The Journal of Immunology: 196 (7)

April 1, 2016; Volume 196,Issue 7

IN THIS ISSUE

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In This Issue
Watching Wnt in FA See article p. 2986
Going beyond GWAS in T1D See article p. 3043
Smoking Out POU2AF1 Lung Protection See article p. 3159
Allografts Don’t Want Your Help See article p. 3180

J Immunol April 1, 2016, 196 (7) 2911-2912; DOI: https://doi.org/10.4049/jimmunol.1690003

PILLARS OF IMMUNOLOGY

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Promiscuity Promotes Tolerance
Diane Mathis and Christophe Benoist

J Immunol April 1, 2016, 196 (7) 2913-2914; DOI: https://doi.org/10.4049/jimmunol.1600225
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Pillars Article: Promiscuous Gene Expression in Medullary Thymic Epithelial Cells Mirrors the Peripheral Self. Nat. Immunol. 2001. 2: 1032–1039
Jens Derbinski, Antje Schulte, Bruno Kyewski and Ludger Klein

J Immunol April 1, 2016, 196 (7) 2915-2922;

BRIEF REVIEWS

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Human CD56^bright NK Cells: An Update
Tatiana Michel, Aurélie Poli, Angelica Cuapio, Benjamin Briquemont, Gilles Iserentant, Markus Ollert and Jacques Zimmer

J Immunol April 1, 2016, 196 (7) 2923-2931; DOI: https://doi.org/10.4049/jimmunol.1502570

CUTTING EDGE

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Cutting Edge: Engineering Active IKKβ in T Cells Drives Tumor Rejection
César Evaristo, Stefani Spranger, Sarah E. Barnes, Michelle L. Miller, Luciana L. Molinero, Frederick L. Locke, Thomas F. Gajewski and Maria-Luisa Alegre

J Immunol April 1, 2016, 196 (7) 2933-2938; DOI: https://doi.org/10.4049/jimmunol.1501144

ANTIGEN RECOGNITION AND RESPONSES

Open Access
T Cell Priming by Activated Nlrc5-Deficient Dendritic Cells Is Unaffected despite Partially Reduced MHC Class I Levels
Author Choice Article

Giorgia Rota, Kristina Ludigs, Stefanie Siegert, Aubry Tardivel, Leonor Morgado, Walter Reith, Aude De Gassart and Greta Guarda

J Immunol April 1, 2016, 196 (7) 2939-2946; DOI: https://doi.org/10.4049/jimmunol.1502084

AUTOIMMUNITY

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Pathogenic Function of Herpesvirus Entry Mediator in Experimental Autoimmune Uveitis by Induction of Th1- and Th17-Type T Cell Responses
Yukimi Sakoda, Tomohiko Nagai, Sizuka Murata, Yukari Mizuno, Hiromi Kurosawa, Hiromi Shoda, Naoyuki Morishige, Ryoji Yanai, Koh-Hei Sonoda and Koji Tamada

J Immunol April 1, 2016, 196 (7) 2947-2954; DOI: https://doi.org/10.4049/jimmunol.1501742

CLINICAL AND HUMAN IMMUNOLOGY

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Anticommensal Responses Are Associated with Regulatory T Cell Defect in Autoimmune Polyendocrinopathy–Candidiasis–Ectodermal Dystrophy Patients
Iivo Hetemäki, Hanna Jarva, Nicolas Kluger, Hanna-Mari Baldauf, Sini Laakso, Eirik Bratland, Eystein S. Husebye, Kai Kisand, Annamari Ranki, Pärt Peterson and T. Petteri Arstila

J Immunol April 1, 2016, 196 (7) 2955-2964; DOI: https://doi.org/10.4049/jimmunol.1500301
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Vitamin D [1,25(OH)₂D₃] Differentially Regulates Human Innate Cytokine Responses to Bacterial versus Viral Pattern Recognition Receptor Stimuli
Natascha Fitch, Allan B. Becker and Kent T. HayGlass

J Immunol April 1, 2016, 196 (7) 2965-2972; DOI: https://doi.org/10.4049/jimmunol.1500460

IMMUNE REGULATION

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Differential T Cell Cytokine Receptivity and Not Signal Quality Distinguishes IL-6 and IL-10 Signaling during Th17 Differentiation
Lindsay L. Jones, Rajshekhar Alli, Bofeng Li and Terrence L. Geiger

J Immunol April 1, 2016, 196 (7) 2973-2985; DOI: https://doi.org/10.4049/jimmunol.1402953
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Loss of Fancc Impairs Antibody-Secreting Cell Differentiation in Mice through Deregulating the Wnt Signaling Pathway
Mathieu Sertorio, Surya Amarachintha, Andrew Wilson and Qishen Pang

J Immunol April 1, 2016, 196 (7) 2986-2994; DOI: https://doi.org/10.4049/jimmunol.1501056
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Grb2 Is Important for T Cell Development, Th Cell Differentiation, and Induction of Experimental Autoimmune Encephalomyelitis
Daniel Radtke, Sonja M. Lacher, Nadine Szumilas, Lena Sandrock, Jochen Ackermann, Lars Nitschke and Elisabeth Zinser

J Immunol April 1, 2016, 196 (7) 2995-3005; DOI: https://doi.org/10.4049/jimmunol.1501764
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HIV Skews the Lineage-Defining Transcriptional Profile of Mycobacterium tuberculosis–Specific CD4⁺ T Cells
Catherine Riou, Natalie Strickland, Andreia P. Soares, Björn Corleis, Douglas S. Kwon, E. John Wherry, Robert J. Wilkinson and Wendy A. Burgers

J Immunol April 1, 2016, 196 (7) 3006-3018; DOI: https://doi.org/10.4049/jimmunol.1502094
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Sema3e/Plexin D1 Modulates Immunological Synapse and Migration of Thymocytes by Rap1 Inhibition
Yoshihiro Ueda, Naoyuki Kondo, Madoka Ozawa, Kaneki Yasuda, Takashi Tomiyama and Tatsuo Kinashi

J Immunol April 1, 2016, 196 (7) 3019-3031; DOI: https://doi.org/10.4049/jimmunol.1502121

IMMUNOGENETICS

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Restoration of ATM Expression in DNA-PKcs–Deficient Cells Inhibits Signal End Joining
Jessica A. Neal, Yao Xu, Masumi Abe, Eric Hendrickson and Katheryn Meek

J Immunol April 1, 2016, 196 (7) 3032-3042; DOI: https://doi.org/10.4049/jimmunol.1501654
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Systematic Evaluation of Genes and Genetic Variants Associated with Type 1 Diabetes Susceptibility
Ramesh Ram, Munish Mehta, Quang T. Nguyen, Irma Larma, Bernhard O. Boehm, Flemming Pociot, Patrick Concannon and Grant Morahan

J Immunol April 1, 2016, 196 (7) 3043-3053; DOI: https://doi.org/10.4049/jimmunol.1502056

IMMUNOTHERAPY AND VACCINES

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Shortened Intervals during Heterologous Boosting Preserve Memory CD8 T Cell Function but Compromise Longevity
Emily A. Thompson, Lalit K. Beura, Christine E. Nelson, Kristin G. Anderson and Vaiva Vezys

J Immunol April 1, 2016, 196 (7) 3054-3063; DOI: https://doi.org/10.4049/jimmunol.1501797
Open Access
Achieving Potent Autologous Neutralizing Antibody Responses against Tier 2 HIV-1 Viruses by Strategic Selection of Envelope Immunogens
Author Choice Article

Ann J. Hessell, Delphine C. Malherbe, Franco Pissani, Sean McBurney, Shelly J. Krebs, Michelle Gomes, Shilpi Pandey, William F. Sutton, Benjamin J. Burwitz, Matthew Gray, Harlan Robins, Byung S. Park, Jonah B. Sacha, Celia C. LaBranche, Deborah H. Fuller, David C. Montefiori, Leonidas Stamatatos, D. Noah Sather and Nancy L. Haigwood

J Immunol April 1, 2016, 196 (7) 3064-3078; DOI: https://doi.org/10.4049/jimmunol.1500527
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Clearing Persistent Extracellular Antigen of Hepatitis B Virus: An Immunomodulatory Strategy To Reverse Tolerance for an Effective Therapeutic Vaccination
Danming Zhu, Longchao Liu, Dan Yang, Sherry Fu, Yingjie Bian, Zhichen Sun, Junming He, Lishan Su, Liguo Zhang, Hua Peng and Yang-Xin Fu

J Immunol April 1, 2016, 196 (7) 3079-3087; DOI: https://doi.org/10.4049/jimmunol.1502061

INFECTIOUS DISEASE AND HOST RESPONSE

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Macrophage Galactose-Type Lectin-1 Deficiency Is Associated with Increased Neutrophilia and Hyperinflammation in Gram-Negative Pneumonia
Christopher N. Jondle, Atul Sharma, Tanner J. Simonson, Benjamin Larson, Bibhuti B. Mishra and Jyotika Sharma

J Immunol April 1, 2016, 196 (7) 3088-3096; DOI: https://doi.org/10.4049/jimmunol.1501790
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Clinical Isolates of Pseudomonas aeruginosa from Chronically Infected Cystic Fibrosis Patients Fail To Activate the Inflammasome during Both Stable Infection and Pulmonary Exacerbation
Kelsey E. Huus, Julie Joseph, Li Zhang, Alex Wong, Shawn D. Aaron, Thien-Fah Mah and Subash Sad

J Immunol April 1, 2016, 196 (7) 3097-3108; DOI: https://doi.org/10.4049/jimmunol.1501642
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Type I IFN Does Not Promote Susceptibility to Foodborne Listeria monocytogenes
Michelle G. Pitts, Tanya Myers-Morales and Sarah E. F. D’Orazio

J Immunol April 1, 2016, 196 (7) 3109-3116; DOI: https://doi.org/10.4049/jimmunol.1502192

INNATE IMMUNITY AND INFLAMMATION

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MLN4924, a First-in-Class NEDD8-Activating Enzyme Inhibitor, Attenuates IFN-β Production
Hui Song, Wanwan Huai, Zhongxia Yu, Wenwen Wang, Jing Zhao, Lining Zhang and Wei Zhao

J Immunol April 1, 2016, 196 (7) 3117-3123; DOI: https://doi.org/10.4049/jimmunol.1501752
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Mouse Cytomegalovirus Infection in BALB/c Mice Resembles Virus-Associated Secondary Hemophagocytic Lymphohistiocytosis and Shows a Pathogenesis Distinct from Primary Hemophagocytic Lymphohistiocytosis
Ellen Brisse, Maya Imbrechts, Karen Put, Anneleen Avau, Tania Mitera, Nele Berghmans, Omer Rutgeerts, Mark Waer, Marisa Ninivaggi, Hilde Kelchtermans, Louis Boon, Robert Snoeck, Carine H. Wouters, Graciela Andrei and Patrick Matthys

J Immunol April 1, 2016, 196 (7) 3124-3134; DOI: https://doi.org/10.4049/jimmunol.1501035
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Human SR-BI and SR-BII Potentiate Lipopolysaccharide-Induced Inflammation and Acute Liver and Kidney Injury in Mice
Irina N. Baranova, Ana C. P. Souza, Alexander V. Bocharov, Tatyana G. Vishnyakova, Xuzhen Hu, Boris L. Vaisman, Marcelo J. Amar, Zhigang Chen, Yana Kost, Alan T. Remaley, Amy P. Patterson, Peter S. T. Yuen, Robert A. Star and Thomas L. Eggerman

J Immunol April 1, 2016, 196 (7) 3135-3147; DOI: https://doi.org/10.4049/jimmunol.1501709
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Mincle Activation and the Syk/Card9 Signaling Axis Are Central to the Development of Autoimmune Disease of the Eye
Ellen J. Lee, Brieanna R. Brown, Emily E. Vance, Paige E. Snow, Phyllis B. Silver, David Heinrichs, Xin Lin, Yoichiro Iwakura, Christine A. Wells, Rachel R. Caspi and Holly L. Rosenzweig

J Immunol April 1, 2016, 196 (7) 3148-3158; DOI: https://doi.org/10.4049/jimmunol.1502355

MUCOSAL IMMUNOLOGY

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POU2AF1 Functions in the Human Airway Epithelium To Regulate Expression of Host Defense Genes
Haixia Zhou, Angelika Brekman, Wu-Lin Zuo, Xuemei Ou, Renat Shaykhiev, Francisco J. Agosto-Perez, Rui Wang, Matthew S. Walters, Jacqueline Salit, Yael Strulovici-Barel, Michelle R. Staudt, Robert J. Kaner, Jason G. Mezey, Ronald G. Crystal and Guoqing Wang

J Immunol April 1, 2016, 196 (7) 3159-3167; DOI: https://doi.org/10.4049/jimmunol.1502400

TRANSPLANTATION

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T-bet Promotes Acute Graft-versus-Host Disease by Regulating Recipient Hematopoietic Cells in Mice
Jianing Fu, Yongxia Wu, Hung Nguyen, Jessica Heinrichs, Steven Schutt, Yuejun Liu, Chen Liu, Junfei Jin, Claudio Anasetti and Xue-Zhong Yu

J Immunol April 1, 2016, 196 (7) 3168-3179; DOI: https://doi.org/10.4049/jimmunol.1501020
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CD4 T Cell Help via B Cells Is Required for Lymphopenia-Induced CD8 T Cell Proliferation
Katayoun Ayasoufi, Ran Fan, Robert L. Fairchild and Anna Valujskikh

J Immunol April 1, 2016, 196 (7) 3180-3190; DOI: https://doi.org/10.4049/jimmunol.1501435

TUMOR IMMUNOLOGY

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Antagonism of the STING Pathway via Activation of the AIM2 Inflammasome by Intracellular DNA
Leticia Corrales, Seng-Ryong Woo, Jason B. Williams, Sarah M. McWhirter, Thomas W. Dubensky Jr. and Thomas F. Gajewski

J Immunol April 1, 2016, 196 (7) 3191-3198; DOI: https://doi.org/10.4049/jimmunol.1502538

NOVEL IMMUNOLOGICAL METHODS

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Design and Validation of a Novel Generic Platform for the Production of Tetravalent IgG1-like Bispecific Antibodies
Josée Golay, Sylvie Choblet, Justyna Iwaszkiewicz, Pierre Cérutti, Annick Ozil, Séverine Loisel, Martine Pugnière, Greta Ubiali, Vincent Zoete, Olivier Michielin, Christian Berthou, Jean Kadouche, Jean-Pierre Mach and Martine Duonor-Cérutti

J Immunol April 1, 2016, 196 (7) 3199-3211; DOI: https://doi.org/10.4049/jimmunol.1501592

CORRECTIONS

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Correction: Cutting Edge: Role of NK Cells and Surfactant Protein D in Dendritic Cell Lymph Node Homing: Effects of Ozone Exposure
Moyar Qing Ge, Blerina Kokalari, Cameron H. Flayer, Sarah S. Killingbeck, Imre G. Redai, Alexander W. MacFarlane IV, Jin W. Hwang, Anisha Kolupoti, David M. Kemeny, Kerry S. Campbell and Angela Haczku

J Immunol April 1, 2016, 196 (7) 3212; DOI: https://doi.org/10.4049/jimmunol.1600095

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Table of Contents

IN THIS ISSUE

PILLARS OF IMMUNOLOGY

BRIEF REVIEWS

CUTTING EDGE

ANTIGEN RECOGNITION AND RESPONSES

AUTOIMMUNITY

CLINICAL AND HUMAN IMMUNOLOGY

IMMUNE REGULATION

IMMUNOGENETICS

IMMUNOTHERAPY AND VACCINES

INFECTIOUS DISEASE AND HOST RESPONSE

INNATE IMMUNITY AND INFLAMMATION

MUCOSAL IMMUNOLOGY

TRANSPLANTATION

TUMOR IMMUNOLOGY

NOVEL IMMUNOLOGICAL METHODS

CORRECTIONS

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