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The Journal of Immunology

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Table of Contents

August 1, 2015; Volume 195,Issue 3

IN THIS ISSUE

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    In This Issue

    Metalloproteinase Mischief in TB See article p. 882

    Clec9A Ab Targets TFH Response See article p. 1006

    Enigmatic Erythroid Splenocytes in Neonates See article p. 1064

    ANXA1 Attracts Monocytes See article p. 1139

    De-Emphasizing Decontraction See article p. 1262

    J Immunol August 1, 2015, 195 (3) 753-754; DOI: https://doi.org/10.4049/jimmunol.1590014

TRANSLATING IMMUNOLOGY

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    Chimeric Antigen Receptor– and TCR-Modified T Cells Enter Main Street and Wall Street
    David M. Barrett, Stephan A. Grupp and Carl H. June
    J Immunol August 1, 2015, 195 (3) 755-761; DOI: https://doi.org/10.4049/jimmunol.1500751

PILLARS OF IMMUNOLOGY

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    Masterminding B Cells
    Suzanne Cory
    J Immunol August 1, 2015, 195 (3) 763-765; DOI: https://doi.org/10.4049/jimmunol.1501277
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    Pillars Article: Commitment to the B-lymphoid lineage depends on the transcription factor Pax5. Nature. 1999. 401: 556–562
    Stephen L. Nutt, Barry Heavey, Antonius G. Rolink and Meinrad Busslinger
    J Immunol August 1, 2015, 195 (3) 766-772;

BRIEF REVIEWS

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    Algorithmic Tools for Mining High-Dimensional Cytometry Data
    Cariad Chester and Holden T. Maecker
    J Immunol August 1, 2015, 195 (3) 773-779; DOI: https://doi.org/10.4049/jimmunol.1500633
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    IL-17–Mediated Immunity to the Opportunistic Fungal Pathogen Candida albicans
    Heather R. Conti and Sarah L. Gaffen
    J Immunol August 1, 2015, 195 (3) 780-788; DOI: https://doi.org/10.4049/jimmunol.1500909

CUTTING EDGE

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    Cutting Edge: Chronic NF-κB Activation in CD4+ T Cells in Rheumatoid Arthritis Is Genetically Determined by HLA Risk Alleles
    Charles F. Spurlock III, John T. Tossberg, Nancy J. Olsen and Thomas M. Aune
    J Immunol August 1, 2015, 195 (3) 791-795; DOI: https://doi.org/10.4049/jimmunol.1500267
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    Cutting Edge: IFN-γ Produced by Brain-Resident Cells Is Crucial To Control Cerebral Infection with Toxoplasma gondii
    Qila Sa, Eri Ochiai, Ashish Tiwari, Sara Perkins, Jeremi Mullins, Marie Gehman, William Huckle, Willard H. Eyestone, Thomas L. Saunders, Brent J. Shelton and Yasuhiro Suzuki
    J Immunol August 1, 2015, 195 (3) 796-800; DOI: https://doi.org/10.4049/jimmunol.1500814
  • Open Access
    Cutting Edge: Synchronization of IRF1, JunB, and C/EBPβ Activities during TLR3–TLR7 Cross-Talk Orchestrates Timely Cytokine Synergy in the Proinflammatory Response

    Author Choice Article

    Qian Liu, Yong Zhu, Wai Khang Yong, Newman Siu Kwan Sze, Nguan Soon Tan and Jeak Ling Ding
    J Immunol August 1, 2015, 195 (3) 801-805; DOI: https://doi.org/10.4049/jimmunol.1402358
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    Cutting Edge: Induction of Inflammatory Disease by Adoptive Transfer of an Atypical NK Cell Subset
    Elisaveta Voynova, Chen-Feng Qi, Bethany Scott and Silvia Bolland
    J Immunol August 1, 2015, 195 (3) 806-809; DOI: https://doi.org/10.4049/jimmunol.1500540
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    Cutting Edge: Regulation of Exosome Secretion by the Integral MAL Protein in T Cells
    Leandro N. Ventimiglia, Laura Fernández-Martín, Emma Martínez-Alonso, Olga M. Antón, Milagros Guerra, José Angel Martínez-Menárguez, Germán Andrés and Miguel A. Alonso
    J Immunol August 1, 2015, 195 (3) 810-814; DOI: https://doi.org/10.4049/jimmunol.1500891
  • Open Access
    Cutting Edge: Inflammasome Activation in Primary Human Macrophages Is Dependent on Flagellin

    Author Choice Article

    Jens Kortmann, Sky W. Brubaker and Denise M. Monack
    J Immunol August 1, 2015, 195 (3) 815-819; DOI: https://doi.org/10.4049/jimmunol.1403100

ANTIGEN RECOGNITION AND RESPONSES

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    Activated NKT Cells Can Condition Different Splenic Dendritic Cell Subsets To Respond More Effectively to TLR Engagement and Enhance Cross-Priming
    Taryn L. Osmond, Kathryn J. Farrand, Gavin F. Painter, Christiane Ruedl, Troels R. Petersen and Ian F. Hermans
    J Immunol August 1, 2015, 195 (3) 821-831; DOI: https://doi.org/10.4049/jimmunol.1401751

AUTOIMMUNITY

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    Circulating Follicular Regulatory T Cells Are Defective in Multiple Sclerosis
    Tessa Dhaeze, Evelyn Peelen, Anneleen Hombrouck, Liesbet Peeters, Bart Van Wijmeersch, Nele Lemkens, Peter Lemkens, Veerle Somers, Sophie Lucas, Bieke Broux, Piet Stinissen and Niels Hellings
    J Immunol August 1, 2015, 195 (3) 832-840; DOI: https://doi.org/10.4049/jimmunol.1500759
  • Open Access
    Preferential Recruitment of Neutrophils into the Cerebellum and Brainstem Contributes to the Atypical Experimental Autoimmune Encephalomyelitis Phenotype

    Author Choice Article

    Yudong Liu, Andrew T. Holdbrooks, Gordon P. Meares, Jessica A. Buckley, Etty N. Benveniste and Hongwei Qin
    J Immunol August 1, 2015, 195 (3) 841-852; DOI: https://doi.org/10.4049/jimmunol.1403063
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    Reversing Tolerance in Isotype Switch–Competent Anti-Insulin B Lymphocytes
    Jonathan M. Williams, Rachel H. Bonami, Chrys Hulbert and James W. Thomas
    J Immunol August 1, 2015, 195 (3) 853-864; DOI: https://doi.org/10.4049/jimmunol.1403114

CLINICAL AND HUMAN IMMUNOLOGY

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    Age-Associated Failure To Adjust Type I IFN Receptor Signaling Thresholds after T Cell Activation
    Guangjin Li, Jihang Ju, Cornelia M. Weyand and Jörg J. Goronzy
    J Immunol August 1, 2015, 195 (3) 865-874; DOI: https://doi.org/10.4049/jimmunol.1402389
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    Human Mesenchymal Stem (Stromal) Cells Promote the Resolution of Acute Lung Injury in Part through Lipoxin A4
    Xiaohui Fang, Jason Abbott, Linda Cheng, Jennifer K. Colby, Jae Woo Lee, Bruce D. Levy and Michael A. Matthay
    J Immunol August 1, 2015, 195 (3) 875-881; DOI: https://doi.org/10.4049/jimmunol.1500244
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    Membrane Type 1 Matrix Metalloproteinase Regulates Monocyte Migration and Collagen Destruction in Tuberculosis

    Author Choice Article

    Tarangini Sathyamoorthy, Liku B. Tezera, Naomi F. Walker, Sara Brilha, Luisa Saraiva, Francesco A. Mauri, Robert J. Wilkinson, Jon S. Friedland and Paul T. Elkington
    J Immunol August 1, 2015, 195 (3) 882-891; DOI: https://doi.org/10.4049/jimmunol.1403110
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    Increased CD226 Expression on CD8+ T Cells Is Associated with Upregulated Cytokine Production and Endothelial Cell Injury in Patients with Systemic Sclerosis
    Masahiro Ayano, Hiroshi Tsukamoto, Kentaro Kohno, Naoyasu Ueda, Atsushi Tanaka, Hiroki Mitoma, Mitsuteru Akahoshi, Yojiro Arinobu, Hiroaki Niiro, Takahiko Horiuchi and Koichi Akashi
    J Immunol August 1, 2015, 195 (3) 892-900; DOI: https://doi.org/10.4049/jimmunol.1403046
  • Open Access
    TLR-9 and IL-15 Synergy Promotes the In Vitro Clonal Expansion of Chronic Lymphocytic Leukemia B Cells

    Author Choice Article

    Patricia K. A. Mongini, Rashmi Gupta, Erin Boyle, Jennifer Nieto, Hyunjoo Lee, Joanna Stein, Jela Bandovic, Tatjana Stankovic, Jacqueline Barrientos, Jonathan E. Kolitz, Steven L. Allen, Kanti Rai, Charles C. Chu and Nicholas Chiorazzi
    J Immunol August 1, 2015, 195 (3) 901-923; DOI: https://doi.org/10.4049/jimmunol.1403189

IMMUNE REGULATION

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    A Novel Glycolipid Antigen for NKT Cells That Preferentially Induces IFN-γ Production
    Alysia M. Birkholz, Enrico Girardi, Gerhard Wingender, Archana Khurana, Jing Wang, Meng Zhao, Sonja Zahner, Petr A. Illarionov, Xiangshu Wen, Michelle Li, Weiming Yuan, Steven A. Porcelli, Gurdyal S. Besra, Dirk M. Zajonc and Mitchell Kronenberg
    J Immunol August 1, 2015, 195 (3) 924-933; DOI: https://doi.org/10.4049/jimmunol.1500070
  • Open Access
    mTOR Complex Signaling through the SEMA4A–Plexin B2 Axis Is Required for Optimal Activation and Differentiation of CD8+ T Cells

    Author Choice Article

    Daisuke Ito, Satoshi Nojima, Masayuki Nishide, Tatsusada Okuno, Hyota Takamatsu, Sujin Kang, Tetsuya Kimura, Yuji Yoshida, Keiko Morimoto, Yohei Maeda, Takashi Hosokawa, Toshihiko Toyofuku, Jun Ohshima, Daisuke Kamimura, Masahiro Yamamoto, Masaaki Murakami, Eiichi Morii, Hiromi Rakugi, Yoshitaka Isaka and Atsushi Kumanogoh
    J Immunol August 1, 2015, 195 (3) 934-943; DOI: https://doi.org/10.4049/jimmunol.1403038
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    IL-6 and ICOS Antagonize Bim and Promote Regulatory T Cell Accrual with Age
    Jana Raynor, Rebekah Karns, Maha Almanan, Kun-Po Li, Senad Divanovic, Claire A. Chougnet and David A. Hildeman
    J Immunol August 1, 2015, 195 (3) 944-952; DOI: https://doi.org/10.4049/jimmunol.1500443
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    Conditional Deletion of NF-κB–Inducing Kinase (NIK) in Adult Mice Disrupts Mature B Cell Survival and Activation
    Hans D. Brightbill, Janet K. Jackman, Eric Suto, Heather Kennedy, Charles Jones III, Sreedevi Chalasani, Zhonghua Lin, Lucinda Tam, Meron Roose-Girma, Mercedesz Balazs, Cary D. Austin, Wyne P. Lee and Lawren C. Wu
    J Immunol August 1, 2015, 195 (3) 953-964; DOI: https://doi.org/10.4049/jimmunol.1401514
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    CD56brightCD16− NK Cells Produce Adenosine through a CD38-Mediated Pathway and Act as Regulatory Cells Inhibiting Autologous CD4+ T Cell Proliferation
    Fabio Morandi, Alberto L. Horenstein, Antonella Chillemi, Valeria Quarona, Sabrina Chiesa, Andrea Imperatori, Silvia Zanellato, Lorenzo Mortara, Marco Gattorno, Vito Pistoia and Fabio Malavasi
    J Immunol August 1, 2015, 195 (3) 965-972; DOI: https://doi.org/10.4049/jimmunol.1500591
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    The Mammalian Sterile 20–like 1 Kinase Controls Selective CCR7-Dependent Functions in Human Dendritic Cells
    Jesús Torres-Bacete, Cristina Delgado-Martín, Carolina Gómez-Moreira, Siro Simizu and José Luis Rodríguez-Fernández
    J Immunol August 1, 2015, 195 (3) 973-981; DOI: https://doi.org/10.4049/jimmunol.1401966

IMMUNE SYSTEM DEVELOPMENT

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    BTB-ZF Protein Znf131 Regulates Cell Growth of Developing and Mature T Cells
    Tomohiro Iguchi, Kazuhisa Aoki, Tomokatsu Ikawa, Masato Taoka, Choji Taya, Hiroshi Yoshitani, Makiko Toma-Hirano, Osamu Koiwai, Toshiaki Isobe, Hiroshi Kawamoto, Hisao Masai and Shoichiro Miyatake
    J Immunol August 1, 2015, 195 (3) 982-993; DOI: https://doi.org/10.4049/jimmunol.1500602

IMMUNOTHERAPY AND VACCINES

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    Codelivery of Envelope Protein in Alum with MVA Vaccine Induces CXCR3-Biased CXCR5+ and CXCR5− CD4 T Cell Responses in Rhesus Macaques
    Smita S. Iyer, Sailaja Gangadhara, Blandine Victor, Rosy Gomez, Rahul Basu, Jung Joo Hong, Celia Labranche, David C. Montefiori, Francois Villinger, Bernard Moss and Rama Rao Amara
    J Immunol August 1, 2015, 195 (3) 994-1005; DOI: https://doi.org/10.4049/jimmunol.1500083
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    Targeting Antigen to Clec9A Primes Follicular Th Cell Memory Responses Capable of Robust Recall
    Yu Kato, Ali Zaid, Gayle M. Davey, Scott N. Mueller, Stephen L. Nutt, Dimitra Zotos, David M. Tarlinton, Ken Shortman, Mireille H. Lahoud, William R. Heath and Irina Caminschi
    J Immunol August 1, 2015, 195 (3) 1006-1014; DOI: https://doi.org/10.4049/jimmunol.1500767
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    Human Anti-CD40 Antibody and Poly IC:LC Adjuvant Combination Induces Potent T Cell Responses in the Lung of Nonhuman Primates
    Elizabeth A. Thompson, Frank Liang, Gustaf Lindgren, Kerrie J. Sandgren, Kylie M. Quinn, Patricia A. Darrah, Richard A. Koup, Robert A. Seder, Ross M. Kedl and Karin Loré
    J Immunol August 1, 2015, 195 (3) 1015-1024; DOI: https://doi.org/10.4049/jimmunol.1500078

INFECTIOUS DISEASE AND HOST RESPONSE

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    TLR3-Mediated CD8+ Dendritic Cell Activation Is Coupled with Establishment of a Cell-Intrinsic Antiviral State
    Lajos Széles, Felix Meissner, Isabelle Dunand-Sauthier, Christoph Thelemann, Micha Hersch, Simon Singovski, Sergio Haller, Florian Gobet, Silvia A. Fuertes Marraco, Matthias Mann, Dominique Garcin, Hans Acha-Orbea and Walter Reith
    J Immunol August 1, 2015, 195 (3) 1025-1033; DOI: https://doi.org/10.4049/jimmunol.1402033
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    Differential Interaction of the Staphylococcal Toxins Panton–Valentine Leukocidin and γ-Hemolysin CB with Human C5a Receptors
    András N. Spaan, Ariën Schiepers, Carla J. C. de Haas, Davy D. J. J. van Hooijdonk, Cédric Badiou, Hugues Contamin, François Vandenesch, Gérard Lina, Norma P. Gerard, Craig Gerard, Kok P. M. van Kessel, Thomas Henry and Jos A. G. van Strijp
    J Immunol August 1, 2015, 195 (3) 1034-1043; DOI: https://doi.org/10.4049/jimmunol.1500604
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    Bacterial Membrane Vesicles Mediate the Release of Mycobacterium tuberculosis Lipoglycans and Lipoproteins from Infected Macrophages
    Jaffre J. Athman, Ying Wang, David J. McDonald, W. Henry Boom, Clifford V. Harding and Pamela A. Wearsch
    J Immunol August 1, 2015, 195 (3) 1044-1053; DOI: https://doi.org/10.4049/jimmunol.1402894
  • Open Access
    CD4 T Cell Depletion Substantially Augments the Rescue Potential of PD-L1 Blockade for Deeply Exhausted CD8 T Cells

    Author Choice Article

    Pablo Penaloza-MacMaster, Nicholas M. Provine, Eryn Blass and Dan H. Barouch
    J Immunol August 1, 2015, 195 (3) 1054-1063; DOI: https://doi.org/10.4049/jimmunol.1403237
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    Neonatal CD71+ Erythroid Cells Do Not Modify Murine Sepsis Mortality
    James L. Wynn, Philip O. Scumpia, Blair T. Stocks, Joann Romano-Keeler, Mhd Wael Alrifai, Jin-Hua Liu, Annette S. Kim, Catherine E. Alford, Pranathi Matta, Jörn-Hendrik Weitkamp and Daniel J. Moore
    J Immunol August 1, 2015, 195 (3) 1064-1070; DOI: https://doi.org/10.4049/jimmunol.1500771
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    Cell-Intrinsic gp130 Signaling on CD4+ T Cells Shapes Long-Lasting Antiviral Immunity
    James A. Harker, Kurt A. Wong, Aleksandr Dolgoter and Elina I. Zuniga
    J Immunol August 1, 2015, 195 (3) 1071-1081; DOI: https://doi.org/10.4049/jimmunol.1402402
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    Control of Viremia Enables Acquisition of Resting Memory B Cells with Age and Normalization of Activated B Cell Phenotypes in HIV-Infected Children

    Author Choice Article

    Daniel M. Muema, Gladys N. Macharia, Amin S. Hassan, Shalton M. Mwaringa, Greg W. Fegan, James A. Berkley, Eunice W. Nduati and Britta C. Urban
    J Immunol August 1, 2015, 195 (3) 1082-1091; DOI: https://doi.org/10.4049/jimmunol.1500491

INNATE IMMUNITY AND INFLAMMATION

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    TLR8 Senses Bacterial RNA in Human Monocytes and Plays a Nonredundant Role for Recognition of Streptococcus pyogenes
    Tatjana Eigenbrod, Karin Pelka, Eicke Latz, Bernd Kreikemeyer and Alexander H. Dalpke
    J Immunol August 1, 2015, 195 (3) 1092-1099; DOI: https://doi.org/10.4049/jimmunol.1403173
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    TLR8 Senses Staphylococcus aureus RNA in Human Primary Monocytes and Macrophages and Induces IFN-β Production via a TAK1–IKKβ–IRF5 Signaling Pathway
    Bjarte Bergstrøm, Marie H. Aune, Jane A. Awuh, June F. Kojen, Kjetil J. Blix, Liv Ryan, Trude H. Flo, Tom E. Mollnes, Terje Espevik and Jørgen Stenvik
    J Immunol August 1, 2015, 195 (3) 1100-1111; DOI: https://doi.org/10.4049/jimmunol.1403176
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    Dissecting CD8+ NKT Cell Responses to Listeria Infection Reveals a Component of Innate Resistance
    Sergey S. Seregin, Grace Y. Chen and Yasmina Laouar
    J Immunol August 1, 2015, 195 (3) 1112-1120; DOI: https://doi.org/10.4049/jimmunol.1500084
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    TLR-Stimulated Neutrophils Instruct NK Cells To Trigger Dendritic Cell Maturation and Promote Adaptive T Cell Responses
    Rebecca E. Riise, Elin Bernson, Johan Aurelius, Anna Martner, Silvia Pesce, Mariella Della Chiesa, Emanuela Marcenaro, Johan Bylund, Kristoffer Hellstrand, Lorenzo Moretta, Alessandro Moretta and Fredrik B. Thorén
    J Immunol August 1, 2015, 195 (3) 1121-1128; DOI: https://doi.org/10.4049/jimmunol.1500709
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    Prevention of Defective Placentation and Pregnancy Loss by Blocking Innate Immune Pathways in a Syngeneic Model of Placental Insufficiency
    Shari E. Gelber, Elyssa Brent, Patricia Redecha, Giorgio Perino, Stephen Tomlinson, Robin L. Davisson and Jane E. Salmon
    J Immunol August 1, 2015, 195 (3) 1129-1138; DOI: https://doi.org/10.4049/jimmunol.1402220
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    Definition of a Novel Pathway Centered on Lysophosphatidic Acid To Recruit Monocytes during the Resolution Phase of Tissue Inflammation

    Author Choice Article

    Simon McArthur, Thomas Gobbetti, Dennis H. M. Kusters, Christopher P. Reutelingsperger, Roderick J. Flower and Mauro Perretti
    J Immunol August 1, 2015, 195 (3) 1139-1151; DOI: https://doi.org/10.4049/jimmunol.1500733
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    Cross-Talk between Shp1 and PIPKIγ Controls Leukocyte Recruitment
    Anika Stadtmann, Helena Block, Stephanie Volmering, Clare Abram, Charlotte Sohlbach, Mark Boras, Clifford A. Lowell and Alexander Zarbock
    J Immunol August 1, 2015, 195 (3) 1152-1161; DOI: https://doi.org/10.4049/jimmunol.1500606
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    Heterogeneity in the Locomotory Behavior of Human Monocyte Subsets over Human Vascular Endothelium In Vitro
    Joanna L. Collison, Leo M. Carlin, Martin Eichmann, Frederic Geissmann and Mark Peakman
    J Immunol August 1, 2015, 195 (3) 1162-1170; DOI: https://doi.org/10.4049/jimmunol.1401806
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    Properdin Contributes to Allergic Airway Inflammation through Local C3a Generation
    Yuan Wang, Takashi Miwa, Blerina Ducka-Kokalari, Imre G. Redai, Sayaka Sato, Damodar Gullipalli, James G. Zangrilli, Angela Haczku and Wen-Chao Song
    J Immunol August 1, 2015, 195 (3) 1171-1181; DOI: https://doi.org/10.4049/jimmunol.1401819
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    TGF-β–Dependent Dendritic Cell Chemokinesis in Murine Models of Airway Disease
    Mitsuo Hashimoto, Haruhiko Yanagisawa, Shunsuke Minagawa, Debasish Sen, Royce Ma, Lynne A. Murray, Ping Tsui, Jianlong Lou, James D. Marks, Jody L. Baron, Matthew F. Krummel and Stephen L. Nishimura
    J Immunol August 1, 2015, 195 (3) 1182-1190; DOI: https://doi.org/10.4049/jimmunol.1500348
  • Open Access
    P2X7 Receptor Regulates Internalization of Antimicrobial Peptide LL-37 by Human Macrophages That Promotes Intracellular Pathogen Clearance

    Author Choice Article

    Xiao Tang, Devaraj Basavarajappa, Jesper Z. Haeggström and Min Wan
    J Immunol August 1, 2015, 195 (3) 1191-1201; DOI: https://doi.org/10.4049/jimmunol.1402845
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    Ca2+ Signaling but Not Store-Operated Ca2+ Entry Is Required for the Function of Macrophages and Dendritic Cells
    Martin Vaeth, Isabelle Zee, Axel R. Concepcion, Mate Maus, Patrick Shaw, Cynthia Portal-Celhay, Aleena Zahra, Lina Kozhaya, Carl Weidinger, Jennifer Philips, Derya Unutmaz and Stefan Feske
    J Immunol August 1, 2015, 195 (3) 1202-1217; DOI: https://doi.org/10.4049/jimmunol.1403013
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    IL-10 Production in Macrophages Is Regulated by a TLR-Driven CREB-Mediated Mechanism That Is Linked to Genes Involved in Cell Metabolism

    Author Choice Article

    David E. Sanin, Catriona T. Prendergast and Adrian P. Mountford
    J Immunol August 1, 2015, 195 (3) 1218-1232; DOI: https://doi.org/10.4049/jimmunol.1500146
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    Deficient NLRP3 and AIM2 Inflammasome Function in Autoimmune NZB Mice
    David P. Sester, Vitaliya Sagulenko, Sara J. Thygesen, Jasmyn A. Cridland, Yen Siew Loi, Simon O. Cridland, Seth L. Masters, Ulrich Genske, Veit Hornung, Christopher E. Andoniou, Matthew J. Sweet, Mariapia A. Degli-Esposti, Kate Schroder and Katryn J. Stacey
    J Immunol August 1, 2015, 195 (3) 1233-1241; DOI: https://doi.org/10.4049/jimmunol.1402859

MOLECULAR AND STRUCTURAL IMMUNOLOGY

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    KIR3DS1-Specific D0 Domain Polymorphisms Disrupt KIR3DL1 Surface Expression and HLA Binding
    Tiernan J. Mulrooney, Aaron C. Zhang, Yehuda Goldgur, Jeanette E. Boudreau and Katharine C. Hsu
    J Immunol August 1, 2015, 195 (3) 1242-1250; DOI: https://doi.org/10.4049/jimmunol.1500243
  • Open Access
    The Thermodynamic Mechanism of Peptide–MHC Class II Complex Formation Is a Determinant of Susceptibility to HLA-DM

    Author Choice Article

    Andrea Ferrante, Megan Templeton, Megan Hoffman and Margaret J. Castellini
    J Immunol August 1, 2015, 195 (3) 1251-1261; DOI: https://doi.org/10.4049/jimmunol.1402367
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    Domain-Specific and Stage-Intrinsic Changes in Tcrb Conformation during Thymocyte Development
    Kinjal Majumder, Levi J. Rupp, Katherine S. Yang-Iott, Olivia I. Koues, Katherine E. Kyle, Craig H. Bassing and Eugene M. Oltz
    J Immunol August 1, 2015, 195 (3) 1262-1272; DOI: https://doi.org/10.4049/jimmunol.1500692
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    Spred1, a Suppressor of the Ras–ERK Pathway, Negatively Regulates Expansion and Function of Group 2 Innate Lymphoid Cells
    Mayu Suzuki, Rimpei Morita, Yasuko Hirata, Takashi Shichita and Akihiko Yoshimura
    J Immunol August 1, 2015, 195 (3) 1273-1281; DOI: https://doi.org/10.4049/jimmunol.1500531

TRANSPLANTATION

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    Rapid Functional Decline of Activated and Memory Graft-versus-Host–Reactive T Cells Encountering Host Antigens in the Absence of Inflammation
    Hao Wei Li, Giovanna Andreola, Alicia L. Carlson, Steven Shao, Charles P. Lin, Guiling Zhao and Megan Sykes
    J Immunol August 1, 2015, 195 (3) 1282-1292; DOI: https://doi.org/10.4049/jimmunol.1401511

TUMOR IMMUNOLOGY

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    Regulatory Rebound in IL-12–Treated Tumors Is Driven by Uncommitted Peripheral Regulatory T Cells
    Qingsheng Li, Lauren P. Virtuoso, Charles D. Anderson and Nejat K. Egilmez
    J Immunol August 1, 2015, 195 (3) 1293-1300; DOI: https://doi.org/10.4049/jimmunol.1403078
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    MicroRNA-9 Regulates the Differentiation and Function of Myeloid-Derived Suppressor Cells via Targeting Runx1
    Jie Tian, Ke Rui, Xinyi Tang, Jie Ma, Yungang Wang, Xinyu Tian, Yue Zhang, Huaxi Xu, Liwei Lu and Shengjun Wang
    J Immunol August 1, 2015, 195 (3) 1301-1311; DOI: https://doi.org/10.4049/jimmunol.1500209
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    Primary Central Nervous System (CNS) Lymphoma B Cell Receptors Recognize CNS Proteins
    Manuel Montesinos-Rongen, Frauke G. Purschke, Anna Brunn, Caroline May, Eckhard Nordhoff, Katrin Marcus and Martina Deckert
    J Immunol August 1, 2015, 195 (3) 1312-1319; DOI: https://doi.org/10.4049/jimmunol.1402341

NOVEL IMMUNOLOGICAL METHODS

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    Imaging of Cell–Cell Communication in a Vertical Orientation Reveals High-Resolution Structure of Immunological Synapse and Novel PD-1 Dynamics
    Joon Hee Jang, Yu Huang, Peilin Zheng, Myeong Chan Jo, Grant Bertolet, Michael Xi Zhu, Lidong Qin and Dongfang Liu
    J Immunol August 1, 2015, 195 (3) 1320-1330; DOI: https://doi.org/10.4049/jimmunol.1403143

CORRECTIONS

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    Correction: Phosphatase Holoenzyme PP1/GADD34 Negatively Regulates TLR Response by Inhibiting TAK1 Serine 412 Phosphorylation
    Meidi Gu, Chuan Ouyang, Wenlong Lin, Ting Zhang, Xuetao Cao, Zongping Xia and Xiaojian Wang
    J Immunol August 1, 2015, 195 (3) 1331-1332; DOI: https://doi.org/10.4049/jimmunol.1501233
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The Journal of Immunology: 195 (3)
The Journal of Immunology
Vol. 195, Issue 3
1 Aug 2015
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  • IN THIS ISSUE
  • TRANSLATING IMMUNOLOGY
  • PILLARS OF IMMUNOLOGY
  • BRIEF REVIEWS
  • CUTTING EDGE
  • ANTIGEN RECOGNITION AND RESPONSES
  • AUTOIMMUNITY
  • CLINICAL AND HUMAN IMMUNOLOGY
  • IMMUNE REGULATION
  • IMMUNE SYSTEM DEVELOPMENT
  • IMMUNOTHERAPY AND VACCINES
  • INFECTIOUS DISEASE AND HOST RESPONSE
  • INNATE IMMUNITY AND INFLAMMATION
  • MOLECULAR AND STRUCTURAL IMMUNOLOGY
  • TRANSPLANTATION
  • TUMOR IMMUNOLOGY
  • NOVEL IMMUNOLOGICAL METHODS
  • CORRECTIONS
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Immunodominant AH1 Antigen-Deficient Necroptotic, but Not Apoptotic, Murine Cancer Cells Induce Antitumor Protection
Osteoclasts Derive Predominantly from Bone Marrow–Resident CX3CR1+ Precursor Cells in Homeostasis, whereas Circulating CX3CR1+ Cells Contribute to Osteoclast Development during Fracture Repair
Intracellular IL-1 Receptor Antagonist Isoform 1 Released from Keratinocytes upon Cell Death Acts as an Inhibitor for the Alarmin IL-1α
Polysaccharide Capsules Equip the Human Symbiont Bacteroides thetaiotaomicron to Modulate Immune Responses to a Dominant Antigen in the Intestine
Natural and Induced Tolerogenic Dendritic Cells
Cutting Edge: IL-6–Driven Immune Dysregulation Is Strictly Dependent on IL-6R α-Chain Expression

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