The Journal of Immunology: 195 (5)

September 1, 2015; Volume 195,Issue 5

IN THIS ISSUE

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In This Issue
Ab Attack on Skin See article p. 1945
Autoreactive T Cells under the Radar See article p. 2067
T Cell Immunity in Its Infancy See article p. 2115
Calcium Coddles Cancer Cells See article p. 2207
Interfering with Antibacterial Immunity See article p. 2461

J Immunol September 1, 2015, 195 (5) 1907-1908; DOI: https://doi.org/10.4049/jimmunol.1590016

PILLARS OF IMMUNOLOGY

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Interference with Virus Infection
Michael Gale Jr.

J Immunol September 1, 2015, 195 (5) 1909-1910; DOI: https://doi.org/10.4049/jimmunol.1501575
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Pillars Article: Virus Interference. I. The Interferon. Proc R Soc Lond B Biol Sci. 1957. 147: 258-267
A. Isaacs and J. Lindenmann

J Immunol September 1, 2015, 195 (5) 1911-1920;
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Pillars Article: Virus Interference. II. Some Properties of Interferon. Proc R Soc Lond B Biol Sci. 1957. 147: 268–273
A. Isaacs, J. Lindenmann and R. C. Valentine

J Immunol September 1, 2015, 195 (5) 1921-1926;

BRIEF REVIEWS

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Donor Unrestricted T Cells: A Shared Human T Cell Response
Ildiko Van Rhijn and D. Branch Moody

J Immunol September 1, 2015, 195 (5) 1927-1932; DOI: https://doi.org/10.4049/jimmunol.1500943
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Age-Associated B Cells: A T-bet–Dependent Effector with Roles in Protective and Pathogenic Immunity
Kira Rubtsova, Anatoly V. Rubtsov, Michael P. Cancro and Philippa Marrack

J Immunol September 1, 2015, 195 (5) 1933-1937; DOI: https://doi.org/10.4049/jimmunol.1501209

CUTTING EDGE

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Cutting Edge: cGAS Is Required for Lethal Autoimmune Disease in the Trex1-Deficient Mouse Model of Aicardi–Goutières Syndrome
Elizabeth E. Gray, Piper M. Treuting, Joshua J. Woodward and Daniel B. Stetson

J Immunol September 1, 2015, 195 (5) 1939-1943; DOI: https://doi.org/10.4049/jimmunol.1500969

AUTOIMMUNITY

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Radiosensitive Hematopoietic Cells Determine the Extent of Skin Inflammation in Experimental Epidermolysis Bullosa Acquisita
Hiroaki Iwata, Mareike Witte, Unni Krishna S. R. L. Samavedam, Yask Gupta, Atsushi Shimizu, Akira Ishiko, Tobias Schröder, Karsten Seeger, Markus Dahlke, Dirk Rades, Detlef Zillikens and Ralf J. Ludwig

J Immunol September 1, 2015, 195 (5) 1945-1954; DOI: https://doi.org/10.4049/jimmunol.1501003
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Genetic Interaction between Lyn, Ets1, and Btk in the Control of Antibody Levels
Jessica Mayeux, Brian Skaug, Wei Luo, Lisa M. Russell, Shinu John, Prontip Saelee, Hansaa Abbasi, Quan-Zhen Li, Lee Ann Garrett-Sinha and Anne B. Satterthwaite

J Immunol September 1, 2015, 195 (5) 1955-1963; DOI: https://doi.org/10.4049/jimmunol.1500165
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The T Cell Repertoire–Diversifying Enzyme TSSP Contributes to Thymic Selection of Diabetogenic CD4 T Cell Specificities Reactive to ChgA and IAPP Autoantigens
Christophe Viret, Karim Mahiddine, Rocky Lee Baker, Kathryn Haskins and Sylvie Guerder

J Immunol September 1, 2015, 195 (5) 1964-1973; DOI: https://doi.org/10.4049/jimmunol.1401683
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IL-7/IL-7 Receptor Signaling Differentially Affects Effector CD4⁺ T Cell Subsets Involved in Experimental Autoimmune Encephalomyelitis
Carlos A. Arbelaez, Simon Glatigny, Rebekka Duhen, Gerard Eberl, Mohamed Oukka and Estelle Bettelli

J Immunol September 1, 2015, 195 (5) 1974-1983; DOI: https://doi.org/10.4049/jimmunol.1403135

CLINICAL AND HUMAN IMMUNOLOGY

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Au-ACRAMTU-PEt₃ Alters Redox Balance To Inhibit T Cell Proliferation and Function
P. Kent Langston, Mu Yang, Ulrich Bierbach, Derek Parsonage, Leslie B. Poole, Madeline J. Price and Jason M. Grayson

J Immunol September 1, 2015, 195 (5) 1984-1994; DOI: https://doi.org/10.4049/jimmunol.1400391
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The Raf Kinase Inhibitor Sorafenib Inhibits JAK–STAT Signal Transduction in Human Immune Cells
Sara E. Martin del Campo, Kala M. Levine, Bethany L. Mundy-Bosse, Valerie P. Grignol, Ene T. Fairchild, Amanda R. Campbell, Prashant Trikha, Thomas A. Mace, Bonnie K. Paul, Alena Cristina Jaime-Ramirez, Joseph Markowitz, Sri Vidya Kondadasula, Kristan D. Guenterberg, Susan McClory, Volodymyr I. Karpa, Xueliang Pan, Thomas E. Olencki, J. Paul Monk, Amir Mortazavi, Susheela Tridandapani, Gregory B. Lesinski, John C. Byrd, Michael A. Caligiuri, Manisha H. Shah and William E. Carson III

J Immunol September 1, 2015, 195 (5) 1995-2005; DOI: https://doi.org/10.4049/jimmunol.1400084
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Chronic Psoriatic Skin Inflammation Leads to Increased Monocyte Adhesion and Aggregation
Jackelyn B. Golden, Sarah G. Groft, Michael V. Squeri, Sara M. Debanne, Nicole L. Ward, Thomas S. McCormick and Kevin D. Cooper

J Immunol September 1, 2015, 195 (5) 2006-2018; DOI: https://doi.org/10.4049/jimmunol.1402307
Open Access
γ-Tilmanocept, a New Radiopharmaceutical Tracer for Cancer Sentinel Lymph Nodes, Binds to the Mannose Receptor (CD206)
Author Choice Article

Abul K. Azad, Murugesan V. S. Rajaram, Wendy L. Metz, Frederick O. Cope, Michael S. Blue, David R. Vera and Larry S. Schlesinger

J Immunol September 1, 2015, 195 (5) 2019-2029; DOI: https://doi.org/10.4049/jimmunol.1402005
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Phenotypic Complexity of the Human Regulatory T Cell Compartment Revealed by Mass Cytometry
Gavin M. Mason, Katie Lowe, Rossella Melchiotti, Richard Ellis, Emanuele de Rinaldis, Mark Peakman, Susanne Heck, Giovanna Lombardi and Timothy I. M. Tree

J Immunol September 1, 2015, 195 (5) 2030-2037; DOI: https://doi.org/10.4049/jimmunol.1500703
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mTOR Inhibition Per Se Induces Nuclear Localization of FOXP3 and Conversion of Invariant NKT (iNKT) Cells into Immunosuppressive Regulatory iNKT Cells
Charlotte M. Huijts, Famke L. Schneiders, Juan J. Garcia-Vallejo, Henk M. Verheul, Tanja D. de Gruijl and Hans J. van der Vliet

J Immunol September 1, 2015, 195 (5) 2038-2045; DOI: https://doi.org/10.4049/jimmunol.1402710

IMMUNE REGULATION

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Identification of a New Exo-Endocytic Mechanism Triggered by Corticotropin-Releasing Hormone in Mast Cells
Santiago Balseiro-Gomez, Juan A. Flores, Jorge Acosta, M. Pilar Ramirez-Ponce and Eva Ales

J Immunol September 1, 2015, 195 (5) 2046-2056; DOI: https://doi.org/10.4049/jimmunol.1500253
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Nucleotide-Induced Membrane-Proximal Proteolysis Controls the Substrate Specificity of T Cell Ecto–ADP-Ribosyltransferase ARTC2.2
Stephan Menzel, Björn Rissiek, Peter Bannas, Thomas Jakoby, Maria Miksiewicz, Nicole Schwarz, Marion Nissen, Friedrich Haag, Andreas Tholey and Friedrich Koch-Nolte

J Immunol September 1, 2015, 195 (5) 2057-2066; DOI: https://doi.org/10.4049/jimmunol.1401677
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The Contained Self-Reactive Peripheral T Cell Repertoire: Size, Diversity, and Cellular Composition
David M. Richards, Eliana Ruggiero, Ann-Cathrin Hofer, Julian P. Sefrin, Manfred Schmidt, Christof von Kalle and Markus Feuerer

J Immunol September 1, 2015, 195 (5) 2067-2079; DOI: https://doi.org/10.4049/jimmunol.1500880
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An Inhibitory Role for the Transcription Factor Stat3 in Controlling IL-4 and Bcl6 Expression in Follicular Helper T Cells
Hao Wu, Lin-Lin Xu, Paulla Teuscher, Hong Liu, Mark H. Kaplan and Alexander L. Dent

J Immunol September 1, 2015, 195 (5) 2080-2089; DOI: https://doi.org/10.4049/jimmunol.1500335
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B Lymphocyte–Specific Loss of Ric-8A Results in a Gα Protein Deficit and Severe Humoral Immunodeficiency
Cedric Boularan, Il-Young Hwang, Olena Kamenyeva, Chung Park, Kathleen Harrison, Zhen Huang and John H. Kehrl

J Immunol September 1, 2015, 195 (5) 2090-2102; DOI: https://doi.org/10.4049/jimmunol.1500523
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Id3 Controls Cell Death of 2B4⁺ Virus-Specific CD8⁺ T Cells in Chronic Viral Infection
Alexandra J. Menner, Katharina S. Rauch, Peter Aichele, Hanspeter Pircher, Christian Schachtrup and Kristina Schachtrup

J Immunol September 1, 2015, 195 (5) 2103-2114; DOI: https://doi.org/10.4049/jimmunol.1402607
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The Neonatal CD4⁺ T Cell Response to a Single Epitope Varies in Genetically Identical Mice
Ryan W. Nelson, Miriam N. Rajpal and Marc K. Jenkins

J Immunol September 1, 2015, 195 (5) 2115-2121; DOI: https://doi.org/10.4049/jimmunol.1500405
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Store-Operated Ca²⁺ Release-Activated Ca²⁺ Channels Regulate PAR2-Activated Ca²⁺ Signaling and Cytokine Production in Airway Epithelial Cells
Amit Jairaman, Megumi Yamashita, Robert P. Schleimer and Murali Prakriya

J Immunol September 1, 2015, 195 (5) 2122-2133; DOI: https://doi.org/10.4049/jimmunol.1500396
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MicroRNAs miR-155 and miR-16 Decrease AID and E47 in B Cells from Elderly Individuals
Daniela Frasca, Alain Diaz, Maria Romero, Franco Ferracci and Bonnie B. Blomberg

J Immunol September 1, 2015, 195 (5) 2134-2140; DOI: https://doi.org/10.4049/jimmunol.1500520
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Regulatory Dendritic Cells Restrain NK Cell IFN-γ Production through Mechanisms Involving NKp46, IL-10, and MHC Class I–Specific Inhibitory Receptors
Raúl G. Spallanzani, Nicolás I. Torres, Damián E. Avila, Andrea Ziblat, Ximena L. Raffo Iraolagoitia, Lucas E. Rossi, Carolina I. Domaica, Mercedes B. Fuertes, Gabriel A. Rabinovich and Norberto W. Zwirner

J Immunol September 1, 2015, 195 (5) 2141-2148; DOI: https://doi.org/10.4049/jimmunol.1403161

IMMUNE SYSTEM DEVELOPMENT

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Role of SHIP1 in Invariant NKT Cell Development and Functions
Courtney K. Anderson, Alexander I. Salter, Leon E. Toussaint, Emma C. Reilly, Céline Fugère, Neetu Srivastava, William G. Kerr and Laurent Brossay

J Immunol September 1, 2015, 195 (5) 2149-2156; DOI: https://doi.org/10.4049/jimmunol.1500567
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Cardif (MAVS) Regulates the Maturation of NK Cells
LaTeira D. Haynes, Shilpi Verma, Bryan McDonald, Runpei Wu, Robert Tacke, Heba N. Nowyhed, Jennifer Ekstein, Ariana Feuvrier, Chris A. Benedict and Catherine C. Hedrick

J Immunol September 1, 2015, 195 (5) 2157-2167; DOI: https://doi.org/10.4049/jimmunol.1402060
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Frizzled-6 Regulates Hematopoietic Stem/Progenitor Cell Survival and Self-Renewal
Belma Melda Abidin, Edward Owusu Kwarteng and Krista M. Heinonen

J Immunol September 1, 2015, 195 (5) 2168-2176; DOI: https://doi.org/10.4049/jimmunol.1403213
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Noninvasive In Toto Imaging of the Thymus Reveals Heterogeneous Migratory Behavior of Developing T Cells
Baubak Bajoghli, Paola Kuri, Daigo Inoue, Narges Aghaallaei, Marleen Hanelt, Thomas Thumberger, Matteo Rauzi, Joachim Wittbrodt and Maria Leptin

J Immunol September 1, 2015, 195 (5) 2177-2186; DOI: https://doi.org/10.4049/jimmunol.1500361

IMMUNOGENETICS

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CXCR3 Polymorphism and Expression Associate with Spontaneous Preterm Birth
Minna K. Karjalainen, Marja Ojaniemi, Antti M. Haapalainen, Mari Mahlman, Annamari Salminen, Johanna M. Huusko, Tomi A. Määttä, Tuula Kaukola, Julia Anttonen, Johanna Ulvila, Ritva Haataja, Kari Teramo, Stephen F. Kingsmore, Aarno Palotie, Louis J. Muglia, Mika Rämet and Mikko Hallman

J Immunol September 1, 2015, 195 (5) 2187-2198; DOI: https://doi.org/10.4049/jimmunol.1501174
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Cattle NK Cell Heterogeneity and the Influence of MHC Class I
Author Choice Article

Alasdair J. Allan, Nicholas D. Sanderson, Simon Gubbins, Shirley A. Ellis and John A. Hammond

J Immunol September 1, 2015, 195 (5) 2199-2206; DOI: https://doi.org/10.4049/jimmunol.1500227

IMMUNOTHERAPY AND VACCINES

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Localized Store-Operated Calcium Influx Represses CD95-Dependent Apoptotic Effects of Rituximab in Non-Hodgkin B Lymphomas
Pierre Vacher, Anne-Marie Vacher, Raphael Pineau, Simon Latour, Isabelle Soubeyran, Celine Pangault, Karin Tarte, Pierre Soubeyran, Thomas Ducret and Laurence Bresson-Bepoldin

J Immunol September 1, 2015, 195 (5) 2207-2215; DOI: https://doi.org/10.4049/jimmunol.1402942
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Cholesterol Modification of p40-Specific Small Interfering RNA Enables Therapeutic Targeting of Dendritic Cells
Jürgen Brück, Steve Pascolo, Kerstin Fuchs, Christina Kellerer, Ivana Glocova, Julia Geisel, Katja Dengler, Amir S. Yazdi, Martin Röcken and Kamran Ghoreschi

J Immunol September 1, 2015, 195 (5) 2216-2223; DOI: https://doi.org/10.4049/jimmunol.1402989
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IgG-Mediated Immune Suppression to Erythrocytes by Polyclonal Antibodies Can Occur in the Absence of Activating or Inhibitory Fcγ Receptors in a Full Mouse Model
Lidice Bernardo, Honghui Yu, Alaa Amash, James C. Zimring and Alan H. Lazarus

J Immunol September 1, 2015, 195 (5) 2224-2230; DOI: https://doi.org/10.4049/jimmunol.1500790

INFECTIOUS DISEASE AND HOST RESPONSE

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A Metalloproteinase Mirolysin of Tannerella forsythia Inhibits All Pathways of the Complement System
Monika Jusko, Jan Potempa, Danuta Mizgalska, Ewa Bielecka, Miroslaw Ksiazek, Kristian Riesbeck, Peter Garred, Sigrun Eick and Anna M. Blom

J Immunol September 1, 2015, 195 (5) 2231-2240; DOI: https://doi.org/10.4049/jimmunol.1402892
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Parasite Antigen-Specific Regulation of Th1, Th2, and Th17 Responses in Strongyloides stercoralis Infection
Rajamanickam Anuradha, Saravanan Munisankar, Chandrakumar Dolla, Paul Kumaran, Thomas B. Nutman and Subash Babu

J Immunol September 1, 2015, 195 (5) 2241-2250; DOI: https://doi.org/10.4049/jimmunol.1500745
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MicroRNA-15b Modulates Japanese Encephalitis Virus–Mediated Inflammation via Targeting RNF125
Bibo Zhu, Jing Ye, Yanru Nie, Usama Ashraf, Ali Zohaib, Xiaodong Duan, Zhen F. Fu, Yunfeng Song, Huanchun Chen and Shengbo Cao

J Immunol September 1, 2015, 195 (5) 2251-2262; DOI: https://doi.org/10.4049/jimmunol.1500370
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Extent of Systemic Spread Determines CD8⁺ T Cell Immunodominance for Laboratory Strains, Smallpox Vaccines, and Zoonotic Isolates of Vaccinia Virus
Inge E. A. Flesch, Natasha A. Hollett, Yik Chun Wong, Bárbara Resende Quinan, Debbie Howard, Flávio G. da Fonseca and David C. Tscharke

J Immunol September 1, 2015, 195 (5) 2263-2272; DOI: https://doi.org/10.4049/jimmunol.1402508
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Restoration of CD4⁺ Responses to Copathogens in HIV-Infected Individuals on Antiretroviral Therapy Is Dependent on T Cell Memory Phenotype
Catherine Riou, Ramla F. Tanko, Andreia P. Soares, Lindi Masson, Lise Werner, Nigel J. Garrett, Natasha Samsunder, Quarraisha Abdool Karim, Salim S. Abdool Karim and Wendy A. Burgers

J Immunol September 1, 2015, 195 (5) 2273-2281; DOI: https://doi.org/10.4049/jimmunol.1500803
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Vibrio vulnificus VvpE Stimulates IL-1β Production by the Hypomethylation of the IL-1β Promoter and NF-κB Activation via Lipid Raft–Dependent ANXA2 Recruitment and Reactive Oxygen Species Signaling in Intestinal Epithelial Cells
Sei-Jung Lee, Young Hyun Jung, Eun Ju Song, Kyung Ku Jang, Sang Ho Choi and Ho Jae Han

J Immunol September 1, 2015, 195 (5) 2282-2293; DOI: https://doi.org/10.4049/jimmunol.1500951
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CD36 Is Essential for Regulation of the Host Innate Response to Staphylococcus aureus α-Toxin–Mediated Dermonecrosis
Moriah J. Castleman, Maria Febbraio and Pamela R. Hall

J Immunol September 1, 2015, 195 (5) 2294-2302; DOI: https://doi.org/10.4049/jimmunol.1500500
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Caspase-1 but Not Caspase-11 Is Required for NLRC4-Mediated Pyroptosis and Restriction of Infection by Flagellated Legionella Species in Mouse Macrophages and In Vivo
Daiane M. Cerqueira, Marcelo S. F. Pereira, Alexandre L. N. Silva, Larissa D. Cunha and Dario S. Zamboni

J Immunol September 1, 2015, 195 (5) 2303-2311; DOI: https://doi.org/10.4049/jimmunol.1501223

INNATE IMMUNITY AND INFLAMMATION

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Small Ubiquitin-like Modifier Alters IFN Response
Ghizlane Maarifi, Mohamed Ali Maroui, Jacques Dutrieux, Laurent Dianoux, Sébastien Nisole and Mounira K. Chelbi-Alix

J Immunol September 1, 2015, 195 (5) 2312-2324; DOI: https://doi.org/10.4049/jimmunol.1500035
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Phosphocholine-Modified Macromolecules and Canonical Nicotinic Agonists Inhibit ATP-Induced IL-1β Release
Andreas Hecker, Mira Küllmar, Sigrid Wilker, Katrin Richter, Anna Zakrzewicz, Srebrena Atanasova, Verena Mathes, Thomas Timm, Sabrina Lerner, Jochen Klein, Andreas Kaufmann, Stefan Bauer, Winfried Padberg, Wolfgang Kummer, Sabina Janciauskiene, Martin Fronius, Elke K. H. Schweda, Günter Lochnit and Veronika Grau

J Immunol September 1, 2015, 195 (5) 2325-2334; DOI: https://doi.org/10.4049/jimmunol.1400974
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Langerhans Cells Suppress CD49a⁺ NK Cell–Mediated Skin Inflammation
Felix Scholz, Shruti Naik, Fayyaz S. Sutterwala and Daniel H. Kaplan

J Immunol September 1, 2015, 195 (5) 2335-2342; DOI: https://doi.org/10.4049/jimmunol.1500935
Open Access
Selective Targeting of a Disease-Related Conformational Isoform of Macrophage Migration Inhibitory Factor Ameliorates Inflammatory Conditions
Author Choice Article

Michael Thiele, Randolf J. Kerschbaumer, Frederick W. K. Tam, Dirk Völkel, Patrice Douillard, Alexander Schinagl, Harald Kühnel, Jennifer Smith, John P. McDaid, Gurjeet Bhangal, Mei-Ching Yu, Charles D. Pusey, H. Terence Cook, Josef Kovarik, Erica Magelky, Atul Bhan, Manfred Rieger, Geert C. Mudde, Hartmut Ehrlich, Bernd Jilma, Herbert Tilg, Alexander Moschen, Cox Terhorst and Friedrich Scheiflinger

J Immunol September 1, 2015, 195 (5) 2343-2352; DOI: https://doi.org/10.4049/jimmunol.1500572
Open Access
IL-15 Superagonist–Mediated Immunotoxicity: Role of NK Cells and IFN-γ
Author Choice Article

Yin Guo, Liming Luan, Whitney Rabacal, Julia K. Bohannon, Benjamin A. Fensterheim, Antonio Hernandez and Edward R. Sherwood

J Immunol September 1, 2015, 195 (5) 2353-2364; DOI: https://doi.org/10.4049/jimmunol.1500300
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The Inflammatory Caspases-1 and -11 Mediate the Pathogenesis of Dermatitis in Sharpin-Deficient Mice
Todd Douglas, Claudia Champagne, Alexandre Morizot, Jean-Martin Lapointe and Maya Saleh

J Immunol September 1, 2015, 195 (5) 2365-2373; DOI: https://doi.org/10.4049/jimmunol.1500542
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B Cell–Intrinsic IDO1 Regulates Humoral Immunity to T Cell–Independent Antigens
Rahul Shinde, Michiko Shimoda, Kapil Chaudhary, Haiyun Liu, Eslam Mohamed, Jillian Bradley, Sridhar Kandala, Xia Li, Kebin Liu and Tracy L. McGaha

J Immunol September 1, 2015, 195 (5) 2374-2382; DOI: https://doi.org/10.4049/jimmunol.1402854
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The Src-Family Kinases Hck and Fgr Regulate Early Lipopolysaccharide-Induced Myeloid Cell Recruitment into the Lung and Their Ability To Secrete Chemokines
Paola Mazzi, Elena Caveggion, Josè A. Lapinet-Vera, Clifford A. Lowell and Giorgio Berton

J Immunol September 1, 2015, 195 (5) 2383-2395; DOI: https://doi.org/10.4049/jimmunol.1402011
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A Detailed Characterization of the Dysfunctional Immunity and Abnormal Myelopoiesis Induced by Severe Shock and Trauma in the Aged
Dina C. Nacionales, Benjamin Szpila, Ricardo Ungaro, M. Cecilia Lopez, Jianyi Zhang, Lori F. Gentile, Angela L. Cuenca, Erin Vanzant, Brittany Mathias, Jeevan Jyot, Donevan Westerveld, Azra Bihorac, Anna Joseph, Alicia Mohr, Lizette V. Duckworth, Frederick A. Moore, Henry V. Baker, Christiaan Leeuwenburgh, Lyle L. Moldawer, Scott Brakenridge and Philip A. Efron

J Immunol September 1, 2015, 195 (5) 2396-2407; DOI: https://doi.org/10.4049/jimmunol.1500984
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Endothelial LSP1 Modulates Extravascular Neutrophil Chemotaxis by Regulating Nonhematopoietic Vascular PECAM-1 Expression
Mokarram Hossain, Syed M. Qadri, Najia Xu, Yang Su, Francisco S. Cayabyab, Bryan Heit and Lixin Liu

J Immunol September 1, 2015, 195 (5) 2408-2416; DOI: https://doi.org/10.4049/jimmunol.1402225
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Contribution of MINCLE–SYK Signaling to Activation of Primary Human APCs by Mycobacterial Cord Factor and the Novel Adjuvant TDB
Jenny Ostrop, Katrin Jozefowski, Stephanie Zimmermann, Katharina Hofmann, Erwin Strasser, Bernd Lepenies and Roland Lang

J Immunol September 1, 2015, 195 (5) 2417-2428; DOI: https://doi.org/10.4049/jimmunol.1500102
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The TNF Family Molecules LIGHT and Lymphotoxin αβ Induce a Distinct Steroid-Resistant Inflammatory Phenotype in Human Lung Epithelial Cells
Ricardo da Silva Antunes, Lisa Madge, Pejman Soroosh, Joel Tocker and Michael Croft

J Immunol September 1, 2015, 195 (5) 2429-2441; DOI: https://doi.org/10.4049/jimmunol.1500356
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Reshaping of Human Macrophage Polarization through Modulation of Glucose Catabolic Pathways
Elena Izquierdo, Víctor Delgado Cuevas, Salvador Fernández-Arroyo, Marta Riera-Borrull, Emmanuel Orta-Zavalza, Jorge Joven, Eduardo Rial, Angel L. Corbi and María M. Escribese

J Immunol September 1, 2015, 195 (5) 2442-2451; DOI: https://doi.org/10.4049/jimmunol.1403045
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Proteolytic Cleavage of AMPKα and Intracellular MMP9 Expression Are Both Required for TLR4-Mediated mTORC1 Activation and HIF-1α Expression in Leukocytes
Zhiyong Zhang, Louis F. Amorosa, Susette M. Coyle, Marie A. Macor, Sara E. Lubitz, Jeffrey L. Carson, Morris J. Birnbaum, Leonard Y. Lee and Beatrice Haimovich

J Immunol September 1, 2015, 195 (5) 2452-2460; DOI: https://doi.org/10.4049/jimmunol.1500944
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Salmonella Typhimurium Co-Opts the Host Type I IFN System To Restrict Macrophage Innate Immune Transcriptional Responses Selectively
Darren J. Perkins, Rajesh Rajaiah, Sharon M. Tennant, Girish Ramachandran, Ellen E. Higginson, Tristan N. Dyson and Stefanie N. Vogel

J Immunol September 1, 2015, 195 (5) 2461-2471; DOI: https://doi.org/10.4049/jimmunol.1500105

MUCOSAL IMMUNOLOGY

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Programming of Influenza Vaccine Broadness and Persistence by Mucoadhesive Polymer-Based Adjuvant Systems
Hyun Jong Noh, Mohammed Y. E. Chowdhury, Seonghun Cho, Jae-Hoon Kim, Hye Sun Park, Chul-Joong Kim, Haryoung Poo, Moon-Hee Sung, Jong-Soo Lee and Yong Taik Lim

J Immunol September 1, 2015, 195 (5) 2472-2482; DOI: https://doi.org/10.4049/jimmunol.1500492

TUMOR IMMUNOLOGY

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IL-18 Is Involved in Eosinophil-Mediated Tumoricidal Activity against a Colon Carcinoma Cell Line by Upregulating LFA-1 and ICAM-1
Solène Gatault, Marie Delbeke, Virginie Driss, Aurore Sarazin, Arnaud Dendooven, Jean-Emmanuel Kahn, Guillaume Lefèvre and Monique Capron

J Immunol September 1, 2015, 195 (5) 2483-2492; DOI: https://doi.org/10.4049/jimmunol.1402914

NOVEL IMMUNOLOGICAL METHODS

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Exclusive Transduction of Human CD4⁺ T Cells upon Systemic Delivery of CD4-Targeted Lentiviral Vectors
Qi Zhou, Katharina M. Uhlig, Anke Muth, Janine Kimpel, Camille Lévy, Robert C. Münch, Janna Seifried, Anett Pfeiffer, Alexandra Trkola, Cheick Coulibaly, Dorothee von Laer, Winfried S. Wels, Udo F. Hartwig, Els Verhoeyen and Christian J. Buchholz

J Immunol September 1, 2015, 195 (5) 2493-2501; DOI: https://doi.org/10.4049/jimmunol.1500956

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Table of Contents

IN THIS ISSUE

PILLARS OF IMMUNOLOGY

BRIEF REVIEWS

CUTTING EDGE

AUTOIMMUNITY

CLINICAL AND HUMAN IMMUNOLOGY

IMMUNE REGULATION

IMMUNE SYSTEM DEVELOPMENT

IMMUNOGENETICS

IMMUNOTHERAPY AND VACCINES

INFECTIOUS DISEASE AND HOST RESPONSE

INNATE IMMUNITY AND INFLAMMATION

MUCOSAL IMMUNOLOGY

TUMOR IMMUNOLOGY

NOVEL IMMUNOLOGICAL METHODS

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