Skip to main content

Main menu

  • Home
  • Articles
    • Current Issue
    • Next in The JI
    • Archive
    • Brief Reviews
    • Pillars of Immunology
    • Translating Immunology
    • Most Read
    • Top Downloads
    • Annual Meeting Abstracts
  • COVID-19/SARS/MERS Articles
  • Info
    • About the Journal
    • For Authors
    • Journal Policies
    • Influence Statement
    • For Advertisers
  • Editors
  • Submit
    • Submit a Manuscript
    • Instructions for Authors
    • Journal Policies
  • Subscribe
    • Journal Subscriptions
    • Email Alerts
    • RSS Feeds
    • ImmunoCasts
  • More
    • Most Read
    • Most Cited
    • ImmunoCasts
    • AAI Disclaimer
    • Feedback
    • Help
    • Accessibility Statement
  • Other Publications
    • American Association of Immunologists
    • ImmunoHorizons

User menu

  • Subscribe
  • Log in

Search

  • Advanced search
The Journal of Immunology
  • Other Publications
    • American Association of Immunologists
    • ImmunoHorizons
  • Subscribe
  • Log in
The Journal of Immunology

Advanced Search

  • Home
  • Articles
    • Current Issue
    • Next in The JI
    • Archive
    • Brief Reviews
    • Pillars of Immunology
    • Translating Immunology
    • Most Read
    • Top Downloads
    • Annual Meeting Abstracts
  • COVID-19/SARS/MERS Articles
  • Info
    • About the Journal
    • For Authors
    • Journal Policies
    • Influence Statement
    • For Advertisers
  • Editors
  • Submit
    • Submit a Manuscript
    • Instructions for Authors
    • Journal Policies
  • Subscribe
    • Journal Subscriptions
    • Email Alerts
    • RSS Feeds
    • ImmunoCasts
  • More
    • Most Read
    • Most Cited
    • ImmunoCasts
    • AAI Disclaimer
    • Feedback
    • Help
    • Accessibility Statement
  • Follow The Journal of Immunology on Twitter
  • Follow The Journal of Immunology on RSS

IL-17A negatively regulates lymphatic vessel formation

Hyeung Ju Park, Min-Gyo Kim and Seung-Hyo Lee
J Immunol May 1, 2016, 196 (1 Supplement) 196.14;
Hyeung Ju Park
1Korea Advanced Inst. of Sci. and Technol., South Korea
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Min-Gyo Kim
1Korea Advanced Inst. of Sci. and Technol., South Korea
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Seung-Hyo Lee
1Korea Advanced Inst. of Sci. and Technol., South Korea
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • Article
  • Info & Metrics
Loading

Abstract

Lymphatic vessels (LVs), well-known conduits of immune cells, enable antigen presenting cells (APCs) to enter draining lymph node resulting in the induction of adaptive immune responses against various antigens. During inflammation, LVs are increased and enlarged by the effect of pro-lymphangiogenic factors including vascular endothelial growth factor -A, C, and D secreted by APCs and stromal cells, and facilitate the migration of activated immune cells. However, after antigen clearance, these expanded LVs should be shrunk similar to apoptotic cell death of activated immune cells to maintain homeostasis. It is known that, failure of inflammation resolution causes chronic inflammation in many diseases. Chronic inflammation often accompanies increased LVs which enable continuous antigen delivery and immune cell trafficking from infection sites to draining lymph node. Previously, it was discovered that several cytokines secreted by type 1 and 2 helper T (Th) cells inhibit lymphangiogenesis during resolution phase but less is known about the effect of Th17 cytokines. Here, we show that interleukin-17A (IL-17A) secreted from Th17 cells is a putative negative regulator of lymphangiogenesis in Th17-mediated immune responses, especially during resolution phase. IL-17A suppressed gene expression of lymphatic specific markers in lymphatic endothelial cells. Also, we utilized cholera toxin mixed with chicken egg ovalbumin peptide (CTO) challenge model which induces Th17 dominant inflammation to examine the in vivo effect of IL-17A. Blockade of IL-17A increased LVs and enhanced their function. Thus, this study will provide expanded knowledge on unidentified role of IL-17A as a negative regulator of lymphangiogenesis.

  • Copyright © 2016 by The American Association of Immunologists, Inc.
Previous
Back to top

In this issue

The Journal of Immunology
Vol. 196, Issue 1 Supplement
1 May 2016
  • Table of Contents
Article Alerts
Sign In to Email Alerts with your Email Address
Email Article

Thank you for your interest in spreading the word about The Journal of Immunology.

NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.

Enter multiple addresses on separate lines or separate them with commas.
IL-17A negatively regulates lymphatic vessel formation
(Your Name) has forwarded a page to you from The Journal of Immunology
(Your Name) thought you would like to see this page from the The Journal of Immunology web site.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Citation Tools
IL-17A negatively regulates lymphatic vessel formation
Hyeung Ju Park, Min-Gyo Kim, Seung-Hyo Lee
The Journal of Immunology May 1, 2016, 196 (1 Supplement) 196.14;

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
Share
IL-17A negatively regulates lymphatic vessel formation
Hyeung Ju Park, Min-Gyo Kim, Seung-Hyo Lee
The Journal of Immunology May 1, 2016, 196 (1 Supplement) 196.14;
del.icio.us logo Digg logo Reddit logo Twitter logo CiteULike logo Facebook logo Google logo Mendeley logo
  • Tweet Widget
  • Facebook Like

Jump to section

  • Article
  • Info & Metrics

Related Articles

Cited By...

More in this TOC Section

  • Adenovirus Serotype 5 Vectors Trigger IL-27-Dependent Inhibitory CD4+ T Cell Responses
  • Type I interferon regulates GITRL on infiltrating monocyte-derived inflammatory APC to establish early viral control during chronic LCMV infection
  • PI3K/mTOR-dependent IL-22 production modulates polyfunctional T cell responses in viral hepatitis.
Show more Cytokine Regulation

Similar Articles

Navigate

  • Home
  • Current Issue
  • Next in The JI
  • Archive
  • Brief Reviews
  • Pillars of Immunology
  • Translating Immunology

For Authors

  • Submit a Manuscript
  • Instructions for Authors
  • About the Journal
  • Journal Policies
  • Editors

General Information

  • Advertisers
  • Subscribers
  • Rights and Permissions
  • Accessibility Statement
  • Public Access
  • Privacy Policy
  • Disclaimer

Journal Services

  • Email Alerts
  • RSS Feeds
  • ImmunoCasts
  • Twitter

Copyright © 2021 by The American Association of Immunologists, Inc.

Print ISSN 0022-1767        Online ISSN 1550-6606