The Journal of Immunology: 196 (2)

January 15, 2016; Volume 196,Issue 2

IN THIS ISSUE

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In This Issue
γδ T Cell Subset Cytokine Selectivity See article p. 645
Fat Body Factor Foils Fly Immunity See article p. 655
EAE Alleviated by Eosinophils See article p. 703
CpG Stems Secondary Bacterial Infection See article p. 767

J Immunol January 15, 2016, 196 (2) 519-520; DOI: https://doi.org/10.4049/jimmunol.1590027

LETTERS TO THE EDITOR

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Comments from the Editor-in-Chief
Pamela J. Fink

J Immunol January 15, 2016, 196 (2) 521; DOI: https://doi.org/10.4049/jimmunol.1502280
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Comment on Three X-ray Crystal Structure Papers
Robyn Stanfield, Edwin Pozharski and Bernhard Rupp

J Immunol January 15, 2016, 196 (2) 521-524; DOI: https://doi.org/10.4049/jimmunol.1501343
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Response to Comment on Three X-ray Crystal Structure Papers
Dinakar M. Salunke, Tarique Khan, Vineet Gaur, Suman Tapryal and Kanwaljeet Kaur

J Immunol January 15, 2016, 196 (2) 524-528; DOI: https://doi.org/10.4049/jimmunol.1501474
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Additional Comment on Three X-ray Crystal Structure Papers
Robyn Stanfield, Edwin Pozharski and Bernhard Rupp

J Immunol January 15, 2016, 196 (2) 528-530; DOI: https://doi.org/10.4049/jimmunol.1502281
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Response to Additional Comment on Three X-ray Crystal Structure Papers
Dinakar M. Salunke, Tarique Khan, Vineet Gaur, Suman Tapryal and Kanwaljeet Kaur

J Immunol January 15, 2016, 196 (2) 530; DOI: https://doi.org/10.4049/jimmunol.1502468
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Comment on “Cutting Edge: Inhibiting TBK1 by Compound II Ameliorates Autoimmune Disease in Mice”
David Brenner, Peter M. Andersen, Albert C. Ludolph and Jochen H. Weishaupt

J Immunol January 15, 2016, 196 (2) 530-531; DOI: https://doi.org/10.4049/jimmunol.1502255
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Response to Comment on “Cutting Edge: Inhibiting TBK1 by Compound II Ameliorates Autoimmune Disease in Mice”
Maroof Hasan and Nan Yan

J Immunol January 15, 2016, 196 (2) 531; DOI: https://doi.org/10.4049/jimmunol.1502300

BRIEF REVIEWS

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Posttranscriptional and Translational Control of Gene Regulation in CD4⁺ T Cell Subsets
Roman Istomine, Nils Pavey and Ciriaco A. Piccirillo

J Immunol January 15, 2016, 196 (2) 533-540; DOI: https://doi.org/10.4049/jimmunol.1501337

CUTTING EDGE

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Cutting Edge: IL-1 Receptor Signaling is Critical for the Development of Autoimmune Uveitis
Chi-Keung Wan, Chang He, Lin Sun, Charles E. Egwuagu and Warren J. Leonard

J Immunol January 15, 2016, 196 (2) 543-546; DOI: https://doi.org/10.4049/jimmunol.1502080
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Cutting Edge: Novel Tmem173 Allele Reveals Importance of STING N Terminus in Trafficking and Type I IFN Production
Guy Surpris, Jennie Chan, Mikayla Thompson, Vladimir Ilyukha, Beiyun C. Liu, Maninjay Atianand, Shruti Sharma, Tatyana Volkova, Irina Smirnova, Katherine A. Fitzgerald and Alexander Poltorak

J Immunol January 15, 2016, 196 (2) 547-552; DOI: https://doi.org/10.4049/jimmunol.1501415
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Cutting Edge: Role of NK Cells and Surfactant Protein D in Dendritic Cell Lymph Node Homing: Effects of Ozone Exposure
Moyar Qing Ge, Blerina Kokalari, Cameron H. Flayer, Sarah S. Killingbeck, Imre G. Redai, Alexander W. MacFarlane IV, Jin W. Hwang, Anisha Kolupoti, Michael D. Kemeny, Kerry S. Campbell and Angela Haczku

J Immunol January 15, 2016, 196 (2) 553-557; DOI: https://doi.org/10.4049/jimmunol.1403042
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Cutting Edge: Ezrin Regulates Inflammation by Limiting B Cell IL-10 Production
Debasis Pore, Ken Matsui, Neetha Parameswaran and Neetu Gupta

J Immunol January 15, 2016, 196 (2) 558-562; DOI: https://doi.org/10.4049/jimmunol.1502098

AUTOIMMUNITY

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SATB1 Plays a Critical Role in Establishment of Immune Tolerance
Motonari Kondo, Yuriko Tanaka, Taku Kuwabara, Taku Naito, Terumi Kohwi-Shigematsu and Akiko Watanabe

J Immunol January 15, 2016, 196 (2) 563-572; DOI: https://doi.org/10.4049/jimmunol.1501429
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Selective ORAI1 Inhibition Ameliorates Autoimmune Central Nervous System Inflammation by Suppressing Effector but Not Regulatory T Cell Function
Ulrike Kaufmann, Patrick J. Shaw, Lina Kozhaya, Raju Subramanian, Kevin Gaida, Derya Unutmaz, Helen J. McBride and Stefan Feske

J Immunol January 15, 2016, 196 (2) 573-585; DOI: https://doi.org/10.4049/jimmunol.1501406

CLINICAL AND HUMAN IMMUNOLOGY

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Phosphatidylinositol-3,4-Bisphosphate and Its Binding Protein Lamellipodin Regulate Chemotaxis of Malignant B Lymphocytes
Hongzhao Li, Xun Wu, Sen Hou, Mouhannad Malek, Anna Kielkowska, Edward Noh, Kennedy J. Makondo, Qiujiang Du, John A. Wilkins, James B. Johnston, Spencer B. Gibson, Francis Lin and Aaron J. Marshall

J Immunol January 15, 2016, 196 (2) 586-595; DOI: https://doi.org/10.4049/jimmunol.1500630
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Protein Inhibitor of Activated STAT3 Regulates Migration, Invasion, and Activation of Fibroblast-like Synoviocytes in Rheumatoid Arthritis
Minxi Lao, Maohua Shi, Yaoyao Zou, Mingcheng Huang, Yujin Ye, Qian Qiu, Youjun Xiao, Shan Zeng, Liuqin Liang, Xiuyan Yang and Hanshi Xu

J Immunol January 15, 2016, 196 (2) 596-606; DOI: https://doi.org/10.4049/jimmunol.1403254
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IgG1 Allotypes Influence the Pharmacokinetics of Therapeutic Monoclonal Antibodies through FcRn Binding
David Ternant, Christophe Arnoult, Martine Pugnière, Christine Dhommée, Daniel Drocourt, Eric Perouzel, Christophe Passot, Nadine Baroukh, Denis Mulleman, Gérard Tiraby, Hervé Watier, Gilles Paintaud and Valérie Gouilleux-Gruart

J Immunol January 15, 2016, 196 (2) 607-613; DOI: https://doi.org/10.4049/jimmunol.1501780
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The Transcription Factor ARID3a Is Important for In Vitro Differentiation of Human Hematopoietic Progenitors
Michelle L. Ratliff, Meenu Mishra, Mark B. Frank, Joel M. Guthridge and Carol F. Webb

J Immunol January 15, 2016, 196 (2) 614-623; DOI: https://doi.org/10.4049/jimmunol.1500355

IMMUNE REGULATION

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Monocyte-Derived Dendritic Cells Promote Th Polarization, whereas Conventional Dendritic Cells Promote Th Proliferation
Kevin V. Chow, Andrew M. Lew, Robyn M. Sutherland and Yifan Zhan

J Immunol January 15, 2016, 196 (2) 624-636; DOI: https://doi.org/10.4049/jimmunol.1501202
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Norepinephrine Controls Effector T Cell Differentiation through β₂-Adrenergic Receptor–Mediated Inhibition of NF-κB and AP-1 in Dendritic Cells
Maisa Carla Takenaka, Leandro Pires Araujo, Juliana Terzi Maricato, Vanessa M. Nascimento, Marcia Grando Guereschi, Rafael Machado Rezende, Francisco J. Quintana and Alexandre S. Basso

J Immunol January 15, 2016, 196 (2) 637-644; DOI: https://doi.org/10.4049/jimmunol.1501206
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Differential Responsiveness of Innate-like IL-17– and IFN-γ–Producing γδ T Cells to Homeostatic Cytokines
Theresa M. Corpuz, Jessica Stolp, Hee-Ok Kim, Gabriela V. Pinget, Daniel H. D. Gray, Jae-Ho Cho, Jonathan Sprent and Kylie E. Webster

J Immunol January 15, 2016, 196 (2) 645-654; DOI: https://doi.org/10.4049/jimmunol.1502082
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Identification of Drosophila Zfh2 as a Mediator of Hypercapnic Immune Regulation by a Genome-Wide RNA Interference Screen
Iiro Taneli Helenius, Ryan J. Haake, Yong-Jae Kwon, Jennifer A. Hu, Thomas Krupinski, S. Marina Casalino-Matsuda, Peter H. S. Sporn, Jacob I. Sznajder and Greg J. Beitel

J Immunol January 15, 2016, 196 (2) 655-667; DOI: https://doi.org/10.4049/jimmunol.1501708
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Naturally Occurring Subclinical Endotoxemia in Humans Alters Adaptive and Innate Immune Functions through Reduced MAPK and Increased STAT1 Phosphorylation
Christine D. Palmer, Marisol Romero-Tejeda, Michael Sirignano, Siddhartha Sharma, Todd M. Allen, Marcus Altfeld and Stephanie Jost

J Immunol January 15, 2016, 196 (2) 668-677; DOI: https://doi.org/10.4049/jimmunol.1501888
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Regulatory T Cells Orchestrate Similar Immune Evasion of Fetuses and Tumors in Mice
Djamel Nehar-Belaid, Tristan Courau, Nicolas Dérian, Laura Florez, Maria Grazia Ruocco and David Klatzmann

J Immunol January 15, 2016, 196 (2) 678-690; DOI: https://doi.org/10.4049/jimmunol.1501834
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Mannose-Capped Lipoarabinomannan from Mycobacterium tuberculosis Induces CD4⁺ T Cell Anergy via GRAIL
Obondo J. Sande, Ahmad F. Karim, Qing Li, Xuedong Ding, Clifford V. Harding, Roxana E. Rojas and W. Henry Boom

J Immunol January 15, 2016, 196 (2) 691-702; DOI: https://doi.org/10.4049/jimmunol.1500710
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Helminth Products Protect against Autoimmunity via Innate Type 2 Cytokines IL-5 and IL-33, Which Promote Eosinophilia
Conor M. Finlay, Anna M. Stefanska, Kevin P. Walsh, Patrick J. Kelly, Louis Boon, Ed C. Lavelle, Patrick T. Walsh and Kingston H. G. Mills

J Immunol January 15, 2016, 196 (2) 703-714; DOI: https://doi.org/10.4049/jimmunol.1501820
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Dynamic Regulation of Tandem 3′ Untranslated Regions in Zebrafish Spleen Cells during Immune Response
Guangrui Huang, Shengfeng Huang, Ruihua Wang, Xinyu Yan, Yuxin Li, Yuchao Feng, Shaozhou Wang, Xia Yang, Liutao Chen, Jun Li, Leiming You, Shangwu Chen, Guangbin Luo and Anlong Xu

J Immunol January 15, 2016, 196 (2) 715-725; DOI: https://doi.org/10.4049/jimmunol.1500847
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Targeting of Ly9 (CD229) Disrupts Marginal Zone and B1 B Cell Homeostasis and Antibody Responses
Marta Cuenca, Xavier Romero, Jordi Sintes, Cox Terhorst and Pablo Engel

J Immunol January 15, 2016, 196 (2) 726-737; DOI: https://doi.org/10.4049/jimmunol.1501266

IMMUNE SYSTEM DEVELOPMENT

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TRPV4-Mediated Detection of Hyposmotic Stress by Skin Keratinocytes Activates Developmental Immunity
Jorge Galindo-Villegas, Ana Montalban-Arques, Sergio Liarte, Sofia de Oliveira, Carlos Pardo-Pastor, Fanny Rubio-Moscardo, José Meseguer, Miguel A. Valverde and Victoriano Mulero

J Immunol January 15, 2016, 196 (2) 738-749; DOI: https://doi.org/10.4049/jimmunol.1501729

IMMUNOGENETICS

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Complex MHC Class I Gene Transcription Profiles and Their Functional Impact in Orangutans
Natasja G. de Groot, Corrine M. C. Heijmans, Marit K. H. van der Wiel, Jeroen H. Blokhuis, Arend Mulder, Lisbeth A. Guethlein, Gaby G. M. Doxiadis, Frans H. J. Claas, Peter Parham and Ronald E. Bontrop

J Immunol January 15, 2016, 196 (2) 750-758; DOI: https://doi.org/10.4049/jimmunol.1500820

IMMUNOTHERAPY AND VACCINES

Open Access
Coexpressed Catalase Protects Chimeric Antigen Receptor–Redirected T Cells as well as Bystander Cells from Oxidative Stress–Induced Loss of Antitumor Activity
Author Choice Article

Maarten A. Ligtenberg, Dimitrios Mougiakakos, Madhura Mukhopadhyay, Kristina Witt, Alvaro Lladser, Markus Chmielewski, Tobias Riet, Hinrich Abken and Rolf Kiessling

J Immunol January 15, 2016, 196 (2) 759-766; DOI: https://doi.org/10.4049/jimmunol.1401710

INFECTIOUS DISEASE AND HOST RESPONSE

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Beneficial Effects of CpG-Oligodeoxynucleotide Treatment on Trauma and Secondary Lung Infection
Lorenz Wanke-Jellinek, Joshua W. Keegan, James W. Dolan, Fei Guo, Jianfei Chen and James A. Lederer

J Immunol January 15, 2016, 196 (2) 767-777; DOI: https://doi.org/10.4049/jimmunol.1500597
Open Access
The Costimulatory Molecule ICOS Regulates Host Th1 and Follicular Th Cell Differentiation in Response to Plasmodium chabaudi chabaudi AS Infection
Author Choice Article

Daniel J. Wikenheiser, Debopam Ghosh, Brian Kennedy and Jason S. Stumhofer

J Immunol January 15, 2016, 196 (2) 778-791; DOI: https://doi.org/10.4049/jimmunol.1403206
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Salmonella Virulence Factor SsrAB Regulated Factor Modulates Inflammatory Responses by Enhancing the Activation of NF-κB Signaling Pathway
Lei Lei, Wenbiao Wang, Chuan Xia and Fenyong Liu

J Immunol January 15, 2016, 196 (2) 792-802; DOI: https://doi.org/10.4049/jimmunol.1500679
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IL-17A Is an Important Effector of the Immune Response of the Mammary Gland to Escherichia coli Infection
Adeline Porcherie, Florence B. Gilbert, Pierre Germon, Patricia Cunha, Angélina Trotereau, Christelle Rossignol, Nathalie Winter, Patricia Berthon and Pascal Rainard

J Immunol January 15, 2016, 196 (2) 803-812; DOI: https://doi.org/10.4049/jimmunol.1500705

INNATE IMMUNITY AND INFLAMMATION

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Enhancer Turnover Is Associated with a Divergent Transcriptional Response to Glucocorticoid in Mouse and Human Macrophages
Alasdair W. Jubb, Robert S. Young, David A. Hume and Wendy A. Bickmore

J Immunol January 15, 2016, 196 (2) 813-822; DOI: https://doi.org/10.4049/jimmunol.1502009
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Mevalonate Biosynthesis Intermediates Are Key Regulators of Innate Immunity in Bovine Endometritis
Author Choice Article

Gareth D. Healey, Christine Collier, Sholeem Griffin, Hans-Joachim Schuberth, Olivier Sandra, David G. Smith, Suman Mahan, Isabelle Dieuzy-Labaye and I. Martin Sheldon

J Immunol January 15, 2016, 196 (2) 823-831; DOI: https://doi.org/10.4049/jimmunol.1501080
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TNF Regulates Essential Alternative Complement Pathway Components and Impairs Activation of Protein C in Human Glomerular Endothelial Cells
Sarah E. Sartain, Nancy A. Turner and Joel L. Moake

J Immunol January 15, 2016, 196 (2) 832-845; DOI: https://doi.org/10.4049/jimmunol.1500960
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Activator of G-Protein Signaling 3–Induced Lysosomal Biogenesis Limits Macrophage Intracellular Bacterial Infection
Ali Vural, Souhaila Al-Khodor, Gordon Y. C. Cheung, Chong-Shan Shi, Lalitha Srinivasan, Travis J. McQuiston, Il-Young Hwang, Anthony J. Yeh, Joe B. Blumer, Volker Briken, Peter R. Williamson, Michael Otto, Iain D. C. Fraser and John H. Kehrl

J Immunol January 15, 2016, 196 (2) 846-856; DOI: https://doi.org/10.4049/jimmunol.1501595
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MASP-1 and MASP-2 Do Not Activate Pro–Factor D in Resting Human Blood, whereas MASP-3 Is a Potential Activator: Kinetic Analysis Involving Specific MASP-1 and MASP-2 Inhibitors
Gábor Oroszlán, Elod Kortvely, Dávid Szakács, Andrea Kocsis, Sascha Dammeier, Anne Zeck, Marius Ueffing, Péter Závodszky, Gábor Pál, Péter Gál and József Dobó

J Immunol January 15, 2016, 196 (2) 857-865; DOI: https://doi.org/10.4049/jimmunol.1501717

MOLECULAR AND STRUCTURAL IMMUNOLOGY

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Comparative Analysis of Novel Complement-Targeted Inhibitors, MiniFH, and the Natural Regulators Factor H and Factor H–like Protein 1 Reveal Functional Determinants of Complement Regulation
Markus J. Harder, Markus Anliker, Britta Höchsmann, Thomas Simmet, Markus Huber-Lang, Hubert Schrezenmeier, Daniel Ricklin, John D. Lambris, Paul N. Barlow and Christoph Q. Schmidt

J Immunol January 15, 2016, 196 (2) 866-876; DOI: https://doi.org/10.4049/jimmunol.1501919

TRANSPLANTATION

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IL-12–Dependent Cytomegalovirus-Specific CD4⁺ T Cell Proliferation, T-bet Induction, and Effector Multifunction during Primary Infection Are Key Determinants for Early Immune Control
Iulia Popescu, Matthew R. Pipeling, Hannah Mannem, Pali D. Shah, Jonathan B. Orens, Mark Connors, Stephen A. Migueles and John F. McDyer

J Immunol January 15, 2016, 196 (2) 877-890; DOI: https://doi.org/10.4049/jimmunol.1501589

TUMOR IMMUNOLOGY

Open Access
Deletion of 5-Lipoxygenase in the Tumor Microenvironment Promotes Lung Cancer Progression and Metastasis through Regulating T Cell Recruitment
Author Choice Article

Joanna M. Poczobutt, Teresa T. Nguyen, Dwight Hanson, Howard Li, Trisha R. Sippel, Mary C. M. Weiser-Evans, Miguel Gijon, Robert C. Murphy and Raphael A. Nemenoff

J Immunol January 15, 2016, 196 (2) 891-901; DOI: https://doi.org/10.4049/jimmunol.1501648
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The Fractalkine-Receptor Axis Improves Human Colorectal Cancer Prognosis by Limiting Tumor Metastatic Dissemination
Marco Erreni, Imran Siddiqui, Giulia Marelli, Fabio Grizzi, Paolo Bianchi, Diego Morone, Federica Marchesi, Giuseppe Celesti, Samantha Pesce, Andrea Doni, Cristiano Rumio, Massimo G. Roncalli, Luigi Laghi, Alberto Mantovani and Paola Allavena

J Immunol January 15, 2016, 196 (2) 902-914; DOI: https://doi.org/10.4049/jimmunol.1501335
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Targeting Ornithine Decarboxylase by α-Difluoromethylornithine Inhibits Tumor Growth by Impairing Myeloid-Derived Suppressor Cells
Cong Ye, Zhe Geng, Donye Dominguez, Siqi Chen, Jie Fan, Lei Qin, Alan Long, Yi Zhang, Timothy M. Kuzel and Bin Zhang

J Immunol January 15, 2016, 196 (2) 915-923; DOI: https://doi.org/10.4049/jimmunol.1500729

NOVEL IMMUNOLOGICAL METHODS

Open Access
Categorical Analysis of Human T Cell Heterogeneity with One-Dimensional Soli-Expression by Nonlinear Stochastic Embedding
Author Choice Article

Yang Cheng, Michael T. Wong, Laurens van der Maaten and Evan W. Newell

J Immunol January 15, 2016, 196 (2) 924-932; DOI: https://doi.org/10.4049/jimmunol.1501928

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Table of Contents

IN THIS ISSUE

LETTERS TO THE EDITOR

BRIEF REVIEWS

CUTTING EDGE

AUTOIMMUNITY

CLINICAL AND HUMAN IMMUNOLOGY

IMMUNE REGULATION

IMMUNE SYSTEM DEVELOPMENT

IMMUNOGENETICS

IMMUNOTHERAPY AND VACCINES

INFECTIOUS DISEASE AND HOST RESPONSE

INNATE IMMUNITY AND INFLAMMATION

MOLECULAR AND STRUCTURAL IMMUNOLOGY

TRANSPLANTATION

TUMOR IMMUNOLOGY

NOVEL IMMUNOLOGICAL METHODS

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