi.org/10.4049/jimmunol.1600203

INNATE IMMUNITY AND INFLAMMATION

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The Ron Receptor Tyrosine Kinase Regulates Macrophage Heterogeneity and Plays a Protective Role in Diet-Induced Obesity, Atherosclerosis, and Hepatosteatosis
Shan Yu, Joselyn N. Allen, Adwitia Dey, Limin Zhang, Gayathri Balandaram, Mary J. Kennett, Mingcan Xia, Na Xiong, Jeffrey M. Peters, Andrew Patterson and Pamela A. Hankey-Giblin

J Immunol July 1, 2016, 197 (1) 256-265; DOI: https://doi.org/10.4049/jimmunol.1600450
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CysLT₁ Receptor Is Protective against Oxidative Stress in a Model of Irritant-Induced Asthma
Toby McGovern, Madison Goldberger, Michael Chen, Benoit Allard, Yoichiro Hamamoto, Yoshihide Kanaoka, K. Frank Austen, William S. Powell and James G. Martin

J Immunol July 1, 2016, 197 (1) 266-277; DOI: https://doi.org/10.4049/jimmunol.1501084
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Phosphoinositide 3-Kinase δ Regulates Dectin-2 Signaling and the Generation of Th2 and Th17 Immunity
Min Jung Lee, Eri Yoshimoto, Shinobu Saijo, Yoichiro Iwakura, Xin Lin, Howard R. Katz, Yoshihide Kanaoka and Nora A. Barrett

J Immunol July 1, 2016, 197 (1) 278-287; DOI: https://doi.org/10.4049/jimmunol.1502485
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Defective Association of the Platelet Glycoprotein Ib–IX Complex with the Glycosphingolipid-Enriched Membrane Domain Inhibits Murine Thrombus and Atheroma Formation
Hao Zhou, Yali Ran, Qi Da, Tanner S. Shaw, Dan Shang, Anilkumar K. Reddy, José A. López, Christie M. Ballantyne, Jerry Ware, Huaizhu Wu and Yuandong Peng

J Immunol July 1, 2016, 197 (1) 288-295; DOI: https://doi.org/10.4049/jimmunol.1501946
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MMP-25 Metalloprotease Regulates Innate Immune Response through NF-κB Signaling
Clara Soria-Valles, Ana Gutiérrez-Fernández, Fernando G. Osorio, Dido Carrero, Adolfo A. Ferrando, Enrique Colado, M. Soledad Fernández-García, Elena Bonzon-Kulichenko, Jesús Vázquez, Antonio Fueyo and Carlos López-Otín

J Immunol July 1, 2016, 197 (1) 296-302; DOI: https://doi.org/10.4049/jimmunol.1600094
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Bone Marrow CD11c⁺ Cell–Derived Amphiregulin Promotes Pulmonary Fibrosis
Lin Ding, Tianju Liu, Zhe Wu, Biao Hu, Taku Nakashima, Matthew Ullenbruch, Francina Gonzalez De Los Santos and Sem H. Phan

J Immunol July 1, 2016, 197 (1) 303-312; DOI: https://doi.org/10.4049/jimmunol.1502479
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Influenza Vaccination Generates Cytokine-Induced Memory-like NK Cells: Impact of Human Cytomegalovirus Infection
Author Choice Article

Martin R. Goodier, Ana Rodriguez-Galan, Chiara Lusa, Carolyn M. Nielsen, Alansana Darboe, Ana L. Moldoveanu, Matthew J. White, Ron Behrens and Eleanor M. Riley

J Immunol July 1, 2016, 197 (1) 313-325; DOI: https://doi.org/10.4049/jimmunol.1502049
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STAT2 Is Required for TLR-Induced Murine Dendritic Cell Activation and Cross-Presentation
Jun Xu, Michael H. Lee, Marita Chakhtoura, Benjamin L. Green, Kevin P. Kotredes, Robert W. Chain, Uma Sriram, Ana M. Gamero and Stefania Gallucci

J Immunol July 1, 2016, 197 (1) 326-336; DOI: https://doi.org/10.4049/jimmunol.1500152

MOLECULAR AND STRUCTURAL IMMUNOLOGY

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Structural Basis for Eculizumab-Mediated Inhibition of the Complement Terminal Pathway
Janus Asbjørn Schatz-Jakobsen, Yuchun Zhang, Krista Johnson, Alyssa Neill, Douglas Sheridan and Gregers Rom Andersen

J Immunol July 1, 2016, 197 (1) 337-344; DOI: https://doi.org/10.4049/jimmunol.1600280

MUCOSAL IMMUNOLOGY

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The Cytosolic Microbial Receptor Nod2 Regulates Small Intestinal Crypt Damage and Epithelial Regeneration following T Cell–Induced Enteropathy
Galliano Zanello, Ashleigh Goethel, Sandrine Rouquier, David Prescott, Susan J. Robertson, Charles Maisonneuve, Catherine Streutker, Dana J. Philpott and Kenneth Croitoru

J Immunol July 1, 2016, 197 (1) 345-355; DOI: https://doi.org/10.4049/jimmunol.1600185
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Characterization of the Inflammasome in Human Kupffer Cells in Response to Synthetic Agonists and Pathogens
Claudia Zannetti, Guillaume Roblot, Emily Charrier, Michelle Ainouze, Issam Tout, François Briat, Nathalie Isorce, Suzanne Faure-Dupuy, Maud Michelet, Marie Marotel, Semra Kati, Thomas F. Schulz, Michel Rivoire, Alexandra Traverse-Glehen, Souphalone Luangsay, Omran Alatiff, Thomas Henry, Thierry Walzer, David Durantel and Uzma Hasan

J Immunol July 1, 2016, 197 (1) 356-367; DOI: https://doi.org/10.4049/jimmunol.1502301
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Progesterone Levels Associate with a Novel Population of CCR5⁺CD38⁺ CD4 T Cells Resident in the Genital Mucosa with Lymphoid Trafficking Potential
Alison Swaims-Kohlmeier, Richard E. Haaland, Lisa B. Haddad, Anandi N. Sheth, Tammy Evans-Strickfaden, L. Davis Lupo, Sarah Cordes, Alfredo J. Aguirre, Kathryn A. Lupoli, Cheng-Yen Chen, Igho Ofotukun, Clyde E. Hart and Jacob E. Kohlmeier

J Immunol July 1, 2016, 197 (1) 368-376; DOI: https://doi.org/10.4049/jimmunol.1502628
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A Novel Role for TL1A/DR3 in Protection against Intestinal Injury and Infection
Li-Guo Jia, Giorgos Bamias, Kristen O. Arseneau, Linda C. Burkly, Eddy C. Y. Wang, Dennis Gruszka, Theresa T. Pizarro and Fabio Cominelli

J Immunol July 1, 2016, 197 (1) 377-386; DOI: https://doi.org/10.4049/jimmunol.1502466

CORRECTIONS

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Correction: SOCS3 Deficiency Promotes M1 Macrophage Polarization and Inflammation
Hongwei Qin, Andrew T. Holdbrooks, Yudong Liu, Stephanie L. Reynolds, Lora L. Yanagisawa and Etty N. Benveniste

J Immunol July 1, 2016, 197 (1) 387-389; DOI: https://doi.org/10.4049/jimmunol.1600710

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Table of Contents

IN THIS ISSUE

PILLARS OF IMMUNOLOGY

BRIEF REVIEWS

CUTTING EDGE

AUTOIMMUNITY

CLINICAL AND HUMAN IMMUNOLOGY

IMMUNE REGULATION

IMMUNE SYSTEM DEVELOPMENT

IMMUNOGENETICS

IMMUNOTHERAPY AND VACCINES

INFECTIOUS DISEASE AND HOST RESPONSE

INNATE IMMUNITY AND INFLAMMATION

MOLECULAR AND STRUCTURAL IMMUNOLOGY

MUCOSAL IMMUNOLOGY

CORRECTIONS

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