The Journal of Immunology: 196 (12)

June 15, 2016; Volume 196,Issue 12

IN THIS ISSUE

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In This Issue
MicroRNA Maneuvers in Osteoclastogenesis See article p. 4977
Universal Flu Vaccine Potential in Pigs See article p. 5014
Slaying Pneumonia with M-CSF See article p. 5047
Fyn Foils LPS Activity in Mast Cells See article p. 5075

J Immunol June 15, 2016, 196 (12) 4837-4838; DOI: https://doi.org/10.4049/jimmunol.1690008

BRIEF REVIEWS

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The Lung Microbiome, Immunity, and the Pathogenesis of Chronic Lung Disease
David N. O’Dwyer, Robert P. Dickson and Bethany B. Moore

J Immunol June 15, 2016, 196 (12) 4839-4847; DOI: https://doi.org/10.4049/jimmunol.1600279
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What Happens in the Thymus Does Not Stay in the Thymus: How T Cells Recycle the CD4⁺–CD8⁺ Lineage Commitment Transcriptional Circuitry To Control Their Function
Melanie S. Vacchio and Rémy Bosselut

J Immunol June 15, 2016, 196 (12) 4848-4856; DOI: https://doi.org/10.4049/jimmunol.1600415

CUTTING EDGE

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Cutting Edge: Skin CCR10⁺ CD8⁺ T Cells Support Resident Regulatory T Cells through the B7.2/Receptor Axis To Regulate Local Immune Homeostasis and Response
Yaoyao Fu, Jie Yang and Na Xiong

J Immunol June 15, 2016, 196 (12) 4859-4864; DOI: https://doi.org/10.4049/jimmunol.1502662

ALLERGY AND OTHER HYPERSENSITIVITIES

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IL-10 Enhances IgE-Mediated Mast Cell Responses and Is Essential for the Development of Experimental Food Allergy in IL-10–Deficient Mice
Stephanie H. Polukort, Jeffrey Rovatti, Logan Carlson, Chelsea Thompson, Jennifer Ser-Dolansky, Shannon R. M. Kinney, Sallie S. Schneider and Clinton B. Mathias

J Immunol June 15, 2016, 196 (12) 4865-4876; DOI: https://doi.org/10.4049/jimmunol.1600066
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Impaired P2X1 Receptor–Mediated Adhesion in Eosinophils from Asthmatic Patients
Adam Wright, Martyn Mahaut-Smith, Fiona Symon, Nicolas Sylvius, Shaun Ran, Mona Bafadhel, Michelle Muessel, Peter Bradding, Andrew Wardlaw and Catherine Vial

J Immunol June 15, 2016, 196 (12) 4877-4884; DOI: https://doi.org/10.4049/jimmunol.1501585
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Unlike in Children with Allergic Asthma, IgE Transcripts from Preschool Children with Atopic Dermatitis Display Signs of Superantigen-Driven Activation
Sebastian Kerzel, Tobias Rogosch, Benjamin Struecker, Rolf F. Maier, Michael Kabesch and Michael Zemlin

J Immunol June 15, 2016, 196 (12) 4885-4892; DOI: https://doi.org/10.4049/jimmunol.1402889

AUTOIMMUNITY

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Tbet or Continued RORγt Expression Is Not Required for Th17-Associated Immunopathology
Author Choice Article

Verena Brucklacher-Waldert, Cristina Ferreira, Silvia Innocentin, Shraddha Kamdar, David R. Withers, Marika C. Kullberg and Marc Veldhoen

J Immunol June 15, 2016, 196 (12) 4893-4904; DOI: https://doi.org/10.4049/jimmunol.1600137
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Preferential Use of Public TCR during Autoimmune Encephalomyelitis
Yunqian Zhao, Phuong Nguyen, Jing Ma, Tianhua Wu, Lindsay L. Jones, Deqing Pei, Cheng Cheng and Terrence L. Geiger

J Immunol June 15, 2016, 196 (12) 4905-4914; DOI: https://doi.org/10.4049/jimmunol.1501029
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Decreased SAP Expression in T Cells from Patients with Systemic Lupus Erythematosus Contributes to Early Signaling Abnormalities and Reduced IL-2 Production
Maria P. Karampetsou, Denis Comte, Katalin Kis-Toth, Cox Terhorst, Vasileios C. Kyttaris and George C. Tsokos

J Immunol June 15, 2016, 196 (12) 4915-4924; DOI: https://doi.org/10.4049/jimmunol.1501523
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Piperlongumine Suppresses Dendritic Cell Maturation by Reducing Production of Reactive Oxygen Species and Has Therapeutic Potential for Rheumatoid Arthritis
Youjun Xiao, Maohua Shi, Qian Qiu, Mingcheng Huang, Shan Zeng, Yaoyao Zou, Zhongping Zhan, Liuqin Liang, Xiuyan Yang and Hanshi Xu

J Immunol June 15, 2016, 196 (12) 4925-4934; DOI: https://doi.org/10.4049/jimmunol.1501281
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CD275-Independent IL-17–Producing T Follicular Helper–like Cells in Lymphopenic Autoimmune-Prone Mice
Christopher Smith, Janet E. Buhlmann, Xiaogan Wang, Amber Bartlett, Bing Lim and Robert A. Barrington

J Immunol June 15, 2016, 196 (12) 4935-4946; DOI: https://doi.org/10.4049/jimmunol.1402193
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ERβ in CD4⁺ T Cells Is Crucial for Ligand-Mediated Suppression of Central Nervous System Autoimmunity
Maria Aggelakopoulou, Evangelia Kourepini, Nikolaos Paschalidis and Vily Panoutsakopoulou

J Immunol June 15, 2016, 196 (12) 4947-4956; DOI: https://doi.org/10.4049/jimmunol.1600246

CLINICAL AND HUMAN IMMUNOLOGY

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Heightened Immune Activation in Fetuses with Gastroschisis May Be Blocked by Targeting IL-5
Michela Frascoli, Cerine Jeanty, Shannon Fleck, Patriss W. Moradi, Sheila Keating, Aras N. Mattis, Qizhi Tang and Tippi C. MacKenzie

J Immunol June 15, 2016, 196 (12) 4957-4966; DOI: https://doi.org/10.4049/jimmunol.1502587

IMMUNE REGULATION

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HNRNPR Regulates the Expression of Classical and Nonclassical MHC Class I Proteins
Adi Reches, Daphna Nachmani, Orit Berhani, Alexandra Duev-Cohen, Dorin Shreibman, Yael Ophir, Barbara Seliger and Ofer Mandelboim

J Immunol June 15, 2016, 196 (12) 4967-4976; DOI: https://doi.org/10.4049/jimmunol.1501550
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RBP-J–Regulated miR-182 Promotes TNF-α–Induced Osteoclastogenesis
Christine H. Miller, Sinead M. Smith, Mahmoud Elguindy, Tuo Zhang, Jenny Z. Xiang, Xiaoyu Hu, Lionel B. Ivashkiv and Baohong Zhao

J Immunol June 15, 2016, 196 (12) 4977-4986; DOI: https://doi.org/10.4049/jimmunol.1502044

IMMUNE SYSTEM DEVELOPMENT

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NKAP Regulates Invariant NKT Cell Proliferation and Differentiation into ROR-γt–Expressing NKT17 Cells
Puspa Thapa, Meibo W. Chen, Douglas C. McWilliams, Paul Belmonte, Megan Constans, Derek B. Sant’Angelo and Virginia Smith Shapiro

J Immunol June 15, 2016, 196 (12) 4987-4998; DOI: https://doi.org/10.4049/jimmunol.1501653
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The Hayflick Limit May Determine the Effective Clonal Diversity of Naive T Cells
Wilfred Ndifon and Jonathan Dushoff

J Immunol June 15, 2016, 196 (12) 4999-5004; DOI: https://doi.org/10.4049/jimmunol.1502343

IMMUNOGENETICS

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Dynamics of Individual T Cell Repertoires: From Cord Blood to Centenarians
Olga V. Britanova, Mikhail Shugay, Ekaterina M. Merzlyak, Dmitriy B. Staroverov, Ekaterina V. Putintseva, Maria A. Turchaninova, Ilgar Z. Mamedov, Mikhail V. Pogorelyy, Dmitriy A. Bolotin, Mark Izraelson, Alexey N. Davydov, Evgeny S. Egorov, Sofya A. Kasatskaya, Denis V. Rebrikov, Sergey Lukyanov and Dmitriy M. Chudakov

J Immunol June 15, 2016, 196 (12) 5005-5013; DOI: https://doi.org/10.4049/jimmunol.1600005

IMMUNOTHERAPY AND VACCINES

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Aerosol Delivery of a Candidate Universal Influenza Vaccine Reduces Viral Load in Pigs Challenged with Pandemic H1N1 Virus
Author Choice Article

Sophie B. Morgan, Johanneke D. Hemmink, Emily Porter, Ross Harley, Holly Shelton, Mario Aramouni, Helen E. Everett, Sharon M. Brookes, Michael Bailey, Alain M. Townsend, Bryan Charleston and Elma Tchilian

J Immunol June 15, 2016, 196 (12) 5014-5023; DOI: https://doi.org/10.4049/jimmunol.1502632
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IL-3 Decreases Cartilage Degeneration by Downregulating Matrix Metalloproteinases and Reduces Joint Destruction in Osteoarthritic Mice
Supinder Kour, Manasa G. Garimella, Divya A. Shiroor, Suhas T. Mhaske, Snehal R. Joshi, Kanupriya Singh, Subhashis Pal, Monika Mittal, Hari B. Krishnan, Naibedya Chattopadhyay, Anil H. Ulemale and Mohan R. Wani

J Immunol June 15, 2016, 196 (12) 5024-5035; DOI: https://doi.org/10.4049/jimmunol.1500907
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Regulatory T Cell Dysfunction Acquiesces to BTLA⁺ Regulatory B Cells Subsequent to Oral Intervention in Experimental Autoimmune Encephalomyelitis
Eduardo Huarte, SangMu Jun, Agnieszka Rynda-Apple, Sara Golden, Larissa Jackiw, Carol Hoffman, Massimo Maddaloni and David W. Pascual

J Immunol June 15, 2016, 196 (12) 5036-5046; DOI: https://doi.org/10.4049/jimmunol.1501973

INFECTIOUS DISEASE AND HOST RESPONSE

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M-CSF Mediates Host Defense during Bacterial Pneumonia by Promoting the Survival of Lung and Liver Mononuclear Phagocytes
Alexandra Bettina, Zhimin Zhang, Kathryn Michels, R. Elaine Cagnina, Isaah S. Vincent, Marie D. Burdick, Alexandra Kadl and Borna Mehrad

J Immunol June 15, 2016, 196 (12) 5047-5055; DOI: https://doi.org/10.4049/jimmunol.1600306
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RIPK1 and PGAM5 Control Leishmania Replication through Distinct Mechanisms
Nivea Farias Luz, Sakthi Balaji, Kendi Okuda, Aline Silva Barreto, John Bertin, Peter J. Gough, Ricardo Gazzinelli, Roque P. Almeida, Marcelo T. Bozza, Valeria M. Borges and Francis Ka-Ming Chan

J Immunol June 15, 2016, 196 (12) 5056-5063; DOI: https://doi.org/10.4049/jimmunol.1502492

INNATE IMMUNITY AND INFLAMMATION

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Cholesterol Crystals Activate the Lectin Complement Pathway via Ficolin-2 and Mannose-Binding Lectin: Implications for the Progression of Atherosclerosis
Katrine Pilely, Anne Rosbjerg, Ninette Genster, Peter Gal, Gábor Pál, Bente Halvorsen, Sverre Holm, Pål Aukrust, Siril Skaret Bakke, Bjørnar Sporsheim, Ingunn Nervik, Nathalie Niyonzima, Emil D. Bartels, Gregory L. Stahl, Tom Eirik Mollnes, Terje Espevik and Peter Garred

J Immunol June 15, 2016, 196 (12) 5064-5074; DOI: https://doi.org/10.4049/jimmunol.1502595
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Protein Tyrosine Kinase Fyn Regulates TLR4-Elicited Responses on Mast Cells Controlling the Function of a PP2A-PKCα/β Signaling Node Leading to TNF Secretion
Alejandro Martín-Ávila, Jaciel Medina-Tamayo, Alfredo Ibarra-Sánchez, Genaro Vázquez-Victorio, Jorge Iván Castillo-Arellano, Alma Cristal Hernández-Mondragón, Juan Rivera, Iris K. Madera-Salcedo, Ulrich Blank, Marina Macías-Silva and Claudia González-Espinosa

J Immunol June 15, 2016, 196 (12) 5075-5088; DOI: https://doi.org/10.4049/jimmunol.1501823
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Correction of MFG-E8 Resolves Inflammation and Promotes Cutaneous Wound Healing in Diabetes
Amitava Das, Subhadip Ghatak, Mithun Sinha, Scott Chaffee, Noha S. Ahmed, Narasimham L. Parinandi, Eric S. Wohleb, John F. Sheridan, Chandan K. Sen and Sashwati Roy

J Immunol June 15, 2016, 196 (12) 5089-5100; DOI: https://doi.org/10.4049/jimmunol.1502270
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LSm14A Plays a Critical Role in Antiviral Immune Responses by Regulating MITA Level in a Cell-Specific Manner
Tian-Tian Liu, Qing Yang, Mi Li, Bo Zhong, Yong Ran, Li-Li Liu, Yan Yang, Yan-Yi Wang and Hong-Bing Shu

J Immunol June 15, 2016, 196 (12) 5101-5111; DOI: https://doi.org/10.4049/jimmunol.1600212
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Alveolar Epithelial Cell–Derived Prostaglandin E₂ Serves as a Request Signal for Macrophage Secretion of Suppressor of Cytokine Signaling 3 during Innate Inflammation
Jennifer M. Speth, Emilie Bourdonnay, Loka Raghu Kumar Penke, Peter Mancuso, Bethany B. Moore, Jason B. Weinberg and Marc Peters-Golden

J Immunol June 15, 2016, 196 (12) 5112-5120; DOI: https://doi.org/10.4049/jimmunol.1502153
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Nod1 Limits Colitis-Associated Tumorigenesis by Regulating IFN-γ Production
Yu Zhan, Sergey S. Seregin, Jiachen Chen and Grace Y. Chen

J Immunol June 15, 2016, 196 (12) 5121-5129; DOI: https://doi.org/10.4049/jimmunol.1501822
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Experimental Anti-Inflammatory Drug Semapimod Inhibits TLR Signaling by Targeting the TLR Chaperone gp96
Jin Wang, Anatoly V. Grishin and Henri R. Ford

J Immunol June 15, 2016, 196 (12) 5130-5137; DOI: https://doi.org/10.4049/jimmunol.1502135

MOLECULAR AND STRUCTURAL IMMUNOLOGY

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Multiple IgH Isotypes Including IgD, Subclasses of IgM, and IgY Are Expressed in the Common Ancestors of Modern Birds
Binyue Han, Hui Yuan, Tao Wang, Bo Li, Li Ma, Shuyang Yu, Tian Huang, Yan Li, Dongming Fang, Xiaoli Chen, Yongsi Wang, Si Qiu, Ying Guo, Jing Fei, Liming Ren, Qiang Pan-Hammarström, Lennart Hammarström, Jun Wang, Jian Wang, Yong Hou, Qingjie Pan, Xun Xu and Yaofeng Zhao

J Immunol June 15, 2016, 196 (12) 5138-5147; DOI: https://doi.org/10.4049/jimmunol.1600307

MUCOSAL IMMUNOLOGY

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Vitamin A Controls the Presence of RORγ⁺ Innate Lymphoid Cells and Lymphoid Tissue in the Small Intestine
Gera Goverse, Carlos Labao-Almeida, Manuela Ferreira, Rosalie Molenaar, Sigrid Wahlen, Tanja Konijn, Jasper Koning, Henrique Veiga-Fernandes and Reina E. Mebius

J Immunol June 15, 2016, 196 (12) 5148-5155; DOI: https://doi.org/10.4049/jimmunol.1501106

TUMOR IMMUNOLOGY

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Regulation of Complement-Dependent Cytotoxicity by MicroRNAs miR-200b, miR-200c, and miR-217
Yaron Hillman, Niv Mazkereth, Luba Farberov, Noam Shomron and Zvi Fishelson

J Immunol June 15, 2016, 196 (12) 5156-5165; DOI: https://doi.org/10.4049/jimmunol.1502701

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Table of Contents

IN THIS ISSUE

BRIEF REVIEWS

CUTTING EDGE

ALLERGY AND OTHER HYPERSENSITIVITIES

AUTOIMMUNITY

CLINICAL AND HUMAN IMMUNOLOGY

IMMUNE REGULATION

IMMUNE SYSTEM DEVELOPMENT

IMMUNOGENETICS

IMMUNOTHERAPY AND VACCINES

INFECTIOUS DISEASE AND HOST RESPONSE

INNATE IMMUNITY AND INFLAMMATION

MOLECULAR AND STRUCTURAL IMMUNOLOGY

MUCOSAL IMMUNOLOGY

TUMOR IMMUNOLOGY

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